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Fusion gene ID: 33372 |
FusionGeneSummary for SETD2_POGLUT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SETD2_POGLUT1 | Fusion gene ID: 33372 | Hgene | Tgene | Gene symbol | SETD2 | POGLUT1 | Gene ID | 29072 | 56983 |
| Gene name | SET domain containing 2 | protein O-glucosyltransferase 1 | |
| Synonyms | HBP231|HIF-1|HIP-1|HSPC069|HYPB|KMT3A|LLS|SET2|p231HBP | C3orf9|CLP46|KDELCL1|KTELC1|LGMD2Z|MDS010|MDSRP|Rumi|hCLP46 | |
| Cytomap | 3p21.31 | 3q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone-lysine N-methyltransferase SETD2huntingtin interacting protein 1huntingtin yeast partner Bhuntingtin-interacting protein Blysine N-methyltransferase 3Aprotein-lysine N-methyltransferase SETD2 | protein O-glucosyltransferase 19630046K23RikCAP10-like 46 kDa proteinKDELC family like 1KTEL (Lys-Tyr-Glu-Leu) containing 1KTEL motif-containing protein 1O-glucosyltransferase Rumi homologhRumimyelodysplastic syndromes relative proteinprotein O-x | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9BYW2 | Q8NBL1 | |
| Ensembl transtripts involved in fusion gene | ENST00000409792, ENST00000492397, | ENST00000295588, | |
| Fusion gene scores | * DoF score | 19 X 9 X 10=1710 | 1 X 1 X 1=1 |
| # samples | 21 | 1 | |
| ** MAII score | log2(21/1710*10)=-3.02553509210714 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SETD2 [Title/Abstract] AND POGLUT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SETD2 | GO:0010569 | regulation of double-strand break repair via homologous recombination | 24843002 |
| Hgene | SETD2 | GO:0018023 | peptidyl-lysine trimethylation | 27518565 |
| Hgene | SETD2 | GO:0018026 | peptidyl-lysine monomethylation | 28753426 |
| Hgene | SETD2 | GO:0032465 | regulation of cytokinesis | 27518565 |
| Hgene | SETD2 | GO:0032727 | positive regulation of interferon-alpha production | 28753426 |
| Hgene | SETD2 | GO:0034340 | response to type I interferon | 28753426 |
| Hgene | SETD2 | GO:0051607 | defense response to virus | 28753426 |
| Hgene | SETD2 | GO:0097198 | histone H3-K36 trimethylation | 23043551|24843002|26002201|27474439|28753426 |
| Hgene | SETD2 | GO:0097676 | histone H3-K36 dimethylation | 26002201 |
| Hgene | SETD2 | GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 27518565 |
| Hgene | SETD2 | GO:1905634 | regulation of protein localization to chromatin | 24843002 |
| Tgene | POGLUT1 | GO:0006493 | protein O-linked glycosylation | 21949356 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-50-5044-01A | SETD2 | chr3 | 47139445 | - | POGLUT1 | chr3 | 119207776 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000409792 | ENST00000295588 | SETD2 | chr3 | 47139445 | - | POGLUT1 | chr3 | 119207776 | + |
| intron-3CDS | ENST00000492397 | ENST00000295588 | SETD2 | chr3 | 47139445 | - | POGLUT1 | chr3 | 119207776 | + |
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FusionProtFeatures for SETD2_POGLUT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SETD2 | POGLUT1 |
| Dual specificity glycosyltransferase that catalyzes thetransfer of glucose and xylose from UDP-glucose and UDP-xylose,respectively, to a serine residue found in the consensus sequenceof C-X-S-X-P-C (PubMed:21081508, PubMed:21490058, PubMed:21949356,PubMed:27807076). Specifically targets extracellular EGF repeatsof protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21081508,PubMed:21490058, PubMed:21949356, PubMed:27807076). Acts as apositive regulator of Notch signaling by mediating O-glucosylationof Notch, leading to regulate muscle development(PubMed:27807076). Notch glucosylation does not affect Notchligand binding (PubMed:21490058). Required during earlydevelopment to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization tothe cell membrane (By similarity). {ECO:0000250|UniProtKB:Q8BYB9,ECO:0000269|PubMed:21081508, ECO:0000269|PubMed:21490058,ECO:0000269|PubMed:21949356, ECO:0000269|PubMed:27807076}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SETD2 | chr3:47139445 | chr3:119207776 | ENST00000409792 | - | 9 | 21 | 166_247 | 1714 | 2565 | Compositional bias | Note=Pro-rich |
| Hgene | SETD2 | chr3:47139445 | chr3:119207776 | ENST00000409792 | - | 9 | 21 | 385_456 | 1714 | 2565 | Compositional bias | Note=Arg-rich |
| Hgene | SETD2 | chr3:47139445 | chr3:119207776 | ENST00000409792 | - | 9 | 21 | 1494_1548 | 1714 | 2565 | Domain | AWS |
| Hgene | SETD2 | chr3:47139445 | chr3:119207776 | ENST00000409792 | - | 9 | 21 | 1550_1667 | 1714 | 2565 | Domain | SET |
| Hgene | SETD2 | chr3:47139445 | chr3:119207776 | ENST00000409792 | - | 9 | 21 | 1674_1690 | 1714 | 2565 | Domain | Post-SET |
| Hgene | SETD2 | chr3:47139445 | chr3:119207776 | ENST00000409792 | - | 9 | 21 | 1560_1562 | 1714 | 2565 | Region | S-adenosyl-L-methionine binding |
| Hgene | SETD2 | chr3:47139445 | chr3:119207776 | ENST00000409792 | - | 9 | 21 | 1603_1605 | 1714 | 2565 | Region | S-adenosyl-L-methionine binding |
| Hgene | SETD2 | chr3:47139445 | chr3:119207776 | ENST00000409792 | - | 9 | 21 | 1628_1629 | 1714 | 2565 | Region | S-adenosyl-L-methionine binding |
| Tgene | >POGLUT1 | chr3:47139445 | chr3:119207776 | ENST00000295588 | + | 6 | 11 | 389_392 | 246 | 393 | Motif | Prevents secretion from ER |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SETD2 | chr3:47139445 | chr3:119207776 | ENST00000409792 | - | 9 | 21 | 2117_2146 | 1714 | 2565 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >SETD2 | chr3:47139445 | chr3:119207776 | ENST00000409792 | - | 9 | 21 | 2149_2232 | 1714 | 2565 | Compositional bias | Note=Pro-rich |
| Hgene | >SETD2 | chr3:47139445 | chr3:119207776 | ENST00000409792 | - | 9 | 21 | 2266_2365 | 1714 | 2565 | Compositional bias | Note=Gln-rich |
| Hgene | >SETD2 | chr3:47139445 | chr3:119207776 | ENST00000409792 | - | 9 | 21 | 2389_2422 | 1714 | 2565 | Domain | WW |
| Hgene | >SETD2 | chr3:47139445 | chr3:119207776 | ENST00000409792 | - | 9 | 21 | 2137_2366 | 1714 | 2565 | Region | Low charge region |
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FusionGeneSequence for SETD2_POGLUT1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SETD2_ENST00000409792_chr3_47139445_-_POGLUT1_ENST00000295588_chr3_119207776_+_1861aa MKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTKTKVNLEEQGRQKVSFSFSLTKKTLQNRFLT ALGNEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASPPTHAAPLPAVIAES TTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQDTISNSLEEHVTQI LNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIEKERDFKKSSAPLKS EDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHRSSPYRERTRYSRPY TDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEAIKRCCSPPNELGFR RGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPAPSNRLNDSPTLKKL DELPIFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSELSPLVKACMLSSNG FQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRVSCCKTKDSDIYCTLNDSNPSLCNSEAE NIEPSVMKISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSLPPGIKVDSLTLLKC GENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQEEGNSILPERRGRPEISLDERGEGGHV HTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQSVVVVPKNSTLPM EETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKNPEISFTQSSRKQIDNRLPELSHPQSDGVDS TSHTDVKSDPLGHPNSEETVKAKIPSRQQEELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGW DFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDSLTDDREEEENWDQQDGSHFS DQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKKVRVEVEQGETSVPP GSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIACGEDCLNRLLMIECS SRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMALKNDEIIDATQK GNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVSIRAAGGKMKKERSR KKDSDTLGKPAAKDVHLVDHCKYKYLFNFRGVAASFRFKHLFLCGSLVFHVGDEWLEFFYPQLKPWVHYIPVKTDLSNVQELLQFVKAND |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SETD2_ENST00000409792_chr3_47139445_-_POGLUT1_ENST00000295588_chr3_119207776_+_5583nt ATGAAGCAGCTGCAGCCGCAGCCGCCTCCGAAGATGGGGGATTTCTACGACCCGGAGCACCCGACCCCTGAAGAAGAAGAAAATGAGGCA AAGATTGAAAATGTGCAGAAAACAGGTTTCATCAAAGGACCAATGTTCAAAGGTGTTGCTTCTAGTCGATTTTTGCCCAAAGGCACCAAA ACAAAAGTTAATTTGGAAGAACAGGGACGACAGAAGGTGTCATTCAGCTTCAGCCTTACAAAGAAAACTTTGCAGAATAGGTTTCTCACT GCACTTGGCAATGAAAAGCAAAGTGATACTCCAAACCCTCCAGCTGTACCTCTTCAGGTAGACTCGACTCCTAAAATGAAAATGGAAATT GGTGATACCTTATCTACTGCAGAAGAATCTTCCCCACCAAAGTCAAGGGTGGAATTGGGCAAAATTCATTTTAAGAAACATCTGCTTCAT GTAACATCCAGGCCACTGCTGGCTACTACCACAGCAGTAGCATCTCCACCTACTCATGCAGCACCATTACCAGCAGTGATAGCAGAATCA ACAACTGTAGACTCACCGCCCTCATCTCCGCCTCCACCGCCTCCACCTGCCCAAGCCACAACACTCTCATCACCAGCACCAGTAACAGAG CCAGTGGCCTTGCCACATACACCAATAACAGTTCTAATGGCAGCACCAGTACCCTTACCAGTAGATGTAGCAGTTAGATCTCTGAAAGAA CCACCAATTATAATTGTACCAGAATCTTTAGAAGCAGATACTAAGCAGGACACTATATCTAATAGTTTAGAAGAACACGTAACTCAAATA TTGAATGAGCAAGCAGATATTTCCTCAAAAAAAGAAGATTCCCATATTGGGAAGGATGAAGAAATTCCAGATAGTTCTAAGATTAGTCTG AGCTGTAAAAAAACAGGTTCTAAGAAGAAATCCTCACAATCTGAAGGCATCTTTCTTGGTTCAGAATCTGATGAAGATTCTGTACGGACT TCTTCAAGTCAAAGATCACATGATTTAAAATTTTCAGCAAGCATTGAAAAGGAAAGAGATTTTAAAAAGAGCTCAGCACCTTTAAAAAGT GAGGATCTAGGGAAACCTTCACGATCTAAAACAGACAGAGATGATAAATATTTTAGCTATTCAAAACTTGAAAGAGATACTCGGTATGTA TCTTCCCGATGTAGATCAGAAAGAGAGCGACGGCGGAGCAGATCTCACTCTAGGTCTGAGAGAGGCTCTAGAACTAATTTATCCTATTCC AGGTCAGAACGATCTCATTATTATGACTCTGATCGTCGCTACCATAGGAGCTCCCCTTATCGAGAGAGGACGCGCTATTCTCGGCCATAC ACAGATAACAGAGCACGAGAGAGTTCTGACTCAGAAGAAGAGTATAAGAAGACATACTCAAGGCGTACCTCATCTCATTCCTCTTCTTAC AGAGACCTAAGGACATCATCCTATTCTAAATCTGATCGGGACTGTAAAACTGAGACCTCTTACTTAGAGATGGAAAGAAGAGGCAAGTAT TCTTCAAAACTAGAAAGAGAATCTAAAAGGACTTCAGAAAATGAAGCAATTAAAAGATGTTGTTCTCCCCCTAATGAACTGGGATTCCGA CGAGGGTCATCATATTCTAAGCATGACAGTAGTGCTTCCCGTTATAAATCTACCCTTTCAAAACCTATACCCAAGTCTGATAAATTTAAA AATTCTTTCTGTTGTACAGAATTAAATGAAGAAATCAAACAGTCTCATTCTTTTAGTTTACAGACACCTTGTTCAAAAGGTAGTGAATTA AGAATGATTAATAAAAATCCTGAAAGAGAAAAGGCTGGGTCTCCAGCTCCATCAAATCGATTAAATGATTCACCTACTTTAAAAAAGCTA GATGAATTGCCTATTTTTAAGTCCGAATTTATAACACATGATAGCCATGATAGTATTAAGGAATTAGACTCTTTATCTAAAGTGAAGAAT GATCAATTAAGAAGTTTTTGTCCCATAGAATTAAATATAAATGGATCTCCTGGGGCAGAATCTGATTTGGCAACATTTTGCACTTCTAAA ACTGATGCTGTTTTAATGACTTCTGATGATAGTGTGACTGGATCGGAATTATCCCCTTTGGTCAAAGCATGCATGCTTTCATCAAATGGA TTTCAGAATATTAGTAGGTGCAAAGAAAAAGACTTGGATGATACCTGCATGCTGCATAAGAAGTCAGAAAGCCCATTTAGAGAAACAGAA CCTCTGGTGTCACCACACCAAGATAAACTCATGTCTATGCCAGTTATGACTGTGGATTATTCCAAAACAGTAGTTAAAGAACCAGTTGAT ACGAGGGTTTCTTGCTGCAAAACCAAAGATTCAGACATATACTGTACTTTGAACGATAGCAACCCTTCTTTGTGTAACTCTGAAGCTGAA AATATTGAGCCTTCAGTTATGAAGATTTCTTCAAATAGCTTTATGAATGTGCATTTGGAATCAAAACCAGTTATATGTGATAGTAGAAAT TTGACAGATCACTCAAAATTTGCATGTGAAGAATATAAGCAGAGCATCGGTAGCACTAGTTCAGCTTCTGTTAATCATTTTGATGATTTA TATCAACCTATTGGGAGTTCAGGTATTGCTTCATCTCTTCAGAGTCTTCCACCAGGAATAAAGGTGGACAGTCTAACTCTCTTGAAATGC GGAGAGAACACATCTCCAGTTCTGGATGCAGTGCTAAAGAGTAAAAAAAGTTCAGAGTTTTTAAAGCATGCAGGGAAAGAAACAATAGTA GAAGTAGGTAGTGACCTTCCTGATTCAGGAAAGGGATTTGCTTCCAGGGAGAACAGGCGTAATAATGGGTTATCTGGGAAATGTTTGCAA GAGGCTCAAGAAGAAGGGAATTCCATATTGCCTGAAAGAAGAGGAAGACCAGAAATCTCTTTAGATGAAAGAGGAGAAGGAGGACATGTG CATACTTCTGATGACTCAGAAGTTGTATTTTCTTCTTGTGATTTGAATTTAACCATGGAAGACAGTGATGGTGTAACTTATGCATTAAAG TGTGACAGTAGTGGTCATGCCCCAGAAATTGTGTCTACAGTTCATGAAGATTATTCTGGCTCTTCTGAAAGTTCAAATGATGAAAGTGAT TCAGAAGATACAGATTCGGATGATAGCAGTATTCCAAGAAACCGTCTCCAGTCTGTTGTGGTTGTGCCAAAGAATTCTACTTTGCCCATG GAAGAAACAAGTCCTTGTTCTTCTCGGAGCAGTCAAAGTTATAGACACTATTCTGACCATTGGGAAGATGAGAGATTGGAGTCAAGGAGA CATTTGTATGAGGAAAAATTTGAAAGTATAGCAAGTAAAGCCTGTCCTCAAACTGATAAGTTTTTCCTTCATAAAGGAACAGAGAAGAAT CCGGAAATTTCTTTTACACAGTCCAGTAGAAAACAAATAGATAATCGCCTGCCTGAACTTTCTCATCCTCAGAGTGATGGGGTTGATAGT ACAAGTCATACAGATGTGAAATCTGACCCTCTGGGTCACCCAAATTCAGAGGAAACCGTGAAAGCCAAAATACCTTCTAGGCAGCAAGAA GAGCTGCCAATTTATTCTTCTGATTTTGAAGATGTCCCAAATAAGTCTTGGCAACAGACCACTTTCCAAAACAGGCCAGATAGTAGACTG GGAAAAACAGAATTGAGTTTTTCTTCCTCTTGTGAGATACCACATGTGGATGGCTTGCACTCATCAGAAGAGCTCAGAAACTTAGGTTGG GACTTCTCTCAAGAAAAGCCTTCTACCACGTATCAGCAACCTGACAGTAGCTATGGAGCTTGTGGTGGACACAAGTATCAGCAAAATGCA GAACAGTATGGTGGGACACGTGATTACTGGCAAGGCAATGGTTACTGGGATCCAAGATCAGGTAGACCTCCTGGAACTGGGGTTGTGTAT GATCGAACTCAAGGACAAGTACCAGATTCCCTAACAGATGATCGTGAAGAAGAGGAGAATTGGGATCAACAGGATGGATCCCATTTTTCA GACCAGTCCGATAAATTTCTTCTATCCCTTCAGAAAGACAAGGGGTCAGTGCAAGCACCTGAAATAAGCAGCAATTCCATTAAGGACACT TTAGCTGTGAATGAAAAGAAAGATTTTTCAAAAAACTTAGAAAAAAATGATATCAAAGATAGAGGGCCTCTTAAAAAAAGGAGGCAGGAA ATAGAGAGTGATTCTGAAAGTGATGGTGAGCTTCAGGACAGAAAGAAAGTTAGAGTGGAGGTAGAGCAGGGAGAGACATCAGTGCCCCCA GGTTCAGCACTGGTTGGGCCCTCCTGTGTCATGGATGACTTCAGGGACCCACAGCGATGGAAGGAATGTGCCAAGCAAGGGAAAATGCCA TGTTACTTTGATCTTATTGAAGAAAATGTTTATTTAACAGAAAGAAAGAAGAATAAATCTCATCGAGATATTAAGCGAATGCAGTGTGAG TGTACACCTCTTTCTAAAGATGAAAGAGCTCAAGGTGAAATAGCATGTGGGGAAGATTGTCTTAATCGTCTTCTCATGATTGAATGTTCT TCTCGGTGTCCAAATGGGGATTATTGTTCCAATAGACGGTTTCAGAGAAAACAGCATGCAGATGTGGAAGTCATACTCACAGAAAAGAAA GGCTGGGGCTTGAGAGCTGCCAAAGACCTTCCTTCGAACACCTTTGTCCTAGAATATTGTGGAGAGGTACTCGATCATAAAGAGTTTAAA GCTCGAGTGAAGGAGTATGCACGAAACAAAAACATCCATTACTATTTCATGGCCCTGAAGAATGATGAGATAATAGATGCCACTCAAAAA GGAAATTGCTCTCGTTTCATGAATCACAGCTGTGAACCAAATTGTGAAACCCAAAAATGGACTGTGAACGGACAACTGAGGGTTGGGTTT TTTACCACCAAACTGGTTCCTTCAGGCTCAGAGTTAACGTTTGACTATCAGTTCCAGAGATATGGAAAAGAAGCCCAGAAATGTTTCTGC GGATCAGCCAATTGCCGGGGTTACCTGGGAGGAGAAAACAGAGTCAGCATCAGAGCAGCAGGAGGGAAAATGAAGAAGGAACGATCTCGT AAGAAGGATTCAGATACCTTAGGAAAGCCAGCTGCTAAGGATGTCCATCTTGTGGATCACTGCAAATACAAGTATCTGTTTAATTTTCGA GGCGTAGCTGCAAGTTTCCGGTTTAAACACCTCTTCCTGTGTGGCTCACTTGTTTTCCATGTTGGTGATGAGTGGCTAGAATTCTTCTAT CCACAGCTGAAGCCATGGGTTCACTATATCCCAGTCAAAACAGATCTCTCCAATGTCCAAGAGCTGTTACAATTTGTAAAAGCAAATGAT GATGTAGCTCAAGAGATTGCTGAAAGGGGAAGCCAGTTTATTAGGAACCATTTGCAGATGGATGACATCACCTGTTACTGGGAGAACCTC TTGAGTGAATACTCTAAATTCCTGTCTTATAATGTAACGAGAAGGAAAGGTTATGATCAAATTATTCCCAAAATGTTGAAAACTGAACTA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SETD2_ENST00000409792_chr3_47139445_-_POGLUT1_ENST00000295588_chr3_119207776_+_7896nt GCTGCGGGGAGGGGGCTCGCGTCGCCGTCTCCAGCCGCTCCCGATGAAGCAGCTGCAGCCGCAGCCGCCTCCGAAGATGGGGGATTTCTA CGACCCGGAGCACCCGACCCCTGAAGAAGAAGAAAATGAGGCAAAGATTGAAAATGTGCAGAAAACAGGTTTCATCAAAGGACCAATGTT CAAAGGTGTTGCTTCTAGTCGATTTTTGCCCAAAGGCACCAAAACAAAAGTTAATTTGGAAGAACAGGGACGACAGAAGGTGTCATTCAG CTTCAGCCTTACAAAGAAAACTTTGCAGAATAGGTTTCTCACTGCACTTGGCAATGAAAAGCAAAGTGATACTCCAAACCCTCCAGCTGT ACCTCTTCAGGTAGACTCGACTCCTAAAATGAAAATGGAAATTGGTGATACCTTATCTACTGCAGAAGAATCTTCCCCACCAAAGTCAAG GGTGGAATTGGGCAAAATTCATTTTAAGAAACATCTGCTTCATGTAACATCCAGGCCACTGCTGGCTACTACCACAGCAGTAGCATCTCC ACCTACTCATGCAGCACCATTACCAGCAGTGATAGCAGAATCAACAACTGTAGACTCACCGCCCTCATCTCCGCCTCCACCGCCTCCACC TGCCCAAGCCACAACACTCTCATCACCAGCACCAGTAACAGAGCCAGTGGCCTTGCCACATACACCAATAACAGTTCTAATGGCAGCACC AGTACCCTTACCAGTAGATGTAGCAGTTAGATCTCTGAAAGAACCACCAATTATAATTGTACCAGAATCTTTAGAAGCAGATACTAAGCA GGACACTATATCTAATAGTTTAGAAGAACACGTAACTCAAATATTGAATGAGCAAGCAGATATTTCCTCAAAAAAAGAAGATTCCCATAT TGGGAAGGATGAAGAAATTCCAGATAGTTCTAAGATTAGTCTGAGCTGTAAAAAAACAGGTTCTAAGAAGAAATCCTCACAATCTGAAGG CATCTTTCTTGGTTCAGAATCTGATGAAGATTCTGTACGGACTTCTTCAAGTCAAAGATCACATGATTTAAAATTTTCAGCAAGCATTGA AAAGGAAAGAGATTTTAAAAAGAGCTCAGCACCTTTAAAAAGTGAGGATCTAGGGAAACCTTCACGATCTAAAACAGACAGAGATGATAA ATATTTTAGCTATTCAAAACTTGAAAGAGATACTCGGTATGTATCTTCCCGATGTAGATCAGAAAGAGAGCGACGGCGGAGCAGATCTCA CTCTAGGTCTGAGAGAGGCTCTAGAACTAATTTATCCTATTCCAGGTCAGAACGATCTCATTATTATGACTCTGATCGTCGCTACCATAG GAGCTCCCCTTATCGAGAGAGGACGCGCTATTCTCGGCCATACACAGATAACAGAGCACGAGAGAGTTCTGACTCAGAAGAAGAGTATAA GAAGACATACTCAAGGCGTACCTCATCTCATTCCTCTTCTTACAGAGACCTAAGGACATCATCCTATTCTAAATCTGATCGGGACTGTAA AACTGAGACCTCTTACTTAGAGATGGAAAGAAGAGGCAAGTATTCTTCAAAACTAGAAAGAGAATCTAAAAGGACTTCAGAAAATGAAGC AATTAAAAGATGTTGTTCTCCCCCTAATGAACTGGGATTCCGACGAGGGTCATCATATTCTAAGCATGACAGTAGTGCTTCCCGTTATAA ATCTACCCTTTCAAAACCTATACCCAAGTCTGATAAATTTAAAAATTCTTTCTGTTGTACAGAATTAAATGAAGAAATCAAACAGTCTCA TTCTTTTAGTTTACAGACACCTTGTTCAAAAGGTAGTGAATTAAGAATGATTAATAAAAATCCTGAAAGAGAAAAGGCTGGGTCTCCAGC TCCATCAAATCGATTAAATGATTCACCTACTTTAAAAAAGCTAGATGAATTGCCTATTTTTAAGTCCGAATTTATAACACATGATAGCCA TGATAGTATTAAGGAATTAGACTCTTTATCTAAAGTGAAGAATGATCAATTAAGAAGTTTTTGTCCCATAGAATTAAATATAAATGGATC TCCTGGGGCAGAATCTGATTTGGCAACATTTTGCACTTCTAAAACTGATGCTGTTTTAATGACTTCTGATGATAGTGTGACTGGATCGGA ATTATCCCCTTTGGTCAAAGCATGCATGCTTTCATCAAATGGATTTCAGAATATTAGTAGGTGCAAAGAAAAAGACTTGGATGATACCTG CATGCTGCATAAGAAGTCAGAAAGCCCATTTAGAGAAACAGAACCTCTGGTGTCACCACACCAAGATAAACTCATGTCTATGCCAGTTAT GACTGTGGATTATTCCAAAACAGTAGTTAAAGAACCAGTTGATACGAGGGTTTCTTGCTGCAAAACCAAAGATTCAGACATATACTGTAC TTTGAACGATAGCAACCCTTCTTTGTGTAACTCTGAAGCTGAAAATATTGAGCCTTCAGTTATGAAGATTTCTTCAAATAGCTTTATGAA TGTGCATTTGGAATCAAAACCAGTTATATGTGATAGTAGAAATTTGACAGATCACTCAAAATTTGCATGTGAAGAATATAAGCAGAGCAT CGGTAGCACTAGTTCAGCTTCTGTTAATCATTTTGATGATTTATATCAACCTATTGGGAGTTCAGGTATTGCTTCATCTCTTCAGAGTCT TCCACCAGGAATAAAGGTGGACAGTCTAACTCTCTTGAAATGCGGAGAGAACACATCTCCAGTTCTGGATGCAGTGCTAAAGAGTAAAAA AAGTTCAGAGTTTTTAAAGCATGCAGGGAAAGAAACAATAGTAGAAGTAGGTAGTGACCTTCCTGATTCAGGAAAGGGATTTGCTTCCAG GGAGAACAGGCGTAATAATGGGTTATCTGGGAAATGTTTGCAAGAGGCTCAAGAAGAAGGGAATTCCATATTGCCTGAAAGAAGAGGAAG ACCAGAAATCTCTTTAGATGAAAGAGGAGAAGGAGGACATGTGCATACTTCTGATGACTCAGAAGTTGTATTTTCTTCTTGTGATTTGAA TTTAACCATGGAAGACAGTGATGGTGTAACTTATGCATTAAAGTGTGACAGTAGTGGTCATGCCCCAGAAATTGTGTCTACAGTTCATGA AGATTATTCTGGCTCTTCTGAAAGTTCAAATGATGAAAGTGATTCAGAAGATACAGATTCGGATGATAGCAGTATTCCAAGAAACCGTCT CCAGTCTGTTGTGGTTGTGCCAAAGAATTCTACTTTGCCCATGGAAGAAACAAGTCCTTGTTCTTCTCGGAGCAGTCAAAGTTATAGACA CTATTCTGACCATTGGGAAGATGAGAGATTGGAGTCAAGGAGACATTTGTATGAGGAAAAATTTGAAAGTATAGCAAGTAAAGCCTGTCC TCAAACTGATAAGTTTTTCCTTCATAAAGGAACAGAGAAGAATCCGGAAATTTCTTTTACACAGTCCAGTAGAAAACAAATAGATAATCG CCTGCCTGAACTTTCTCATCCTCAGAGTGATGGGGTTGATAGTACAAGTCATACAGATGTGAAATCTGACCCTCTGGGTCACCCAAATTC AGAGGAAACCGTGAAAGCCAAAATACCTTCTAGGCAGCAAGAAGAGCTGCCAATTTATTCTTCTGATTTTGAAGATGTCCCAAATAAGTC TTGGCAACAGACCACTTTCCAAAACAGGCCAGATAGTAGACTGGGAAAAACAGAATTGAGTTTTTCTTCCTCTTGTGAGATACCACATGT GGATGGCTTGCACTCATCAGAAGAGCTCAGAAACTTAGGTTGGGACTTCTCTCAAGAAAAGCCTTCTACCACGTATCAGCAACCTGACAG TAGCTATGGAGCTTGTGGTGGACACAAGTATCAGCAAAATGCAGAACAGTATGGTGGGACACGTGATTACTGGCAAGGCAATGGTTACTG GGATCCAAGATCAGGTAGACCTCCTGGAACTGGGGTTGTGTATGATCGAACTCAAGGACAAGTACCAGATTCCCTAACAGATGATCGTGA AGAAGAGGAGAATTGGGATCAACAGGATGGATCCCATTTTTCAGACCAGTCCGATAAATTTCTTCTATCCCTTCAGAAAGACAAGGGGTC AGTGCAAGCACCTGAAATAAGCAGCAATTCCATTAAGGACACTTTAGCTGTGAATGAAAAGAAAGATTTTTCAAAAAACTTAGAAAAAAA TGATATCAAAGATAGAGGGCCTCTTAAAAAAAGGAGGCAGGAAATAGAGAGTGATTCTGAAAGTGATGGTGAGCTTCAGGACAGAAAGAA AGTTAGAGTGGAGGTAGAGCAGGGAGAGACATCAGTGCCCCCAGGTTCAGCACTGGTTGGGCCCTCCTGTGTCATGGATGACTTCAGGGA CCCACAGCGATGGAAGGAATGTGCCAAGCAAGGGAAAATGCCATGTTACTTTGATCTTATTGAAGAAAATGTTTATTTAACAGAAAGAAA GAAGAATAAATCTCATCGAGATATTAAGCGAATGCAGTGTGAGTGTACACCTCTTTCTAAAGATGAAAGAGCTCAAGGTGAAATAGCATG TGGGGAAGATTGTCTTAATCGTCTTCTCATGATTGAATGTTCTTCTCGGTGTCCAAATGGGGATTATTGTTCCAATAGACGGTTTCAGAG AAAACAGCATGCAGATGTGGAAGTCATACTCACAGAAAAGAAAGGCTGGGGCTTGAGAGCTGCCAAAGACCTTCCTTCGAACACCTTTGT CCTAGAATATTGTGGAGAGGTACTCGATCATAAAGAGTTTAAAGCTCGAGTGAAGGAGTATGCACGAAACAAAAACATCCATTACTATTT CATGGCCCTGAAGAATGATGAGATAATAGATGCCACTCAAAAAGGAAATTGCTCTCGTTTCATGAATCACAGCTGTGAACCAAATTGTGA AACCCAAAAATGGACTGTGAACGGACAACTGAGGGTTGGGTTTTTTACCACCAAACTGGTTCCTTCAGGCTCAGAGTTAACGTTTGACTA TCAGTTCCAGAGATATGGAAAAGAAGCCCAGAAATGTTTCTGCGGATCAGCCAATTGCCGGGGTTACCTGGGAGGAGAAAACAGAGTCAG CATCAGAGCAGCAGGAGGGAAAATGAAGAAGGAACGATCTCGTAAGAAGGATTCAGATACCTTAGGAAAGCCAGCTGCTAAGGATGTCCA TCTTGTGGATCACTGCAAATACAAGTATCTGTTTAATTTTCGAGGCGTAGCTGCAAGTTTCCGGTTTAAACACCTCTTCCTGTGTGGCTC ACTTGTTTTCCATGTTGGTGATGAGTGGCTAGAATTCTTCTATCCACAGCTGAAGCCATGGGTTCACTATATCCCAGTCAAAACAGATCT CTCCAATGTCCAAGAGCTGTTACAATTTGTAAAAGCAAATGATGATGTAGCTCAAGAGATTGCTGAAAGGGGAAGCCAGTTTATTAGGAA CCATTTGCAGATGGATGACATCACCTGTTACTGGGAGAACCTCTTGAGTGAATACTCTAAATTCCTGTCTTATAATGTAACGAGAAGGAA AGGTTATGATCAAATTATTCCCAAAATGTTGAAAACTGAACTATAGTAGTCATCATAGGACCATAGTCCTCTTTGTGGCAACAGATCTCA GATATCCTACGGTGAGAAGCTTACCATAAGCTTGGCACCTATACCTTGAATATCTGCTATCAAGCCAAATACCTGGTTTTCCTTATCATG CTGCACCCAGAGCAACTCTTGAGAAAGATTTAAAATGTGTCTAATACACTGATATGAAGCAGTTCAACTTTTTGGATGAATAAGGACCAG AAATCGTGAGATGTGGATTTTGAACCCAACTCTACCTTTCATTTTCTTAAGACCAATCACAGCTTGTGCCTCAGATCATCCACCTGTGTG AGTCCATCACTGTGAAATTGACTGTGTCCATGTGATGATGCCCTTTGTCCCATTATTTGGAGCAGAAAATTCGTCATTTGGAAGTAGTAC AACTCATTGCTGGAATTGTGAAATTATTCAAGGCGTGATCTCTGTCACTTTATTTTAATGTAGGAAACCCTATGGGGTTTATGAAAAATA CTTGGGGATCATTCTCTGAATGGTCTAAGGAAGCGGTAGCCATGCCATGCAATGATGTAGGAGTTCTCTTTTGTAAAACCATAAACTGTG TTACTCAGGAGGTTTCTATAATGCCACATAGAAAGAGGCCAATTGCATGAGTAATTATTGCAATTGGATTTCAGGTTCCCTTTTTGTGCC TTCATGCCCTACTTCTTAATGCCTCTCTAAAGCCAAAAAAAAAAAAAAAGACAAAGCCTCTTAATAAATTTAATGGAACTATACATAGAA CAGCAGCTCTTCCTCACCCTTTGCATACCTTTAATATTTTTCCTTCTTAAATTGGCCACAGCAGGGGTCATTCACACTCTCACTGTCTTG CAGGAATCACAAGAAGTCTTCATATGTGAACGTGCCATTCAGTTGGTAGTTAAGAGCATTCAACTTCAAATATATAGAAGATATTTGTTT TAGTGCAAATCCATGATGGAGTGCCTCCCTTTTCCTTTTTTCACTTTTTGAAAAAGATGTTTTGGGTAGTAGTTTAATATCTCAGGGTGC TCTTTCTAACATAGTAAAAAATGAAGAAAAATGTTTAGATTAAAACTCTGTAGTCTGATGACTTAGAACCATCCTTGACCCTTAGGCCCA ACCTTTCCACAGAGAAATCACCTCTCTTCCTTTGTCTTTTAAGAACTATTTGGTATTAACTAGTTTCAGAATTAGTAAATGTGAGATTCA GTCACATAATTATCAGACATTCCATTTGTCAGAAATGTATTTGGCTTTTTAAACTCCTTTCCACAAAAGTTTAAGTCTAATGACCTTCTT AGAGAAGTTGAGCATGCCTGGCAAGATCATTTCATGGAATAAGCAGATGTTTAAAGTTGGATTTTTTTTTTTTTTTTTTTTTGAGTACTA GCAATGCACAGGGACCGTGTTCTTAGGTTCTTAGTCTGTGAATCTAGCAATAGGCAGTCCAGATTTCTGAGTCGTACTATGGTTTTGCCT TGTCACTGTGAGGCCCTACTAGGTGTAAGCATTCTCTCTGAATTTTAATTTCCTCTCATTAAAATAGGAACAAAATTTGCTATCCTTTAG ATTAGGAGCTGAAGATTCATTTCCCTGGGAATGTTTCCCATTTAGCTTCAAGTTTCAGCTCAAACATCACCTTCTTTCTGACTCCTTTCA TTCATTCCTCCAGGCAGTAAGGGGCTACCATAGTACTTTGTTTATGCCTGTATTATATGACATCACTGTAGTTGCTTGACTGTTTCTCCT ACTGTTCTGTAAACTTATTAATGGGTGAGAATCTAATTTTACTCATCTTGATGGCTTCATGATCCAGCACAGTGCCTCACACAAAGAACT ATTGGGTGGGTGGATGGATGGATGGAGGAATGGAGACAGTTGGCTTAACCAGATCCTATATACAGATTATTACTGGCTCCAAAGGATGAG TAGATAAGACCATAAGAATTGGATCAATGTAAATCCTCACCTGCCCTTTGAAGAGCCAATAAGGGCATCTTTGTCTTTAAATACAGCAAA TGTTATTCAGATTTTGTACTTGTCTATCTGTTTACCTCAGTGTAGATGATATGAGGATGGTATAACTATGTAAATTGTTTTTGAAAATAA TTTGTTTCCCCACAACTTTTGAAGGTTTTATTTGTTGTTGTTATTACTAGTTCAGTCCCAAACTTACCCTTTCCTTTTCAGAGAGCTAAT |
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FusionGenePPI for SETD2_POGLUT1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SETD2 | HTT, IWS1, TP53, HIST1H3A, SETD2, POLR2A, ELAVL1, ATXN1, CIC, CBX8, SOX2, SMAD3, SIAH2, CLK2, HIST3H3, WDR37, ARHGEF10, LUC7L, SCARA3, AURKA, EIF3I, XPO1, RASSF8, GAN, ATM, HNRNPLL, NXF2, HSPB8, RSBN1, F9, CPNE7, PIP4K2A, TRPC4AP, JMJD6, TRIM25 | POGLUT1 | DHX40, DHX29, FBXO6, TAZ, SUSD4, PLAUR, TMEM25, ART3, UBR4, CANX, ZZEF1, HECTD3, CSGALNACT2, PON2, KCMF1, PTPRK, DPEP2, NAAA, LYZL1, PRG3, F9, GAA, A2M, PIGT, LYPD4, UBR5, LYZL2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | SETD2 | chr3:47139445 | chr3:119207776 | ENST00000409792 | - | 9 | 21 | 1418_1714 | 1714 | 2565 | TUBA1A |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SETD2 | chr3:47139445 | chr3:119207776 | ENST00000409792 | - | 9 | 21 | 2457_2564 | 1714 | 2565 | POLR2A |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SETD2_POGLUT1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SETD2_POGLUT1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SETD2 | C0007134 | Renal Cell Carcinoma | 2 | CTD_human |
| Hgene | SETD2 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | SETD2 | C0010701 | Phyllodes Tumor | 1 | CTD_human |
| Hgene | SETD2 | C0023418 | leukemia | 1 | CTD_human |
| Hgene | SETD2 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Hgene | SETD2 | C0920269 | Microsatellite Instability | 1 | CTD_human |
| Hgene | SETD2 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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