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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33503

FusionGeneSummary for SFRP2_SFRP2

check button Fusion gene summary
Fusion gene informationFusion gene name: SFRP2_SFRP2
Fusion gene ID: 33503
HgeneTgene
Gene symbol

SFRP2

SFRP2

Gene ID

6423

6423

Gene namesecreted frizzled related protein 2secreted frizzled related protein 2
SynonymsFRP-2|SARP1|SDF-5FRP-2|SARP1|SDF-5
Cytomap

4q31.3

4q31.3

Type of geneprotein-codingprotein-coding
Descriptionsecreted frizzled-related protein 2SARP-1sFRP-2secreted apoptosis related protein 1testicular tissue protein Li 170secreted frizzled-related protein 2SARP-1sFRP-2secreted apoptosis related protein 1testicular tissue protein Li 170
Modification date2018052320180523
UniProtAcc

Q96HF1

Q96HF1

Ensembl transtripts involved in fusion geneENST00000274063, ENST00000274063, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: SFRP2 [Title/Abstract] AND SFRP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSFRP2

GO:0008284

positive regulation of cell proliferation

10980594

HgeneSFRP2

GO:0008285

negative regulation of cell proliferation

20208569

HgeneSFRP2

GO:0010719

negative regulation of epithelial to mesenchymal transition

19095296

HgeneSFRP2

GO:0030178

negative regulation of Wnt signaling pathway

20208569

HgeneSFRP2

GO:0030308

negative regulation of cell growth

20208569

HgeneSFRP2

GO:0045600

positive regulation of fat cell differentiation

12055200

HgeneSFRP2

GO:0045892

negative regulation of transcription, DNA-templated

19095296

HgeneSFRP2

GO:0050680

negative regulation of epithelial cell proliferation

19095296

HgeneSFRP2

GO:0090090

negative regulation of canonical Wnt signaling pathway

17471511

TgeneSFRP2

GO:0008284

positive regulation of cell proliferation

10980594

TgeneSFRP2

GO:0008285

negative regulation of cell proliferation

20208569

TgeneSFRP2

GO:0010719

negative regulation of epithelial to mesenchymal transition

19095296

TgeneSFRP2

GO:0030178

negative regulation of Wnt signaling pathway

20208569

TgeneSFRP2

GO:0030308

negative regulation of cell growth

20208569

TgeneSFRP2

GO:0045600

positive regulation of fat cell differentiation

12055200

TgeneSFRP2

GO:0045892

negative regulation of transcription, DNA-templated

19095296

TgeneSFRP2

GO:0050680

negative regulation of epithelial cell proliferation

19095296

TgeneSFRP2

GO:0090090

negative regulation of canonical Wnt signaling pathway

17471511


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN431023SFRP2chr4

154701977

+SFRP2chr4

154702799

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000274063ENST00000274063SFRP2chr4

154701977

+SFRP2chr4

154702799

-

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FusionProtFeatures for SFRP2_SFRP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SFRP2

Q96HF1

SFRP2

Q96HF1

Soluble frizzled-related proteins (sFRPS) function asmodulators of Wnt signaling through direct interaction with Wnts.They have a role in regulating cell growth and differentiation inspecific cell types. SFRP2 may be important for eye retinaldevelopment and for myogenesis. Soluble frizzled-related proteins (sFRPS) function asmodulators of Wnt signaling through direct interaction with Wnts.They have a role in regulating cell growth and differentiation inspecific cell types. SFRP2 may be important for eye retinaldevelopment and for myogenesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SFRP2_SFRP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SFRP2_SFRP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SFRP2_SFRP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SFRP2_SFRP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSFRP2C0009404Colorectal Neoplasms2CTD_human
HgeneSFRP2C0007134Renal Cell Carcinoma1CTD_human
HgeneSFRP2C0021390Inflammatory Bowel Diseases1CTD_human
HgeneSFRP2C1458155Mammary Neoplasms1CTD_human
TgeneSFRP2C0009404Colorectal Neoplasms2CTD_human
TgeneSFRP2C0007134Renal Cell Carcinoma1CTD_human
TgeneSFRP2C0021390Inflammatory Bowel Diseases1CTD_human
TgeneSFRP2C1458155Mammary Neoplasms1CTD_human