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Fusion gene ID: 33487 |
FusionGeneSummary for SFMBT2_TGM2 |
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Fusion gene information | Fusion gene name: SFMBT2_TGM2 | Fusion gene ID: 33487 | Hgene | Tgene | Gene symbol | SFMBT2 | TGM2 | Gene ID | 57713 | 7052 |
Gene name | Scm like with four mbt domains 2 | transglutaminase 2 | |
Synonyms | - | TG(C)|TGC | |
Cytomap | 10p14 | 20q11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | scm-like with four MBT domains protein 2Scm-related gene containing four mbt domains 2scm-like with 4 MBT domains protein 2 | protein-glutamine gamma-glutamyltransferase 2C polypeptide, protein-glutamine-gamma-glutamyltransferaseTGase CTGase HTGase-2tissue transglutaminasetransglutaminase Ctransglutaminase H | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q5VUG0 | P21980 | |
Ensembl transtripts involved in fusion gene | ENST00000361972, ENST00000397167, ENST00000379713, ENST00000379711, ENST00000397160, | ENST00000361475, ENST00000536701, ENST00000536724, | |
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 7 X 10 X 3=210 |
# samples | 2 | 10 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(10/210*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SFMBT2 [Title/Abstract] AND TGM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SFMBT2 | GO:0010629 | negative regulation of gene expression | 23385818 |
Tgene | TGM2 | GO:0043277 | apoptotic cell clearance | 19628791 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LGG | TCGA-DU-5871-01A | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000361972 | ENST00000361475 | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
Frame-shift | ENST00000361972 | ENST00000536701 | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
5CDS-intron | ENST00000361972 | ENST00000536724 | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
Frame-shift | ENST00000397167 | ENST00000361475 | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
Frame-shift | ENST00000397167 | ENST00000536701 | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
5CDS-intron | ENST00000397167 | ENST00000536724 | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
Frame-shift | ENST00000379713 | ENST00000361475 | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
Frame-shift | ENST00000379713 | ENST00000536701 | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
5CDS-intron | ENST00000379713 | ENST00000536724 | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
Frame-shift | ENST00000379711 | ENST00000361475 | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
Frame-shift | ENST00000379711 | ENST00000536701 | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
5CDS-intron | ENST00000379711 | ENST00000536724 | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
Frame-shift | ENST00000397160 | ENST00000361475 | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
Frame-shift | ENST00000397160 | ENST00000536701 | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
5CDS-intron | ENST00000397160 | ENST00000536724 | SFMBT2 | chr10 | 7409611 | - | TGM2 | chr20 | 36790001 | - |
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FusionProtFeatures for SFMBT2_TGM2 |
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Hgene | Tgene |
SFMBT2 | TGM2 |
Transcriptional repressor of HOXB13 gene.{ECO:0000269|PubMed:23385818}. | Catalyzes the cross-linking of proteins and theconjugation of polyamines to proteins. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SFMBT2_TGM2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SFMBT2_TGM2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SFMBT2 | MOV10, NXF1, CLK1, PHC1 | TGM2 | GSTP1, RB1, KPNA4, FN1, TGM2, PLCD1, HIST3H3, CALM1, PIAS4, PAK1, PSMD4, SQSTM1, APP, VHL, CDH1, SMAD3, SMAD2, ZNF512B, ADAR, HSPA1A, HSPA1B, TMEM176A, A2M, ABCA1, ATF4, BNIP3, C3, CSNK2A2, FNTA, GCGR, GRN, HNRNPF, HP, HSPA8, COL4A3BP, HNRNPUL1, SLC7A9, TAB2, ANKRD28, SERTAD1, SIPA1L2, FBXO6, G6PD, LDHB, PGD, RPS6KA3, CKB, CNDP2, CSE1L, ECHS1, NPEPPS, PAK2, SLC9A3R1, SMEK2, UBE2V1, TXNDC5, UBFD1, YWHAG, YWHAQ, YWHAZ, ZFYVE19, PINK1, CDK11B, COL5A1, COL5A2, CDC42BPA, PLOD3, SRGAP3, MVP, SF3B4, ENOPH1, RBM25, COLGALT1, TMEM126A, TWISTNB, LACRT, MCM2, TP53, CBL, PLA2G2A, YAP1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SFMBT2_TGM2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SFMBT2_TGM2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TGM2 | C0005586 | Bipolar Disorder | 2 | PSYGENET |
Tgene | TGM2 | C0017636 | Glioblastoma | 2 | CTD_human |
Tgene | TGM2 | C0036341 | Schizophrenia | 2 | PSYGENET |
Tgene | TGM2 | C0006118 | Brain Neoplasms | 1 | CTD_human |
Tgene | TGM2 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Tgene | TGM2 | C0007570 | Celiac Disease | 1 | CTD_human |
Tgene | TGM2 | C0014859 | Esophageal Neoplasms | 1 | CTD_human |
Tgene | TGM2 | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | TGM2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | TGM2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |