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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33487

FusionGeneSummary for SFMBT2_TGM2

check button Fusion gene summary
Fusion gene informationFusion gene name: SFMBT2_TGM2
Fusion gene ID: 33487
HgeneTgene
Gene symbol

SFMBT2

TGM2

Gene ID

57713

7052

Gene nameScm like with four mbt domains 2transglutaminase 2
Synonyms-TG(C)|TGC
Cytomap

10p14

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionscm-like with four MBT domains protein 2Scm-related gene containing four mbt domains 2scm-like with 4 MBT domains protein 2protein-glutamine gamma-glutamyltransferase 2C polypeptide, protein-glutamine-gamma-glutamyltransferaseTGase CTGase HTGase-2tissue transglutaminasetransglutaminase Ctransglutaminase H
Modification date2018051920180523
UniProtAcc

Q5VUG0

P21980

Ensembl transtripts involved in fusion geneENST00000361972, ENST00000397167, 
ENST00000379713, ENST00000379711, 
ENST00000397160, 
ENST00000361475, 
ENST00000536701, ENST00000536724, 
Fusion gene scores* DoF score2 X 1 X 2=47 X 10 X 3=210
# samples 210
** MAII scorelog2(2/4*10)=2.32192809488736log2(10/210*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SFMBT2 [Title/Abstract] AND TGM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSFMBT2

GO:0010629

negative regulation of gene expression

23385818

TgeneTGM2

GO:0043277

apoptotic cell clearance

19628791


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLGGTCGA-DU-5871-01ASFMBT2chr10

7409611

-TGM2chr20

36790001

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000361972ENST00000361475SFMBT2chr10

7409611

-TGM2chr20

36790001

-
Frame-shiftENST00000361972ENST00000536701SFMBT2chr10

7409611

-TGM2chr20

36790001

-
5CDS-intronENST00000361972ENST00000536724SFMBT2chr10

7409611

-TGM2chr20

36790001

-
Frame-shiftENST00000397167ENST00000361475SFMBT2chr10

7409611

-TGM2chr20

36790001

-
Frame-shiftENST00000397167ENST00000536701SFMBT2chr10

7409611

-TGM2chr20

36790001

-
5CDS-intronENST00000397167ENST00000536724SFMBT2chr10

7409611

-TGM2chr20

36790001

-
Frame-shiftENST00000379713ENST00000361475SFMBT2chr10

7409611

-TGM2chr20

36790001

-
Frame-shiftENST00000379713ENST00000536701SFMBT2chr10

7409611

-TGM2chr20

36790001

-
5CDS-intronENST00000379713ENST00000536724SFMBT2chr10

7409611

-TGM2chr20

36790001

-
Frame-shiftENST00000379711ENST00000361475SFMBT2chr10

7409611

-TGM2chr20

36790001

-
Frame-shiftENST00000379711ENST00000536701SFMBT2chr10

7409611

-TGM2chr20

36790001

-
5CDS-intronENST00000379711ENST00000536724SFMBT2chr10

7409611

-TGM2chr20

36790001

-
Frame-shiftENST00000397160ENST00000361475SFMBT2chr10

7409611

-TGM2chr20

36790001

-
Frame-shiftENST00000397160ENST00000536701SFMBT2chr10

7409611

-TGM2chr20

36790001

-
5CDS-intronENST00000397160ENST00000536724SFMBT2chr10

7409611

-TGM2chr20

36790001

-

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FusionProtFeatures for SFMBT2_TGM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SFMBT2

Q5VUG0

TGM2

P21980

Transcriptional repressor of HOXB13 gene.{ECO:0000269|PubMed:23385818}. Catalyzes the cross-linking of proteins and theconjugation of polyamines to proteins.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SFMBT2_TGM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SFMBT2_TGM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SFMBT2MOV10, NXF1, CLK1, PHC1TGM2GSTP1, RB1, KPNA4, FN1, TGM2, PLCD1, HIST3H3, CALM1, PIAS4, PAK1, PSMD4, SQSTM1, APP, VHL, CDH1, SMAD3, SMAD2, ZNF512B, ADAR, HSPA1A, HSPA1B, TMEM176A, A2M, ABCA1, ATF4, BNIP3, C3, CSNK2A2, FNTA, GCGR, GRN, HNRNPF, HP, HSPA8, COL4A3BP, HNRNPUL1, SLC7A9, TAB2, ANKRD28, SERTAD1, SIPA1L2, FBXO6, G6PD, LDHB, PGD, RPS6KA3, CKB, CNDP2, CSE1L, ECHS1, NPEPPS, PAK2, SLC9A3R1, SMEK2, UBE2V1, TXNDC5, UBFD1, YWHAG, YWHAQ, YWHAZ, ZFYVE19, PINK1, CDK11B, COL5A1, COL5A2, CDC42BPA, PLOD3, SRGAP3, MVP, SF3B4, ENOPH1, RBM25, COLGALT1, TMEM126A, TWISTNB, LACRT, MCM2, TP53, CBL, PLA2G2A, YAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SFMBT2_TGM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SFMBT2_TGM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTGM2C0005586Bipolar Disorder2PSYGENET
TgeneTGM2C0017636Glioblastoma2CTD_human
TgeneTGM2C0036341Schizophrenia2PSYGENET
TgeneTGM2C0006118Brain Neoplasms1CTD_human
TgeneTGM2C0007134Renal Cell Carcinoma1CTD_human
TgeneTGM2C0007570Celiac Disease1CTD_human
TgeneTGM2C0014859Esophageal Neoplasms1CTD_human
TgeneTGM2C0020538Hypertensive disease1CTD_human
TgeneTGM2C0029408Degenerative polyarthritis1CTD_human
TgeneTGM2C1458155Mammary Neoplasms1CTD_human