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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 33365

FusionGeneSummary for SETD2_KIF9

check button Fusion gene summary
Fusion gene informationFusion gene name: SETD2_KIF9
Fusion gene ID: 33365
HgeneTgene
Gene symbol

SETD2

KIF9

Gene ID

29072

64147

Gene nameSET domain containing 2kinesin family member 9
SynonymsHBP231|HIF-1|HIP-1|HSPC069|HYPB|KMT3A|LLS|SET2|p231HBP-
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase SETD2huntingtin interacting protein 1huntingtin yeast partner Bhuntingtin-interacting protein Blysine N-methyltransferase 3Aprotein-lysine N-methyltransferase SETD2kinesin-like protein KIF9kinesin protein 9
Modification date2018051920180523
UniProtAcc

Q9BYW2

Q9HAQ2

Ensembl transtripts involved in fusion geneENST00000409792, ENST00000492397, 
ENST00000335044, ENST00000265529, 
ENST00000444589, ENST00000452770, 
ENST00000352910, ENST00000487440, 
ENST00000425853, ENST00000432493, 
ENST00000425452, 
Fusion gene scores* DoF score19 X 9 X 10=17103 X 4 X 5=60
# samples 215
** MAII scorelog2(21/1710*10)=-3.02553509210714
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SETD2 [Title/Abstract] AND KIF9 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSETD2

GO:0010569

regulation of double-strand break repair via homologous recombination

24843002

HgeneSETD2

GO:0018023

peptidyl-lysine trimethylation

27518565

HgeneSETD2

GO:0018026

peptidyl-lysine monomethylation

28753426

HgeneSETD2

GO:0032465

regulation of cytokinesis

27518565

HgeneSETD2

GO:0032727

positive regulation of interferon-alpha production

28753426

HgeneSETD2

GO:0034340

response to type I interferon

28753426

HgeneSETD2

GO:0051607

defense response to virus

28753426

HgeneSETD2

GO:0097198

histone H3-K36 trimethylation

23043551|24843002|26002201|27474439|28753426

HgeneSETD2

GO:0097676

histone H3-K36 dimethylation

26002201

HgeneSETD2

GO:1902850

microtubule cytoskeleton organization involved in mitosis

27518565

HgeneSETD2

GO:1905634

regulation of protein localization to chromatin

24843002


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-86-8673-01ASETD2chr3

47205344

-KIF9chr3

47289576

-
TCGALDUCECTCGA-AX-A3FX-01ASETD2chr3

47205344

-KIF9chr3

47316980

-
TCGARVUCSTCGA-N9-A4PZ-01ASETD2chr3

47205344

-KIF9chr3

47289576

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000409792ENST00000335044SETD2chr3

47205344

-KIF9chr3

47289576

-
In-frameENST00000409792ENST00000265529SETD2chr3

47205344

-KIF9chr3

47289576

-
In-frameENST00000409792ENST00000444589SETD2chr3

47205344

-KIF9chr3

47289576

-
In-frameENST00000409792ENST00000452770SETD2chr3

47205344

-KIF9chr3

47289576

-
In-frameENST00000409792ENST00000352910SETD2chr3

47205344

-KIF9chr3

47289576

-
5CDS-5UTRENST00000409792ENST00000487440SETD2chr3

47205344

-KIF9chr3

47289576

-
5CDS-intronENST00000409792ENST00000425853SETD2chr3

47205344

-KIF9chr3

47289576

-
5CDS-intronENST00000409792ENST00000432493SETD2chr3

47205344

-KIF9chr3

47289576

-
5CDS-intronENST00000409792ENST00000425452SETD2chr3

47205344

-KIF9chr3

47289576

-
intron-3CDSENST00000492397ENST00000335044SETD2chr3

47205344

-KIF9chr3

47289576

-
intron-3CDSENST00000492397ENST00000265529SETD2chr3

47205344

-KIF9chr3

47289576

-
intron-3CDSENST00000492397ENST00000444589SETD2chr3

47205344

-KIF9chr3

47289576

-
intron-3CDSENST00000492397ENST00000452770SETD2chr3

47205344

-KIF9chr3

47289576

-
intron-3CDSENST00000492397ENST00000352910SETD2chr3

47205344

-KIF9chr3

47289576

-
intron-5UTRENST00000492397ENST00000487440SETD2chr3

47205344

-KIF9chr3

47289576

-
intron-intronENST00000492397ENST00000425853SETD2chr3

47205344

-KIF9chr3

47289576

-
intron-intronENST00000492397ENST00000432493SETD2chr3

47205344

-KIF9chr3

47289576

-
intron-intronENST00000492397ENST00000425452SETD2chr3

47205344

-KIF9chr3

47289576

-
In-frameENST00000409792ENST00000335044SETD2chr3

47205344

-KIF9chr3

47316980

-
In-frameENST00000409792ENST00000265529SETD2chr3

47205344

-KIF9chr3

47316980

-
In-frameENST00000409792ENST00000444589SETD2chr3

47205344

-KIF9chr3

47316980

-
In-frameENST00000409792ENST00000452770SETD2chr3

47205344

-KIF9chr3

47316980

-
5CDS-5UTRENST00000409792ENST00000352910SETD2chr3

47205344

-KIF9chr3

47316980

-
5CDS-5UTRENST00000409792ENST00000487440SETD2chr3

47205344

-KIF9chr3

47316980

-
5CDS-5UTRENST00000409792ENST00000425853SETD2chr3

47205344

-KIF9chr3

47316980

-
5CDS-5UTRENST00000409792ENST00000432493SETD2chr3

47205344

-KIF9chr3

47316980

-
5CDS-5UTRENST00000409792ENST00000425452SETD2chr3

47205344

-KIF9chr3

47316980

-
intron-3CDSENST00000492397ENST00000335044SETD2chr3

47205344

-KIF9chr3

47316980

-
intron-3CDSENST00000492397ENST00000265529SETD2chr3

47205344

-KIF9chr3

47316980

-
intron-3CDSENST00000492397ENST00000444589SETD2chr3

47205344

-KIF9chr3

47316980

-
intron-3CDSENST00000492397ENST00000452770SETD2chr3

47205344

-KIF9chr3

47316980

-
intron-5UTRENST00000492397ENST00000352910SETD2chr3

47205344

-KIF9chr3

47316980

-
intron-5UTRENST00000492397ENST00000487440SETD2chr3

47205344

-KIF9chr3

47316980

-
intron-5UTRENST00000492397ENST00000425853SETD2chr3

47205344

-KIF9chr3

47316980

-
intron-5UTRENST00000492397ENST00000432493SETD2chr3

47205344

-KIF9chr3

47316980

-
intron-5UTRENST00000492397ENST00000425452SETD2chr3

47205344

-KIF9chr3

47316980

-

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FusionProtFeatures for SETD2_KIF9


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SETD2

Q9BYW2

KIF9

Q9HAQ2


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKIF9chr3:47205344chr3:47289576ENST00000265529-1022658_690353791Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47289576ENST00000335044-921658_690353791Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47289576ENST00000444589-920658_690353726Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47289576ENST00000452770-1022658_690353791Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47316980ENST00000265529-222342_38031791Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47316980ENST00000265529-222658_69031791Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47316980ENST00000335044-121342_38031791Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47316980ENST00000335044-121658_69031791Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47316980ENST00000444589-120342_38031726Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47316980ENST00000444589-120658_69031726Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47316980ENST00000452770-222342_38031791Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47316980ENST00000452770-222658_69031791Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47316980ENST00000265529-22293_10031791Nucleotide bindingNote=ATP
TgeneKIF9chr3:47205344chr3:47316980ENST00000335044-12193_10031791Nucleotide bindingNote=ATP
TgeneKIF9chr3:47205344chr3:47316980ENST00000444589-12093_10031726Nucleotide bindingNote=ATP
TgeneKIF9chr3:47205344chr3:47316980ENST00000452770-22293_10031791Nucleotide bindingNote=ATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSETD2chr3:47205344chr3:47289576ENST00000409792-1212117_2146232565Coiled coilOntology_term=ECO:0000255
HgeneSETD2chr3:47205344chr3:47316980ENST00000409792-1212117_2146232565Coiled coilOntology_term=ECO:0000255
HgeneSETD2chr3:47205344chr3:47289576ENST00000409792-121166_247232565Compositional biasNote=Pro-rich
HgeneSETD2chr3:47205344chr3:47289576ENST00000409792-1212149_2232232565Compositional biasNote=Pro-rich
HgeneSETD2chr3:47205344chr3:47289576ENST00000409792-1212266_2365232565Compositional biasNote=Gln-rich
HgeneSETD2chr3:47205344chr3:47289576ENST00000409792-121385_456232565Compositional biasNote=Arg-rich
HgeneSETD2chr3:47205344chr3:47316980ENST00000409792-121166_247232565Compositional biasNote=Pro-rich
HgeneSETD2chr3:47205344chr3:47316980ENST00000409792-1212149_2232232565Compositional biasNote=Pro-rich
HgeneSETD2chr3:47205344chr3:47316980ENST00000409792-1212266_2365232565Compositional biasNote=Gln-rich
HgeneSETD2chr3:47205344chr3:47316980ENST00000409792-121385_456232565Compositional biasNote=Arg-rich
HgeneSETD2chr3:47205344chr3:47289576ENST00000409792-1211494_1548232565DomainAWS
HgeneSETD2chr3:47205344chr3:47289576ENST00000409792-1211550_1667232565DomainSET
HgeneSETD2chr3:47205344chr3:47289576ENST00000409792-1211674_1690232565DomainPost-SET
HgeneSETD2chr3:47205344chr3:47289576ENST00000409792-1212389_2422232565DomainWW
HgeneSETD2chr3:47205344chr3:47316980ENST00000409792-1211494_1548232565DomainAWS
HgeneSETD2chr3:47205344chr3:47316980ENST00000409792-1211550_1667232565DomainSET
HgeneSETD2chr3:47205344chr3:47316980ENST00000409792-1211674_1690232565DomainPost-SET
HgeneSETD2chr3:47205344chr3:47316980ENST00000409792-1212389_2422232565DomainWW
HgeneSETD2chr3:47205344chr3:47289576ENST00000409792-1211560_1562232565RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47205344chr3:47289576ENST00000409792-1211603_1605232565RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47205344chr3:47289576ENST00000409792-1211628_1629232565RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47205344chr3:47289576ENST00000409792-1212137_2366232565RegionLow charge region
HgeneSETD2chr3:47205344chr3:47316980ENST00000409792-1211560_1562232565RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47205344chr3:47316980ENST00000409792-1211603_1605232565RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47205344chr3:47316980ENST00000409792-1211628_1629232565RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47205344chr3:47316980ENST00000409792-1212137_2366232565RegionLow charge region
TgeneKIF9chr3:47205344chr3:47289576ENST00000265529-1022342_380353791Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47289576ENST00000335044-921342_380353791Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47289576ENST00000444589-920342_380353726Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47289576ENST00000452770-1022342_380353791Coiled coilOntology_term=ECO:0000255
TgeneKIF9chr3:47205344chr3:47289576ENST00000265529-10226_340353791DomainKinesin motor
TgeneKIF9chr3:47205344chr3:47289576ENST00000335044-9216_340353791DomainKinesin motor
TgeneKIF9chr3:47205344chr3:47289576ENST00000444589-9206_340353726DomainKinesin motor
TgeneKIF9chr3:47205344chr3:47289576ENST00000452770-10226_340353791DomainKinesin motor
TgeneKIF9chr3:47205344chr3:47316980ENST00000265529-2226_34031791DomainKinesin motor
TgeneKIF9chr3:47205344chr3:47316980ENST00000335044-1216_34031791DomainKinesin motor
TgeneKIF9chr3:47205344chr3:47316980ENST00000444589-1206_34031726DomainKinesin motor
TgeneKIF9chr3:47205344chr3:47316980ENST00000452770-2226_34031791DomainKinesin motor
TgeneKIF9chr3:47205344chr3:47289576ENST00000265529-102212_14353791Nucleotide bindingNote=ATP
TgeneKIF9chr3:47205344chr3:47289576ENST00000265529-102293_100353791Nucleotide bindingNote=ATP
TgeneKIF9chr3:47205344chr3:47289576ENST00000335044-92112_14353791Nucleotide bindingNote=ATP
TgeneKIF9chr3:47205344chr3:47289576ENST00000335044-92193_100353791Nucleotide bindingNote=ATP
TgeneKIF9chr3:47205344chr3:47289576ENST00000444589-92012_14353726Nucleotide bindingNote=ATP
TgeneKIF9chr3:47205344chr3:47289576ENST00000444589-92093_100353726Nucleotide bindingNote=ATP
TgeneKIF9chr3:47205344chr3:47289576ENST00000452770-102212_14353791Nucleotide bindingNote=ATP
TgeneKIF9chr3:47205344chr3:47289576ENST00000452770-102293_100353791Nucleotide bindingNote=ATP
TgeneKIF9chr3:47205344chr3:47316980ENST00000265529-22212_1431791Nucleotide bindingNote=ATP
TgeneKIF9chr3:47205344chr3:47316980ENST00000335044-12112_1431791Nucleotide bindingNote=ATP
TgeneKIF9chr3:47205344chr3:47316980ENST00000444589-12012_1431726Nucleotide bindingNote=ATP
TgeneKIF9chr3:47205344chr3:47316980ENST00000452770-22212_1431791Nucleotide bindingNote=ATP


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FusionGeneSequence for SETD2_KIF9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SETD2_ENST00000409792_chr3_47205344_-_KIF9_ENST00000335044_chr3_47316980_-_783aa
MKQLQPQPPPKMGDFYDPEHPTPEALIFTXKKTFGEELSITNRQTGRLSWMEFFTMPPRTWFMRQLQRMWFLRPSMAIMAPSCVMGRREL
ARHTPXWGQLRITSTGGSSLVPCSRFLGXSKNAPHMPSLCVFPTWKSIMRACLISCPLCPMLDPQSHQXPSWKTLKESSLRACQFTSQVR
RRMHSASFLRVRPTGLXPPTLXTKTLPDHTAFSPSTXRPIPGPYQRKSTSLPKLTWWIWQAQRGWGSLGLRAKSXRKPPTSTNRSHSWSR
PSLPLGTRSGTTSPFGSASSPTLXRTRXGETAIWSSXQTSMEKLPSXKKRYLHXDLPAGXSXSPLSLPSMKSMMLREWSRTWRRNXHYSS
RSWLSMTAXPTAPLXPMTPWMKSRLLRSTPRCGGTWRGHWTRSTXSALDRSRRCSTSSGWFXANRNRKWSPLCAGSTPSLTGMTLQPFLL
SRRRGLWMLMATXWVSLKDKTLDSESPLSLPNLGRKPSPRRHSKSHSAPWQERKVPAALXMGRTWITFPPPRPSWSHPPKMGMSKTCFRG
TGKLPALSPFPQTPRRRNYAQLGPTPHPPNQWPLRSLRMSKVVRSTEFSKKTNPSXMNGGKGPARPHSTSMPSSGRLMXPRRPXISRSHY
GRSKASTKTRGXXSSMRKNSCXSSSSKTSRSSTAASTRTCVTSGLRSSIASTXWISVATACSWNLTSGTMSPLSSLRTCRWHXSQAAASG

>In-frame_SETD2_ENST00000409792_chr3_47205344_-_KIF9_ENST00000265529_chr3_47316980_-_783aa
MKQLQPQPPPKMGDFYDPEHPTPEALIFTXKKTFGEELSITNRQTGRLSWMEFFTMPPRTWFMRQLQRMWFLRPSMAIMAPSCVMGRREL
ARHTPXWGQLRITSTGGSSLVPCSRFLGXSKNAPHMPSLCVFPTWKSIMRACLISCPLCPMLDPQSHQXPSWKTLKESSLRACQFTSQVR
RRMHSASFLRVRPTGLXPPTLXTKTLPDHTAFSPSTXRPIPGPYQRKSTSLPKLTWWIWQAQRGWGSLGLRAKSXRKPPTSTNRSHSWSR
PSLPLGTRSGTTSPFGSASSPTLXRTRXGETAIWSSXQTSMEKLPSXKKRYLHXDLPAGXSXSPLSLPSMKSMMLREWSRTWRRNXHYSS
RSWLSMTAXPTAPLXPMTPWMKSRLLRSTPRCGGTWRGHWTRSTXSALDRSRRCSTSSGWFXANRNRKWSPLCAGSTPSLTGMTLQPFLL
SRRRGLWMLMATXWVSLKDKTLDSESPLSLPNLGRKPSPRRHSKSHSAPWQERKVPAALXMGRTWITFPPPRPSWSHPPKMGMSKTCFRG
TGKLPALSPFPQTPRRRNYAQLGPTPHPPNQWPLRSLRMSKVVRSTEFSKKTNPSXMNGGKGPARPHSTSMPSSGRLMXPRRPXISRSHY
GRSKASTKTRGXXSSMRKNSCXSSSSKTSRSSTAASTRTCVTSGLRSSIASTXWISVATACSWNLTSGTMSPLSSLRTCRWHXSQAAASG

>In-frame_SETD2_ENST00000409792_chr3_47205344_-_KIF9_ENST00000444589_chr3_47316980_-_718aa
MKQLQPQPPPKMGDFYDPEHPTPEALIFTXKKTFGEELSITNRQTGRLSWMEFFTMPPRTWFMRQLQRMWFLRPSMAIMAPSCVMGRREL
ARHTPXWGQLRITSTGGSSLVPCSRFLGXSKNAPHMPSLCVFPTWKSIMRACLISCPLCPMLDPQSHQXPSWKTLKESSLRACQFTSQVR
RRMHSASFLRVRPTGLXPPTLXTKTLPDHTAFSPSTXRPIPGPYQRKSTSLPKLTWWIWQAQRGWGSLGLRAKSXRKPPTSTNRSHSWSR
PSLPLGTRSGTTSPFGSASSPTLXRTRXGETAIWSSXQTSMEKLPSXKKRYLHXDLPAGXSXSPLSLPSMKSMMLREWSRTWRRNXHYSS
RSWLSMTAXPTAPLXPMTPWMKSRLLRSTPRCGGTWRGHWTRSTXSALDRSRRCSTSSGWFXANRNRKWSPLCAGSTPSLTGMTLQPFLL
SRRRGLWMLMATXWVSLKDKTLDSESPLSLPNLGRKPSPRRHSKSHSGPTPHPPNQWPLRSLRMSKVVRSTEFSKKTNPSXMNGGKGPAR
PHSTSMPSSGRLMXPRRPXISRSHYGRSKASTKTRGXXSSMRKNSCXSSSSKTSRSSTAASTRTCVTSGLRSSIASTXWISVATACSWNL

>In-frame_SETD2_ENST00000409792_chr3_47205344_-_KIF9_ENST00000452770_chr3_47316980_-_783aa
MKQLQPQPPPKMGDFYDPEHPTPEALIFTXKKTFGEELSITNRQTGRLSWMEFFTMPPRTWFMRQLQRMWFLRPSMAIMAPSCVMGRREL
ARHTPXWGQLRITSTGGSSLVPCSRFLGXSKNAPHMPSLCVFPTWKSIMRACLISCPLCPMLDPQSHQXPSWKTLKESSLRACQFTSQVR
RRMHSASFLRVRPTGLXPPTLXTKTLPDHTAFSPSTXRPIPGPYQRKSTSLPKLTWWIWQAQRGWGSLGLRAKSXRKPPTSTNRSHSWSR
PSLPLGTRSGTTSPFGSASSPTLXRTRXGETAIWSSXQTSMEKLPSXKKRYLHXDLPAGXSXSPLSLPSMKSMMLREWSRTWRRNXHYSS
RSWLSMTAXPTAPLXPMTPWMKSRLLRSTPRCGGTWRGHWTRSTXSALDRSRRCSTSSGWFXANRNRKWSPLCAGSTPSLTGMTLQPFLL
SRRRGLWMLMATXWVSLKDKTLDSESPLSLPNLGRKPSPRRHSKSHSAPWQERKVPAALXMGRTWITFPPPRPSWSHPPKMGMSKTCFRG
TGKLPALSPFPQTPRRRNYAQLGPTPHPPNQWPLRSLRMSKVVRSTEFSKKTNPSXMNGGKGPARPHSTSMPSSGRLMXPRRPXISRSHY
GRSKASTKTRGXXSSMRKNSCXSSSSKTSRSSTAASTRTCVTSGLRSSIASTXWISVATACSWNLTSGTMSPLSSLRTCRWHXSQAAASG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SETD2_ENST00000409792_chr3_47205344_-_KIF9_ENST00000335044_chr3_47316980_-_2351nt
ATGAAGCAGCTGCAGCCGCAGCCGCCTCCGAAGATGGGGGATTTCTACGACCCGGAGCACCCGACCCCTGAAGCATTGATATTCACTTAA
AAAAAGACATTCGGAGAGGAGTTGTCAATAACCAACAGACAGACTGGTCGTTTAAGTTGGATGGAGTTCTTCACGATGCCTCCCAGGACT
TGGTTTATGAGACAGTTGCAAAGGATGTGGTTTCTCAGGCCCTCGATGGCTATAATGGCACCATCATGTGTTATGGGCAGACGGGAGCTG
GCAAGACATACACCATGATGGGGGCAACTGAGAATTACAAGCACCGGGGGATCCTCCCTCGTGCCCTGCAGCAGGTTTTTAGGATGATCG
AAGAACGCCCCACACATGCCATCACTGTGCGTGTTTCCTACTTGGAAATCTATAATGAGAGCCTGTTTGATCTCCTGTCCACTCTGCCCT
ATGTTGGACCCTCAGTCACACCAATGACCATCGTGGAAAACCCTCAAGGAGTCTTCATTAAGGGCTTGTCAGTTCACCTCACAAGTCAGG
AGGAGGATGCATTCAGCCTCCTTTTTGAGGGTGAGACCAACAGGATTATAGCCTCCCACACTATGAACAAAAACTCTTCCAGATCACACT
GCATTTTCACCATCTACTTAGAGGCCCATTCCCGGACCTTATCAGAGGAAAAGTACATCACTTCCAAAATTAACTTGGTGGATCTGGCAG
GCTCAGAGAGGCTGGGGAAGTCTGGGTCTGAGGGCCAAGTCCTGAAGGAAGCCACCTACATCAACAAATCGCTCTCATTCCTGGAGCAGG
CCATCATTGCCCTTGGGGACCAGAAGCGGGACCACATCCCCTTTCGGCAGTGCAAGCTCACCCACGCTCTGAAGGACTCGTTAGGGGGAA
ACTGCAATATGGTCCTCGTGACAAACATCTATGGAGAAGCTGCCCAGTTAGAAGAAACGCTATCTTCACTGAGATTTGCCAGCAGGATGA
AGCTAGTCACCACTGAGCCTGCCATCAATGAAAAGTATGATGCTGAGAGAATGGTCAAGAACCTGGAGAAGGAACTAGCACTACTCAAGC
AGGAGCTGGCTATCCATGACAGCCTGACCAACCGCACCTTTGTGACCTATGACCCCATGGATGAAATCCAGATTGCTGAGATCAACTCCC
AGGTGCGGAGGTACCTGGAGGGGACACTGGACGAGATCGACATAATCAGCCTTAGACAGATCAAGGAGGTGTTCAACCAGTTCCGGGTGG
TTCTGAGCCAACAGGAACAGGAAGTGGAGTCCACTTTGCGCAGGAAGTACACCCTCATTGACAGGAATGACTTTGCAGCCATTTCTGCTA
TCCAGAAGGCGGGGCTTGTGGATGTTGATGGCCACCTAGTGGGTGAGCCTGAAGGACAAAACTTTGGACTCGGAGTCGCCCCTTTCTCTA
CCAAACCTGGGAAGAAAGCCAAGTCCAAGAAGACATTCAAAGAGCCACTCAGCTCCTTGGCAAGAAAGGAAGGTGCCAGCAGCCCTGTGA
ATGGGAAGGACTTGGATTACGTTTCCACCTCCAAGACCCAGCTGGTCCCATCCTCCAAAGATGGGGATGTCAAAGACATGCTTTCGCGGG
ACCGGGAAACTTCCAGCATTGAGCCCCTTCCCTCAGACTCCCCGAAGGAGGAATTACGCCCAATTAGGCCCGACACCCCACCCTCCAAAC
CAGTGGCCTTTGAGGAGTTTAAGAATGAGCAAGGTAGTGAGATCAACCGAATTTTCAAAGAAAACAAATCCATCTTGAATGAACGGAGGA
AAAGGGCCAGCGAGACCACACAGCACATCAATGCCATCAAGCGGGAGATTGATGTGACCAAGGAGGCCCTGAATTTCCAGAAGTCACTAC
GGGAGAAGCAAGGCAAGTACGAAAACAAGGGGCTGATGATCATCGATGAGGAAGAATTCCTGCTGATCCTCAAGCTCAAAGACCTCAAGA
AGCAGTACCGCAGCGAGTACCAGGACCTGCGTGACCTCAGGGCTGAGATCCAGTATTGCCAGCACCTAGTGGATCAGTGTCGCCACCGCC
TGCTCATGGAATTTGACATCTGGTACAATGAGTCCTTTGTCATCCCTGAGGACATGCAGATGGCACTGAAGCCAGGCGGCAGCATCCGGC
CAGGCATGGTCCCTGTGAACAGGATTGTGTCTCTGGGAGAAGATGACCAGGACAAATTCAGCCAGCTGCAGCAGAGGGTGCTTCCTGAGG
GCCCTGATTCCATCTCCTTCTACAATGCCAAAGTCAAGATAGAGCAGAAGCATAATTACTTGAAAACCATGATGGGCCTCCAGCAGGCAC

>In-frame_SETD2_ENST00000409792_chr3_47205344_-_KIF9_ENST00000265529_chr3_47316980_-_2351nt
ATGAAGCAGCTGCAGCCGCAGCCGCCTCCGAAGATGGGGGATTTCTACGACCCGGAGCACCCGACCCCTGAAGCATTGATATTCACTTAA
AAAAAGACATTCGGAGAGGAGTTGTCAATAACCAACAGACAGACTGGTCGTTTAAGTTGGATGGAGTTCTTCACGATGCCTCCCAGGACT
TGGTTTATGAGACAGTTGCAAAGGATGTGGTTTCTCAGGCCCTCGATGGCTATAATGGCACCATCATGTGTTATGGGCAGACGGGAGCTG
GCAAGACATACACCATGATGGGGGCAACTGAGAATTACAAGCACCGGGGGATCCTCCCTCGTGCCCTGCAGCAGGTTTTTAGGATGATCG
AAGAACGCCCCACACATGCCATCACTGTGCGTGTTTCCTACTTGGAAATCTATAATGAGAGCCTGTTTGATCTCCTGTCCACTCTGCCCT
ATGTTGGACCCTCAGTCACACCAATGACCATCGTGGAAAACCCTCAAGGAGTCTTCATTAAGGGCTTGTCAGTTCACCTCACAAGTCAGG
AGGAGGATGCATTCAGCCTCCTTTTTGAGGGTGAGACCAACAGGATTATAGCCTCCCACACTATGAACAAAAACTCTTCCAGATCACACT
GCATTTTCACCATCTACTTAGAGGCCCATTCCCGGACCTTATCAGAGGAAAAGTACATCACTTCCAAAATTAACTTGGTGGATCTGGCAG
GCTCAGAGAGGCTGGGGAAGTCTGGGTCTGAGGGCCAAGTCCTGAAGGAAGCCACCTACATCAACAAATCGCTCTCATTCCTGGAGCAGG
CCATCATTGCCCTTGGGGACCAGAAGCGGGACCACATCCCCTTTCGGCAGTGCAAGCTCACCCACGCTCTGAAGGACTCGTTAGGGGGAA
ACTGCAATATGGTCCTCGTGACAAACATCTATGGAGAAGCTGCCCAGTTAGAAGAAACGCTATCTTCACTGAGATTTGCCAGCAGGATGA
AGCTAGTCACCACTGAGCCTGCCATCAATGAAAAGTATGATGCTGAGAGAATGGTCAAGAACCTGGAGAAGGAACTAGCACTACTCAAGC
AGGAGCTGGCTATCCATGACAGCCTGACCAACCGCACCTTTGTGACCTATGACCCCATGGATGAAATCCAGATTGCTGAGATCAACTCCC
AGGTGCGGAGGTACCTGGAGGGGACACTGGACGAGATCGACATAATCAGCCTTAGACAGATCAAGGAGGTGTTCAACCAGTTCCGGGTGG
TTCTGAGCCAACAGGAACAGGAAGTGGAGTCCACTTTGCGCAGGAAGTACACCCTCATTGACAGGAATGACTTTGCAGCCATTTCTGCTA
TCCAGAAGGCGGGGCTTGTGGATGTTGATGGCCACCTAGTGGGTGAGCCTGAAGGACAAAACTTTGGACTCGGAGTCGCCCCTTTCTCTA
CCAAACCTGGGAAGAAAGCCAAGTCCAAGAAGACATTCAAAGAGCCACTCAGCTCCTTGGCAAGAAAGGAAGGTGCCAGCAGCCCTGTGA
ATGGGAAGGACTTGGATTACGTTTCCACCTCCAAGACCCAGCTGGTCCCATCCTCCAAAGATGGGGATGTCAAAGACATGCTTTCGCGGG
ACCGGGAAACTTCCAGCATTGAGCCCCTTCCCTCAGACTCCCCGAAGGAGGAATTACGCCCAATTAGGCCCGACACCCCACCCTCCAAAC
CAGTGGCCTTTGAGGAGTTTAAGAATGAGCAAGGTAGTGAGATCAACCGAATTTTCAAAGAAAACAAATCCATCTTGAATGAACGGAGGA
AAAGGGCCAGCGAGACCACACAGCACATCAATGCCATCAAGCGGGAGATTGATGTGACCAAGGAGGCCCTGAATTTCCAGAAGTCACTAC
GGGAGAAGCAAGGCAAGTACGAAAACAAGGGGCTGATGATCATCGATGAGGAAGAATTCCTGCTGATCCTCAAGCTCAAAGACCTCAAGA
AGCAGTACCGCAGCGAGTACCAGGACCTGCGTGACCTCAGGGCTGAGATCCAGTATTGCCAGCACCTAGTGGATCAGTGTCGCCACCGCC
TGCTCATGGAATTTGACATCTGGTACAATGAGTCCTTTGTCATCCCTGAGGACATGCAGATGGCACTGAAGCCAGGCGGCAGCATCCGGC
CAGGCATGGTCCCTGTGAACAGGATTGTGTCTCTGGGAGAAGATGACCAGGACAAATTCAGCCAGCTGCAGCAGAGGGTGCTTCCTGAGG
GCCCTGATTCCATCTCCTTCTACAATGCCAAAGTCAAGATAGAGCAGAAGCATAATTACTTGAAAACCATGATGGGCCTCCAGCAGGCAC

>In-frame_SETD2_ENST00000409792_chr3_47205344_-_KIF9_ENST00000444589_chr3_47316980_-_2156nt
ATGAAGCAGCTGCAGCCGCAGCCGCCTCCGAAGATGGGGGATTTCTACGACCCGGAGCACCCGACCCCTGAAGCATTGATATTCACTTAA
AAAAAGACATTCGGAGAGGAGTTGTCAATAACCAACAGACAGACTGGTCGTTTAAGTTGGATGGAGTTCTTCACGATGCCTCCCAGGACT
TGGTTTATGAGACAGTTGCAAAGGATGTGGTTTCTCAGGCCCTCGATGGCTATAATGGCACCATCATGTGTTATGGGCAGACGGGAGCTG
GCAAGACATACACCATGATGGGGGCAACTGAGAATTACAAGCACCGGGGGATCCTCCCTCGTGCCCTGCAGCAGGTTTTTAGGATGATCG
AAGAACGCCCCACACATGCCATCACTGTGCGTGTTTCCTACTTGGAAATCTATAATGAGAGCCTGTTTGATCTCCTGTCCACTCTGCCCT
ATGTTGGACCCTCAGTCACACCAATGACCATCGTGGAAAACCCTCAAGGAGTCTTCATTAAGGGCTTGTCAGTTCACCTCACAAGTCAGG
AGGAGGATGCATTCAGCCTCCTTTTTGAGGGTGAGACCAACAGGATTATAGCCTCCCACACTATGAACAAAAACTCTTCCAGATCACACT
GCATTTTCACCATCTACTTAGAGGCCCATTCCCGGACCTTATCAGAGGAAAAGTACATCACTTCCAAAATTAACTTGGTGGATCTGGCAG
GCTCAGAGAGGCTGGGGAAGTCTGGGTCTGAGGGCCAAGTCCTGAAGGAAGCCACCTACATCAACAAATCGCTCTCATTCCTGGAGCAGG
CCATCATTGCCCTTGGGGACCAGAAGCGGGACCACATCCCCTTTCGGCAGTGCAAGCTCACCCACGCTCTGAAGGACTCGTTAGGGGGAA
ACTGCAATATGGTCCTCGTGACAAACATCTATGGAGAAGCTGCCCAGTTAGAAGAAACGCTATCTTCACTGAGATTTGCCAGCAGGATGA
AGCTAGTCACCACTGAGCCTGCCATCAATGAAAAGTATGATGCTGAGAGAATGGTCAAGAACCTGGAGAAGGAACTAGCACTACTCAAGC
AGGAGCTGGCTATCCATGACAGCCTGACCAACCGCACCTTTGTGACCTATGACCCCATGGATGAAATCCAGATTGCTGAGATCAACTCCC
AGGTGCGGAGGTACCTGGAGGGGACACTGGACGAGATCGACATAATCAGCCTTAGACAGATCAAGGAGGTGTTCAACCAGTTCCGGGTGG
TTCTGAGCCAACAGGAACAGGAAGTGGAGTCCACTTTGCGCAGGAAGTACACCCTCATTGACAGGAATGACTTTGCAGCCATTTCTGCTA
TCCAGAAGGCGGGGCTTGTGGATGTTGATGGCCACCTAGTGGGTGAGCCTGAAGGACAAAACTTTGGACTCGGAGTCGCCCCTTTCTCTA
CCAAACCTGGGAAGAAAGCCAAGTCCAAGAAGACATTCAAAGAGCCACTCAGGCCCGACACCCCACCCTCCAAACCAGTGGCCTTTGAGG
AGTTTAAGAATGAGCAAGGTAGTGAGATCAACCGAATTTTCAAAGAAAACAAATCCATCTTGAATGAACGGAGGAAAAGGGCCAGCGAGA
CCACACAGCACATCAATGCCATCAAGCGGGAGATTGATGTGACCAAGGAGGCCCTGAATTTCCAGAAGTCACTACGGGAGAAGCAAGGCA
AGTACGAAAACAAGGGGCTGATGATCATCGATGAGGAAGAATTCCTGCTGATCCTCAAGCTCAAAGACCTCAAGAAGCAGTACCGCAGCG
AGTACCAGGACCTGCGTGACCTCAGGGCTGAGATCCAGTATTGCCAGCACCTAGTGGATCAGTGTCGCCACCGCCTGCTCATGGAATTTG
ACATCTGGTACAATGAGTCCTTTGTCATCCCTGAGGACATGCAGATGGCACTGAAGCCAGGCGGCAGCATCCGGCCAGGCATGGTCCCTG
TGAACAGGATTGTGTCTCTGGGAGAAGATGACCAGGACAAATTCAGCCAGCTGCAGCAGAGGGTGCTTCCTGAGGGCCCTGATTCCATCT

>In-frame_SETD2_ENST00000409792_chr3_47205344_-_KIF9_ENST00000452770_chr3_47316980_-_2351nt
ATGAAGCAGCTGCAGCCGCAGCCGCCTCCGAAGATGGGGGATTTCTACGACCCGGAGCACCCGACCCCTGAAGCATTGATATTCACTTAA
AAAAAGACATTCGGAGAGGAGTTGTCAATAACCAACAGACAGACTGGTCGTTTAAGTTGGATGGAGTTCTTCACGATGCCTCCCAGGACT
TGGTTTATGAGACAGTTGCAAAGGATGTGGTTTCTCAGGCCCTCGATGGCTATAATGGCACCATCATGTGTTATGGGCAGACGGGAGCTG
GCAAGACATACACCATGATGGGGGCAACTGAGAATTACAAGCACCGGGGGATCCTCCCTCGTGCCCTGCAGCAGGTTTTTAGGATGATCG
AAGAACGCCCCACACATGCCATCACTGTGCGTGTTTCCTACTTGGAAATCTATAATGAGAGCCTGTTTGATCTCCTGTCCACTCTGCCCT
ATGTTGGACCCTCAGTCACACCAATGACCATCGTGGAAAACCCTCAAGGAGTCTTCATTAAGGGCTTGTCAGTTCACCTCACAAGTCAGG
AGGAGGATGCATTCAGCCTCCTTTTTGAGGGTGAGACCAACAGGATTATAGCCTCCCACACTATGAACAAAAACTCTTCCAGATCACACT
GCATTTTCACCATCTACTTAGAGGCCCATTCCCGGACCTTATCAGAGGAAAAGTACATCACTTCCAAAATTAACTTGGTGGATCTGGCAG
GCTCAGAGAGGCTGGGGAAGTCTGGGTCTGAGGGCCAAGTCCTGAAGGAAGCCACCTACATCAACAAATCGCTCTCATTCCTGGAGCAGG
CCATCATTGCCCTTGGGGACCAGAAGCGGGACCACATCCCCTTTCGGCAGTGCAAGCTCACCCACGCTCTGAAGGACTCGTTAGGGGGAA
ACTGCAATATGGTCCTCGTGACAAACATCTATGGAGAAGCTGCCCAGTTAGAAGAAACGCTATCTTCACTGAGATTTGCCAGCAGGATGA
AGCTAGTCACCACTGAGCCTGCCATCAATGAAAAGTATGATGCTGAGAGAATGGTCAAGAACCTGGAGAAGGAACTAGCACTACTCAAGC
AGGAGCTGGCTATCCATGACAGCCTGACCAACCGCACCTTTGTGACCTATGACCCCATGGATGAAATCCAGATTGCTGAGATCAACTCCC
AGGTGCGGAGGTACCTGGAGGGGACACTGGACGAGATCGACATAATCAGCCTTAGACAGATCAAGGAGGTGTTCAACCAGTTCCGGGTGG
TTCTGAGCCAACAGGAACAGGAAGTGGAGTCCACTTTGCGCAGGAAGTACACCCTCATTGACAGGAATGACTTTGCAGCCATTTCTGCTA
TCCAGAAGGCGGGGCTTGTGGATGTTGATGGCCACCTAGTGGGTGAGCCTGAAGGACAAAACTTTGGACTCGGAGTCGCCCCTTTCTCTA
CCAAACCTGGGAAGAAAGCCAAGTCCAAGAAGACATTCAAAGAGCCACTCAGCTCCTTGGCAAGAAAGGAAGGTGCCAGCAGCCCTGTGA
ATGGGAAGGACTTGGATTACGTTTCCACCTCCAAGACCCAGCTGGTCCCATCCTCCAAAGATGGGGATGTCAAAGACATGCTTTCGCGGG
ACCGGGAAACTTCCAGCATTGAGCCCCTTCCCTCAGACTCCCCGAAGGAGGAATTACGCCCAATTAGGCCCGACACCCCACCCTCCAAAC
CAGTGGCCTTTGAGGAGTTTAAGAATGAGCAAGGTAGTGAGATCAACCGAATTTTCAAAGAAAACAAATCCATCTTGAATGAACGGAGGA
AAAGGGCCAGCGAGACCACACAGCACATCAATGCCATCAAGCGGGAGATTGATGTGACCAAGGAGGCCCTGAATTTCCAGAAGTCACTAC
GGGAGAAGCAAGGCAAGTACGAAAACAAGGGGCTGATGATCATCGATGAGGAAGAATTCCTGCTGATCCTCAAGCTCAAAGACCTCAAGA
AGCAGTACCGCAGCGAGTACCAGGACCTGCGTGACCTCAGGGCTGAGATCCAGTATTGCCAGCACCTAGTGGATCAGTGTCGCCACCGCC
TGCTCATGGAATTTGACATCTGGTACAATGAGTCCTTTGTCATCCCTGAGGACATGCAGATGGCACTGAAGCCAGGCGGCAGCATCCGGC
CAGGCATGGTCCCTGTGAACAGGATTGTGTCTCTGGGAGAAGATGACCAGGACAAATTCAGCCAGCTGCAGCAGAGGGTGCTTCCTGAGG
GCCCTGATTCCATCTCCTTCTACAATGCCAAAGTCAAGATAGAGCAGAAGCATAATTACTTGAAAACCATGATGGGCCTCCAGCAGGCAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_SETD2_ENST00000409792_chr3_47205344_-_KIF9_ENST00000335044_chr3_47316980_-_3020nt
GCTGCGGGGAGGGGGCTCGCGTCGCCGTCTCCAGCCGCTCCCGATGAAGCAGCTGCAGCCGCAGCCGCCTCCGAAGATGGGGGATTTCTA
CGACCCGGAGCACCCGACCCCTGAAGCATTGATATTCACTTAAAAAAAGACATTCGGAGAGGAGTTGTCAATAACCAACAGACAGACTGG
TCGTTTAAGTTGGATGGAGTTCTTCACGATGCCTCCCAGGACTTGGTTTATGAGACAGTTGCAAAGGATGTGGTTTCTCAGGCCCTCGAT
GGCTATAATGGCACCATCATGTGTTATGGGCAGACGGGAGCTGGCAAGACATACACCATGATGGGGGCAACTGAGAATTACAAGCACCGG
GGGATCCTCCCTCGTGCCCTGCAGCAGGTTTTTAGGATGATCGAAGAACGCCCCACACATGCCATCACTGTGCGTGTTTCCTACTTGGAA
ATCTATAATGAGAGCCTGTTTGATCTCCTGTCCACTCTGCCCTATGTTGGACCCTCAGTCACACCAATGACCATCGTGGAAAACCCTCAA
GGAGTCTTCATTAAGGGCTTGTCAGTTCACCTCACAAGTCAGGAGGAGGATGCATTCAGCCTCCTTTTTGAGGGTGAGACCAACAGGATT
ATAGCCTCCCACACTATGAACAAAAACTCTTCCAGATCACACTGCATTTTCACCATCTACTTAGAGGCCCATTCCCGGACCTTATCAGAG
GAAAAGTACATCACTTCCAAAATTAACTTGGTGGATCTGGCAGGCTCAGAGAGGCTGGGGAAGTCTGGGTCTGAGGGCCAAGTCCTGAAG
GAAGCCACCTACATCAACAAATCGCTCTCATTCCTGGAGCAGGCCATCATTGCCCTTGGGGACCAGAAGCGGGACCACATCCCCTTTCGG
CAGTGCAAGCTCACCCACGCTCTGAAGGACTCGTTAGGGGGAAACTGCAATATGGTCCTCGTGACAAACATCTATGGAGAAGCTGCCCAG
TTAGAAGAAACGCTATCTTCACTGAGATTTGCCAGCAGGATGAAGCTAGTCACCACTGAGCCTGCCATCAATGAAAAGTATGATGCTGAG
AGAATGGTCAAGAACCTGGAGAAGGAACTAGCACTACTCAAGCAGGAGCTGGCTATCCATGACAGCCTGACCAACCGCACCTTTGTGACC
TATGACCCCATGGATGAAATCCAGATTGCTGAGATCAACTCCCAGGTGCGGAGGTACCTGGAGGGGACACTGGACGAGATCGACATAATC
AGCCTTAGACAGATCAAGGAGGTGTTCAACCAGTTCCGGGTGGTTCTGAGCCAACAGGAACAGGAAGTGGAGTCCACTTTGCGCAGGAAG
TACACCCTCATTGACAGGAATGACTTTGCAGCCATTTCTGCTATCCAGAAGGCGGGGCTTGTGGATGTTGATGGCCACCTAGTGGGTGAG
CCTGAAGGACAAAACTTTGGACTCGGAGTCGCCCCTTTCTCTACCAAACCTGGGAAGAAAGCCAAGTCCAAGAAGACATTCAAAGAGCCA
CTCAGCTCCTTGGCAAGAAAGGAAGGTGCCAGCAGCCCTGTGAATGGGAAGGACTTGGATTACGTTTCCACCTCCAAGACCCAGCTGGTC
CCATCCTCCAAAGATGGGGATGTCAAAGACATGCTTTCGCGGGACCGGGAAACTTCCAGCATTGAGCCCCTTCCCTCAGACTCCCCGAAG
GAGGAATTACGCCCAATTAGGCCCGACACCCCACCCTCCAAACCAGTGGCCTTTGAGGAGTTTAAGAATGAGCAAGGTAGTGAGATCAAC
CGAATTTTCAAAGAAAACAAATCCATCTTGAATGAACGGAGGAAAAGGGCCAGCGAGACCACACAGCACATCAATGCCATCAAGCGGGAG
ATTGATGTGACCAAGGAGGCCCTGAATTTCCAGAAGTCACTACGGGAGAAGCAAGGCAAGTACGAAAACAAGGGGCTGATGATCATCGAT
GAGGAAGAATTCCTGCTGATCCTCAAGCTCAAAGACCTCAAGAAGCAGTACCGCAGCGAGTACCAGGACCTGCGTGACCTCAGGGCTGAG
ATCCAGTATTGCCAGCACCTAGTGGATCAGTGTCGCCACCGCCTGCTCATGGAATTTGACATCTGGTACAATGAGTCCTTTGTCATCCCT
GAGGACATGCAGATGGCACTGAAGCCAGGCGGCAGCATCCGGCCAGGCATGGTCCCTGTGAACAGGATTGTGTCTCTGGGAGAAGATGAC
CAGGACAAATTCAGCCAGCTGCAGCAGAGGGTGCTTCCTGAGGGCCCTGATTCCATCTCCTTCTACAATGCCAAAGTCAAGATAGAGCAG
AAGCATAATTACTTGAAAACCATGATGGGCCTCCAGCAGGCACATAGAAAATAGAACCTCATCGCCAGTACCTTAAAGGACAAGACCAGC
AACTCCCACCTACTGTAGTGGAGCTGCTCAACCACCTGCCCAGAGCTGCAGCCCCCTCTACTCCAATGCTGGGACCCAGCACAGAGAACA
CATTTGGCCTGCATGTTGGGAGGAGCATCCTCCAAGGACAACCTTGCTCATCTCCACAGAGCACTTTGGGTTTTAATTCACTGTCTTATA
TGCAGGGACAGGATAAAATAACTTTCTAGTTTGGACTTTCAGTGCTCATCTGAGAACTTTGTCTTATTTCCTGTCTGAAAGGACATATTC
TCTATGTATGTGTGAGGTCAGAACTGAGTCTCAAGTAGGAAGGCAGAAAAGTAGCTCAGCCAGGCTCCTCCTGGCAGGCCTTTGTCACAC
TGGTCAGCCCCTTTCCTGGATAGACATCCTAGGGTGGGGGTGGTGAGCTCGGTCTGAGGAGCTCTGCTTCTCACAGCTCCCTCAGACCCT
AAGTTCTCTCAAGACATCTTTTCTGTGTTTCTGAGCCAGTGAAGAAGACAGGAGGAGGCCCTCCTTCATTTGGCAACCAGGGGAGGATAA

>In-frame_SETD2_ENST00000409792_chr3_47205344_-_KIF9_ENST00000265529_chr3_47316980_-_2651nt
GCTGCGGGGAGGGGGCTCGCGTCGCCGTCTCCAGCCGCTCCCGATGAAGCAGCTGCAGCCGCAGCCGCCTCCGAAGATGGGGGATTTCTA
CGACCCGGAGCACCCGACCCCTGAAGCATTGATATTCACTTAAAAAAAGACATTCGGAGAGGAGTTGTCAATAACCAACAGACAGACTGG
TCGTTTAAGTTGGATGGAGTTCTTCACGATGCCTCCCAGGACTTGGTTTATGAGACAGTTGCAAAGGATGTGGTTTCTCAGGCCCTCGAT
GGCTATAATGGCACCATCATGTGTTATGGGCAGACGGGAGCTGGCAAGACATACACCATGATGGGGGCAACTGAGAATTACAAGCACCGG
GGGATCCTCCCTCGTGCCCTGCAGCAGGTTTTTAGGATGATCGAAGAACGCCCCACACATGCCATCACTGTGCGTGTTTCCTACTTGGAA
ATCTATAATGAGAGCCTGTTTGATCTCCTGTCCACTCTGCCCTATGTTGGACCCTCAGTCACACCAATGACCATCGTGGAAAACCCTCAA
GGAGTCTTCATTAAGGGCTTGTCAGTTCACCTCACAAGTCAGGAGGAGGATGCATTCAGCCTCCTTTTTGAGGGTGAGACCAACAGGATT
ATAGCCTCCCACACTATGAACAAAAACTCTTCCAGATCACACTGCATTTTCACCATCTACTTAGAGGCCCATTCCCGGACCTTATCAGAG
GAAAAGTACATCACTTCCAAAATTAACTTGGTGGATCTGGCAGGCTCAGAGAGGCTGGGGAAGTCTGGGTCTGAGGGCCAAGTCCTGAAG
GAAGCCACCTACATCAACAAATCGCTCTCATTCCTGGAGCAGGCCATCATTGCCCTTGGGGACCAGAAGCGGGACCACATCCCCTTTCGG
CAGTGCAAGCTCACCCACGCTCTGAAGGACTCGTTAGGGGGAAACTGCAATATGGTCCTCGTGACAAACATCTATGGAGAAGCTGCCCAG
TTAGAAGAAACGCTATCTTCACTGAGATTTGCCAGCAGGATGAAGCTAGTCACCACTGAGCCTGCCATCAATGAAAAGTATGATGCTGAG
AGAATGGTCAAGAACCTGGAGAAGGAACTAGCACTACTCAAGCAGGAGCTGGCTATCCATGACAGCCTGACCAACCGCACCTTTGTGACC
TATGACCCCATGGATGAAATCCAGATTGCTGAGATCAACTCCCAGGTGCGGAGGTACCTGGAGGGGACACTGGACGAGATCGACATAATC
AGCCTTAGACAGATCAAGGAGGTGTTCAACCAGTTCCGGGTGGTTCTGAGCCAACAGGAACAGGAAGTGGAGTCCACTTTGCGCAGGAAG
TACACCCTCATTGACAGGAATGACTTTGCAGCCATTTCTGCTATCCAGAAGGCGGGGCTTGTGGATGTTGATGGCCACCTAGTGGGTGAG
CCTGAAGGACAAAACTTTGGACTCGGAGTCGCCCCTTTCTCTACCAAACCTGGGAAGAAAGCCAAGTCCAAGAAGACATTCAAAGAGCCA
CTCAGCTCCTTGGCAAGAAAGGAAGGTGCCAGCAGCCCTGTGAATGGGAAGGACTTGGATTACGTTTCCACCTCCAAGACCCAGCTGGTC
CCATCCTCCAAAGATGGGGATGTCAAAGACATGCTTTCGCGGGACCGGGAAACTTCCAGCATTGAGCCCCTTCCCTCAGACTCCCCGAAG
GAGGAATTACGCCCAATTAGGCCCGACACCCCACCCTCCAAACCAGTGGCCTTTGAGGAGTTTAAGAATGAGCAAGGTAGTGAGATCAAC
CGAATTTTCAAAGAAAACAAATCCATCTTGAATGAACGGAGGAAAAGGGCCAGCGAGACCACACAGCACATCAATGCCATCAAGCGGGAG
ATTGATGTGACCAAGGAGGCCCTGAATTTCCAGAAGTCACTACGGGAGAAGCAAGGCAAGTACGAAAACAAGGGGCTGATGATCATCGAT
GAGGAAGAATTCCTGCTGATCCTCAAGCTCAAAGACCTCAAGAAGCAGTACCGCAGCGAGTACCAGGACCTGCGTGACCTCAGGGCTGAG
ATCCAGTATTGCCAGCACCTAGTGGATCAGTGTCGCCACCGCCTGCTCATGGAATTTGACATCTGGTACAATGAGTCCTTTGTCATCCCT
GAGGACATGCAGATGGCACTGAAGCCAGGCGGCAGCATCCGGCCAGGCATGGTCCCTGTGAACAGGATTGTGTCTCTGGGAGAAGATGAC
CAGGACAAATTCAGCCAGCTGCAGCAGAGGGTGCTTCCTGAGGGCCCTGATTCCATCTCCTTCTACAATGCCAAAGTCAAGATAGAGCAG
AAGCATAATTACTTGAAAACCATGATGGGCCTCCAGCAGGCACATAGAAAATAGAACCTCATCGCCAGTACCTTAAAGGACAAGACCAGC
AACTCCCACCTACTGTAGTGGAGCTGCTCAACCACCTGCCCAGAGCTGCAGCCCCCTCTACTCCAATGCTGGGACCCAGCACAGAGAACA
CATTTGGCCTGCATGTTGGGAGGAGCATCCTCCAAGGACAACCTTGCTCATCTCCACAGAGCACTTTGGGTTTTAATTCACTGTCTTATA

>In-frame_SETD2_ENST00000409792_chr3_47205344_-_KIF9_ENST00000444589_chr3_47316980_-_2454nt
GCTGCGGGGAGGGGGCTCGCGTCGCCGTCTCCAGCCGCTCCCGATGAAGCAGCTGCAGCCGCAGCCGCCTCCGAAGATGGGGGATTTCTA
CGACCCGGAGCACCCGACCCCTGAAGCATTGATATTCACTTAAAAAAAGACATTCGGAGAGGAGTTGTCAATAACCAACAGACAGACTGG
TCGTTTAAGTTGGATGGAGTTCTTCACGATGCCTCCCAGGACTTGGTTTATGAGACAGTTGCAAAGGATGTGGTTTCTCAGGCCCTCGAT
GGCTATAATGGCACCATCATGTGTTATGGGCAGACGGGAGCTGGCAAGACATACACCATGATGGGGGCAACTGAGAATTACAAGCACCGG
GGGATCCTCCCTCGTGCCCTGCAGCAGGTTTTTAGGATGATCGAAGAACGCCCCACACATGCCATCACTGTGCGTGTTTCCTACTTGGAA
ATCTATAATGAGAGCCTGTTTGATCTCCTGTCCACTCTGCCCTATGTTGGACCCTCAGTCACACCAATGACCATCGTGGAAAACCCTCAA
GGAGTCTTCATTAAGGGCTTGTCAGTTCACCTCACAAGTCAGGAGGAGGATGCATTCAGCCTCCTTTTTGAGGGTGAGACCAACAGGATT
ATAGCCTCCCACACTATGAACAAAAACTCTTCCAGATCACACTGCATTTTCACCATCTACTTAGAGGCCCATTCCCGGACCTTATCAGAG
GAAAAGTACATCACTTCCAAAATTAACTTGGTGGATCTGGCAGGCTCAGAGAGGCTGGGGAAGTCTGGGTCTGAGGGCCAAGTCCTGAAG
GAAGCCACCTACATCAACAAATCGCTCTCATTCCTGGAGCAGGCCATCATTGCCCTTGGGGACCAGAAGCGGGACCACATCCCCTTTCGG
CAGTGCAAGCTCACCCACGCTCTGAAGGACTCGTTAGGGGGAAACTGCAATATGGTCCTCGTGACAAACATCTATGGAGAAGCTGCCCAG
TTAGAAGAAACGCTATCTTCACTGAGATTTGCCAGCAGGATGAAGCTAGTCACCACTGAGCCTGCCATCAATGAAAAGTATGATGCTGAG
AGAATGGTCAAGAACCTGGAGAAGGAACTAGCACTACTCAAGCAGGAGCTGGCTATCCATGACAGCCTGACCAACCGCACCTTTGTGACC
TATGACCCCATGGATGAAATCCAGATTGCTGAGATCAACTCCCAGGTGCGGAGGTACCTGGAGGGGACACTGGACGAGATCGACATAATC
AGCCTTAGACAGATCAAGGAGGTGTTCAACCAGTTCCGGGTGGTTCTGAGCCAACAGGAACAGGAAGTGGAGTCCACTTTGCGCAGGAAG
TACACCCTCATTGACAGGAATGACTTTGCAGCCATTTCTGCTATCCAGAAGGCGGGGCTTGTGGATGTTGATGGCCACCTAGTGGGTGAG
CCTGAAGGACAAAACTTTGGACTCGGAGTCGCCCCTTTCTCTACCAAACCTGGGAAGAAAGCCAAGTCCAAGAAGACATTCAAAGAGCCA
CTCAGGCCCGACACCCCACCCTCCAAACCAGTGGCCTTTGAGGAGTTTAAGAATGAGCAAGGTAGTGAGATCAACCGAATTTTCAAAGAA
AACAAATCCATCTTGAATGAACGGAGGAAAAGGGCCAGCGAGACCACACAGCACATCAATGCCATCAAGCGGGAGATTGATGTGACCAAG
GAGGCCCTGAATTTCCAGAAGTCACTACGGGAGAAGCAAGGCAAGTACGAAAACAAGGGGCTGATGATCATCGATGAGGAAGAATTCCTG
CTGATCCTCAAGCTCAAAGACCTCAAGAAGCAGTACCGCAGCGAGTACCAGGACCTGCGTGACCTCAGGGCTGAGATCCAGTATTGCCAG
CACCTAGTGGATCAGTGTCGCCACCGCCTGCTCATGGAATTTGACATCTGGTACAATGAGTCCTTTGTCATCCCTGAGGACATGCAGATG
GCACTGAAGCCAGGCGGCAGCATCCGGCCAGGCATGGTCCCTGTGAACAGGATTGTGTCTCTGGGAGAAGATGACCAGGACAAATTCAGC
CAGCTGCAGCAGAGGGTGCTTCCTGAGGGCCCTGATTCCATCTCCTTCTACAATGCCAAAGTCAAGATAGAGCAGAAGCATAATTACTTG
AAAACCATGATGGGCCTCCAGCAGGCACATAGAAAATAGAACCTCATCGCCAGTACCTTAAAGGACAAGACCAGCAACTCCCACCTACTG
TAGTGGAGCTGCTCAACCACCTGCCCAGAGCTGCAGCCCCCTCTACTCCAATGCTGGGACCCAGCACAGAGAACACATTTGGCCTGCATG
TTGGGAGGAGCATCCTCCAAGGACAACCTTGCTCATCTCCACAGAGCACTTTGGGTTTTAATTCACTGTCTTATATGCAGGGACAGGATA

>In-frame_SETD2_ENST00000409792_chr3_47205344_-_KIF9_ENST00000452770_chr3_47316980_-_2394nt
GCTGCGGGGAGGGGGCTCGCGTCGCCGTCTCCAGCCGCTCCCGATGAAGCAGCTGCAGCCGCAGCCGCCTCCGAAGATGGGGGATTTCTA
CGACCCGGAGCACCCGACCCCTGAAGCATTGATATTCACTTAAAAAAAGACATTCGGAGAGGAGTTGTCAATAACCAACAGACAGACTGG
TCGTTTAAGTTGGATGGAGTTCTTCACGATGCCTCCCAGGACTTGGTTTATGAGACAGTTGCAAAGGATGTGGTTTCTCAGGCCCTCGAT
GGCTATAATGGCACCATCATGTGTTATGGGCAGACGGGAGCTGGCAAGACATACACCATGATGGGGGCAACTGAGAATTACAAGCACCGG
GGGATCCTCCCTCGTGCCCTGCAGCAGGTTTTTAGGATGATCGAAGAACGCCCCACACATGCCATCACTGTGCGTGTTTCCTACTTGGAA
ATCTATAATGAGAGCCTGTTTGATCTCCTGTCCACTCTGCCCTATGTTGGACCCTCAGTCACACCAATGACCATCGTGGAAAACCCTCAA
GGAGTCTTCATTAAGGGCTTGTCAGTTCACCTCACAAGTCAGGAGGAGGATGCATTCAGCCTCCTTTTTGAGGGTGAGACCAACAGGATT
ATAGCCTCCCACACTATGAACAAAAACTCTTCCAGATCACACTGCATTTTCACCATCTACTTAGAGGCCCATTCCCGGACCTTATCAGAG
GAAAAGTACATCACTTCCAAAATTAACTTGGTGGATCTGGCAGGCTCAGAGAGGCTGGGGAAGTCTGGGTCTGAGGGCCAAGTCCTGAAG
GAAGCCACCTACATCAACAAATCGCTCTCATTCCTGGAGCAGGCCATCATTGCCCTTGGGGACCAGAAGCGGGACCACATCCCCTTTCGG
CAGTGCAAGCTCACCCACGCTCTGAAGGACTCGTTAGGGGGAAACTGCAATATGGTCCTCGTGACAAACATCTATGGAGAAGCTGCCCAG
TTAGAAGAAACGCTATCTTCACTGAGATTTGCCAGCAGGATGAAGCTAGTCACCACTGAGCCTGCCATCAATGAAAAGTATGATGCTGAG
AGAATGGTCAAGAACCTGGAGAAGGAACTAGCACTACTCAAGCAGGAGCTGGCTATCCATGACAGCCTGACCAACCGCACCTTTGTGACC
TATGACCCCATGGATGAAATCCAGATTGCTGAGATCAACTCCCAGGTGCGGAGGTACCTGGAGGGGACACTGGACGAGATCGACATAATC
AGCCTTAGACAGATCAAGGAGGTGTTCAACCAGTTCCGGGTGGTTCTGAGCCAACAGGAACAGGAAGTGGAGTCCACTTTGCGCAGGAAG
TACACCCTCATTGACAGGAATGACTTTGCAGCCATTTCTGCTATCCAGAAGGCGGGGCTTGTGGATGTTGATGGCCACCTAGTGGGTGAG
CCTGAAGGACAAAACTTTGGACTCGGAGTCGCCCCTTTCTCTACCAAACCTGGGAAGAAAGCCAAGTCCAAGAAGACATTCAAAGAGCCA
CTCAGCTCCTTGGCAAGAAAGGAAGGTGCCAGCAGCCCTGTGAATGGGAAGGACTTGGATTACGTTTCCACCTCCAAGACCCAGCTGGTC
CCATCCTCCAAAGATGGGGATGTCAAAGACATGCTTTCGCGGGACCGGGAAACTTCCAGCATTGAGCCCCTTCCCTCAGACTCCCCGAAG
GAGGAATTACGCCCAATTAGGCCCGACACCCCACCCTCCAAACCAGTGGCCTTTGAGGAGTTTAAGAATGAGCAAGGTAGTGAGATCAAC
CGAATTTTCAAAGAAAACAAATCCATCTTGAATGAACGGAGGAAAAGGGCCAGCGAGACCACACAGCACATCAATGCCATCAAGCGGGAG
ATTGATGTGACCAAGGAGGCCCTGAATTTCCAGAAGTCACTACGGGAGAAGCAAGGCAAGTACGAAAACAAGGGGCTGATGATCATCGAT
GAGGAAGAATTCCTGCTGATCCTCAAGCTCAAAGACCTCAAGAAGCAGTACCGCAGCGAGTACCAGGACCTGCGTGACCTCAGGGCTGAG
ATCCAGTATTGCCAGCACCTAGTGGATCAGTGTCGCCACCGCCTGCTCATGGAATTTGACATCTGGTACAATGAGTCCTTTGTCATCCCT
GAGGACATGCAGATGGCACTGAAGCCAGGCGGCAGCATCCGGCCAGGCATGGTCCCTGTGAACAGGATTGTGTCTCTGGGAGAAGATGAC
CAGGACAAATTCAGCCAGCTGCAGCAGAGGGTGCTTCCTGAGGGCCCTGATTCCATCTCCTTCTACAATGCCAAAGTCAAGATAGAGCAG


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FusionGenePPI for SETD2_KIF9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SETD2HTT, IWS1, TP53, HIST1H3A, SETD2, POLR2A, ELAVL1, ATXN1, CIC, CBX8, SOX2, SMAD3, SIAH2, CLK2, HIST3H3, WDR37, ARHGEF10, LUC7L, SCARA3, AURKA, EIF3I, XPO1, RASSF8, GAN, ATM, HNRNPLL, NXF2, HSPB8, RSBN1, F9, CPNE7, PIP4K2A, TRPC4AP, JMJD6, TRIM25KIF9PRMT6, TRIM37, TRIM27, JAKMIP2, IKZF1, ROPN1, CARD9, EFHC2, LZTS2, SSX2IP, KRTAP10-9, KRTAP10-3, ZBTB8A, FAM188A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSETD2chr3:47205344chr3:47289576ENST00000409792-1212457_2564232565POLR2A
HgeneSETD2chr3:47205344chr3:47316980ENST00000409792-1212457_2564232565POLR2A
HgeneSETD2chr3:47205344chr3:47289576ENST00000409792-1211418_1714232565TUBA1A
HgeneSETD2chr3:47205344chr3:47316980ENST00000409792-1211418_1714232565TUBA1A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SETD2_KIF9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SETD2_KIF9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSETD2C0007134Renal Cell Carcinoma2CTD_human
HgeneSETD2C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneSETD2C0010701Phyllodes Tumor1CTD_human
HgeneSETD2C0023418leukemia1CTD_human
HgeneSETD2C0345967Malignant mesothelioma1CTD_human
HgeneSETD2C0920269Microsatellite Instability1CTD_human
HgeneSETD2C1458155Mammary Neoplasms1CTD_human