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Fusion gene ID: 33489 |
FusionGeneSummary for SFN_CLASP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SFN_CLASP1 | Fusion gene ID: 33489 | Hgene | Tgene | Gene symbol | SFN | CLASP1 | Gene ID | 25996 | 23332 |
| Gene name | RNA exonuclease 2 | cytoplasmic linker associated protein 1 | |
| Synonyms | CGI-114|REX2|RFN|SFN | MAST1 | |
| Cytomap | 11q23.2 | 2q14.2-q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | oligoribonuclease, mitochondrialREX2, RNA exonuclease 2 homologRNA exonuclease 2 homologsmall fragment nuclease | CLIP-associating protein 1multiple asters 1multiple asters homolog 1protein Orbit homolog 1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P31947 | Q7Z460 | |
| Ensembl transtripts involved in fusion gene | ENST00000339276, | ENST00000409078, ENST00000541859, ENST00000541377, ENST00000455322, ENST00000397587, ENST00000263710, ENST00000545861, ENST00000430234, | |
| Fusion gene scores | * DoF score | 6 X 1 X 2=12 | 5 X 5 X 3=75 |
| # samples | 7 | 6 | |
| ** MAII score | log2(7/12*10)=2.54432051622381 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SFN [Title/Abstract] AND CLASP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SFN | GO:0006139 | nucleobase-containing compound metabolic process | 10851236 |
| Tgene | CLASP1 | GO:0051294 | establishment of spindle orientation | 21822276 |
| Tgene | CLASP1 | GO:0051301 | cell division | 21822276 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CESC | TCGA-C5-A1M8-01A | SFN | chr1 | 27190947 | + | CLASP1 | chr2 | 122217701 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000339276 | ENST00000409078 | SFN | chr1 | 27190947 | + | CLASP1 | chr2 | 122217701 | - |
| Frame-shift | ENST00000339276 | ENST00000541859 | SFN | chr1 | 27190947 | + | CLASP1 | chr2 | 122217701 | - |
| Frame-shift | ENST00000339276 | ENST00000541377 | SFN | chr1 | 27190947 | + | CLASP1 | chr2 | 122217701 | - |
| Frame-shift | ENST00000339276 | ENST00000455322 | SFN | chr1 | 27190947 | + | CLASP1 | chr2 | 122217701 | - |
| Frame-shift | ENST00000339276 | ENST00000397587 | SFN | chr1 | 27190947 | + | CLASP1 | chr2 | 122217701 | - |
| Frame-shift | ENST00000339276 | ENST00000263710 | SFN | chr1 | 27190947 | + | CLASP1 | chr2 | 122217701 | - |
| Frame-shift | ENST00000339276 | ENST00000545861 | SFN | chr1 | 27190947 | + | CLASP1 | chr2 | 122217701 | - |
| 5CDS-5UTR | ENST00000339276 | ENST00000430234 | SFN | chr1 | 27190947 | + | CLASP1 | chr2 | 122217701 | - |
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FusionProtFeatures for SFN_CLASP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SFN | CLASP1 |
| Adapter protein implicated in the regulation of a largespectrum of both general and specialized signaling pathways. Bindsto a large number of partners, usually by recognition of aphosphoserine or phosphothreonine motif. Binding generally resultsin the modulation of the activity of the binding partner. Whenbound to KRT17, regulates protein synthesis and epithelial cellgrowth by stimulating Akt/mTOR pathway. May also regulate MDM2autoubiquitination and degradation and thereby activate p53/TP53.{ECO:0000269|PubMed:18382127}. p53-regulated inhibitor of G2/M progression.{ECO:0000269|PubMed:18382127}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SFN_CLASP1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SFN_CLASP1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SFN | NR3C1, BAD, PLEKHF2, PLK4, MARK3, WDYHV1, CHST1, TBL3, FAM189A2, KIAA0408, GPRIN2, CHEK1, ABLIM1, PARD3B, ANKS1A, APC, APLP2, ARAF, SORBS2, ARHGAP11A, ARHGAP21, ARHGEF16, ARHGEF17, ARHGEF5, BCAR1, BRAF, CGN, CSNK2A1, DTX2, DYRK1A, ERRFI1, SRSF10, GAN, GRB7, HDAC4, HDAC7, HNRNPU, IRS1, IRS2, ITCH, AJUBA, KIF23, KIF5B, KLC2, KLHDC2, KLC1, LAD1, LSR, LMO7, MAGI1, MAP3K2, MAPKAP1, MARK1, MARK2, MPRIP, MYCBP2, NEDD4L, ISCU, OSBPL3, PAK4, PARD3, PIK3C2B, PI4KB, PKP2, PKP3, PPFIBP1, PPFIBP2, PPP1R3D, CYTH2, PTOV1, PTPN2, PTPN3, RACGAP1, RAE1, RAF1, RALGPS2, RHPN2, ARHGAP32, RND3, SASH1, SAV1, YWHAG, SH2D3A, SH3BP4, SHCBP1, SHROOM3, SIPA1L1, SIPA1L3, SPIRE1, SRRM2, ST5, SYNJ2, TJP2, TNK1, TNS4, TRIM32, USP8, DCAF7, WEE1, ZAK, ZNF638, TP53, CDK1, TRIM25, MDM2, MDM4, ING1, HDAC9, SAMSN1, YWHAQ, EXO1, CBL, ISG15, USP4, TP63, RNF115, CRK, ESR1, HNRNPD, COPS6, RFWD2, ATF2, ABL1, MST1R, CDC25C, HDAC5, EGFR, TARDBP, G6PD, PAK2, SNRPF, UBE2R2, UBE2V1, VCL, YWHAZ, ZFYVE19, SIK3, DTL, CCNH, MAGEA1, FOXO4, MKRN3, FAM53C, ZC2HC1C, CCDC102B, LONRF1, RAB3IP, FAM9B, AKT1, KIAA0930, CDCA7, TRIM62, PLD6, PABPC1, PPP1R2, EIF4B, HSPA5, IGBP1, IPO5, NSFL1C, PGK1, PPIB, PSME3, SLK, TRIM28, TXNL1, EEF1A1, EIF2S1, SRSF4, DKC1, HNRNPM, NONO, G3BP1, RBM39, SNRPN, SRSF1, SRSF8, SRSF2, SFPQ, TAF15, DDX5, EIF3I, EIF3H, EIF3C, RPS2, RPS3A, RPS6, RPS8, RPS9, RPS11, RPS13, RPS15A, RPS16, RPS18, RPS19, RPS20, RPS21, RPS25, RPL4, RPL7A, RPL8, RPL13, RPL17, RPL18, RPL23A, RPL24, RPL26, RPL27A, RPL34, RPL35, RPL38, ACTA1, ACTG1, RPSA, PLEC, SNRPA, MYH11, SUPT16H, H1F0, HIST1H1C, HIST1H1D, HIST1H2BB, CYR61, DEK, CHTOP, DRG1, GNB2L1, LRRC59, KRT2, G3BP2, DHX15, LUC7L2, SERBP1, RBM25, SUB1, EIF3G, EIF5B, RPL10, MAP1B, SAP18, IMPDH2, KRT1, KRT10, MAGEB2, RPS3, NTRK1, SFN, MCM2, CBY1, CTNNB1, CDC73, CDH1, CDC25A, SMTNL2, YWHAB, YAP1 | CLASP1 | YWHAG, CLIP2, ELAVL1, ZW10, VCP, YWHAE, YWHAB, JAKMIP2, MAPRE1, GCC2, NTRK1, CENPJ, SRPK2, SPICE1, CNTRL, NIN, DCTN1, XPO1, MARK2, MYO1C, PHKG2, RNF41, GAN, FBXW7, CDC5L, ARHGEF38, SYBU, BSG, CBY1, MTNR1A, MTNR1B, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SFN_CLASP1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SFN_CLASP1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SFN | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Hgene | SFN | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
| Hgene | SFN | C0022548 | Keloid | 1 | CTD_human |
| Hgene | SFN | C0024232 | Lymphatic Metastasis | 1 | CTD_human |
| Hgene | SFN | C0026640 | Mouth Neoplasms | 1 | CTD_human |
| Hgene | SFN | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Hgene | SFN | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Hgene | SFN | C2239176 | Liver carcinoma | 1 | CTD_human |
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