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Fusion gene ID: 33355 |
FusionGeneSummary for SETBP1_NFYC |
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Fusion gene information | Fusion gene name: SETBP1_NFYC | Fusion gene ID: 33355 | Hgene | Tgene | Gene symbol | SETBP1 | NFYC | Gene ID | 26040 | 4802 |
Gene name | SET binding protein 1 | nuclear transcription factor Y subunit gamma | |
Synonyms | MRD29|SEB | CBF-C|CBFC|H1TF2A|HAP5|HSM|NF-YC | |
Cytomap | 18q12.3 | 1p34.2 | |
Type of gene | protein-coding | protein-coding | |
Description | SET-binding protein | nuclear transcription factor Y subunit gammaCAAT box DNA-binding protein subunit CCCAAT binding factor subunit CCCAAT transcription binding factor subunit gammahistone H1 transcription factor large subunit 2Anuclear transcription factor Y subunit Cn | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9Y6X0 | Q13952 | |
Ensembl transtripts involved in fusion gene | ENST00000426838, ENST00000282030, | ENST00000427410, ENST00000447388, ENST00000425457, ENST00000456393, ENST00000372654, ENST00000372653, ENST00000372652, ENST00000372651, ENST00000440226, ENST00000308733, ENST00000483091, | |
Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 8 X 5 X 6=240 |
# samples | 4 | 9 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/240*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SETBP1 [Title/Abstract] AND NFYC [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | NFYC | GO:0006355 | regulation of transcription, DNA-templated | 15243141 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-FD-A43Y-01A | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000426838 | ENST00000427410 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000426838 | ENST00000447388 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000426838 | ENST00000425457 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000426838 | ENST00000456393 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000426838 | ENST00000372654 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000426838 | ENST00000372653 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000426838 | ENST00000372652 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000426838 | ENST00000372651 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000426838 | ENST00000440226 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000426838 | ENST00000308733 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-intron | ENST00000426838 | ENST00000483091 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000282030 | ENST00000427410 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000282030 | ENST00000447388 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000282030 | ENST00000425457 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000282030 | ENST00000456393 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000282030 | ENST00000372654 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000282030 | ENST00000372653 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000282030 | ENST00000372652 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000282030 | ENST00000372651 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000282030 | ENST00000440226 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-5UTR | ENST00000282030 | ENST00000308733 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
5CDS-intron | ENST00000282030 | ENST00000483091 | SETBP1 | chr18 | 42449248 | + | NFYC | chr1 | 41204508 | + |
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FusionProtFeatures for SETBP1_NFYC |
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Hgene | Tgene |
SETBP1 | NFYC |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SETBP1_NFYC |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SETBP1_NFYC |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SETBP1 | SET, APP, PPP2CA, UBE2I, XAGE1E, YAF2, SETBP1, SPANXA1, KIAA1147, SPANXD, SPANXC, PLEKHF2, LRRC37A11P, SUMO1P1 | NFYC | MYC, SMAD3, SMAD2, TBP, ATF6, ATF6B, TP73, DST, CSN2, DR1, NFYA, NFYB, SP1, SREBF2, LMO4, ADNP2, POGZ, CIC, ZDHHC17, GLTSCR1L, GLTSCR1, ARID2, KIAA2018, TRIM27, TBPL2, HDAC1, TAF12, TAF11, TAF6, KAT2B, GAPDH, ELAVL1, CDK2, SNX2, FCGR2A, CORO1B, CORO1C, FOXJ2, FOXK2, NFATC2, PON1, ENDOG, PON3, NFKB1, COMMD1, PRR20E |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SETBP1_NFYC |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SETBP1_NFYC |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SETBP1 | C0265227 | Schinzel-Giedion syndrome | 6 | CTD_human;ORPHANET;UNIPROT |
Hgene | SETBP1 | C3463824 | MYELODYSPLASTIC SYNDROME | 4 | UNIPROT |
Hgene | SETBP1 | C0023467 | Leukemia, Myelocytic, Acute | 2 | UNIPROT |
Hgene | SETBP1 | C0023473 | Myeloid Leukemia, Chronic | 2 | UNIPROT |
Hgene | SETBP1 | C0349639 | Juvenile Myelomonocytic Leukemia | 2 | CTD_human;UNIPROT |
Hgene | SETBP1 | C3714756 | Intellectual Disability | 2 | CTD_human;HPO |
Hgene | SETBP1 | C0023014 | Language Development Disorders | 1 | CTD_human |
Hgene | SETBP1 | C0023470 | Myeloid Leukemia | 1 | CTD_human |
Hgene | SETBP1 | C0043094 | Weight Gain | 1 | CTD_human |
Hgene | SETBP1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
Hgene | SETBP1 | C1292772 | Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative | 1 | CTD_human |
Hgene | SETBP1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |