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Fusion gene ID: 33606 |
FusionGeneSummary for SGTA_YIPF3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SGTA_YIPF3 | Fusion gene ID: 33606 | Hgene | Tgene | Gene symbol | SGTA | YIPF3 | Gene ID | 6449 | 25844 |
| Gene name | small glutamine rich tetratricopeptide repeat containing alpha | Yip1 domain family member 3 | |
| Synonyms | SGT|alphaSGT|hSGT | C6orf109|FinGER3|KLIP1|dJ337H4.3 | |
| Cytomap | 19p13.3 | 6p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | small glutamine-rich tetratricopeptide repeat-containing protein alphaUBPalpha-SGTprotein containing three tetratricopeptide repeatssmall glutamine-rich tetratricopeptide repeat (TPR)-containing, alphavpu-binding protein | protein YIPF3killer lineage protein 1natural killer cell-specific antigen KLIP1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O43765 | Q9GZM5 | |
| Ensembl transtripts involved in fusion gene | ENST00000221566, ENST00000586711, | ENST00000372422, ENST00000506469, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 1=4 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: SGTA [Title/Abstract] AND YIPF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SGTA | GO:0030433 | ubiquitin-dependent ERAD pathway | 23129660 |
| Hgene | SGTA | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process | 23129660 |
| Hgene | SGTA | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process | 23129660 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM729296 | SGTA | chr19 | 2762041 | - | YIPF3 | chr6 | 43481371 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000221566 | ENST00000372422 | SGTA | chr19 | 2762041 | - | YIPF3 | chr6 | 43481371 | - |
| intron-3CDS | ENST00000221566 | ENST00000506469 | SGTA | chr19 | 2762041 | - | YIPF3 | chr6 | 43481371 | - |
| intron-3CDS | ENST00000586711 | ENST00000372422 | SGTA | chr19 | 2762041 | - | YIPF3 | chr6 | 43481371 | - |
| intron-3CDS | ENST00000586711 | ENST00000506469 | SGTA | chr19 | 2762041 | - | YIPF3 | chr6 | 43481371 | - |
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FusionProtFeatures for SGTA_YIPF3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SGTA | YIPF3 |
| Co-chaperone that binds misfolded and hydrophobicpatches-containing client proteins in the cytosol. Mediates theirtargeting to the endoplasmic reticulum but also regulates theirsorting to the proteasome when targeting fails (PubMed:28104892).Functions in tail-anchored/type II transmembrane proteins membraneinsertion constituting with ASNA1 and the BAG6 complex a targetingmodule (PubMed:28104892). Functions upstream of the BAG6 complexand ASNA1, binding more rapidly the transmembrane domain of newlysynthesized proteins (PubMed:28104892, PubMed:25535373). It isalso involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interactionwith BAG6: collaborates with the BAG6 complex to maintainhydrophobic substrates in non-ubiquitinated states(PubMed:23129660, PubMed:25179605). Competes with RNF126 forinteraction with BAG6, preventing the ubiquitination of clientproteins associated with the BAG6 complex (PubMed:27193484). Bindsdirectly to HSC70 and HSP70 and regulates their ATPase activity(PubMed:18759457). {ECO:0000269|PubMed:18759457,ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:25179605,ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:27193484,ECO:0000269|PubMed:28104892}. (Microbial infection) In case of infection bypolyomavirus, involved in the virus endoplasmic reticulum membranepenetration and infection via interaction with DNAJB12, DNAJB14and HSPA8/Hsc70 (PubMed:24675744). {ECO:0000269|PubMed:24675744}. | Involved in the maintenance of the Golgi structure. Mayplay a role in hematopoiesis. {ECO:0000269|PubMed:12490290,ECO:0000269|PubMed:21757827}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SGTA_YIPF3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SGTA_YIPF3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SGTA_YIPF3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SGTA_YIPF3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | YIPF3 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
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