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Fusion gene ID: 336 |
FusionGeneSummary for ACADL_MAML2 |
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Fusion gene information | Fusion gene name: ACADL_MAML2 | Fusion gene ID: 336 | Hgene | Tgene | Gene symbol | ACADL | MAML2 | Gene ID | 33 | 84441 |
Gene name | acyl-CoA dehydrogenase long chain | mastermind like transcriptional coactivator 2 | |
Synonyms | ACAD4|LCAD | MAM-3|MAM2|MAM3|MLL-MAML2 | |
Cytomap | 2q34 | 11q21 | |
Type of gene | protein-coding | protein-coding | |
Description | long-chain specific acyl-CoA dehydrogenase, mitochondrialacyl-Coenzyme A dehydrogenase, long chain | mastermind-like protein 2mam-2mastermind-like 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P28330 | Q8IZL2 | |
Ensembl transtripts involved in fusion gene | ENST00000233710, | ENST00000524717, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 10 X 12 X 4=480 |
# samples | 1 | 16 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(16/480*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACADL [Title/Abstract] AND MAML2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | MAML2 | GO:0007219 | Notch signaling pathway | 12370315 |
Tgene | MAML2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12370315 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ343589 | ACADL | chr2 | 211069357 | - | MAML2 | chr11 | 95805643 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000233710 | ENST00000524717 | ACADL | chr2 | 211069357 | - | MAML2 | chr11 | 95805643 | - |
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FusionProtFeatures for ACADL_MAML2 |
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Hgene | Tgene |
ACADL | MAML2 |
Acts as a transcriptional coactivator for NOTCHproteins. Has been shown to amplify NOTCH-induced transcription ofHES1. Potentiates activation by NOTCH3 and NOTCH4 more efficientlythan MAML1 or MAML3. {ECO:0000269|PubMed:12370315,ECO:0000269|PubMed:12386158, ECO:0000269|PubMed:12539049}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACADL_MAML2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACADL_MAML2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACADL_MAML2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACADL_MAML2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MAML2 | C3495559 | Juvenile arthritis | 1 | CTD_human |