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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 33451

FusionGeneSummary for SF3B1_SATB2

check button Fusion gene summary
Fusion gene informationFusion gene name: SF3B1_SATB2
Fusion gene ID: 33451
HgeneTgene
Gene symbol

SF3B1

SATB2

Gene ID

23451

23314

Gene namesplicing factor 3b subunit 1SATB homeobox 2
SynonymsHsh155|MDS|PRP10|PRPF10|SAP155|SF3b155GLSS
Cytomap

2q33.1

2q33.1

Type of geneprotein-codingprotein-coding
Descriptionsplicing factor 3B subunit 1pre-mRNA processing 10pre-mRNA splicing factor SF3b, 155 kDa subunitspliceosome-associated protein 155splicing factor 3b, subunit 1, 155kDaDNA-binding protein SATB2SATB family member 2special AT-rich sequence-binding protein 2
Modification date2018052720180523
UniProtAcc

O75533

Q9UPW6

Ensembl transtripts involved in fusion geneENST00000335508, ENST00000462613, 
ENST00000409915, ENST00000414963, 
ENST00000487698, 		ENST00000417098, 
ENST00000443023, ENST00000260926, 
ENST00000428695, ENST00000457245, 
ENST00000484124, 
Fusion gene scores* DoF score5 X 8 X 3=1203 X 4 X 3=36
# samples 84
** MAII scorelog2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SF3B1 [Title/Abstract] AND SATB2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Transcription factor involved fusion gene, inframe and retained DNA-binding domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSF3B1

GO:0000398

mRNA splicing, via spliceosome

11252167|28781166


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSTADTCGA-VQ-A92D-01ASF3B1chr2

198283233

-SATB2chr2

200173680

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000335508ENST00000417098SF3B1chr2

198283233

-SATB2chr2

200173680

-
In-frameENST00000335508ENST00000443023SF3B1chr2

198283233

-SATB2chr2

200173680

-
In-frameENST00000335508ENST00000260926SF3B1chr2

198283233

-SATB2chr2

200173680

-
In-frameENST00000335508ENST00000428695SF3B1chr2

198283233

-SATB2chr2

200173680

-
In-frameENST00000335508ENST00000457245SF3B1chr2

198283233

-SATB2chr2

200173680

-
5CDS-intronENST00000335508ENST00000484124SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-3CDSENST00000462613ENST00000417098SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-3CDSENST00000462613ENST00000443023SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-3CDSENST00000462613ENST00000260926SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-3CDSENST00000462613ENST00000428695SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-3CDSENST00000462613ENST00000457245SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-intronENST00000462613ENST00000484124SF3B1chr2

198283233

-SATB2chr2

200173680

-
3UTR-3CDSENST00000409915ENST00000417098SF3B1chr2

198283233

-SATB2chr2

200173680

-
3UTR-3CDSENST00000409915ENST00000443023SF3B1chr2

198283233

-SATB2chr2

200173680

-
3UTR-3CDSENST00000409915ENST00000260926SF3B1chr2

198283233

-SATB2chr2

200173680

-
3UTR-3CDSENST00000409915ENST00000428695SF3B1chr2

198283233

-SATB2chr2

200173680

-
3UTR-3CDSENST00000409915ENST00000457245SF3B1chr2

198283233

-SATB2chr2

200173680

-
3UTR-intronENST00000409915ENST00000484124SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-3CDSENST00000414963ENST00000417098SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-3CDSENST00000414963ENST00000443023SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-3CDSENST00000414963ENST00000260926SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-3CDSENST00000414963ENST00000428695SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-3CDSENST00000414963ENST00000457245SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-intronENST00000414963ENST00000484124SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-3CDSENST00000487698ENST00000417098SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-3CDSENST00000487698ENST00000443023SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-3CDSENST00000487698ENST00000260926SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-3CDSENST00000487698ENST00000428695SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-3CDSENST00000487698ENST00000457245SF3B1chr2

198283233

-SATB2chr2

200173680

-
intron-intronENST00000487698ENST00000484124SF3B1chr2

198283233

-SATB2chr2

200173680

-

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FusionProtFeatures for SF3B1_SATB2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SF3B1

O75533

SATB2

Q9UPW6

Involved in pre-mRNA splicing as a component of thesplicing factor SF3B complex (PubMed:27720643). SF3B complex isrequired for 'A' complex assembly formed by the stable binding ofU2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequenceindependent binding of SF3A/SF3B complex upstream of the branchsite is essential, it may anchor U2 snRNP to the pre-mRNA(PubMed:12234937). May also be involved in the assembly of the 'E'complex (PubMed:10882114). Belongs also to the minor U12-dependentspliceosome, which is involved in the splicing of rare class ofnuclear pre-mRNA intron (PubMed:15146077).{ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:12234937,ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:27720643}. Binds to DNA, at nuclear matrix- or scaffold-associatedregions. Thought to recognize the sugar-phosphate structure ofdouble-stranded DNA. Transcription factor controlling nuclear geneexpression, by binding to matrix attachment regions (MARs) of DNAand inducing a local chromatin-loop remodeling. Acts as a dockingsite for several chromatin remodeling enzymes and also byrecruiting corepressors (HDACs) or coactivators (HATs) directly topromoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for theinactivation of deep-layer neurons (DL) and UL2 specific genes,probably by modulating BCL11B expression. Repressor of Ctip2 andregulatory determinant of corticocortical connections in thedeveloping cerebral cortex. May play an important role in palateformation. Acts as a molecular node in a transcriptional networkregulating skeletal development and osteoblast differentiation.{ECO:0000269|PubMed:14701874}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF3B1chr2:198283233chr2:200173680ENST00000409915-671010_104818388RepeatNote=HEAT 8
HgeneSF3B1chr2:198283233chr2:200173680ENST00000409915-671052_109018388RepeatNote=HEAT 9
HgeneSF3B1chr2:198283233chr2:200173680ENST00000409915-671122_116018388RepeatNote=HEAT 10
HgeneSF3B1chr2:198283233chr2:200173680ENST00000409915-671163_120118388RepeatNote=HEAT 11
HgeneSF3B1chr2:198283233chr2:200173680ENST00000409915-67569_60318388RepeatNote=HEAT 2
HgeneSF3B1chr2:198283233chr2:200173680ENST00000409915-67604_64118388RepeatNote=HEAT 3
HgeneSF3B1chr2:198283233chr2:200173680ENST00000409915-67643_67718388RepeatNote=HEAT 4
HgeneSF3B1chr2:198283233chr2:200173680ENST00000409915-67680_71818388RepeatNote=HEAT 5
HgeneSF3B1chr2:198283233chr2:200173680ENST00000409915-67763_80118388RepeatNote=HEAT 6
HgeneSF3B1chr2:198283233chr2:200173680ENST00000409915-67843_88118388RepeatNote=HEAT 7
TgeneSATB2chr2:198283233chr2:200173680ENST00000260926-912615_674514734DNA bindingHomeobox
TgeneSATB2chr2:198283233chr2:200173680ENST00000417098-811615_674514734DNA bindingHomeobox
TgeneSATB2chr2:198283233chr2:200173680ENST00000457245-912615_674514734DNA bindingHomeobox

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF3B1chr2:198283233chr2:200173680ENST00000335508-5251010_10481651305RepeatNote=HEAT 8
HgeneSF3B1chr2:198283233chr2:200173680ENST00000335508-5251052_10901651305RepeatNote=HEAT 9
HgeneSF3B1chr2:198283233chr2:200173680ENST00000335508-5251122_11601651305RepeatNote=HEAT 10
HgeneSF3B1chr2:198283233chr2:200173680ENST00000335508-5251163_12011651305RepeatNote=HEAT 11
HgeneSF3B1chr2:198283233chr2:200173680ENST00000335508-525569_6031651305RepeatNote=HEAT 2
HgeneSF3B1chr2:198283233chr2:200173680ENST00000335508-525604_6411651305RepeatNote=HEAT 3
HgeneSF3B1chr2:198283233chr2:200173680ENST00000335508-525643_6771651305RepeatNote=HEAT 4
HgeneSF3B1chr2:198283233chr2:200173680ENST00000335508-525680_7181651305RepeatNote=HEAT 5
HgeneSF3B1chr2:198283233chr2:200173680ENST00000335508-525763_8011651305RepeatNote=HEAT 6
HgeneSF3B1chr2:198283233chr2:200173680ENST00000335508-525843_8811651305RepeatNote=HEAT 7
HgeneSF3B1chr2:198283233chr2:200173680ENST00000414963-151010_1048-27145RepeatNote=HEAT 8
HgeneSF3B1chr2:198283233chr2:200173680ENST00000414963-151052_1090-27145RepeatNote=HEAT 9
HgeneSF3B1chr2:198283233chr2:200173680ENST00000414963-151122_1160-27145RepeatNote=HEAT 10
HgeneSF3B1chr2:198283233chr2:200173680ENST00000414963-151163_1201-27145RepeatNote=HEAT 11
HgeneSF3B1chr2:198283233chr2:200173680ENST00000414963-15569_603-27145RepeatNote=HEAT 2
HgeneSF3B1chr2:198283233chr2:200173680ENST00000414963-15604_641-27145RepeatNote=HEAT 3
HgeneSF3B1chr2:198283233chr2:200173680ENST00000414963-15643_677-27145RepeatNote=HEAT 4
HgeneSF3B1chr2:198283233chr2:200173680ENST00000414963-15680_718-27145RepeatNote=HEAT 5
HgeneSF3B1chr2:198283233chr2:200173680ENST00000414963-15763_801-27145RepeatNote=HEAT 6
HgeneSF3B1chr2:198283233chr2:200173680ENST00000414963-15843_881-27145RepeatNote=HEAT 7
TgeneSATB2chr2:198283233chr2:200173680ENST00000260926-912350_437514734DNA bindingCUT 1
TgeneSATB2chr2:198283233chr2:200173680ENST00000260926-912473_560514734DNA bindingCUT 2
TgeneSATB2chr2:198283233chr2:200173680ENST00000417098-811350_437514734DNA bindingCUT 1
TgeneSATB2chr2:198283233chr2:200173680ENST00000417098-811473_560514734DNA bindingCUT 2
TgeneSATB2chr2:198283233chr2:200173680ENST00000457245-912350_437514734DNA bindingCUT 1
TgeneSATB2chr2:198283233chr2:200173680ENST00000457245-912473_560514734DNA bindingCUT 2


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FusionGeneSequence for SF3B1_SATB2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SF3B1_ENST00000335508_chr2_198283233_-_SATB2_ENST00000417098_chr2_200173680_-_385aa
MAKIAKTHEDIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIYGGSDSRFAGYVTSIAATELEDDDDDYSSSTSLLGQKKPGYHAPVAL
LNDIPQSTEQYDPFAEHRPPKIADREDEYKKHRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEGWLCELLRWKENPSP
ENRTLWENLCTIRRFLNLPQHERDVIYEEESRHHHSERMQHVVQLPPEPVQVLHRQQSQPAKESSPPREEAPPPPPPTEDSCAKKPRSRT
KISLEALGILQSFIHDVGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHHGKLKEHLGSAVDVAEYKDEELLTESEENDSEEGSEE

>In-frame_SF3B1_ENST00000335508_chr2_198283233_-_SATB2_ENST00000443023_chr2_200173680_-_385aa
MAKIAKTHEDIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIYGGSDSRFAGYVTSIAATELEDDDDDYSSSTSLLGQKKPGYHAPVAL
LNDIPQSTEQYDPFAEHRPPKIADREDEYKKHRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEGWLCELLRWKENPSP
ENRTLWENLCTIRRFLNLPQHERDVIYEEESRHHHSERMQHVVQLPPEPVQVLHRQQSQPAKESSPPREEAPPPPPPTEDSCAKKPRSRT
KISLEALGILQSFIHDVGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHHGKLKEHLGSAVDVAEYKDEELLTESEENDSEEGSEE

>In-frame_SF3B1_ENST00000335508_chr2_198283233_-_SATB2_ENST00000260926_chr2_200173680_-_385aa
MAKIAKTHEDIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIYGGSDSRFAGYVTSIAATELEDDDDDYSSSTSLLGQKKPGYHAPVAL
LNDIPQSTEQYDPFAEHRPPKIADREDEYKKHRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEGWLCELLRWKENPSP
ENRTLWENLCTIRRFLNLPQHERDVIYEEESRHHHSERMQHVVQLPPEPVQVLHRQQSQPAKESSPPREEAPPPPPPTEDSCAKKPRSRT
KISLEALGILQSFIHDVGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHHGKLKEHLGSAVDVAEYKDEELLTESEENDSEEGSEE

>In-frame_SF3B1_ENST00000335508_chr2_198283233_-_SATB2_ENST00000428695_chr2_200173680_-_385aa
MAKIAKTHEDIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIYGGSDSRFAGYVTSIAATELEDDDDDYSSSTSLLGQKKPGYHAPVAL
LNDIPQSTEQYDPFAEHRPPKIADREDEYKKHRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEGWLCELLRWKENPSP
ENRTLWENLCTIRRFLNLPQHERDVIYEEESRHHHSERMQHVVQLPPEPVQVLHRQQSQPAKESSPPREEAPPPPPPTEDSCAKKPRSRT
KISLEALGILQSFIHDVGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHHGKLKEHLGSAVDVAEYKDEELLTESEENDSEEGSEE

>In-frame_SF3B1_ENST00000335508_chr2_198283233_-_SATB2_ENST00000457245_chr2_200173680_-_385aa
MAKIAKTHEDIEAQIREIQGKKAALDEAQGVGLDSTGYYDQEIYGGSDSRFAGYVTSIAATELEDDDDDYSSSTSLLGQKKPGYHAPVAL
LNDIPQSTEQYDPFAEHRPPKIADREDEYKKHRRTMIISPERLDPFADGGKTPDPKMNARTYMDVMREQHLTKEEGWLCELLRWKENPSP
ENRTLWENLCTIRRFLNLPQHERDVIYEEESRHHHSERMQHVVQLPPEPVQVLHRQQSQPAKESSPPREEAPPPPPPTEDSCAKKPRSRT
KISLEALGILQSFIHDVGLYPDQEAIHTLSAQLDLPKHTIIKFFQNQRYHVKHHGKLKEHLGSAVDVAEYKDEELLTESEENDSEEGSEE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SF3B1_ENST00000335508_chr2_198283233_-_SATB2_ENST00000417098_chr2_200173680_-_1155nt
ATGGCGAAGATCGCCAAGACTCACGAAGATATTGAAGCACAGATTCGAGAAATTCAAGGCAAGAAGGCAGCTCTTGATGAAGCTCAAGGA
GTGGGCCTCGATTCTACAGGTTATTATGACCAGGAAATTTATGGTGGAAGTGACAGCAGATTTGCTGGATACGTGACATCAATTGCTGCA
ACTGAACTTGAAGATGATGACGATGACTATTCATCATCTACGAGTTTGCTTGGTCAGAAGAAGCCAGGATATCATGCCCCTGTGGCATTG
CTTAATGATATACCACAGTCAACAGAACAGTATGATCCATTTGCTGAGCACAGACCTCCAAAGATTGCAGACCGGGAAGATGAATACAAA
AAGCATAGGCGGACCATGATAATTTCCCCAGAGCGTCTTGATCCTTTTGCAGATGGAGGGAAAACCCCTGATCCTAAAATGAATGCTAGG
ACTTACATGGATGTAATGCGAGAACAACACTTGACTAAAGAAGAAGGCTGGCTGTGTGAACTGCTCCGCTGGAAGGAGAACCCAAGCCCA
GAAAACCGCACCCTCTGGGAAAACCTCTGTACCATCCGTCGCTTCCTGAACCTTCCCCAGCATGAGAGGGATGTCATCTATGAGGAGGAG
TCAAGGCATCACCACAGCGAACGCATGCAACACGTGGTCCAGCTTCCCCCTGAGCCGGTGCAGGTACTTCATAGACAGCAGTCTCAGCCA
GCCAAGGAGAGTTCCCCTCCCAGAGAAGAAGCGCCTCCCCCACCTCCTCCGACTGAAGACAGTTGTGCCAAAAAGCCCCGGTCTCGCACA
AAGATCTCCTTAGAAGCCCTGGGGATCCTCCAAAGCTTTATTCATGATGTAGGCCTGTACCCAGACCAGGAAGCCATCCACACTCTTTCG
GCTCAGCTGGATCTCCCCAAACACACCATCATCAAGTTCTTCCAGAACCAGCGGTACCACGTGAAGCACCACGGGAAGCTGAAAGAGCAC
CTGGGCTCCGCGGTGGACGTGGCTGAATATAAGGACGAGGAGCTGCTGACCGAGTCAGAGGAGAACGACAGCGAGGAAGGCTCCGAGGAG

>In-frame_SF3B1_ENST00000335508_chr2_198283233_-_SATB2_ENST00000443023_chr2_200173680_-_1155nt
ATGGCGAAGATCGCCAAGACTCACGAAGATATTGAAGCACAGATTCGAGAAATTCAAGGCAAGAAGGCAGCTCTTGATGAAGCTCAAGGA
GTGGGCCTCGATTCTACAGGTTATTATGACCAGGAAATTTATGGTGGAAGTGACAGCAGATTTGCTGGATACGTGACATCAATTGCTGCA
ACTGAACTTGAAGATGATGACGATGACTATTCATCATCTACGAGTTTGCTTGGTCAGAAGAAGCCAGGATATCATGCCCCTGTGGCATTG
CTTAATGATATACCACAGTCAACAGAACAGTATGATCCATTTGCTGAGCACAGACCTCCAAAGATTGCAGACCGGGAAGATGAATACAAA
AAGCATAGGCGGACCATGATAATTTCCCCAGAGCGTCTTGATCCTTTTGCAGATGGAGGGAAAACCCCTGATCCTAAAATGAATGCTAGG
ACTTACATGGATGTAATGCGAGAACAACACTTGACTAAAGAAGAAGGCTGGCTGTGTGAACTGCTCCGCTGGAAGGAGAACCCAAGCCCA
GAAAACCGCACCCTCTGGGAAAACCTCTGTACCATCCGTCGCTTCCTGAACCTTCCCCAGCATGAGAGGGATGTCATCTATGAGGAGGAG
TCAAGGCATCACCACAGCGAACGCATGCAACACGTGGTCCAGCTTCCCCCTGAGCCGGTGCAGGTACTTCATAGACAGCAGTCTCAGCCA
GCCAAGGAGAGTTCCCCTCCCAGAGAAGAAGCGCCTCCCCCACCTCCTCCGACTGAAGACAGTTGTGCCAAAAAGCCCCGGTCTCGCACA
AAGATCTCCTTAGAAGCCCTGGGGATCCTCCAAAGCTTTATTCATGATGTAGGCCTGTACCCAGACCAGGAAGCCATCCACACTCTTTCG
GCTCAGCTGGATCTCCCCAAACACACCATCATCAAGTTCTTCCAGAACCAGCGGTACCACGTGAAGCACCACGGGAAGCTGAAAGAGCAC
CTGGGCTCCGCGGTGGACGTGGCTGAATATAAGGACGAGGAGCTGCTGACCGAGTCAGAGGAGAACGACAGCGAGGAAGGCTCCGAGGAG

>In-frame_SF3B1_ENST00000335508_chr2_198283233_-_SATB2_ENST00000260926_chr2_200173680_-_1155nt
ATGGCGAAGATCGCCAAGACTCACGAAGATATTGAAGCACAGATTCGAGAAATTCAAGGCAAGAAGGCAGCTCTTGATGAAGCTCAAGGA
GTGGGCCTCGATTCTACAGGTTATTATGACCAGGAAATTTATGGTGGAAGTGACAGCAGATTTGCTGGATACGTGACATCAATTGCTGCA
ACTGAACTTGAAGATGATGACGATGACTATTCATCATCTACGAGTTTGCTTGGTCAGAAGAAGCCAGGATATCATGCCCCTGTGGCATTG
CTTAATGATATACCACAGTCAACAGAACAGTATGATCCATTTGCTGAGCACAGACCTCCAAAGATTGCAGACCGGGAAGATGAATACAAA
AAGCATAGGCGGACCATGATAATTTCCCCAGAGCGTCTTGATCCTTTTGCAGATGGAGGGAAAACCCCTGATCCTAAAATGAATGCTAGG
ACTTACATGGATGTAATGCGAGAACAACACTTGACTAAAGAAGAAGGCTGGCTGTGTGAACTGCTCCGCTGGAAGGAGAACCCAAGCCCA
GAAAACCGCACCCTCTGGGAAAACCTCTGTACCATCCGTCGCTTCCTGAACCTTCCCCAGCATGAGAGGGATGTCATCTATGAGGAGGAG
TCAAGGCATCACCACAGCGAACGCATGCAACACGTGGTCCAGCTTCCCCCTGAGCCGGTGCAGGTACTTCATAGACAGCAGTCTCAGCCA
GCCAAGGAGAGTTCCCCTCCCAGAGAAGAAGCGCCTCCCCCACCTCCTCCGACTGAAGACAGTTGTGCCAAAAAGCCCCGGTCTCGCACA
AAGATCTCCTTAGAAGCCCTGGGGATCCTCCAAAGCTTTATTCATGATGTAGGCCTGTACCCAGACCAGGAAGCCATCCACACTCTTTCG
GCTCAGCTGGATCTCCCCAAACACACCATCATCAAGTTCTTCCAGAACCAGCGGTACCACGTGAAGCACCACGGGAAGCTGAAAGAGCAC
CTGGGCTCCGCGGTGGACGTGGCTGAATATAAGGACGAGGAGCTGCTGACCGAGTCAGAGGAGAACGACAGCGAGGAAGGCTCCGAGGAG

>In-frame_SF3B1_ENST00000335508_chr2_198283233_-_SATB2_ENST00000428695_chr2_200173680_-_1155nt
ATGGCGAAGATCGCCAAGACTCACGAAGATATTGAAGCACAGATTCGAGAAATTCAAGGCAAGAAGGCAGCTCTTGATGAAGCTCAAGGA
GTGGGCCTCGATTCTACAGGTTATTATGACCAGGAAATTTATGGTGGAAGTGACAGCAGATTTGCTGGATACGTGACATCAATTGCTGCA
ACTGAACTTGAAGATGATGACGATGACTATTCATCATCTACGAGTTTGCTTGGTCAGAAGAAGCCAGGATATCATGCCCCTGTGGCATTG
CTTAATGATATACCACAGTCAACAGAACAGTATGATCCATTTGCTGAGCACAGACCTCCAAAGATTGCAGACCGGGAAGATGAATACAAA
AAGCATAGGCGGACCATGATAATTTCCCCAGAGCGTCTTGATCCTTTTGCAGATGGAGGGAAAACCCCTGATCCTAAAATGAATGCTAGG
ACTTACATGGATGTAATGCGAGAACAACACTTGACTAAAGAAGAAGGCTGGCTGTGTGAACTGCTCCGCTGGAAGGAGAACCCAAGCCCA
GAAAACCGCACCCTCTGGGAAAACCTCTGTACCATCCGTCGCTTCCTGAACCTTCCCCAGCATGAGAGGGATGTCATCTATGAGGAGGAG
TCAAGGCATCACCACAGCGAACGCATGCAACACGTGGTCCAGCTTCCCCCTGAGCCGGTGCAGGTACTTCATAGACAGCAGTCTCAGCCA
GCCAAGGAGAGTTCCCCTCCCAGAGAAGAAGCGCCTCCCCCACCTCCTCCGACTGAAGACAGTTGTGCCAAAAAGCCCCGGTCTCGCACA
AAGATCTCCTTAGAAGCCCTGGGGATCCTCCAAAGCTTTATTCATGATGTAGGCCTGTACCCAGACCAGGAAGCCATCCACACTCTTTCG
GCTCAGCTGGATCTCCCCAAACACACCATCATCAAGTTCTTCCAGAACCAGCGGTACCACGTGAAGCACCACGGGAAGCTGAAAGAGCAC
CTGGGCTCCGCGGTGGACGTGGCTGAATATAAGGACGAGGAGCTGCTGACCGAGTCAGAGGAGAACGACAGCGAGGAAGGCTCCGAGGAG

>In-frame_SF3B1_ENST00000335508_chr2_198283233_-_SATB2_ENST00000457245_chr2_200173680_-_1155nt
ATGGCGAAGATCGCCAAGACTCACGAAGATATTGAAGCACAGATTCGAGAAATTCAAGGCAAGAAGGCAGCTCTTGATGAAGCTCAAGGA
GTGGGCCTCGATTCTACAGGTTATTATGACCAGGAAATTTATGGTGGAAGTGACAGCAGATTTGCTGGATACGTGACATCAATTGCTGCA
ACTGAACTTGAAGATGATGACGATGACTATTCATCATCTACGAGTTTGCTTGGTCAGAAGAAGCCAGGATATCATGCCCCTGTGGCATTG
CTTAATGATATACCACAGTCAACAGAACAGTATGATCCATTTGCTGAGCACAGACCTCCAAAGATTGCAGACCGGGAAGATGAATACAAA
AAGCATAGGCGGACCATGATAATTTCCCCAGAGCGTCTTGATCCTTTTGCAGATGGAGGGAAAACCCCTGATCCTAAAATGAATGCTAGG
ACTTACATGGATGTAATGCGAGAACAACACTTGACTAAAGAAGAAGGCTGGCTGTGTGAACTGCTCCGCTGGAAGGAGAACCCAAGCCCA
GAAAACCGCACCCTCTGGGAAAACCTCTGTACCATCCGTCGCTTCCTGAACCTTCCCCAGCATGAGAGGGATGTCATCTATGAGGAGGAG
TCAAGGCATCACCACAGCGAACGCATGCAACACGTGGTCCAGCTTCCCCCTGAGCCGGTGCAGGTACTTCATAGACAGCAGTCTCAGCCA
GCCAAGGAGAGTTCCCCTCCCAGAGAAGAAGCGCCTCCCCCACCTCCTCCGACTGAAGACAGTTGTGCCAAAAAGCCCCGGTCTCGCACA
AAGATCTCCTTAGAAGCCCTGGGGATCCTCCAAAGCTTTATTCATGATGTAGGCCTGTACCCAGACCAGGAAGCCATCCACACTCTTTCG
GCTCAGCTGGATCTCCCCAAACACACCATCATCAAGTTCTTCCAGAACCAGCGGTACCACGTGAAGCACCACGGGAAGCTGAAAGAGCAC
CTGGGCTCCGCGGTGGACGTGGCTGAATATAAGGACGAGGAGCTGCTGACCGAGTCAGAGGAGAACGACAGCGAGGAAGGCTCCGAGGAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_SF3B1_ENST00000335508_chr2_198283233_-_SATB2_ENST00000417098_chr2_200173680_-_3958nt
AGTGCAGCCCCCAGCTATTTTTCTCCGTGGCGGCGGCGACGAGCGGAAGTTCTTGGGAGCGCCAGTTCCGTCTGTGTGTTCGAGTGGACA
AAATGGCGAAGATCGCCAAGACTCACGAAGATATTGAAGCACAGATTCGAGAAATTCAAGGCAAGAAGGCAGCTCTTGATGAAGCTCAAG
GAGTGGGCCTCGATTCTACAGGTTATTATGACCAGGAAATTTATGGTGGAAGTGACAGCAGATTTGCTGGATACGTGACATCAATTGCTG
CAACTGAACTTGAAGATGATGACGATGACTATTCATCATCTACGAGTTTGCTTGGTCAGAAGAAGCCAGGATATCATGCCCCTGTGGCAT
TGCTTAATGATATACCACAGTCAACAGAACAGTATGATCCATTTGCTGAGCACAGACCTCCAAAGATTGCAGACCGGGAAGATGAATACA
AAAAGCATAGGCGGACCATGATAATTTCCCCAGAGCGTCTTGATCCTTTTGCAGATGGAGGGAAAACCCCTGATCCTAAAATGAATGCTA
GGACTTACATGGATGTAATGCGAGAACAACACTTGACTAAAGAAGAAGGCTGGCTGTGTGAACTGCTCCGCTGGAAGGAGAACCCAAGCC
CAGAAAACCGCACCCTCTGGGAAAACCTCTGTACCATCCGTCGCTTCCTGAACCTTCCCCAGCATGAGAGGGATGTCATCTATGAGGAGG
AGTCAAGGCATCACCACAGCGAACGCATGCAACACGTGGTCCAGCTTCCCCCTGAGCCGGTGCAGGTACTTCATAGACAGCAGTCTCAGC
CAGCCAAGGAGAGTTCCCCTCCCAGAGAAGAAGCGCCTCCCCCACCTCCTCCGACTGAAGACAGTTGTGCCAAAAAGCCCCGGTCTCGCA
CAAAGATCTCCTTAGAAGCCCTGGGGATCCTCCAAAGCTTTATTCATGATGTAGGCCTGTACCCAGACCAGGAAGCCATCCACACTCTTT
CGGCTCAGCTGGATCTCCCCAAACACACCATCATCAAGTTCTTCCAGAACCAGCGGTACCACGTGAAGCACCACGGGAAGCTGAAAGAGC
ACCTGGGCTCCGCGGTGGACGTGGCTGAATATAAGGACGAGGAGCTGCTGACCGAGTCAGAGGAGAACGACAGCGAGGAAGGCTCCGAGG
AGATGTACAAAGTGGAGGCTGAGGAGGAAAATGCTGACAAAAGCAAGGCAGCACCTGCCGAAATTGACCAGAGATAATGTGAACTTCTAC
TAGGCAAAGCAATACATCGGTCCAAGGATTTTCTGCTTTCATTTCTTTAAAAGTTTTTTGTTAGTTTGTTTTTTGTTTTTGTTTTTGGGT
TTTTTTGGCTTTATTTTTGTCTTTTTATGTCTGTTTTGTTTTTCTTACCCTTTTGGACATTTCTTTGTTGCACAGGATACACCTATAGAC
TGAATAAGTTCAGTATTTCCGAATCAGACATCGCCTTGGCAAAGACACTAAAGCGTTACACTTTATCCCGTCTCTATGACTGGATCATAG
TCATTATAATCACAGGAGACTCTGCCTTCATTATCCTTGCACTTAACGGAAGTTACATCAGGCAAGTACCAGGATGAAAAGAACTATGAA
ATAAATGAAGGAAGCTACAAGTGTGTGTGTATATGTATATGTATATATCTCTATATTTACATATATATATTAAAATTGCATGGGACAGAG
ACTTTGCAATCCGAAAGAATAGACTGTGAAATGAGTTCTTAAAGAAAAGACTTGTTTATGTATTAAAAAAACCACTTCACAGTGAGTCGC
TTTGGCTTTTTGATAAACTGCGGCCTGCTCTCAGGGTGGGGTGACTATTTTTGAATTCCTATTTATTTTTTGTGTTTGTCCCTGATTTTT
TTTTTTTAATTCTATGGCTTCCTATCTGGCAGCTTAATGGGTAATTTTTGAGGTATGTATTTAACAAAATAAACGACACTGCCGAAAAAA
AAAAAAGTGAAGTGAAAACAATCAGGGCACATTAAAATGATACAAGTCAAATAAATCTTAAAGACACAATGCACACTTAAAATGACTCAA
TAAAATGACTTGCTACGTTCCGTTATTCAATTTGTCATTACTGTAGTGAACAGATGCATTTCTGTGGAATTCCAAATAAGTAAAACTGAA
ATTCAGTGCAGAGAAAACTTTGTCCACTAGTGCAAGTCTTGATCAAATGACATTTTGACATTGGACATATGGAATTCATAGTATGAGCCA
CATTTTGTTGTGAAATTTATTTACCTGCTTGTGGCTTCAAATCTGAAAATTAATAAGCCTGCTCGTTTAAAAGTTGTTTGTTGTTGCTGT
TTTTTTGTCTTTTTGTTTTTTACTAGAAAATAGTTCAGTGTAATATTAAGTTAGAAAAGAAGTTGCTGCCCAGTTAAAGGGGCTCCCTCT
CAAATAAATCTCCATCCTTCCCTCTCCCAAAAGACATTTCTGATTTCTGCTTCACTTTGGGCTTCCTCTTCTTCGTACACATTCCATCTA
CCTAATCAAACATTTTCAGTCCCTGATCTCTCCTGTCCCTTTTCCTGGGATGACAGCCCTAACAAGAACTGTTTTTGAATCGTTGTGCAG
CTCCAGGCAATAGAGTATGTGAAGCGATTTCAGTAGAATCACTTACTCATCCTAAAAGAAAACATTATCCCAGTTACCTACATCGCAATT
ACCTTATGTAAAGCAGAACTAATGCTGACTGGATGTTTAATGGGATGAGCATTAAAGCTGCAATCTACTATAGTACTCCAGATCTCTTTC
GGCTTCCTATGAGAAACACCAGAAGCATTACTTTCCACTTCTACTTACAGTAATTGCAAGAGGAGACCTCACATTCAGGACTGGCCTAGT
GAACGTAATCCATGCTTTAAACTGGCCATTAAACAGTCCCACATGGTTGGATTTTTTTTTTTTTTTTGAGTTGTGCTTTCACAAAACCTT
GTCAAAGACCTCATGCAATATCACTTTGAAAGTTATTTTCTGTTTACTACACAAACATTGTAATATAACTGTTAATACTATTTATATATT
TGAAAGGTATAAAAGGTAGGAGTTAAAAAAAAAACCTCTATGTGTAGATATTAACTCAGAACTTACAATATACAGGGAGAAGACATGTTG
CAATACAAGCTAATTCTAGCTGCTCAGTAACCTCTGGAGTTTTTAAAGGGACATTTTCCTGTACTTTTTCAAATAATGATGTTTAAAAAT
TATCTTGACATAAGCGTCATATACCTTTGCAAAAGGATGGTTGTTTGCAGTTAGCCCTGGCCCCATCCTTCCTATTTCTGTAGTATGCTG
CAGCTTTAATCAGAAAGTCCATGGTTGCTGCTTCCTGATCTCCGAGTTACTCTTTCCAAATTGTCTTCTTACACTGTTGCTGAAGGTCAC
TCTGTACACGTAATGGAAACTGATTTTGCCAAGCTCTTACAAGGTGGTTCATCTATCGATGGCATCCGCATTTGGTATCTTTTACACTTC
AACCAAAAATTTATTAGGTATTTTTCAATGCTAAGTCTTGCCTTTTATTTTTTAATTTCACTGCCAAGTTTGCAGTGGTTCTAAGTGAAT
CTGTGGGCATTTTAGCCTGTGGTCTTGCCAGATCTTTGCGAATTACAATGCATATATGTCTATTTATTCAATATCTGTCATATAATATCT
ATTTGGAAGAAGAAACTTTCTCTTGTAGTGCCTCTTGACAAAGCACAATTTCCCGCCTTTTTTTTTTTTTGTGAAATGAAAAAAACAAAT
TGTGTTTTATTGCGGTATCAACAATGTGAATAAGGATTAACATATTGTAAATGTTCTTTTTTCCATGTAAATCAACTATCTTTGTTATCA

>In-frame_SF3B1_ENST00000335508_chr2_198283233_-_SATB2_ENST00000443023_chr2_200173680_-_3950nt
AGTGCAGCCCCCAGCTATTTTTCTCCGTGGCGGCGGCGACGAGCGGAAGTTCTTGGGAGCGCCAGTTCCGTCTGTGTGTTCGAGTGGACA
AAATGGCGAAGATCGCCAAGACTCACGAAGATATTGAAGCACAGATTCGAGAAATTCAAGGCAAGAAGGCAGCTCTTGATGAAGCTCAAG
GAGTGGGCCTCGATTCTACAGGTTATTATGACCAGGAAATTTATGGTGGAAGTGACAGCAGATTTGCTGGATACGTGACATCAATTGCTG
CAACTGAACTTGAAGATGATGACGATGACTATTCATCATCTACGAGTTTGCTTGGTCAGAAGAAGCCAGGATATCATGCCCCTGTGGCAT
TGCTTAATGATATACCACAGTCAACAGAACAGTATGATCCATTTGCTGAGCACAGACCTCCAAAGATTGCAGACCGGGAAGATGAATACA
AAAAGCATAGGCGGACCATGATAATTTCCCCAGAGCGTCTTGATCCTTTTGCAGATGGAGGGAAAACCCCTGATCCTAAAATGAATGCTA
GGACTTACATGGATGTAATGCGAGAACAACACTTGACTAAAGAAGAAGGCTGGCTGTGTGAACTGCTCCGCTGGAAGGAGAACCCAAGCC
CAGAAAACCGCACCCTCTGGGAAAACCTCTGTACCATCCGTCGCTTCCTGAACCTTCCCCAGCATGAGAGGGATGTCATCTATGAGGAGG
AGTCAAGGCATCACCACAGCGAACGCATGCAACACGTGGTCCAGCTTCCCCCTGAGCCGGTGCAGGTACTTCATAGACAGCAGTCTCAGC
CAGCCAAGGAGAGTTCCCCTCCCAGAGAAGAAGCGCCTCCCCCACCTCCTCCGACTGAAGACAGTTGTGCCAAAAAGCCCCGGTCTCGCA
CAAAGATCTCCTTAGAAGCCCTGGGGATCCTCCAAAGCTTTATTCATGATGTAGGCCTGTACCCAGACCAGGAAGCCATCCACACTCTTT
CGGCTCAGCTGGATCTCCCCAAACACACCATCATCAAGTTCTTCCAGAACCAGCGGTACCACGTGAAGCACCACGGGAAGCTGAAAGAGC
ACCTGGGCTCCGCGGTGGACGTGGCTGAATATAAGGACGAGGAGCTGCTGACCGAGTCAGAGGAGAACGACAGCGAGGAAGGCTCCGAGG
AGATGTACAAAGTGGAGGCTGAGGAGGAAAATGCTGACAAAAGCAAGGCAGCACCTGCCGAAATTGACCAGAGATAATGTGAACTTCTAC
TAGGCAAAGCAATACATCGGTCCAAGGATTTTCTGCTTTCATTTCTTTAAAAGTTTTTTGTTAGTTTGTTTTTTGTTTTTGTTTTTGGGT
TTTTTTGGCTTTATTTTTGTCTTTTTATGTCTGTTTTGTTTTTCTTACCCTTTTGGACATTTCTTTGTTGCACAGGATACACCTATAGAC
TGAATAAGTTCAGTATTTCCGAATCAGACATCGCCTTGGCAAAGACACTAAAGCGTTACACTTTATCCCGTCTCTATGACTGGATCATAG
TCATTATAATCACAGGAGACTCTGCCTTCATTATCCTTGCACTTAACGGAAGTTACATCAGGCAAGTACCAGGATGAAAAGAACTATGAA
ATAAATGAAGGAAGCTACAAGTGTGTGTGTATATGTATATGTATATATCTCTATATTTACATATATATATTAAAATTGCATGGGACAGAG
ACTTTGCAATCCGAAAGAATAGACTGTGAAATGAGTTCTTAAAGAAAAGACTTGTTTATGTATTAAAAAAACCACTTCACAGTGAGTCGC
TTTGGCTTTTTGATAAACTGCGGCCTGCTCTCAGGGTGGGGTGACTATTTTTGAATTCCTATTTATTTTTTGTGTTTGTCCCTGATTTTT
TTTTTTTAATTCTATGGCTTCCTATCTGGCAGCTTAATGGGTAATTTTTGAGGTATGTATTTAACAAAATAAACGACACTGCCGAAAAAA
AAAAAAGTGAAGTGAAAACAATCAGGGCACATTAAAATGATACAAGTCAAATAAATCTTAAAGACACAATGCACACTTAAAATGACTCAA
TAAAATGACTTGCTACGTTCCGTTATTCAATTTGTCATTACTGTAGTGAACAGATGCATTTCTGTGGAATTCCAAATAAGTAAAACTGAA
ATTCAGTGCAGAGAAAACTTTGTCCACTAGTGCAAGTCTTGATCAAATGACATTTTGACATTGGACATATGGAATTCATAGTATGAGCCA
CATTTTGTTGTGAAATTTATTTACCTGCTTGTGGCTTCAAATCTGAAAATTAATAAGCCTGCTCGTTTAAAAGTTGTTTGTTGTTGCTGT
TTTTTTGTCTTTTTGTTTTTTACTAGAAAATAGTTCAGTGTAATATTAAGTTAGAAAAGAAGTTGCTGCCCAGTTAAAGGGGCTCCCTCT
CAAATAAATCTCCATCCTTCCCTCTCCCAAAAGACATTTCTGATTTCTGCTTCACTTTGGGCTTCCTCTTCTTCGTACACATTCCATCTA
CCTAATCAAACATTTTCAGTCCCTGATCTCTCCTGTCCCTTTTCCTGGGATGACAGCCCTAACAAGAACTGTTTTTGAATCGTTGTGCAG
CTCCAGGCAATAGAGTATGTGAAGCGATTTCAGTAGAATCACTTACTCATCCTAAAAGAAAACATTATCCCAGTTACCTACATCGCAATT
ACCTTATGTAAAGCAGAACTAATGCTGACTGGATGTTTAATGGGATGAGCATTAAAGCTGCAATCTACTATAGTACTCCAGATCTCTTTC
GGCTTCCTATGAGAAACACCAGAAGCATTACTTTCCACTTCTACTTACAGTAATTGCAAGAGGAGACCTCACATTCAGGACTGGCCTAGT
GAACGTAATCCATGCTTTAAACTGGCCATTAAACAGTCCCACATGGTTGGATTTTTTTTTTTTTTTTGAGTTGTGCTTTCACAAAACCTT
GTCAAAGACCTCATGCAATATCACTTTGAAAGTTATTTTCTGTTTACTACACAAACATTGTAATATAACTGTTAATACTATTTATATATT
TGAAAGGTATAAAAGGTAGGAGTTAAAAAAAAAACCTCTATGTGTAGATATTAACTCAGAACTTACAATATACAGGGAGAAGACATGTTG
CAATACAAGCTAATTCTAGCTGCTCAGTAACCTCTGGAGTTTTTAAAGGGACATTTTCCTGTACTTTTTCAAATAATGATGTTTAAAAAT
TATCTTGACATAAGCGTCATATACCTTTGCAAAAGGATGGTTGTTTGCAGTTAGCCCTGGCCCCATCCTTCCTATTTCTGTAGTATGCTG
CAGCTTTAATCAGAAAGTCCATGGTTGCTGCTTCCTGATCTCCGAGTTACTCTTTCCAAATTGTCTTCTTACACTGTTGCTGAAGGTCAC
TCTGTACACGTAATGGAAACTGATTTTGCCAAGCTCTTACAAGGTGGTTCATCTATCGATGGCATCCGCATTTGGTATCTTTTACACTTC
AACCAAAAATTTATTAGGTATTTTTCAATGCTAAGTCTTGCCTTTTATTTTTTAATTTCACTGCCAAGTTTGCAGTGGTTCTAAGTGAAT
CTGTGGGCATTTTAGCCTGTGGTCTTGCCAGATCTTTGCGAATTACAATGCATATATGTCTATTTATTCAATATCTGTCATATAATATCT
ATTTGGAAGAAGAAACTTTCTCTTGTAGTGCCTCTTGACAAAGCACAATTTCCCGCCTTTTTTTTTTTTTGTGAAATGAAAAAAACAAAT
TGTGTTTTATTGCGGTATCAACAATGTGAATAAGGATTAACATATTGTAAATGTTCTTTTTTCCATGTAAATCAACTATCTTTGTTATCA

>In-frame_SF3B1_ENST00000335508_chr2_198283233_-_SATB2_ENST00000260926_chr2_200173680_-_3950nt
AGTGCAGCCCCCAGCTATTTTTCTCCGTGGCGGCGGCGACGAGCGGAAGTTCTTGGGAGCGCCAGTTCCGTCTGTGTGTTCGAGTGGACA
AAATGGCGAAGATCGCCAAGACTCACGAAGATATTGAAGCACAGATTCGAGAAATTCAAGGCAAGAAGGCAGCTCTTGATGAAGCTCAAG
GAGTGGGCCTCGATTCTACAGGTTATTATGACCAGGAAATTTATGGTGGAAGTGACAGCAGATTTGCTGGATACGTGACATCAATTGCTG
CAACTGAACTTGAAGATGATGACGATGACTATTCATCATCTACGAGTTTGCTTGGTCAGAAGAAGCCAGGATATCATGCCCCTGTGGCAT
TGCTTAATGATATACCACAGTCAACAGAACAGTATGATCCATTTGCTGAGCACAGACCTCCAAAGATTGCAGACCGGGAAGATGAATACA
AAAAGCATAGGCGGACCATGATAATTTCCCCAGAGCGTCTTGATCCTTTTGCAGATGGAGGGAAAACCCCTGATCCTAAAATGAATGCTA
GGACTTACATGGATGTAATGCGAGAACAACACTTGACTAAAGAAGAAGGCTGGCTGTGTGAACTGCTCCGCTGGAAGGAGAACCCAAGCC
CAGAAAACCGCACCCTCTGGGAAAACCTCTGTACCATCCGTCGCTTCCTGAACCTTCCCCAGCATGAGAGGGATGTCATCTATGAGGAGG
AGTCAAGGCATCACCACAGCGAACGCATGCAACACGTGGTCCAGCTTCCCCCTGAGCCGGTGCAGGTACTTCATAGACAGCAGTCTCAGC
CAGCCAAGGAGAGTTCCCCTCCCAGAGAAGAAGCGCCTCCCCCACCTCCTCCGACTGAAGACAGTTGTGCCAAAAAGCCCCGGTCTCGCA
CAAAGATCTCCTTAGAAGCCCTGGGGATCCTCCAAAGCTTTATTCATGATGTAGGCCTGTACCCAGACCAGGAAGCCATCCACACTCTTT
CGGCTCAGCTGGATCTCCCCAAACACACCATCATCAAGTTCTTCCAGAACCAGCGGTACCACGTGAAGCACCACGGGAAGCTGAAAGAGC
ACCTGGGCTCCGCGGTGGACGTGGCTGAATATAAGGACGAGGAGCTGCTGACCGAGTCAGAGGAGAACGACAGCGAGGAAGGCTCCGAGG
AGATGTACAAAGTGGAGGCTGAGGAGGAAAATGCTGACAAAAGCAAGGCAGCACCTGCCGAAATTGACCAGAGATAATGTGAACTTCTAC
TAGGCAAAGCAATACATCGGTCCAAGGATTTTCTGCTTTCATTTCTTTAAAAGTTTTTTGTTAGTTTGTTTTTTGTTTTTGTTTTTGGGT
TTTTTTGGCTTTATTTTTGTCTTTTTATGTCTGTTTTGTTTTTCTTACCCTTTTGGACATTTCTTTGTTGCACAGGATACACCTATAGAC
TGAATAAGTTCAGTATTTCCGAATCAGACATCGCCTTGGCAAAGACACTAAAGCGTTACACTTTATCCCGTCTCTATGACTGGATCATAG
TCATTATAATCACAGGAGACTCTGCCTTCATTATCCTTGCACTTAACGGAAGTTACATCAGGCAAGTACCAGGATGAAAAGAACTATGAA
ATAAATGAAGGAAGCTACAAGTGTGTGTGTATATGTATATGTATATATCTCTATATTTACATATATATATTAAAATTGCATGGGACAGAG
ACTTTGCAATCCGAAAGAATAGACTGTGAAATGAGTTCTTAAAGAAAAGACTTGTTTATGTATTAAAAAAACCACTTCACAGTGAGTCGC
TTTGGCTTTTTGATAAACTGCGGCCTGCTCTCAGGGTGGGGTGACTATTTTTGAATTCCTATTTATTTTTTGTGTTTGTCCCTGATTTTT
TTTTTTTAATTCTATGGCTTCCTATCTGGCAGCTTAATGGGTAATTTTTGAGGTATGTATTTAACAAAATAAACGACACTGCCGAAAAAA
AAAAAAGTGAAGTGAAAACAATCAGGGCACATTAAAATGATACAAGTCAAATAAATCTTAAAGACACAATGCACACTTAAAATGACTCAA
TAAAATGACTTGCTACGTTCCGTTATTCAATTTGTCATTACTGTAGTGAACAGATGCATTTCTGTGGAATTCCAAATAAGTAAAACTGAA
ATTCAGTGCAGAGAAAACTTTGTCCACTAGTGCAAGTCTTGATCAAATGACATTTTGACATTGGACATATGGAATTCATAGTATGAGCCA
CATTTTGTTGTGAAATTTATTTACCTGCTTGTGGCTTCAAATCTGAAAATTAATAAGCCTGCTCGTTTAAAAGTTGTTTGTTGTTGCTGT
TTTTTTGTCTTTTTGTTTTTTACTAGAAAATAGTTCAGTGTAATATTAAGTTAGAAAAGAAGTTGCTGCCCAGTTAAAGGGGCTCCCTCT
CAAATAAATCTCCATCCTTCCCTCTCCCAAAAGACATTTCTGATTTCTGCTTCACTTTGGGCTTCCTCTTCTTCGTACACATTCCATCTA
CCTAATCAAACATTTTCAGTCCCTGATCTCTCCTGTCCCTTTTCCTGGGATGACAGCCCTAACAAGAACTGTTTTTGAATCGTTGTGCAG
CTCCAGGCAATAGAGTATGTGAAGCGATTTCAGTAGAATCACTTACTCATCCTAAAAGAAAACATTATCCCAGTTACCTACATCGCAATT
ACCTTATGTAAAGCAGAACTAATGCTGACTGGATGTTTAATGGGATGAGCATTAAAGCTGCAATCTACTATAGTACTCCAGATCTCTTTC
GGCTTCCTATGAGAAACACCAGAAGCATTACTTTCCACTTCTACTTACAGTAATTGCAAGAGGAGACCTCACATTCAGGACTGGCCTAGT
GAACGTAATCCATGCTTTAAACTGGCCATTAAACAGTCCCACATGGTTGGATTTTTTTTTTTTTTTTGAGTTGTGCTTTCACAAAACCTT
GTCAAAGACCTCATGCAATATCACTTTGAAAGTTATTTTCTGTTTACTACACAAACATTGTAATATAACTGTTAATACTATTTATATATT
TGAAAGGTATAAAAGGTAGGAGTTAAAAAAAAAACCTCTATGTGTAGATATTAACTCAGAACTTACAATATACAGGGAGAAGACATGTTG
CAATACAAGCTAATTCTAGCTGCTCAGTAACCTCTGGAGTTTTTAAAGGGACATTTTCCTGTACTTTTTCAAATAATGATGTTTAAAAAT
TATCTTGACATAAGCGTCATATACCTTTGCAAAAGGATGGTTGTTTGCAGTTAGCCCTGGCCCCATCCTTCCTATTTCTGTAGTATGCTG
CAGCTTTAATCAGAAAGTCCATGGTTGCTGCTTCCTGATCTCCGAGTTACTCTTTCCAAATTGTCTTCTTACACTGTTGCTGAAGGTCAC
TCTGTACACGTAATGGAAACTGATTTTGCCAAGCTCTTACAAGGTGGTTCATCTATCGATGGCATCCGCATTTGGTATCTTTTACACTTC
AACCAAAAATTTATTAGGTATTTTTCAATGCTAAGTCTTGCCTTTTATTTTTTAATTTCACTGCCAAGTTTGCAGTGGTTCTAAGTGAAT
CTGTGGGCATTTTAGCCTGTGGTCTTGCCAGATCTTTGCGAATTACAATGCATATATGTCTATTTATTCAATATCTGTCATATAATATCT
ATTTGGAAGAAGAAACTTTCTCTTGTAGTGCCTCTTGACAAAGCACAATTTCCCGCCTTTTTTTTTTTTTGTGAAATGAAAAAAACAAAT
TGTGTTTTATTGCGGTATCAACAATGTGAATAAGGATTAACATATTGTAAATGTTCTTTTTTCCATGTAAATCAACTATCTTTGTTATCA

>In-frame_SF3B1_ENST00000335508_chr2_198283233_-_SATB2_ENST00000428695_chr2_200173680_-_1483nt
AGTGCAGCCCCCAGCTATTTTTCTCCGTGGCGGCGGCGACGAGCGGAAGTTCTTGGGAGCGCCAGTTCCGTCTGTGTGTTCGAGTGGACA
AAATGGCGAAGATCGCCAAGACTCACGAAGATATTGAAGCACAGATTCGAGAAATTCAAGGCAAGAAGGCAGCTCTTGATGAAGCTCAAG
GAGTGGGCCTCGATTCTACAGGTTATTATGACCAGGAAATTTATGGTGGAAGTGACAGCAGATTTGCTGGATACGTGACATCAATTGCTG
CAACTGAACTTGAAGATGATGACGATGACTATTCATCATCTACGAGTTTGCTTGGTCAGAAGAAGCCAGGATATCATGCCCCTGTGGCAT
TGCTTAATGATATACCACAGTCAACAGAACAGTATGATCCATTTGCTGAGCACAGACCTCCAAAGATTGCAGACCGGGAAGATGAATACA
AAAAGCATAGGCGGACCATGATAATTTCCCCAGAGCGTCTTGATCCTTTTGCAGATGGAGGGAAAACCCCTGATCCTAAAATGAATGCTA
GGACTTACATGGATGTAATGCGAGAACAACACTTGACTAAAGAAGAAGGCTGGCTGTGTGAACTGCTCCGCTGGAAGGAGAACCCAAGCC
CAGAAAACCGCACCCTCTGGGAAAACCTCTGTACCATCCGTCGCTTCCTGAACCTTCCCCAGCATGAGAGGGATGTCATCTATGAGGAGG
AGTCAAGGCATCACCACAGCGAACGCATGCAACACGTGGTCCAGCTTCCCCCTGAGCCGGTGCAGGTACTTCATAGACAGCAGTCTCAGC
CAGCCAAGGAGAGTTCCCCTCCCAGAGAAGAAGCGCCTCCCCCACCTCCTCCGACTGAAGACAGTTGTGCCAAAAAGCCCCGGTCTCGCA
CAAAGATCTCCTTAGAAGCCCTGGGGATCCTCCAAAGCTTTATTCATGATGTAGGCCTGTACCCAGACCAGGAAGCCATCCACACTCTTT
CGGCTCAGCTGGATCTCCCCAAACACACCATCATCAAGTTCTTCCAGAACCAGCGGTACCACGTGAAGCACCACGGGAAGCTGAAAGAGC
ACCTGGGCTCCGCGGTGGACGTGGCTGAATATAAGGACGAGGAGCTGCTGACCGAGTCAGAGGAGAACGACAGCGAGGAAGGCTCCGAGG
AGATGTACAAAGTGGAGGCTGAGGAGGAAAATGCTGACAAAAGCAAGGCAGCACCTGCCGAAATTGACCAGAGATAATGTGAACTTCTAC
TAGGCAAAGCAATACATCGGTCCAAGGATTTTCTGCTTTCATTTCTTTAAAAGTTTTTTGTTAGTTTGTTTTTTGTTTTTGTTTTTGGGT
TTTTTTGGCTTTATTTTTGTCTTTTTATGTCTGTTTTGTTTTTCTTACCCTTTTGGACATTTCTTTGTTGCACAGGATACACCTATAGAC

>In-frame_SF3B1_ENST00000335508_chr2_198283233_-_SATB2_ENST00000457245_chr2_200173680_-_1308nt
AGTGCAGCCCCCAGCTATTTTTCTCCGTGGCGGCGGCGACGAGCGGAAGTTCTTGGGAGCGCCAGTTCCGTCTGTGTGTTCGAGTGGACA
AAATGGCGAAGATCGCCAAGACTCACGAAGATATTGAAGCACAGATTCGAGAAATTCAAGGCAAGAAGGCAGCTCTTGATGAAGCTCAAG
GAGTGGGCCTCGATTCTACAGGTTATTATGACCAGGAAATTTATGGTGGAAGTGACAGCAGATTTGCTGGATACGTGACATCAATTGCTG
CAACTGAACTTGAAGATGATGACGATGACTATTCATCATCTACGAGTTTGCTTGGTCAGAAGAAGCCAGGATATCATGCCCCTGTGGCAT
TGCTTAATGATATACCACAGTCAACAGAACAGTATGATCCATTTGCTGAGCACAGACCTCCAAAGATTGCAGACCGGGAAGATGAATACA
AAAAGCATAGGCGGACCATGATAATTTCCCCAGAGCGTCTTGATCCTTTTGCAGATGGAGGGAAAACCCCTGATCCTAAAATGAATGCTA
GGACTTACATGGATGTAATGCGAGAACAACACTTGACTAAAGAAGAAGGCTGGCTGTGTGAACTGCTCCGCTGGAAGGAGAACCCAAGCC
CAGAAAACCGCACCCTCTGGGAAAACCTCTGTACCATCCGTCGCTTCCTGAACCTTCCCCAGCATGAGAGGGATGTCATCTATGAGGAGG
AGTCAAGGCATCACCACAGCGAACGCATGCAACACGTGGTCCAGCTTCCCCCTGAGCCGGTGCAGGTACTTCATAGACAGCAGTCTCAGC
CAGCCAAGGAGAGTTCCCCTCCCAGAGAAGAAGCGCCTCCCCCACCTCCTCCGACTGAAGACAGTTGTGCCAAAAAGCCCCGGTCTCGCA
CAAAGATCTCCTTAGAAGCCCTGGGGATCCTCCAAAGCTTTATTCATGATGTAGGCCTGTACCCAGACCAGGAAGCCATCCACACTCTTT
CGGCTCAGCTGGATCTCCCCAAACACACCATCATCAAGTTCTTCCAGAACCAGCGGTACCACGTGAAGCACCACGGGAAGCTGAAAGAGC
ACCTGGGCTCCGCGGTGGACGTGGCTGAATATAAGGACGAGGAGCTGCTGACCGAGTCAGAGGAGAACGACAGCGAGGAAGGCTCCGAGG
AGATGTACAAAGTGGAGGCTGAGGAGGAAAATGCTGACAAAAGCAAGGCAGCACCTGCCGAAATTGACCAGAGATAATGTGAACTTCTAC


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FusionGenePPI for SF3B1_SATB2


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check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SF3B1TCERG1, ATG12, BRF2, GSK3B, HDAC3, SNRNP40, RNPS1, PUF60, SMNDC1, YWHAZ, RNU11, CCNE1, SF3B2, SF3B3, SF3B6, PPP1R8, SF3A2, DDX42, SF3B4, SF3B5, PHF5A, CDC5L, SAP130, MYC, BAZ1B, H3F3A, TOPORS, HDAC5, RBM39, TOP1, CALM1, NUDT21, C11orf58, NELFE, ARRB2, SIRT7, CUL3, CUL1, COPS5, CAND1, SF3A1, SF3A3, SNRPD2, SNRPA1, SNRNP200, SNRPD1, SNRPB2, SRSF1, HNRNPK, SNRPD3, EFTUD2, PRPF8, HNRNPR, U2AF1, SNRPA, RBMX, SRSF5, U2AF2, SFPQ, HNRNPM, ILF2, PRPF31, TRA2B, ILF3, TARDBP, SART1, SRRM2, THOC1, USP39, SSRP1, UBAP2L, ZNF326, EPRS, SON, TRMT112, SURF4, TMED9, SSR3, CCT6A, VTN, MCM6, TPM1, MCM2, TRIM24, TIMM13, RBM14, TUBA1B, SSBP1, TOX4, TFPI, ESR1, MAGOH, EIF4A3, SMURF1, YWHAE, FN1, RBM17, PLRG1, SNIP1, CSNK2A1, SMAD9, SMAD1, SMAD5, IL7R, RPL23A, RPL18A, RPL3, RPL10, RPS2, FBXO6, PRPF40A, WBP4, APBB1, WWOX, RPA1, RPA2, RPA3, ERG, LGR4, STAU1, MDM2, SART3, CUL7, OBSL1, CCDC8, EZH2, SUZ12, EED, RNF2, HIST1H1A, NOL12, RBM7, RPSA, RPS8, PRR11, ZRSR2, FBXW11, UNK, CAPZA1, CCDC97, COPA, COPB1, COPG1, KPNA2, LONP1, PRPF3, PRPF4, ARCN1, COPZ1, DHX15, MCM4, MCM5, MCM7, MOB4, PRPF19, RNU12, NTRK1, SCARNA22, CLK1, HIST1H3E, KPNA1, MYO1C, XRCC3, EMC2, ZBTB33, NES, UGGT1, NAF1, MMGT1, PIGS, ENTHD2, FOXB1, FOXK2, FOXL1, FOXQ1, SNW1, RBM15, FLCN, SNRPE, SNRPN, SNRPG, ZCRB1, RRS1, HIST1H1E, SNRPF, PPAN, E4F1, CYLD, CD2BP2, BRCA1, LMNA, MTF1SATB2MTA2, HDAC1, ELAVL1, RAB3IL1, MAGEA10, KLHL20, RFPL4B, QPRT, LHX6, JUN, RBPJ, TEAD2, FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD3, FOXE1, FOXF1, FOXG1, FOXI2, FOXJ2, FOXK2, FOXL1, FOXN1, FOXO1, FOXP1, FOXP3, FOXQ1, FOXS1, PCGF1, BCOR, NANOG, L3MBTL1, NCAPH2, MORF4L2, HSFY1, C6orf141, ASB3, CPNE5, PLK1, NR1D2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSF3B1chr2:198283233chr2:200173680ENST00000409915-671156_115718388PHF5A
HgeneSF3B1chr2:198283233chr2:200173680ENST00000409915-67547_55018388PHF5A
HgeneSF3B1chr2:198283233chr2:200173680ENST00000409915-67223_49118388PPP1R8
HgeneSF3B1chr2:198283233chr2:200173680ENST00000409915-67529_56818388SF3B14
HgeneSF3B1chr2:198283233chr2:200173680ENST00000409915-671248_130418388SF3B3 and SF3B5


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSF3B1chr2:198283233chr2:200173680ENST00000335508-5251156_11571651305PHF5A
HgeneSF3B1chr2:198283233chr2:200173680ENST00000335508-525547_5501651305PHF5A
HgeneSF3B1chr2:198283233chr2:200173680ENST00000414963-151156_1157-27145PHF5A
HgeneSF3B1chr2:198283233chr2:200173680ENST00000414963-15547_550-27145PHF5A
HgeneSF3B1chr2:198283233chr2:200173680ENST00000335508-525223_4911651305PPP1R8
HgeneSF3B1chr2:198283233chr2:200173680ENST00000414963-15223_491-27145PPP1R8
HgeneSF3B1chr2:198283233chr2:200173680ENST00000335508-525529_5681651305SF3B14
HgeneSF3B1chr2:198283233chr2:200173680ENST00000414963-15529_568-27145SF3B14
HgeneSF3B1chr2:198283233chr2:200173680ENST00000335508-5251248_13041651305SF3B3 and SF3B5
HgeneSF3B1chr2:198283233chr2:200173680ENST00000414963-151248_1304-27145SF3B3 and SF3B5


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SF3B1_SATB2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SF3B1_SATB2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSF3B1C0220633Uveal melanoma2CTD_human;ORPHANET
HgeneSF3B1C0023434Chronic Lymphocytic Leukemia1CTD_human
HgeneSF3B1C0345967Malignant mesothelioma1CTD_human
TgeneSATB2C0008925Cleft Palate2CTD_human;HPO
TgeneSATB2C0007621Neoplastic Cell Transformation1CTD_human
TgeneSATB2C0149925Small cell carcinoma of lung1CTD_human
TgeneSATB2C0376634Craniofacial Abnormalities1CTD_human