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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33403

FusionGeneSummary for SETD7_SETD7

check button Fusion gene summary
Fusion gene informationFusion gene name: SETD7_SETD7
Fusion gene ID: 33403
HgeneTgene
Gene symbol

SETD7

SETD7

Gene ID

80854

80854

Gene nameSET domain containing lysine methyltransferase 7SET domain containing lysine methyltransferase 7
SynonymsKMT7|SET7|SET7/9|SET9KMT7|SET7|SET7/9|SET9
Cytomap

4q31.1

4q31.1

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase SETD7H3-K4-HMTase SETD7SET domain-containing protein 7histone H3-K4 methyltransferase SETD7histone H3-lysine 4-specific methyltransferaselysine N-methyltransferase 7histone-lysine N-methyltransferase SETD7H3-K4-HMTase SETD7SET domain-containing protein 7histone H3-K4 methyltransferase SETD7histone H3-lysine 4-specific methyltransferaselysine N-methyltransferase 7
Modification date2018051920180519
UniProtAcc

Q8WTS6

Q8WTS6

Ensembl transtripts involved in fusion geneENST00000506866, ENST00000274031, 
ENST00000404104, ENST00000406354, 
ENST00000608958, 		ENST00000506866, 
ENST00000274031, ENST00000404104, 
ENST00000406354, ENST00000608958, 
Fusion gene scores* DoF score5 X 4 X 4=802 X 2 X 2=8
# samples 63
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context

PubMed: SETD7 [Title/Abstract] AND SETD7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSETD7

GO:0006974

cellular response to DNA damage stimulus

23509280

HgeneSETD7

GO:0018026

peptidyl-lysine monomethylation

17108971

HgeneSETD7

GO:0018027

peptidyl-lysine dimethylation

17108971

HgeneSETD7

GO:0070828

heterochromatin organization

23509280

TgeneSETD7

GO:0006974

cellular response to DNA damage stimulus

23509280

TgeneSETD7

GO:0018026

peptidyl-lysine monomethylation

17108971

TgeneSETD7

GO:0018027

peptidyl-lysine dimethylation

17108971

TgeneSETD7

GO:0070828

heterochromatin organization

23509280


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA552767SETD7chr4

140452666

-SETD7chr4

140452774

+
ChiTaRS3.1AA552768SETD7chr4

140452666

-SETD7chr4

140452774

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000506866ENST00000506866SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000506866ENST00000274031SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000506866ENST00000404104SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000506866ENST00000406354SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000506866ENST00000608958SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000274031ENST00000506866SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000274031ENST00000274031SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000274031ENST00000404104SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000274031ENST00000406354SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000274031ENST00000608958SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000404104ENST00000506866SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000404104ENST00000274031SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000404104ENST00000404104SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000404104ENST00000406354SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000404104ENST00000608958SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000406354ENST00000506866SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000406354ENST00000274031SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000406354ENST00000404104SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000406354ENST00000406354SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000406354ENST00000608958SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000608958ENST00000506866SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000608958ENST00000274031SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000608958ENST00000404104SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000608958ENST00000406354SETD7chr4

140452666

-SETD7chr4

140452774

+
intron-intronENST00000608958ENST00000608958SETD7chr4

140452666

-SETD7chr4

140452774

+

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FusionProtFeatures for SETD7_SETD7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SETD7

Q8WTS6

SETD7

Q8WTS6

Histone methyltransferase that specificallymonomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylationrepresents a specific tag for epigenetic transcriptionalactivation. Plays a central role in the transcriptional activationof genes such as collagenase or insulin. Recruited by IPF1/PDX-1to the insulin promoter, leading to activate transcription. Hasalso methyltransferase activity toward non-histone proteins suchas p53/TP53, TAF10, and possibly TAF7 by recognizing and bindingthe [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189'of TAF10, leading to increase the affinity of TAF10 for RNApolymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizingp53/TP53 and increasing p53/TP53-mediated transcriptionalactivation. {ECO:0000269|PubMed:12540855,ECO:0000269|PubMed:12588998, ECO:0000269|PubMed:15099517,ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16141209,ECO:0000269|PubMed:17108971}. Histone methyltransferase that specificallymonomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylationrepresents a specific tag for epigenetic transcriptionalactivation. Plays a central role in the transcriptional activationof genes such as collagenase or insulin. Recruited by IPF1/PDX-1to the insulin promoter, leading to activate transcription. Hasalso methyltransferase activity toward non-histone proteins suchas p53/TP53, TAF10, and possibly TAF7 by recognizing and bindingthe [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189'of TAF10, leading to increase the affinity of TAF10 for RNApolymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizingp53/TP53 and increasing p53/TP53-mediated transcriptionalactivation. {ECO:0000269|PubMed:12540855,ECO:0000269|PubMed:12588998, ECO:0000269|PubMed:15099517,ECO:0000269|PubMed:15525938, ECO:0000269|PubMed:16141209,ECO:0000269|PubMed:17108971}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SETD7_SETD7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SETD7_SETD7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SETD7_SETD7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SETD7_SETD7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource