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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33382

FusionGeneSummary for SETD4_ANKRD17

check button Fusion gene summary
Fusion gene informationFusion gene name: SETD4_ANKRD17
Fusion gene ID: 33382
HgeneTgene
Gene symbol

SETD4

ANKRD17

Gene ID

54093

26057

Gene nameSET domain containing 4ankyrin repeat domain 17
SynonymsC21orf18|C21orf27GTAR|MASK2|NY-BR-16
Cytomap

21q22.12

4q13.3

Type of geneprotein-codingprotein-coding
DescriptionSET domain-containing protein 4ankyrin repeat domain-containing protein 17gene trap ankyrin repeat proteinserologically defined breast cancer antigen NY-BR-16
Modification date2018052320180523
UniProtAcc

Q9NVD3

O75179

Ensembl transtripts involved in fusion geneENST00000399215, ENST00000481477, 
ENST00000399212, ENST00000332131, 
ENST00000399205, ENST00000399208, 
ENST00000399201, ENST00000399207, 
ENST00000358602, ENST00000509867, 
ENST00000330838, ENST00000514252, 
Fusion gene scores* DoF score3 X 3 X 3=278 X 14 X 3=336
# samples 318
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(18/336*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SETD4 [Title/Abstract] AND ANKRD17 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANKRD17

GO:0042742

defense response to bacterium

23711367

TgeneANKRD17

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

22328336

TgeneANKRD17

GO:0045087

innate immune response

23711367

TgeneANKRD17

GO:1900245

positive regulation of MDA-5 signaling pathway

22328336

TgeneANKRD17

GO:1900246

positive regulation of RIG-I signaling pathway

22328336


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB034419SETD4chr21

37443269

+ANKRD17chr4

73956613

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000399215ENST00000358602SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399215ENST00000509867SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399215ENST00000330838SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-intronENST00000399215ENST00000514252SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000481477ENST00000358602SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000481477ENST00000509867SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000481477ENST00000330838SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-intronENST00000481477ENST00000514252SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399212ENST00000358602SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399212ENST00000509867SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399212ENST00000330838SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-intronENST00000399212ENST00000514252SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000332131ENST00000358602SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000332131ENST00000509867SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000332131ENST00000330838SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-intronENST00000332131ENST00000514252SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399205ENST00000358602SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399205ENST00000509867SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399205ENST00000330838SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-intronENST00000399205ENST00000514252SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399208ENST00000358602SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399208ENST00000509867SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399208ENST00000330838SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-intronENST00000399208ENST00000514252SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399201ENST00000358602SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399201ENST00000509867SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399201ENST00000330838SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-intronENST00000399201ENST00000514252SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399207ENST00000358602SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399207ENST00000509867SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-3CDSENST00000399207ENST00000330838SETD4chr21

37443269

+ANKRD17chr4

73956613

-
intron-intronENST00000399207ENST00000514252SETD4chr21

37443269

+ANKRD17chr4

73956613

-

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FusionProtFeatures for SETD4_ANKRD17


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SETD4

Q9NVD3

ANKRD17

O75179


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SETD4_ANKRD17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SETD4_ANKRD17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SETD4_ANKRD17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SETD4_ANKRD17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource