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Fusion gene ID: 33503 |
FusionGeneSummary for SFRP2_SFRP2 |
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Fusion gene information | Fusion gene name: SFRP2_SFRP2 | Fusion gene ID: 33503 | Hgene | Tgene | Gene symbol | SFRP2 | SFRP2 | Gene ID | 6423 | 6423 |
Gene name | secreted frizzled related protein 2 | secreted frizzled related protein 2 | |
Synonyms | FRP-2|SARP1|SDF-5 | FRP-2|SARP1|SDF-5 | |
Cytomap | 4q31.3 | 4q31.3 | |
Type of gene | protein-coding | protein-coding | |
Description | secreted frizzled-related protein 2SARP-1sFRP-2secreted apoptosis related protein 1testicular tissue protein Li 170 | secreted frizzled-related protein 2SARP-1sFRP-2secreted apoptosis related protein 1testicular tissue protein Li 170 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96HF1 | Q96HF1 | |
Ensembl transtripts involved in fusion gene | ENST00000274063, | ENST00000274063, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: SFRP2 [Title/Abstract] AND SFRP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SFRP2 | GO:0008284 | positive regulation of cell proliferation | 10980594 |
Hgene | SFRP2 | GO:0008285 | negative regulation of cell proliferation | 20208569 |
Hgene | SFRP2 | GO:0010719 | negative regulation of epithelial to mesenchymal transition | 19095296 |
Hgene | SFRP2 | GO:0030178 | negative regulation of Wnt signaling pathway | 20208569 |
Hgene | SFRP2 | GO:0030308 | negative regulation of cell growth | 20208569 |
Hgene | SFRP2 | GO:0045600 | positive regulation of fat cell differentiation | 12055200 |
Hgene | SFRP2 | GO:0045892 | negative regulation of transcription, DNA-templated | 19095296 |
Hgene | SFRP2 | GO:0050680 | negative regulation of epithelial cell proliferation | 19095296 |
Hgene | SFRP2 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 17471511 |
Tgene | SFRP2 | GO:0008284 | positive regulation of cell proliferation | 10980594 |
Tgene | SFRP2 | GO:0008285 | negative regulation of cell proliferation | 20208569 |
Tgene | SFRP2 | GO:0010719 | negative regulation of epithelial to mesenchymal transition | 19095296 |
Tgene | SFRP2 | GO:0030178 | negative regulation of Wnt signaling pathway | 20208569 |
Tgene | SFRP2 | GO:0030308 | negative regulation of cell growth | 20208569 |
Tgene | SFRP2 | GO:0045600 | positive regulation of fat cell differentiation | 12055200 |
Tgene | SFRP2 | GO:0045892 | negative regulation of transcription, DNA-templated | 19095296 |
Tgene | SFRP2 | GO:0050680 | negative regulation of epithelial cell proliferation | 19095296 |
Tgene | SFRP2 | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 17471511 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CN431023 | SFRP2 | chr4 | 154701977 | + | SFRP2 | chr4 | 154702799 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000274063 | ENST00000274063 | SFRP2 | chr4 | 154701977 | + | SFRP2 | chr4 | 154702799 | - |
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FusionProtFeatures for SFRP2_SFRP2 |
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Hgene | Tgene |
SFRP2 | SFRP2 |
Soluble frizzled-related proteins (sFRPS) function asmodulators of Wnt signaling through direct interaction with Wnts.They have a role in regulating cell growth and differentiation inspecific cell types. SFRP2 may be important for eye retinaldevelopment and for myogenesis. | Soluble frizzled-related proteins (sFRPS) function asmodulators of Wnt signaling through direct interaction with Wnts.They have a role in regulating cell growth and differentiation inspecific cell types. SFRP2 may be important for eye retinaldevelopment and for myogenesis. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SFRP2_SFRP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SFRP2_SFRP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SFRP2_SFRP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SFRP2_SFRP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SFRP2 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
Hgene | SFRP2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | SFRP2 | C0021390 | Inflammatory Bowel Diseases | 1 | CTD_human |
Hgene | SFRP2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | SFRP2 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
Tgene | SFRP2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | SFRP2 | C0021390 | Inflammatory Bowel Diseases | 1 | CTD_human |
Tgene | SFRP2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |