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Fusion gene ID: 33548 |
FusionGeneSummary for SFXN5_TMEM150A |
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Fusion gene information | Fusion gene name: SFXN5_TMEM150A | Fusion gene ID: 33548 | Hgene | Tgene | Gene symbol | SFXN5 | TMEM150A | Gene ID | 94097 | 129303 |
Gene name | sideroflexin 5 | transmembrane protein 150A | |
Synonyms | BBG-TCC|SLC56A5 | TM6P1|TMEM150|TTN1 | |
Cytomap | 2p13.2 | 2p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | sideroflexin-5 | transmembrane protein 150Afasting-inducible integral membrane protein TM6P1tentonin 1transmembrane protein 150 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8TD22 | Q86TG1 | |
Ensembl transtripts involved in fusion gene | ENST00000474528, ENST00000272433, ENST00000410065, | ENST00000306353, ENST00000334462, ENST00000409668, | |
Fusion gene scores | * DoF score | 8 X 8 X 6=384 | 2 X 2 X 2=8 |
# samples | 9 | 2 | |
** MAII score | log2(9/384*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: SFXN5 [Title/Abstract] AND TMEM150A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TMEM150A | GO:0072659 | protein localization to plasma membrane | 25608530 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-75-6211-01A | SFXN5 | chr2 | 73297589 | - | TMEM150A | chr2 | 85829187 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000474528 | ENST00000306353 | SFXN5 | chr2 | 73297589 | - | TMEM150A | chr2 | 85829187 | - |
intron-5UTR | ENST00000474528 | ENST00000334462 | SFXN5 | chr2 | 73297589 | - | TMEM150A | chr2 | 85829187 | - |
intron-5UTR | ENST00000474528 | ENST00000409668 | SFXN5 | chr2 | 73297589 | - | TMEM150A | chr2 | 85829187 | - |
intron-5UTR | ENST00000272433 | ENST00000306353 | SFXN5 | chr2 | 73297589 | - | TMEM150A | chr2 | 85829187 | - |
intron-5UTR | ENST00000272433 | ENST00000334462 | SFXN5 | chr2 | 73297589 | - | TMEM150A | chr2 | 85829187 | - |
intron-5UTR | ENST00000272433 | ENST00000409668 | SFXN5 | chr2 | 73297589 | - | TMEM150A | chr2 | 85829187 | - |
intron-5UTR | ENST00000410065 | ENST00000306353 | SFXN5 | chr2 | 73297589 | - | TMEM150A | chr2 | 85829187 | - |
intron-5UTR | ENST00000410065 | ENST00000334462 | SFXN5 | chr2 | 73297589 | - | TMEM150A | chr2 | 85829187 | - |
intron-5UTR | ENST00000410065 | ENST00000409668 | SFXN5 | chr2 | 73297589 | - | TMEM150A | chr2 | 85829187 | - |
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FusionProtFeatures for SFXN5_TMEM150A |
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Hgene | Tgene |
SFXN5 | TMEM150A |
Transports citrate. Potential iron transporter (Bysimilarity). {ECO:0000250}. | Regulates localization of phosphatidylinositol 4-kinase(PI4K) to the plasma membrane, possibly by reducing theassociation of TTC7 (TTC7A or TTC7B) with the PI4K complex(PubMed:25608530). Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:25608530). May also playa role in fasting-induced catabolism (By similarity).{ECO:0000250|UniProtKB:Q9QZE9, ECO:0000269|PubMed:25608530}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SFXN5_TMEM150A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SFXN5_TMEM150A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SFXN5 | FAS, LPAR6, SLC18A1, ERGIC3, TNF, LAMP2, SLC6A15, C1orf85, SLC39A9, SLC5A5, SLC15A1, APLNR, TMEM108, PON1, MAS1, SLC2A12, ACTB, CTSA, GLB1, SLC22A6, VSIG1, HTR2C, TRIM25 | TMEM150A | ADAMTSL4, KRTAP10-8, NOTCH2NL, YY1, CCNT1, HELLS, ACOX3, MIS18A, GOSR1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SFXN5_TMEM150A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SFXN5_TMEM150A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |