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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 33465

FusionGeneSummary for SF3B3_DDX19B

check button Fusion gene summary
Fusion gene informationFusion gene name: SF3B3_DDX19B
Fusion gene ID: 33465
HgeneTgene
Gene symbol

SF3B3

DDX19B

Gene ID

23450

11269

Gene namesplicing factor 3b subunit 3DEAD-box helicase 19B
SynonymsRSE1|SAP130|SF3b130|STAF130DBP5|DDX19|RNAh
Cytomap

16q22.1

16q22.1

Type of geneprotein-codingprotein-coding
Descriptionsplicing factor 3B subunit 3SAP 130pre-mRNA splicing factor SF3b, 130 kDa subunitspliceosome-associated protein 130ATP-dependent RNA helicase DDX19BATP-dependent RNA helicase DDX19DEAD (Asp-Glu-Ala-As) box polypeptide 19BDEAD (Asp-Glu-Ala-Asp) box polypeptide 19BDEAD box protein 19BDEAD-box RNA helicase DEAD5DEAD-box protein 5DEAD/H (Asp-Glu-Ala-Asp/His) box po
Modification date2018052320180522
UniProtAcc

Q15393

Q9UMR2

Ensembl transtripts involved in fusion geneENST00000302516, ENST00000563392, 
ENST00000570055, ENST00000563206, 
ENST00000451014, ENST00000568625, 
ENST00000288071, ENST00000393657, 
ENST00000355992, 
Fusion gene scores* DoF score10 X 10 X 7=7005 X 4 X 6=120
# samples 127
** MAII scorelog2(12/700*10)=-2.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SF3B3 [Title/Abstract] AND DDX19B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSF3B3

GO:0000398

mRNA splicing, via spliceosome

28781166

HgeneSF3B3

GO:0042177

negative regulation of protein catabolic process

23951410


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-G2-A2ES-01ASF3B3chr16

70573110

+DDX19Bchr16

70346512

+
TCGARVESCATCGA-L5-A4OQ-01ASF3B3chr16

70573110

+DDX19Bchr16

70346512

+
TCGARVGBMTCGA-26-5133-01ASF3B3chr16

70595687

+DDX19Bchr16

70358488

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000302516ENST00000563392SF3B3chr16

70573110

+DDX19Bchr16

70346512

+
5CDS-3UTRENST00000302516ENST00000570055SF3B3chr16

70573110

+DDX19Bchr16

70346512

+
5CDS-3UTRENST00000302516ENST00000563206SF3B3chr16

70573110

+DDX19Bchr16

70346512

+
5CDS-3UTRENST00000302516ENST00000451014SF3B3chr16

70573110

+DDX19Bchr16

70346512

+
5CDS-intronENST00000302516ENST00000568625SF3B3chr16

70573110

+DDX19Bchr16

70346512

+
5CDS-intronENST00000302516ENST00000288071SF3B3chr16

70573110

+DDX19Bchr16

70346512

+
5CDS-intronENST00000302516ENST00000393657SF3B3chr16

70573110

+DDX19Bchr16

70346512

+
5CDS-intronENST00000302516ENST00000355992SF3B3chr16

70573110

+DDX19Bchr16

70346512

+
In-frameENST00000302516ENST00000563392SF3B3chr16

70595687

+DDX19Bchr16

70358488

+
5CDS-intronENST00000302516ENST00000570055SF3B3chr16

70595687

+DDX19Bchr16

70358488

+
5CDS-intronENST00000302516ENST00000563206SF3B3chr16

70595687

+DDX19Bchr16

70358488

+
5CDS-intronENST00000302516ENST00000451014SF3B3chr16

70595687

+DDX19Bchr16

70358488

+
5CDS-intronENST00000302516ENST00000568625SF3B3chr16

70595687

+DDX19Bchr16

70358488

+
5CDS-intronENST00000302516ENST00000288071SF3B3chr16

70595687

+DDX19Bchr16

70358488

+
5CDS-intronENST00000302516ENST00000393657SF3B3chr16

70595687

+DDX19Bchr16

70358488

+
5CDS-intronENST00000302516ENST00000355992SF3B3chr16

70595687

+DDX19Bchr16

70358488

+

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FusionProtFeatures for SF3B3_DDX19B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SF3B3

Q15393

DDX19B

Q9UMR2

Involved in pre-mRNA splicing as a component of thesplicing factor SF3B complex, a constituent of the spliceosome(PubMed:10490618, PubMed:10882114, PubMed:27720643,PubMed:28781166). SF3B complex is required for 'A' complexassembly formed by the stable binding of U2 snRNP to thebranchpoint sequence (BPS) in pre-mRNA. Sequence independentbinding of SF3A/SF3B complex upstream of the branch site isessential, it may anchor U2 snRNP to the pre-mRNA(PubMed:12234937). May also be involved in the assembly of the 'E'complex (PubMed:10882114). Belongs also to the minor U12-dependentspliceosome, which is involved in the splicing of rare class ofnuclear pre-mRNA intron (PubMed:15146077).{ECO:0000269|PubMed:10490618, ECO:0000269|PubMed:10882114,ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:15146077,ECO:0000269|PubMed:27720643, ECO:0000269|PubMed:28781166}. ATP-dependent RNA helicase involved in mRNA export fromthe nucleus. Rather than unwinding RNA duplexes, DDX19B functionsas a remodeler of ribonucleoprotein particles, whereby proteinsbound to nuclear mRNA are dissociated and replaced by cytoplasmicmRNA binding proteins.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000288071+412306_474129480DomainHelicase C-terminal
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000355992+311125_29598449DomainHelicase ATP-binding
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000355992+311306_47498449DomainHelicase C-terminal
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000393657+210125_29520371DomainHelicase ATP-binding
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000393657+210306_47420371DomainHelicase C-terminal
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000451014+311125_295103454DomainHelicase ATP-binding
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000451014+311306_474103454DomainHelicase C-terminal
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000563392+210125_29520371DomainHelicase ATP-binding
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000563392+210306_47420371DomainHelicase C-terminal
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000568625+311125_29520371DomainHelicase ATP-binding
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000568625+311306_47420371DomainHelicase C-terminal
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000288071+412242_245129480MotifNote=DEAD box
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000355992+311242_24598449MotifNote=DEAD box
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000393657+210242_24520371MotifNote=DEAD box
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000393657+21092_12020371MotifNote=Q motif
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000451014+311242_245103454MotifNote=DEAD box
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000563392+210242_24520371MotifNote=DEAD box
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000563392+21092_12020371MotifNote=Q motif
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000568625+311242_24520371MotifNote=DEAD box
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000568625+31192_12020371MotifNote=Q motif
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000288071+412138_145129480Nucleotide bindingNote=ATP
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000355992+311138_14598449Nucleotide bindingNote=ATP
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000393657+210138_14520371Nucleotide bindingNote=ATP
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000451014+311138_145103454Nucleotide bindingNote=ATP
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000563392+210138_14520371Nucleotide bindingNote=ATP
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000568625+311138_14520371Nucleotide bindingNote=ATP
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000288071+412301_479129480RegionNote=C-terminal lobe
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000355992+311301_47998449RegionNote=C-terminal lobe
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000393657+210301_47920371RegionNote=C-terminal lobe
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000393657+21055_6820371RegionNote=N-terminal helix
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000451014+311301_479103454RegionNote=C-terminal lobe
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000563392+210301_47920371RegionNote=C-terminal lobe
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000563392+21055_6820371RegionNote=N-terminal helix
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000568625+311301_47920371RegionNote=C-terminal lobe
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000568625+31155_6820371RegionNote=N-terminal helix

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000288071+412125_295129480DomainHelicase ATP-binding
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000288071+41292_120129480MotifNote=Q motif
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000355992+31192_12098449MotifNote=Q motif
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000451014+31192_120103454MotifNote=Q motif
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000288071+4122_300129480RegionNote=N-terminal lobe
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000288071+41255_68129480RegionNote=N-terminal helix
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000355992+3112_30098449RegionNote=N-terminal lobe
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000355992+31155_6898449RegionNote=N-terminal helix
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000393657+2102_30020371RegionNote=N-terminal lobe
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000451014+3112_300103454RegionNote=N-terminal lobe
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000451014+31155_68103454RegionNote=N-terminal helix
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000563392+2102_30020371RegionNote=N-terminal lobe
TgeneDDX19Bchr16:70595687chr16:70358488ENST00000568625+3112_30020371RegionNote=N-terminal lobe


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FusionGeneSequence for SF3B3_DDX19B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SF3B3_ENST00000302516_chr16_70595687_+_DDX19B_ENST00000563392_chr16_70358488_+_1113aa
MFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTVEVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVIL
EYQPSKNMFEKIHQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNRDAAARLTISSPLEAHKANTLVYHVVGVDVGFENP
MFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLITVPGGSDGPSGVLICSENYITYKNFGDQPDIRCP
IPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIRLKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQ
IAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLANEDTPQLYVACGRGPRSSLRVLRHGLEVSEMAVS
ELPGNPNAVWTVRRHIEDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTLSCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPG
KKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVPPGEQRSRFLAVGLVDNTVRIISLDPSDCLQPLSM
QALPAQPESLCIVEMGGTEKQDELGERGSIGFLYLNIGLQNGVLLRTVLDPVTGDLSDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSW
LSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQ
TGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDPKKIKVFVLDEADVMIATQGHQDQSIRIQRMLPRN
CQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREEETLDTIKQYYVLCSSRDEKFQALCNLYGAITIAQAMIFCHTRKTASWLAAELSKEG
HQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVDKDGNPDNETYLHRIGRTGRFGKRGLAVNMVDSKH


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SF3B3_ENST00000302516_chr16_70595687_+_DDX19B_ENST00000563392_chr16_70358488_+_3339nt
ATGTTTCTGTACAACTTAACCTTGCAGAGAGCCACTGGCATCAGCTTTGCCATTCATGGAAACTTTTCTGGAACCAAACAACAAGAAATT
GTTGTTTCCCGTGGGAAGATCTTGGAGCTGCTTCGCCCAGACCCCAACACTGGCAAAGTACATACCCTACTCACTGTGGAAGTATTCGGT
GTTATCCGGTCACTCATGGCCTTTAGGCTGACAGGTGGCACCAAAGACTACATTGTAGTTGGCAGTGACTCTGGTCGAATTGTTATTTTG
GAATACCAGCCATCTAAGAATATGTTTGAGAAGATTCACCAAGAAACCTTTGGCAAGAGTGGATGCCGTCGCATCGTTCCTGGCCAGTTC
TTAGCTGTGGATCCCAAAGGGCGAGCCGTTATGATTAGTGCCATTGAGAAACAGAAATTGGTGTATATTTTGAACAGAGATGCTGCAGCC
CGACTTACCATTTCATCTCCCCTGGAAGCCCACAAAGCAAACACTTTAGTGTATCATGTAGTTGGAGTAGATGTCGGATTTGAAAATCCA
ATGTTTGCTTGTCTGGAAATGGATTATGAGGAAGCAGACAATGATCCAACAGGGGAAGCAGCAGCTAATACCCAGCAGACACTTACTTTC
TATGAGCTAGACCTTGGTTTAAATCATGTGGTCCGAAAATACAGTGAACCTTTGGAGGAACACGGCAACTTCCTTATTACAGTTCCAGGA
GGGTCAGATGGTCCAAGTGGAGTACTGATCTGCTCTGAAAACTATATTACTTACAAGAACTTTGGTGACCAGCCAGATATCCGCTGTCCA
ATTCCCAGGAGGCGGAATGACCTGGATGACCCTGAAAGAGGAATGATTTTTGTCTGCTCTGCAACCCATAAAACCAAATCGATGTTCTTC
TTTTTGGCTCAAACTGAGCAGGGAGATATCTTTAAGATCACTTTGGAGACAGATGAAGATATGGTTACTGAGATCCGGCTCAAATATTTT
GATACTGTACCCGTTGCTGCTGCCATGTGTGTGCTTAAAACAGGGTTCCTTTTTGTAGCATCAGAATTTGGAAACCATTACTTATATCAA
ATTGCACATCTTGGAGATGATGATGAAGAACCTGAGTTTTCATCAGCCATGCCTCTGGAAGAAGGAGACACATTCTTTTTTCAGCCAAGA
CCACTTAAAAACCTTGTGCTGGTTGATGAGTTGGACAGCCTCTCTCCCATTCTGTTTTGCCAGATAGCTGATCTGGCCAATGAAGATACT
CCACAGTTGTATGTGGCCTGTGGTAGGGGACCCCGATCATCTCTGAGAGTCCTAAGACATGGACTTGAGGTGTCAGAAATGGCTGTTTCT
GAGCTACCTGGTAACCCCAACGCTGTCTGGACAGTGCGTCGACACATTGAAGATGAGTTTGATGCCTACATCATTGTGTCTTTCGTGAAT
GCCACCCTAGTGTTGTCCATTGGAGAAACTGTAGAAGAAGTGACTGACTCTGGGTTCCTGGGGACCACCCCGACCTTGTCCTGCTCCTTA
TTAGGAGATGATGCCTTGGTGCAGGTCTATCCAGATGGCATTCGGCACATACGAGCAGACAAGAGAGTCAATGAGTGGAAGACCCCTGGA
AAGAAAACAATTGTGAAGTGTGCAGTGAACCAGCGACAAGTGGTGATTGCCCTGACAGGAGGAGAGCTGGTCTATTTCGAGATGGATCCT
TCAGGACAGCTGAATGAGTACACAGAACGGAAGGAGATGTCAGCAGATGTGGTGTGCATGAGTCTGGCCAATGTACCCCCTGGAGAGCAG
CGGTCTCGCTTCCTGGCTGTGGGGCTTGTGGACAACACTGTCAGAATCATCTCCCTGGATCCCTCAGACTGTTTGCAACCTCTAAGCATG
CAGGCTCTCCCAGCCCAGCCTGAGTCCTTGTGTATCGTGGAAATGGGTGGGACTGAGAAGCAGGATGAGCTGGGTGAGAGGGGCTCGATT
GGCTTCCTATACCTGAATATTGGGCTACAGAACGGTGTGCTGCTGAGGACTGTCTTGGACCCTGTCACTGGGGATTTGTCTGATACTCGC
ACTCGGTACCTGGGGTCCCGTCCTGTGAAGCTCTTCCGAGTCCGAATGCAAGGCCAGGAGGCAGTATTGGCCATGTCAAGCCGCTCATGG
TTGAGCTATTCTTACCAATCTCGCTTCCATCTCACCCCACTGTCTTACGAGACACTGGAATTTGCATCGGGTTTTGCCTCGGAACAGTGT
CCCGAGGGCATTGTGGCCATCTCCACCAACACCCTACGCCCACAGAACTTAATTGCCCAATCTCAGTCTGGTACTGGTAAAACAGCTGCC
TTCGTGCTGGCCATGCTTAGCCAAGTAGAACCTGCAAACAAATACCCCCAGTGTCTATGTCTCTCCCCAACGTATGAGCTCGCCCTCCAA
ACAGGAAAAGTGATTGAACAAATGGGCAAATTTTACCCTGAACTGAAGCTAGCTTATGCTGTTCGAGGCAATAAATTGGAAAGAGGCCAG
AAGATCAGTGAGCAGATTGTCATTGGCACCCCTGGGACTGTGCTGGACTGGTGCTCCAAGCTCAAGTTCATTGATCCCAAGAAAATCAAG
GTGTTTGTTCTGGATGAGGCTGATGTCATGATAGCCACTCAGGGCCACCAAGATCAGAGCATCCGCATCCAGAGGATGCTGCCCAGGAAC
TGCCAGATGCTGCTTTTCTCCGCCACCTTTGAAGACTCTGTGTGGAAGTTTGCCCAGAAAGTGGTCCCAGACCCAAACGTTATCAAACTG
AAGCGTGAGGAAGAGACCCTGGACACCATCAAGCAGTACTATGTCCTGTGCAGCAGCAGAGACGAGAAGTTCCAGGCCTTGTGTAACCTC
TACGGGGCCATCACCATTGCTCAAGCCATGATCTTCTGCCATACTCGCAAAACAGCTAGTTGGCTGGCAGCAGAGCTCTCAAAAGAAGGC
CACCAGGTGGCTCTGCTGAGTGGGGAGATGATGGTGGAACAGAGGGCTGCAGTGATTGAGCGCTTCCGAGAGGGCAAAGAGAAGGTTTTG
GTGACCACCAACGTGTGTGCCCGCGGCATTGATGTTGAACAAGTGTCTGTCGTCATCAACTTTGATCTTCCCGTGGACAAGGACGGGAAT
CCTGACAATGAGACCTACCTGCACCGGATCGGGCGCACGGGCCGCTTTGGCAAGAGGGGCCTGGCAGTGAACATGGTGGACAGCAAGCAC
AGCATGAACATCCTGAACAGAATCCAGGAGCATTTTAATAAGAAGATAGAAAGATTGGACACAGATGATTTGGACGAGATTGAGAAAATA


* Fusion transcript sequences (Full-length transcript).
>In-frame_SF3B3_ENST00000302516_chr16_70595687_+_DDX19B_ENST00000563392_chr16_70358488_+_3788nt
GCCTTTTTCCGCCGCGCGCCACCAGAATGTCCCTGTCTTGAGGTCTAATGGCGGACGCCAGTATGTTGGAGTTGGTGGTGGCTTAAGTTT
TGAAGGGAGGTAGCATCCGTTGGATATCCACACCATCCTTCTCGCTGCAGGCTTTCTTGGACTCCGTACTGTTGGTGTAACCAAGGCCTG
GAGGTCTGGGTGGCTCAGGTTTCCTGCAGCCATGTTTCTGTACAACTTAACCTTGCAGAGAGCCACTGGCATCAGCTTTGCCATTCATGG
AAACTTTTCTGGAACCAAACAACAAGAAATTGTTGTTTCCCGTGGGAAGATCTTGGAGCTGCTTCGCCCAGACCCCAACACTGGCAAAGT
ACATACCCTACTCACTGTGGAAGTATTCGGTGTTATCCGGTCACTCATGGCCTTTAGGCTGACAGGTGGCACCAAAGACTACATTGTAGT
TGGCAGTGACTCTGGTCGAATTGTTATTTTGGAATACCAGCCATCTAAGAATATGTTTGAGAAGATTCACCAAGAAACCTTTGGCAAGAG
TGGATGCCGTCGCATCGTTCCTGGCCAGTTCTTAGCTGTGGATCCCAAAGGGCGAGCCGTTATGATTAGTGCCATTGAGAAACAGAAATT
GGTGTATATTTTGAACAGAGATGCTGCAGCCCGACTTACCATTTCATCTCCCCTGGAAGCCCACAAAGCAAACACTTTAGTGTATCATGT
AGTTGGAGTAGATGTCGGATTTGAAAATCCAATGTTTGCTTGTCTGGAAATGGATTATGAGGAAGCAGACAATGATCCAACAGGGGAAGC
AGCAGCTAATACCCAGCAGACACTTACTTTCTATGAGCTAGACCTTGGTTTAAATCATGTGGTCCGAAAATACAGTGAACCTTTGGAGGA
ACACGGCAACTTCCTTATTACAGTTCCAGGAGGGTCAGATGGTCCAAGTGGAGTACTGATCTGCTCTGAAAACTATATTACTTACAAGAA
CTTTGGTGACCAGCCAGATATCCGCTGTCCAATTCCCAGGAGGCGGAATGACCTGGATGACCCTGAAAGAGGAATGATTTTTGTCTGCTC
TGCAACCCATAAAACCAAATCGATGTTCTTCTTTTTGGCTCAAACTGAGCAGGGAGATATCTTTAAGATCACTTTGGAGACAGATGAAGA
TATGGTTACTGAGATCCGGCTCAAATATTTTGATACTGTACCCGTTGCTGCTGCCATGTGTGTGCTTAAAACAGGGTTCCTTTTTGTAGC
ATCAGAATTTGGAAACCATTACTTATATCAAATTGCACATCTTGGAGATGATGATGAAGAACCTGAGTTTTCATCAGCCATGCCTCTGGA
AGAAGGAGACACATTCTTTTTTCAGCCAAGACCACTTAAAAACCTTGTGCTGGTTGATGAGTTGGACAGCCTCTCTCCCATTCTGTTTTG
CCAGATAGCTGATCTGGCCAATGAAGATACTCCACAGTTGTATGTGGCCTGTGGTAGGGGACCCCGATCATCTCTGAGAGTCCTAAGACA
TGGACTTGAGGTGTCAGAAATGGCTGTTTCTGAGCTACCTGGTAACCCCAACGCTGTCTGGACAGTGCGTCGACACATTGAAGATGAGTT
TGATGCCTACATCATTGTGTCTTTCGTGAATGCCACCCTAGTGTTGTCCATTGGAGAAACTGTAGAAGAAGTGACTGACTCTGGGTTCCT
GGGGACCACCCCGACCTTGTCCTGCTCCTTATTAGGAGATGATGCCTTGGTGCAGGTCTATCCAGATGGCATTCGGCACATACGAGCAGA
CAAGAGAGTCAATGAGTGGAAGACCCCTGGAAAGAAAACAATTGTGAAGTGTGCAGTGAACCAGCGACAAGTGGTGATTGCCCTGACAGG
AGGAGAGCTGGTCTATTTCGAGATGGATCCTTCAGGACAGCTGAATGAGTACACAGAACGGAAGGAGATGTCAGCAGATGTGGTGTGCAT
GAGTCTGGCCAATGTACCCCCTGGAGAGCAGCGGTCTCGCTTCCTGGCTGTGGGGCTTGTGGACAACACTGTCAGAATCATCTCCCTGGA
TCCCTCAGACTGTTTGCAACCTCTAAGCATGCAGGCTCTCCCAGCCCAGCCTGAGTCCTTGTGTATCGTGGAAATGGGTGGGACTGAGAA
GCAGGATGAGCTGGGTGAGAGGGGCTCGATTGGCTTCCTATACCTGAATATTGGGCTACAGAACGGTGTGCTGCTGAGGACTGTCTTGGA
CCCTGTCACTGGGGATTTGTCTGATACTCGCACTCGGTACCTGGGGTCCCGTCCTGTGAAGCTCTTCCGAGTCCGAATGCAAGGCCAGGA
GGCAGTATTGGCCATGTCAAGCCGCTCATGGTTGAGCTATTCTTACCAATCTCGCTTCCATCTCACCCCACTGTCTTACGAGACACTGGA
ATTTGCATCGGGTTTTGCCTCGGAACAGTGTCCCGAGGGCATTGTGGCCATCTCCACCAACACCCTACGCCCACAGAACTTAATTGCCCA
ATCTCAGTCTGGTACTGGTAAAACAGCTGCCTTCGTGCTGGCCATGCTTAGCCAAGTAGAACCTGCAAACAAATACCCCCAGTGTCTATG
TCTCTCCCCAACGTATGAGCTCGCCCTCCAAACAGGAAAAGTGATTGAACAAATGGGCAAATTTTACCCTGAACTGAAGCTAGCTTATGC
TGTTCGAGGCAATAAATTGGAAAGAGGCCAGAAGATCAGTGAGCAGATTGTCATTGGCACCCCTGGGACTGTGCTGGACTGGTGCTCCAA
GCTCAAGTTCATTGATCCCAAGAAAATCAAGGTGTTTGTTCTGGATGAGGCTGATGTCATGATAGCCACTCAGGGCCACCAAGATCAGAG
CATCCGCATCCAGAGGATGCTGCCCAGGAACTGCCAGATGCTGCTTTTCTCCGCCACCTTTGAAGACTCTGTGTGGAAGTTTGCCCAGAA
AGTGGTCCCAGACCCAAACGTTATCAAACTGAAGCGTGAGGAAGAGACCCTGGACACCATCAAGCAGTACTATGTCCTGTGCAGCAGCAG
AGACGAGAAGTTCCAGGCCTTGTGTAACCTCTACGGGGCCATCACCATTGCTCAAGCCATGATCTTCTGCCATACTCGCAAAACAGCTAG
TTGGCTGGCAGCAGAGCTCTCAAAAGAAGGCCACCAGGTGGCTCTGCTGAGTGGGGAGATGATGGTGGAACAGAGGGCTGCAGTGATTGA
GCGCTTCCGAGAGGGCAAAGAGAAGGTTTTGGTGACCACCAACGTGTGTGCCCGCGGCATTGATGTTGAACAAGTGTCTGTCGTCATCAA
CTTTGATCTTCCCGTGGACAAGGACGGGAATCCTGACAATGAGACCTACCTGCACCGGATCGGGCGCACGGGCCGCTTTGGCAAGAGGGG
CCTGGCAGTGAACATGGTGGACAGCAAGCACAGCATGAACATCCTGAACAGAATCCAGGAGCATTTTAATAAGAAGATAGAAAGATTGGA
CACAGATGATTTGGACGAGATTGAGAAAATAGCCAACTGAGAAGCTCCACCAGCCACTGATGCCAGCCCTGGCACTGCCCCTGCACAGGA
GACAAGTGCGTTCAGGGCACAGGCCCCGACATCACCCCAAGGACAACGGCACAAGTAGAGAGAAACTACCTACCTCACTTCAAATTATGT
TTGGACTTGACAAAAATGTATGCAAATGATGGGGGATGGTAGAAAAAAATTATTTACACAACCTTGGAAGATTAGGCATGAATACACAGA


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FusionGenePPI for SF3B3_DDX19B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SF3B3SMNDC1, CFLAR, TNFRSF10D, RNPS1, RNU11, NCOR1, SF3B2, SF3B1, SF3A2, SUPT3H, TAF9, HGS, TCEA1, SRRM1, SRRM2, KAT2A, HDAC5, TOP1, YWHAG, SMAD5, KLF10, OSGEP, RUFY2, RAD9A, ZNF579, NAGK, SMARCAD1, SREK1, TAF10, ARRB2, CUL3, CUL2, CDK2, CUL1, COPS5, CAND1, SF3A1, SNRPD1, HNRNPK, SNRPD2, SF3A3, SNRPA1, SF3B4, SF3B5, SF3B6, PHF5A, SNRNP200, PRPF8, SNRPB2, SRSF1, HNRNPR, TCERG1, EFTUD2, PRPF6, RBMX, YBX1, SNRPA, SRSF7, HNRNPM, U2AF1, U2AF2, SRSF2, DDX5, PRPF31, SFPQ, SMC1A, PRPF19, SART1, SMU1, LMNA, TUBB, WDR18, STOML2, CCT2, TPBG, LAMP2, TRA2A, TXNRD1, ZC3H18, TJAP1, UBE3A, SPDL1, UTP14A, VTN, VPS33B, AGMAT, THRAP3, MTHFD1, TMOD2, STOM, TRIM55, SSR3, MAGOH, EIF4A3, PPIL1, HSPB1, TOE1, HSP90AA1, IFIT3, CD81, IGSF8, SKP1, SKP2, CUL4A, EPS8, RBM6, FBXO6, PRPF40A, WBP4, APBB1, WWOX, RPA3, RPA2, RPA1, ERG, LGR4, NUDCD3, HUWE1, FUS, MDM2, CCDC101, CUL7, OBSL1, CCDC8, EZH2, SUZ12, EED, RNF2, USP7, UNK, BCAS2, CCAR1, CCAR2, DCTN1, ISY1-RAB43, ISY1, LUC7L, PRPF3, PRPF4, CCDC97, CDC40, CDC5L, COPA, COPE, COPG1, DHX15, EIF4G1, ELP4, KPNB1, LMNB1, LSM4, LUC7L2, PLRG1, PSME3, RPL18A, SRRT, USP10, XAB2, SMC3, SNRPD3, SPTAN1, SSSCA1, SYNCRIP, RNU12, NTRK1, SCARNA22, TAF4, HIST1H3E, MCM5, SNW1, AIRE, ZNF746, FLCN, SNRPE, PLK1, CYLD, CD2BP2, TRIM25, BRCA1, YAP1DDX19BKLHDC2, DCK, GNB2L1, XPO7, RAE1, IKBKG, TERF1, POT1, COPS5, APP, AICDA, CTBP2, MIF4GD, HLA-DQA1, KLK8, RTBDN, IGKC, TF, PLEC, EPPK1, EVPL, C3, ANXA1, SERPINA3, TRIM29, CALML5, GSN, FGB, TGM1, FGG, PPL, APOA1, AKR1B10, TRIM25, IGHG2, IGHG1, LCP1, HLA-DRA, PSME1, TREX2, IQGAP1, SERPINB5, CALML3, MVP, SERPINB4, SERPINB3, SULT2B1, FGA, RNASE7, POF1B, CAPG, LCN2, NARS, IVL, HMOX1, GM2A, SERPINB1, RAB5A, TYMP, STAT3, ACPP, LTF, ANXA8, S100A7, NAGK, SERPINA1, SERPINB2, ALOX15, LGALS1, FCGBP, HAL, HP, NDRG2, ORM1, CRABP2, CFB, IGLL5, ACOX1, SERPINB7, EHD4, ART3, PTCH1, TNF, DDX19A, CSTF2, XPO1, RRM2, NUP35, SCLT1, USP11, CCDC132, SNW1, CDC5L, ALPI, RAB2B, ENSA, HIST1H1B, S100A9, GSDMA, CCM2, IL36RN, CD79A, LGALS7B, CTSV, APOBEC3A, LAMP2, PKM, LGALS7, UBC


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSF3B3chr16:70595687chr16:70358488ENST00000302516+1726105_1197621218PHF5A%2C SF3B1 and SF3B5
HgeneSF3B3chr16:70595687chr16:70358488ENST00000302516+1726145_1687621218PHF5A%2C SF3B1 and SF3B5
HgeneSF3B3chr16:70595687chr16:70358488ENST00000302516+1726193_2317621218SF3B1 and SF3B5


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSF3B3chr16:70595687chr16:70358488ENST00000302516+1726786_8047621218SF3B1 and SF3B5
HgeneSF3B3chr16:70595687chr16:70358488ENST00000302516+17261028_10497621218SF3B1
HgeneSF3B3chr16:70595687chr16:70358488ENST00000302516+17261100_11237621218SF3B5


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SF3B3_DDX19B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SF3B3_DDX19B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource