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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33439

FusionGeneSummary for SF1_ZFP28

check button Fusion gene summary
Fusion gene informationFusion gene name: SF1_ZFP28
Fusion gene ID: 33439
HgeneTgene
Gene symbol

SF1

ZFP28

Gene ID

7536

140612

Gene namesplicing factor 1ZFP28 zinc finger protein
SynonymsBBP|D11S636|MBBP|ZCCHC25|ZFM1|ZNF162mkr5
Cytomap

11q13.1

19q13.43

Type of geneprotein-codingprotein-coding
Descriptionsplicing factor 1mammalian branch point-binding proteintranscription factor ZFM1zinc finger gene in MEN1 locuszinc finger protein 162zinc finger protein 28 homologkrueppel-like zinc finger factor X6zfp-28zinc finger factor X6
Modification date2018052620180522
UniProtAcc

Q15637

Q8NHY6

Ensembl transtripts involved in fusion geneENST00000377387, ENST00000377390, 
ENST00000377394, ENST00000227503, 
ENST00000334944, ENST00000422298, 
ENST00000433274, ENST00000489544, 
ENST00000301318, ENST00000591844, 
ENST00000594386, 
Fusion gene scores* DoF score9 X 6 X 7=3782 X 2 X 1=4
# samples 92
** MAII scorelog2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: SF1 [Title/Abstract] AND ZFP28 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BX491432SF1chr11

64543969

-ZFP28chr19

57065051

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000377387ENST00000301318SF1chr11

64543969

-ZFP28chr19

57065051

+
5CDS-intronENST00000377387ENST00000591844SF1chr11

64543969

-ZFP28chr19

57065051

+
5CDS-intronENST00000377387ENST00000594386SF1chr11

64543969

-ZFP28chr19

57065051

+
Frame-shiftENST00000377390ENST00000301318SF1chr11

64543969

-ZFP28chr19

57065051

+
5CDS-intronENST00000377390ENST00000591844SF1chr11

64543969

-ZFP28chr19

57065051

+
5CDS-intronENST00000377390ENST00000594386SF1chr11

64543969

-ZFP28chr19

57065051

+
Frame-shiftENST00000377394ENST00000301318SF1chr11

64543969

-ZFP28chr19

57065051

+
5CDS-intronENST00000377394ENST00000591844SF1chr11

64543969

-ZFP28chr19

57065051

+
5CDS-intronENST00000377394ENST00000594386SF1chr11

64543969

-ZFP28chr19

57065051

+
Frame-shiftENST00000227503ENST00000301318SF1chr11

64543969

-ZFP28chr19

57065051

+
5CDS-intronENST00000227503ENST00000591844SF1chr11

64543969

-ZFP28chr19

57065051

+
5CDS-intronENST00000227503ENST00000594386SF1chr11

64543969

-ZFP28chr19

57065051

+
Frame-shiftENST00000334944ENST00000301318SF1chr11

64543969

-ZFP28chr19

57065051

+
5CDS-intronENST00000334944ENST00000591844SF1chr11

64543969

-ZFP28chr19

57065051

+
5CDS-intronENST00000334944ENST00000594386SF1chr11

64543969

-ZFP28chr19

57065051

+
5UTR-3CDSENST00000422298ENST00000301318SF1chr11

64543969

-ZFP28chr19

57065051

+
5UTR-intronENST00000422298ENST00000591844SF1chr11

64543969

-ZFP28chr19

57065051

+
5UTR-intronENST00000422298ENST00000594386SF1chr11

64543969

-ZFP28chr19

57065051

+
In-frameENST00000433274ENST00000301318SF1chr11

64543969

-ZFP28chr19

57065051

+
5CDS-intronENST00000433274ENST00000591844SF1chr11

64543969

-ZFP28chr19

57065051

+
5CDS-intronENST00000433274ENST00000594386SF1chr11

64543969

-ZFP28chr19

57065051

+
intron-3CDSENST00000489544ENST00000301318SF1chr11

64543969

-ZFP28chr19

57065051

+
intron-intronENST00000489544ENST00000591844SF1chr11

64543969

-ZFP28chr19

57065051

+
intron-intronENST00000489544ENST00000594386SF1chr11

64543969

-ZFP28chr19

57065051

+

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FusionProtFeatures for SF1_ZFP28


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SF1

Q15637

ZFP28

Q8NHY6

May be involved in transcriptional regulation. May havea role in embryonic development.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SF1_ZFP28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SF1_ENST00000433274_chr11_64543969_-_ZFP28_ENST00000301318_chr19_57065051_+_85aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SF1_ENST00000433274_chr11_64543969_-_ZFP28_ENST00000301318_chr19_57065051_+_256nt
ATGGAACAGAAGACAGTGATTCCAGGAATGCCTACAGTTATTCCCCCTGGACTTACTCGAGAACAAGAAAGAGCTTATATAGAAGCCCTT
CAGCGGCCAGTAGCATCTGACTTTGAGCCTCAGGGTCTGAGTGAAGCCGCTCGTTGGAACTCCAAGGAAAACCTTCTCGCTGGACCCAGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_SF1_ENST00000433274_chr11_64543969_-_ZFP28_ENST00000301318_chr19_57065051_+_3508nt
GACGCAGTGAGGTGGCCGGGCTGTGCGGCGCAACTGTATAGACTGGGGGCCCACTATTGCTGTCCAGTCCGCTGGTGTCGGGAACAGGGG
TGGCGGGTGTTCAGCGCTGGACGGGGTGCTAGCTGTGAATGCCAGCAGGGCGTGAAAGCCTCACCTGATGACGTGCAGCGACTCCCTTCT
GGTCTTGAGGAACCAGAATGGGAACCGTACCAAGGATAGCTCCTCTGCTTCTACAGCAAGGCAGGGTTTTCATCCGGGAGAGACTTCCCA
AGTAAGAAGCGGAAGAGGAGCCGCTGGAACCAAGACACAATGGAACAGAAGACAGTGATTCCAGGAATGCCTACAGTTATTCCCCCTGGA
CTTACTCGAGAACAAGAAAGAGCTTATATAGGCCAGCGATCTGTACATGAGACCCAGGAATTATTTCCAAAGCAAGATTCATATGCTGAA
GGGGTAACAGACAGAACCTCAAACACTAAACTTGATTGTTCCAGTTTCAGAGAAAATTGGGATTCTGACTATGTGTTTGGAAGGAAGCTT
GCAGTAGGTCAAGAGACACAATTCAGGCAAGAGCCAATTACTCATAACAAAACCCTCTCTAAGGAAAGAGAACGTACATATAACAAATCT
GGAAGATGGTTCTATTTGGACGATTCAGAAGAGAAAGTTCATAATCGTGATTCAATTAAAAATTTTCAAAAAAGTTCAGTGGTAATAAAA
CAAACAGGCATCTATGCAGGAAAAAAGCTTTTCAAGTGTAATGAATGTAAGAAAACTTTTACCCAGAGCTCATCTCTTACTGTTCATCAG
AGAATTCACACTGGAGAGAAACCTTATAAATGTAATGAATGTGGGAAGGCCTTTAGTGACGGCTCATCCTTTGCCCGACACCAGAGATGT
CACACTGGCAAGAAGCCCTATGAGTGCATTGAGTGTGGGAAAGCTTTCATACAGAACACATCCCTTATCCGTCACTGGAGATACTATCAT
ACTGGGGAGAAACCCTTTGATTGCATCGATTGTGGGAAAGCCTTCAGTGACCACATAGGGCTTAATCAACACAGGAGAATTCATACTGGA
GAGAAACCTTACAAATGTGATGTATGTCACAAATCCTTCAGGTATGGTTCCTCCCTTACTGTACATCAAAGGATTCATACCGGAGAAAAA
CCATATGAATGTGATGTTTGCAGAAAAGCCTTCAGCCATCATGCATCACTCACTCAACATCAAAGAGTACATTCTGGAGAAAAGCCTTTT
AAGTGTAAAGAGTGCGGAAAAGCTTTTAGGCAGAATATACACCTTGCCAGTCATTTAAGGATTCATACTGGGGAGAAGCCTTTTGAATGT
GCGGAGTGTGGAAAATCCTTCAGCATCAGTTCTCAGCTTGCCACTCATCAGAGAATCCATACTGGAGAGAAGCCCTATGAATGTAAGGTT
TGTAGTAAAGCGTTCACCCAGAAGGCTCACCTTGCACAGCATCAGAAAACCCATACAGGAGAGAAACCATATGAGTGCAAGGAATGCGGT
AAAGCCTTCAGCCAGACCACACACCTCATTCAACATCAGAGAGTTCACACTGGTGAGAAACCCTATAAATGTATGGAATGTGGGAAGGCC
TTTGGTGATAACTCATCCTGTACTCAACATCAAAGACTGCACACTGGCCAAAGACCTTATGAATGTATTGAGTGTGGAAAGGCATTCAAG
ACAAAATCCTCCCTTATTTGTCATCGCAGAAGTCATACTGGAGAAAAACCTTATGAATGCAGTGTGTGTGGCAAAGCCTTTAGTCATCGT
CAATCCCTTAGTGTACATCAGAGAATCCATTCTGGAAAGAAACCATATGAATGTAAGGAATGTAGGAAAACCTTCATCCAAATTGGACAC
CTTAATCAACATAAGAGAGTTCATACTGGAGAGAGATCTTATAACTATAAGAAAAGCAGAAAAGTCTTCAGGCAAACTGCTCACTTAGCT
CATCATCAGCGAATTCATACTGGAGAGTCGTCAACATGCCCCTCTTTACCTTCCACGTCAAATCCTGTGGATCTGTTTCCCAAATTTCTC
TGGAATCCATCCTCCCTCCCATCACCATAGCCTCGAGACGTCATTTCTGTTTGACTACTCCAGCAGTTTAAAACCCCATCTCCCTGCCCT
TTTGTTTTCTTTTTGTCCCTTATTAGTTAGTTCTTCACATAAGTGTAAATGTAACTTATTCACTCCTCTTGTAAAACTTATAGTTTCTTT
AAATTGGTTAATGTGTGAGATGTGCTCAGCACAGTGCCTGGTCCATAGTAAGTGCTCAGTAAACTTAGCTGTTTTAAAAACTTTGTATTT
GAACATTGAAAAGTTACAGTAGTCAGCTCTGATAAAAAAATGATGCAGTAGGGTGAGGGTAGGAAAAAGCACATTTTCTATCAGGAACAG
AATTCTCCAGTAGTGGGTGAGGTTTTGCCTTTGTTGGTTTTAAAACTTGATTCTATAATGCCAAGTTAGTTTTGTGGCTTTCCATCTGAC
CCTATGTGAATGTAAGGTGATGTGACCTTGTTGGTGAGAAAATTAAACTTTACATTTGACTTGATTTGTTTTAGAAAGTCTAGGGACCAT
GAATGAATAGGCCAGCTGGGACAAATGAATTTAAAAAATCAGAAAAATGCAAGATTTATATGCATGAAGTTAAAACAACTGACGTTACTC
AAGAATTAGAAAACTTTGCAAGATTTGACTTGTTTAAAAATCACATTTATAAGTGAACCGTATTAAAACTTTTAAGGAACCATTCATTGT
GAGGTAAACTGATCCAGAATAGGGGTCAGCAAACTATGACTCATGGCCACAGTCTCACTGACTGTTTTTGTATGGTCCATGATCTAGAAT
TTAAAAAAATTTTAAAGGGTTGAAAAAAGTGAAAAGAATATTTTCAACATGAAAATTATATGAAATTTAAGTTTTGGTGTCTGTAAATAA
AGTTTTGTTGGCTTCAGCCACACAGTGATTTACACCTTGATTGTGCTGCTTCCAGGCTGTAGCAGCAGAGTTGAGCAGTTGTGACAGGAG
ACCATGTGGCCTGCAGAGCCCAAATATCTACTGTCTGATCCTACACAGAAAATGTGTGTGATCCCTGCTATGGAGCAGAGGTTATCAAAC
TAAAGCCCATGGACCAAATCCTATCTGCTGCTTGTTTTTGTAAATAGAGTTTTATCAAACCACAGCCATGCTTACTTGTTTAGCTATTGA
CTATGGCTGCTTTAGACAACTGTGACAGACTATATGGCTCGCAAAACTGCAAATATTTCCTATCCTTTAACAGAAAGTTTGCCAACCTCT
GCTCTAGAGTAGAGAAAAATGTATAAAAGATTTTAATTTTATGAGGGCAATACAACTGTCACATCAGAAACAAGAAAACAAATGATAAAG


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FusionGenePPI for SF1_ZFP28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SF1PLSCR1, TRIM23, DDX17, WWP2, RBPMS, U2AF2, EWSR1, FUS, TAF15, TCERG1, ZNF461, NCOR2, PML, PPARGC1A, NFKB1, HDAC5, HDAC4, SF3A2, CUL3, CIRBP, EFTUD2, VDAC1, MPLKIP, ZC3H11A, TMED4, TOMM40, SRPRB, VDAC3, STIM1, UBE2L3, VAMP2, TAGLN, ZFR, SORCS3, SBDS, SEPT11, SIN3A, STOM, NNT, SRP9, ATXN1, FN1, VCAM1, SF3A1, SF3B4, RBM17, RBM10, SF1, ILF3, BCAS2, WDR83, RBM7, HNRNPK, HNRNPUL1, RBM4, WDR77, HNRNPF, HNRNPH1, HNRNPH2, IL7R, METTL22, ITGA4, LMNA, ITCH, PRPF40A, WBP4, APBB1, GAS7, RANBP3, EIF4B, FAF1, FARSB, GART, GFPT1, HIRIP3, HIST1H4A, HSPH1, NARS, OSBP, PLOD2, RPL24, SAMHD1, SUPT5H, TROVE2, XPO7, XRCC5, CIAO1, PSMA3, MKRN3, FAM168A, TRIM69, KRTAP26-1, CUL7, OBSL1, CCDC8, SUZ12, EED, PRMT2, ACTL6A, ZFP41, CAB39, CCDC25, ALDOC, CNN2, HADH, HNRNPL, HSDL2, IREB2, PGK1, PLAA, PPID, TKT, UBE2N, NTRK1, NCOA1, CDC42, CSNK2A2, LLGL2, MAPK8, EMC2, RNF41, PARD6B, KLC3, NAGK, P4HA3, BCHE, CAPN13, HSPBP1, HAO2, SFPQ, FOXA1, TESZFP28PPP2CB, HMOX2, PRKRA, C8orf33, KDM1A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SF1_ZFP28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSF1Q15637DB11638ArtenimolSplicing factor 1small moleculeapproved|investigational

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RelatedDiseases for SF1_ZFP28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSF1C0025202melanoma1CTD_human