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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33529

FusionGeneSummary for SFTPB_USP39

check button Fusion gene summary
Fusion gene informationFusion gene name: SFTPB_USP39
Fusion gene ID: 33529
HgeneTgene
Gene symbol

SFTPB

USP39

Gene ID

6439

10713

Gene namesurfactant protein Bubiquitin specific peptidase 39
SynonymsPSP-B|SFTB3|SFTP3|SMDP1|SP-B65K|CGI-21|HSPC332|SAD1|SNRNP65
Cytomap

2p11.2

2p11.2

Type of geneprotein-codingprotein-coding
Descriptionpulmonary surfactant-associated protein B18 kDa pulmonary-surfactant protein6 kDa proteinpulmonary surfactant-associated proteolipid SPL(Phe)U4/U6.U5 tri-snRNP-associated protein 2SAD1 homologSnRNP assembly defective 1 homologU4/U6.U5 tri-snRNP-associated 65 kDa proteininactive ubiquitin-specific peptidase 39small nuclear ribonucleoprotein 65kDa (U4/U6.U5)ubiquitin specific protease 39
Modification date2018052320180522
UniProtAcc

P07988

Q53GS9

Ensembl transtripts involved in fusion geneENST00000519937, ENST00000342375, 
ENST00000393822, ENST00000409383, 
ENST00000459775, ENST00000450066, 
ENST00000409025, ENST00000409470, 
ENST00000323701, ENST00000409766, 
Fusion gene scores* DoF score15 X 13 X 2=3906 X 6 X 4=144
# samples 166
** MAII scorelog2(16/390*10)=-1.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SFTPB [Title/Abstract] AND USP39 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-99-8025-01ASFTPBchr2

85890469

-USP39chr2

85868099

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000519937ENST00000459775SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000519937ENST00000450066SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000519937ENST00000409025SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000519937ENST00000409470SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000519937ENST00000323701SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000519937ENST00000409766SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000342375ENST00000459775SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000342375ENST00000450066SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000342375ENST00000409025SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000342375ENST00000409470SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000342375ENST00000323701SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000342375ENST00000409766SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000393822ENST00000459775SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000393822ENST00000450066SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000393822ENST00000409025SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000393822ENST00000409470SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000393822ENST00000323701SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000393822ENST00000409766SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000409383ENST00000459775SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000409383ENST00000450066SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000409383ENST00000409025SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000409383ENST00000409470SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000409383ENST00000323701SFTPBchr2

85890469

-USP39chr2

85868099

+
5CDS-3UTRENST00000409383ENST00000409766SFTPBchr2

85890469

-USP39chr2

85868099

+

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FusionProtFeatures for SFTPB_USP39


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SFTPB

P07988

USP39

Q53GS9

Pulmonary surfactant-associated proteins promotealveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases thecollapse pressure of palmitic acid to nearly 70 millinewtons permeter.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SFTPB_USP39


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SFTPB_USP39


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SFTPBUSP39CD2BP2, PA2G4, TP53, PRPF4B, SART1, PRPF4, PRPF3, EFTUD2, ZRANB2, SNRNP40, DDX23, DHX38, PRPF8, USP12, TXNL4A, SNRNP27, SNRNP200, RRP8, PRPF6, PRPF31, LSM8, GAR1, TRMT10C, RNMTL1, COPRS, DDX24, NOC3L, TSR2, RPL22L1, MEPCE, SART3, CAND1, RNU4ATAC, RNU6ATAC, APP, SF3B6, SRSF11, SF3A1, SRSF3, SRSF5, SF3B1, RBM39, DHX9, SRSF7, HNRNPC, HNRNPU, NCSTN, SON, GTF3C1, SAFB, TPBG, TRIM55, ZC3H18, SRSF10, VTN, SUPT16H, CETN2, TRAF6, TRIM25, TRIM26, TRIM39, TRIM8, TRIM5, FN1, MMS19, SP1, SRPK1, WWOX, PTEN, SAE1, CUL7, OBSL1, CCDC8, ADARB1, CSNK1E, LGALS9, NSUN2, PCNA, APEH, ARF1, HSPA4, HSPH1, NCAPD3, PRPF19, RUVBL2, NTRK1, SCARNA22, SRPK2, CDC5L, NCL, EAPP, ZNHIT2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SFTPB_USP39


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SFTPB_USP39


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSFTPBC0019284Diaphragmatic Hernia2CTD_human
HgeneSFTPBC0024115Lung diseases1CTD_human
HgeneSFTPBC0024121Lung Neoplasms1CTD_human
HgeneSFTPBC1968602Surfactant Metabolism Dysfunction, Pulmonary, 11CTD_human;ORPHANET;UNIPROT