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Fusion gene ID: 33540 |
FusionGeneSummary for SFXN3_RCHY1 |
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Fusion gene information | Fusion gene name: SFXN3_RCHY1 | Fusion gene ID: 33540 | Hgene | Tgene | Gene symbol | SFXN3 | RCHY1 | Gene ID | 81855 | 25898 |
Gene name | sideroflexin 3 | ring finger and CHY zinc finger domain containing 1 | |
Synonyms | BA108L7.2|SFX3|SLC56A3 | ARNIP|CHIMP|PIRH2|PRO1996|RNF199|ZCHY|ZNF363 | |
Cytomap | 10q24.31 | 4q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | sideroflexin-3 | RING finger and CHY zinc finger domain-containing protein 1CH-rich interacting match with PLAG1E3 ubiquitin-protein ligase Pirh2RING finger protein 199RING-type E3 ubiquitin transferase RCHY1androgen-receptor N-terminal-interacting proteinp53-induce | |
Modification date | 20180519 | 20180522 | |
UniProtAcc | Q9BWM7 | Q96PM5 | |
Ensembl transtripts involved in fusion gene | ENST00000393459, ENST00000224807, ENST00000466982, | ENST00000324439, ENST00000451788, ENST00000380840, ENST00000512706, ENST00000513257, ENST00000514021, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: SFXN3 [Title/Abstract] AND RCHY1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RCHY1 | GO:0006511 | ubiquitin-dependent protein catabolic process | 19483087 |
Tgene | RCHY1 | GO:0016567 | protein ubiquitination | 19043414|19483087 |
Tgene | RCHY1 | GO:0031398 | positive regulation of protein ubiquitination | 19483087 |
Tgene | RCHY1 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 19483087 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CA425666 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000393459 | ENST00000324439 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
3UTR-3UTR | ENST00000393459 | ENST00000451788 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
3UTR-3UTR | ENST00000393459 | ENST00000380840 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
3UTR-intron | ENST00000393459 | ENST00000512706 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
3UTR-intron | ENST00000393459 | ENST00000513257 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
3UTR-intron | ENST00000393459 | ENST00000514021 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
3UTR-3UTR | ENST00000224807 | ENST00000324439 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
3UTR-3UTR | ENST00000224807 | ENST00000451788 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
3UTR-3UTR | ENST00000224807 | ENST00000380840 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
3UTR-intron | ENST00000224807 | ENST00000512706 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
3UTR-intron | ENST00000224807 | ENST00000513257 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
3UTR-intron | ENST00000224807 | ENST00000514021 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
intron-3UTR | ENST00000466982 | ENST00000324439 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
intron-3UTR | ENST00000466982 | ENST00000451788 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
intron-3UTR | ENST00000466982 | ENST00000380840 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
intron-intron | ENST00000466982 | ENST00000512706 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
intron-intron | ENST00000466982 | ENST00000513257 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
intron-intron | ENST00000466982 | ENST00000514021 | SFXN3 | chr10 | 102800777 | - | RCHY1 | chr4 | 76407301 | + |
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FusionProtFeatures for SFXN3_RCHY1 |
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Hgene | Tgene |
SFXN3 | RCHY1 |
Potential iron transporter. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SFXN3_RCHY1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SFXN3_RCHY1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SFXN3_RCHY1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SFXN3_RCHY1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |