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Fusion gene ID: 33529 |
FusionGeneSummary for SFTPB_USP39 |
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Fusion gene information | Fusion gene name: SFTPB_USP39 | Fusion gene ID: 33529 | Hgene | Tgene | Gene symbol | SFTPB | USP39 | Gene ID | 6439 | 10713 |
Gene name | surfactant protein B | ubiquitin specific peptidase 39 | |
Synonyms | PSP-B|SFTB3|SFTP3|SMDP1|SP-B | 65K|CGI-21|HSPC332|SAD1|SNRNP65 | |
Cytomap | 2p11.2 | 2p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | pulmonary surfactant-associated protein B18 kDa pulmonary-surfactant protein6 kDa proteinpulmonary surfactant-associated proteolipid SPL(Phe) | U4/U6.U5 tri-snRNP-associated protein 2SAD1 homologSnRNP assembly defective 1 homologU4/U6.U5 tri-snRNP-associated 65 kDa proteininactive ubiquitin-specific peptidase 39small nuclear ribonucleoprotein 65kDa (U4/U6.U5)ubiquitin specific protease 39 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P07988 | Q53GS9 | |
Ensembl transtripts involved in fusion gene | ENST00000519937, ENST00000342375, ENST00000393822, ENST00000409383, | ENST00000459775, ENST00000450066, ENST00000409025, ENST00000409470, ENST00000323701, ENST00000409766, | |
Fusion gene scores | * DoF score | 15 X 13 X 2=390 | 6 X 6 X 4=144 |
# samples | 16 | 6 | |
** MAII score | log2(16/390*10)=-1.28540221886225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SFTPB [Title/Abstract] AND USP39 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-99-8025-01A | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000519937 | ENST00000459775 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000519937 | ENST00000450066 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000519937 | ENST00000409025 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000519937 | ENST00000409470 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000519937 | ENST00000323701 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000519937 | ENST00000409766 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000342375 | ENST00000459775 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000342375 | ENST00000450066 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000342375 | ENST00000409025 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000342375 | ENST00000409470 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000342375 | ENST00000323701 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000342375 | ENST00000409766 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000393822 | ENST00000459775 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000393822 | ENST00000450066 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000393822 | ENST00000409025 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000393822 | ENST00000409470 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000393822 | ENST00000323701 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000393822 | ENST00000409766 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000409383 | ENST00000459775 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000409383 | ENST00000450066 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000409383 | ENST00000409025 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000409383 | ENST00000409470 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000409383 | ENST00000323701 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
5CDS-3UTR | ENST00000409383 | ENST00000409766 | SFTPB | chr2 | 85890469 | - | USP39 | chr2 | 85868099 | + |
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FusionProtFeatures for SFTPB_USP39 |
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Hgene | Tgene |
SFTPB | USP39 |
Pulmonary surfactant-associated proteins promotealveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases thecollapse pressure of palmitic acid to nearly 70 millinewtons permeter. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SFTPB_USP39 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SFTPB_USP39 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SFTPB | USP39 | CD2BP2, PA2G4, TP53, PRPF4B, SART1, PRPF4, PRPF3, EFTUD2, ZRANB2, SNRNP40, DDX23, DHX38, PRPF8, USP12, TXNL4A, SNRNP27, SNRNP200, RRP8, PRPF6, PRPF31, LSM8, GAR1, TRMT10C, RNMTL1, COPRS, DDX24, NOC3L, TSR2, RPL22L1, MEPCE, SART3, CAND1, RNU4ATAC, RNU6ATAC, APP, SF3B6, SRSF11, SF3A1, SRSF3, SRSF5, SF3B1, RBM39, DHX9, SRSF7, HNRNPC, HNRNPU, NCSTN, SON, GTF3C1, SAFB, TPBG, TRIM55, ZC3H18, SRSF10, VTN, SUPT16H, CETN2, TRAF6, TRIM25, TRIM26, TRIM39, TRIM8, TRIM5, FN1, MMS19, SP1, SRPK1, WWOX, PTEN, SAE1, CUL7, OBSL1, CCDC8, ADARB1, CSNK1E, LGALS9, NSUN2, PCNA, APEH, ARF1, HSPA4, HSPH1, NCAPD3, PRPF19, RUVBL2, NTRK1, SCARNA22, SRPK2, CDC5L, NCL, EAPP, ZNHIT2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SFTPB_USP39 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SFTPB_USP39 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SFTPB | C0019284 | Diaphragmatic Hernia | 2 | CTD_human |
Hgene | SFTPB | C0024115 | Lung diseases | 1 | CTD_human |
Hgene | SFTPB | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | SFTPB | C1968602 | Surfactant Metabolism Dysfunction, Pulmonary, 1 | 1 | CTD_human;ORPHANET;UNIPROT |