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Fusion gene ID: 3356 |
FusionGeneSummary for ATP2B4_CCNI |
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Fusion gene information | Fusion gene name: ATP2B4_CCNI | Fusion gene ID: 3356 | Hgene | Tgene | Gene symbol | ATP2B4 | CCNI | Gene ID | 493 | 10983 |
Gene name | ATPase plasma membrane Ca2+ transporting 4 | cyclin I | |
Synonyms | ATP2B2|MXRA1|PMCA4|PMCA4b|PMCA4x | CCNI1|CYC1|CYI | |
Cytomap | 1q32.1 | 4q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | plasma membrane calcium-transporting ATPase 4ATPase, Ca++ transporting, plasma membrane 4matrix-remodeling-associated protein 1sarcolemmal calcium pump | cyclin-Icyclin ITI | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P23634 | Q14094 | |
Ensembl transtripts involved in fusion gene | ENST00000357681, ENST00000391954, ENST00000367218, ENST00000367219, ENST00000341360, ENST00000466407, | ENST00000237654, ENST00000537948, ENST00000504697, | |
Fusion gene scores | * DoF score | 8 X 4 X 6=192 | 4 X 4 X 2=32 |
# samples | 8 | 4 | |
** MAII score | log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ATP2B4 [Title/Abstract] AND CCNI [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ATP2B4 | GO:0006874 | cellular calcium ion homeostasis | 19278978 |
Hgene | ATP2B4 | GO:0010751 | negative regulation of nitric oxide mediated signal transduction | 19278978 |
Hgene | ATP2B4 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19278978 |
Hgene | ATP2B4 | GO:0045019 | negative regulation of nitric oxide biosynthetic process | 11591728|19278978 |
Hgene | ATP2B4 | GO:0051001 | negative regulation of nitric-oxide synthase activity | 11591728|17242280|19278978|19287093 |
Hgene | ATP2B4 | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade | 19287093 |
Hgene | ATP2B4 | GO:0071872 | cellular response to epinephrine stimulus | 19278978 |
Hgene | ATP2B4 | GO:0098736 | negative regulation of the force of heart contraction | 17242280 |
Hgene | ATP2B4 | GO:0140199 | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process | 17242280 |
Hgene | ATP2B4 | GO:1900082 | negative regulation of arginine catabolic process | 19278978 |
Hgene | ATP2B4 | GO:1903249 | negative regulation of citrulline biosynthetic process | 19278978 |
Hgene | ATP2B4 | GO:2000481 | positive regulation of cAMP-dependent protein kinase activity | 19278978 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-HU-A4GH-01A | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-5UTR | ENST00000357681 | ENST00000237654 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
5UTR-intron | ENST00000357681 | ENST00000537948 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
5UTR-intron | ENST00000357681 | ENST00000504697 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
5UTR-5UTR | ENST00000391954 | ENST00000237654 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
5UTR-intron | ENST00000391954 | ENST00000537948 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
5UTR-intron | ENST00000391954 | ENST00000504697 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
5UTR-5UTR | ENST00000367218 | ENST00000237654 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
5UTR-intron | ENST00000367218 | ENST00000537948 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
5UTR-intron | ENST00000367218 | ENST00000504697 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
5UTR-5UTR | ENST00000367219 | ENST00000237654 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
5UTR-intron | ENST00000367219 | ENST00000537948 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
5UTR-intron | ENST00000367219 | ENST00000504697 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
intron-5UTR | ENST00000341360 | ENST00000237654 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
intron-intron | ENST00000341360 | ENST00000537948 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
intron-intron | ENST00000341360 | ENST00000504697 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
intron-5UTR | ENST00000466407 | ENST00000237654 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
intron-intron | ENST00000466407 | ENST00000537948 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
intron-intron | ENST00000466407 | ENST00000504697 | ATP2B4 | chr1 | 203596347 | + | CCNI | chr4 | 77987558 | - |
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FusionProtFeatures for ATP2B4_CCNI |
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Hgene | Tgene |
ATP2B4 | CCNI |
Calcium/calmodulin-regulated and magnesium-dependentenzyme that catalyzes the hydrolysis of ATP coupled with thetransport of calcium out of the cell (PubMed:8530416). Byregulating sperm cell calcium homeostasis, may play a role insperm motility (By similarity). {ECO:0000250|UniProtKB:Q6Q477,ECO:0000269|PubMed:8530416}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATP2B4_CCNI |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATP2B4_CCNI |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ATP2B4 | DLG1, CASK, DLG2, DLG3, ERBB2IP, ADRB2, CDK7, LGALS3, BSG, LGALS8, TAS2R7, EDA2R, HSD17B6, LGALS9, AGTR1, LGALS9C, SLC39A4, LYPD3, DLK1, WBP1, PTGER3, TMEM52B, ATP1A1, ATP9A, HM13, ATP5J, CANX, CLGN, TMEM17, EGFR, CDH1, CTDSPL, ATP2B2, TMEM5, LPAR1, LILRB4, FPR2, IPPK, FAM174A, C3AR1, GPC1, CYP2B6, PCDHGB1, APLNR, KCNA5, NMUR2, HTR3A, VAC14, TRIM25 | CCNI | CEP63, ELAVL1, KRT18, CDC25A, IL1RAP, NXF1, CDK5, AKT1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATP2B4_CCNI |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP2B4_CCNI |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |