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Fusion gene ID: 33580 |
FusionGeneSummary for SGOL2_FBXO8 |
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Fusion gene information | Fusion gene name: SGOL2_FBXO8 | Fusion gene ID: 33580 | Hgene | Tgene | Gene symbol | SGOL2 | FBXO8 | Gene ID | 151246 | 26269 |
Gene name | shugoshin 2 | F-box protein 8 | |
Synonyms | SGOL2|TRIPIN | DC10|FBS|FBX8 | |
Cytomap | 2q33.1 | 4q34.1 | |
Type of gene | protein-coding | protein-coding | |
Description | shugoshin 2shugoshin-like 2 | F-box only protein 8F-box protein Fbx8F-box/SEC7 protein FBS | |
Modification date | 20180522 | 20180519 | |
UniProtAcc | Q9NRD0 | ||
Ensembl transtripts involved in fusion gene | ENST00000357799, ENST00000409203, ENST00000469840, | ENST00000393674, ENST00000503293, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 1 X 1 X 1=1 |
# samples | 1 | 1 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: SGOL2 [Title/Abstract] AND FBXO8 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-YL-A8SC-01A | SGOL2 | chr2 | 201390975 | + | FBXO8 | chr4 | 175184251 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000357799 | ENST00000393674 | SGOL2 | chr2 | 201390975 | + | FBXO8 | chr4 | 175184251 | - |
5UTR-5UTR | ENST00000357799 | ENST00000503293 | SGOL2 | chr2 | 201390975 | + | FBXO8 | chr4 | 175184251 | - |
5UTR-5UTR | ENST00000409203 | ENST00000393674 | SGOL2 | chr2 | 201390975 | + | FBXO8 | chr4 | 175184251 | - |
5UTR-5UTR | ENST00000409203 | ENST00000503293 | SGOL2 | chr2 | 201390975 | + | FBXO8 | chr4 | 175184251 | - |
intron-5UTR | ENST00000469840 | ENST00000393674 | SGOL2 | chr2 | 201390975 | + | FBXO8 | chr4 | 175184251 | - |
intron-5UTR | ENST00000469840 | ENST00000503293 | SGOL2 | chr2 | 201390975 | + | FBXO8 | chr4 | 175184251 | - |
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FusionProtFeatures for SGOL2_FBXO8 |
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Hgene | Tgene |
SGOL2 | FBXO8 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | May promote guanine-nucleotide exchange on an ARF.Promotes the activation of ARF through replacement of GDP with GTP(Potential). {ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SGOL2_FBXO8 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SGOL2_FBXO8 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SGOL2 | TUSC2, CDCA8, ALB, SOX2, WDR83, GNB2, HEPHL1, HIST1H2BJ, PPP2R1B, PKP1, EIF1AX, LYPLA2, SERPINB5, ARL8B, PPP2CA, PREP, SELENBP1, LYG2, PADI3, CSNK1E, DUSP14, PKP3, LRRC15, HIST2H3PS2, H3F3B, SERPINB13, DSG4, VSIG8, PLP2, CASQ2, IER2, HIST1H2BG, PPP2R1A, SPATS2L, PPP2R2D, RGN, FAM26D | FBXO8 | SKP1, CUL1, ARF6, MYC, ELAVL1, PTAR1, MTOR, BIN3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SGOL2_FBXO8 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SGOL2_FBXO8 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |