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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 3335

FusionGeneSummary for ATP2A2_RRP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP2A2_RRP1
Fusion gene ID: 3335
HgeneTgene
Gene symbol

ATP2A2

RRP1

Gene ID

488

23076

Gene nameATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2ribosomal RNA processing 1B
SynonymsATP2B|DAR|DD|SERCA2KIAA0179|NNP1L|Nnp1|PPP1R136|RRP1
Cytomap

12q24.11

21q22.3

Type of geneprotein-codingprotein-coding
Descriptionsarcoplasmic/endoplasmic reticulum calcium ATPase 2ATPase Ca++ transporting cardiac muscle slow twitch 2ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2SR Ca(2+)-ATPase 2calcium pump 2calcium-transporting ATPase sarcoplasmic reticulum type, slowribosomal RNA processing protein 1 homolog BRRP1-like protein Bprotein phosphatase 1, regulatory subunit 136ribosomal RNA processing 1 homolog B
Modification date2018052320180523
UniProtAcc

P16615

P56182

Ensembl transtripts involved in fusion geneENST00000308664, ENST00000395494, 
ENST00000539276, ENST00000550248, 
ENST00000552636, 
ENST00000497547, 
ENST00000471909, 
Fusion gene scores* DoF score12 X 16 X 8=15365 X 3 X 5=75
# samples 185
** MAII scorelog2(18/1536*10)=-3.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP2A2 [Title/Abstract] AND RRP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP2A2

GO:0032469

endoplasmic reticulum calcium ion homeostasis

16402920

HgeneATP2A2

GO:0032470

positive regulation of endoplasmic reticulum calcium ion concentration

16402920

HgeneATP2A2

GO:0070588

calcium ion transmembrane transport

16402920

HgeneATP2A2

GO:1903515

calcium ion transport from cytosol to endoplasmic reticulum

16402920

TgeneRRP1

GO:0010923

negative regulation of phosphatase activity

19389623

TgeneRRP1

GO:0098586

cellular response to virus

26311876


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-B6-A0RH-01AATP2A2chr12

110781239

+RRP1chr21

45211231

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000308664ENST00000497547ATP2A2chr12

110781239

+RRP1chr21

45211231

+
5CDS-intronENST00000308664ENST00000471909ATP2A2chr12

110781239

+RRP1chr21

45211231

+
In-frameENST00000395494ENST00000497547ATP2A2chr12

110781239

+RRP1chr21

45211231

+
5CDS-intronENST00000395494ENST00000471909ATP2A2chr12

110781239

+RRP1chr21

45211231

+
In-frameENST00000539276ENST00000497547ATP2A2chr12

110781239

+RRP1chr21

45211231

+
5CDS-intronENST00000539276ENST00000471909ATP2A2chr12

110781239

+RRP1chr21

45211231

+
intron-3CDSENST00000550248ENST00000497547ATP2A2chr12

110781239

+RRP1chr21

45211231

+
intron-intronENST00000550248ENST00000471909ATP2A2chr12

110781239

+RRP1chr21

45211231

+
intron-3CDSENST00000552636ENST00000497547ATP2A2chr12

110781239

+RRP1chr21

45211231

+
intron-intronENST00000552636ENST00000471909ATP2A2chr12

110781239

+RRP1chr21

45211231

+

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FusionProtFeatures for ATP2A2_RRP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP2A2

P16615

RRP1

P56182

This magnesium-dependent enzyme catalyzes the hydrolysisof ATP coupled with the translocation of calcium from the cytosolto the sarcoplasmic reticulum lumen. Isoform 2 is involved in theregulation of the contraction/relaxation cycle (PubMed:16402920).Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathwaysvia its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generationnecessary for proper osteoclast generation. Association betweenTMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking foractivation of NFATC1 and production of mitochondrial ROS, therebytriggering Ca (2+) signaling cascades that promote osteoclastdifferentiation and activation (By similarity).{ECO:0000250|UniProtKB:O55143, ECO:0000269|PubMed:16402920}. Plays a critical role in the generation of 28S rRNA.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621111_253840998Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+16211_48840998Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621274_295840998Topological domainLumenal
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621314_756840998Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+162170_89840998Topological domainLumenal
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621777_786840998Topological domainLumenal
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621808_827840998Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519111_2538131016Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+15191_488131016Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519274_2958131016Topological domainLumenal
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519314_7568131016Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+151970_898131016Topological domainLumenal
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519777_7868131016Topological domainLumenal
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620111_2538401043Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+16201_488401043Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620274_2958401043Topological domainLumenal
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620314_7568401043Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+162070_898401043Topological domainLumenal
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620777_7868401043Topological domainLumenal
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620808_8278401043Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621254_273840998TransmembraneHelical%3B Name%3D3
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621296_313840998TransmembraneHelical%3B Name%3D4
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+162149_69840998TransmembraneHelical%3B Name%3D1
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621757_776840998TransmembraneHelical%3B Name%3D5
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+162190_110840998TransmembraneHelical%3B Name%3D2
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519254_2738131016TransmembraneHelical%3B Name%3D3
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519296_3138131016TransmembraneHelical%3B Name%3D4
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+151949_698131016TransmembraneHelical%3B Name%3D1
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519757_7768131016TransmembraneHelical%3B Name%3D5
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+151990_1108131016TransmembraneHelical%3B Name%3D2
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620254_2738401043TransmembraneHelical%3B Name%3D3
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620296_3138401043TransmembraneHelical%3B Name%3D4
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+162049_698401043TransmembraneHelical%3B Name%3D1
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620757_7768401043TransmembraneHelical%3B Name%3D5
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+162090_1108401043TransmembraneHelical%3B Name%3D2

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621851_896840998Topological domainLumenal
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621917_929840998Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621949_963840998Topological domainLumenal
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621985_1042840998Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519808_8278131016Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519851_8968131016Topological domainLumenal
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519917_9298131016Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519949_9638131016Topological domainLumenal
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519985_10428131016Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620851_8968401043Topological domainLumenal
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620917_9298401043Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620949_9638401043Topological domainLumenal
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620985_10428401043Topological domainCytoplasmic
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621828_850840998TransmembraneHelical%3B Name%3D7
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621897_916840998TransmembraneHelical%3B Name%3D8
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621930_948840998TransmembraneHelical%3B Name%3D9
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621964_984840998TransmembraneHelical%3B Name%3D10
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519828_8508131016TransmembraneHelical%3B Name%3D7
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519897_9168131016TransmembraneHelical%3B Name%3D8
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519930_9488131016TransmembraneHelical%3B Name%3D9
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519964_9848131016TransmembraneHelical%3B Name%3D10
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620828_8508401043TransmembraneHelical%3B Name%3D7
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620897_9168401043TransmembraneHelical%3B Name%3D8
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620930_9488401043TransmembraneHelical%3B Name%3D9
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620964_9848401043TransmembraneHelical%3B Name%3D10


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FusionGeneSequence for ATP2A2_RRP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ATP2A2_ENST00000308664_chr12_110781239_+_RRP1_ENST00000497547_chr21_45211231_+_1258aa
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVE
PFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSIL
TGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIA
VWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
KMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGV
KQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGT
AVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG
SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNP
PDLDIMNKPPRNPKEPLISGWLFFRYLAIGCGFTHDELLKVWKGLFYCMWMQDKPLLQEELGRTISQLVHAFQTTEAQHLFLQAFWQTMN
REWTGIDRLRLDKFYMLMRMVLNESLKVLKMQGWEERQIEELLELLMTEILHPSSQAPNGVKSHFIEIFLEELTKVGAEELTADQNLKFI
DPFCRIAARTKDSLVLNNITRGIFETIVEQAPLAIEDLLNELDTQDEEVASDSDESSEGGERGDALSQKRSEKPPAGSICRAEPEAGEEQ
AGDDRDSGGPVLQFDYEAVANRLFEMASRQSTPSQNRKRLYKVIRKLQDLAGGIFPEDEIPEKACRRLLEGRRQKKTKKQKRLLRLQQER

>In-frame_ATP2A2_ENST00000395494_chr12_110781239_+_RRP1_ENST00000497547_chr21_45211231_+_1231aa
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVE
PFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAGESVSVIKHTDPVPDPRAVNQDKKNM
LFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFK
IAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGS
TYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQ
LMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHD
NPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREF
DELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVE
EGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYL
AIGCGFTHDELLKVWKGLFYCMWMQDKPLLQEELGRTISQLVHAFQTTEAQHLFLQAFWQTMNREWTGIDRLRLDKFYMLMRMVLNESLK
VLKMQGWEERQIEELLELLMTEILHPSSQAPNGVKSHFIEIFLEELTKVGAEELTADQNLKFIDPFCRIAARTKDSLVLNNITRGIFETI
VEQAPLAIEDLLNELDTQDEEVASDSDESSEGGERGDALSQKRSEKPPAGSICRAEPEAGEEQAGDDRDSGGPVLQFDYEAVANRLFEMA
SRQSTPSQNRKRLYKVIRKLQDLAGGIFPEDEIPEKACRRLLEGRRQKKTKKQKRLLRLQQERGKGEKEPPSPGMERKRSRRRGVGADPE

>In-frame_ATP2A2_ENST00000539276_chr12_110781239_+_RRP1_ENST00000497547_chr21_45211231_+_1258aa
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVE
PFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSIL
TGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIA
VWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
KMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGV
KQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGT
AVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG
SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNP
PDLDIMNKPPRNPKEPLISGWLFFRYLAIGCGFTHDELLKVWKGLFYCMWMQDKPLLQEELGRTISQLVHAFQTTEAQHLFLQAFWQTMN
REWTGIDRLRLDKFYMLMRMVLNESLKVLKMQGWEERQIEELLELLMTEILHPSSQAPNGVKSHFIEIFLEELTKVGAEELTADQNLKFI
DPFCRIAARTKDSLVLNNITRGIFETIVEQAPLAIEDLLNELDTQDEEVASDSDESSEGGERGDALSQKRSEKPPAGSICRAEPEAGEEQ
AGDDRDSGGPVLQFDYEAVANRLFEMASRQSTPSQNRKRLYKVIRKLQDLAGGIFPEDEIPEKACRRLLEGRRQKKTKKQKRLLRLQQER


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ATP2A2_ENST00000308664_chr12_110781239_+_RRP1_ENST00000497547_chr21_45211231_+_3774nt
ATGGAGAACGCGCACACCAAGACGGTGGAGGAGGTGCTGGGCCACTTCGGCGTCAACGAGAGTACGGGGCTGAGCCTGGAACAGGTCAAG
AAGCTTAAGGAGAGATGGGGCTCCAACGAGTTACCGGCTGAAGAAGGAAAAACCTTGCTGGAACTTGTGATTGAGCAGTTTGAAGACTTG
CTAGTTAGGATTTTATTACTGGCAGCATGTATATCTTTTGTTTTGGCTTGGTTTGAAGAAGGTGAAGAAACAATTACAGCCTTTGTAGAA
CCTTTTGTAATTTTACTCATATTAGTAGCCAATGCAATTGTGGGTGTATGGCAGGAAAGAAATGCTGAAAATGCCATCGAAGCCCTTAAG
GAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGAGTGTGCAGCGGATTAAAGCTAAAGACATAGTTCCTGGTGATATT
GTAGAAATTGCTGTTGGTGACAAAGTTCCTGCTGATATAAGGTTAACTTCCATCAAATCTACCACACTAAGAGTTGACCAGTCAATTCTC
ACAGGTGAATCTGTCTCTGTCATCAAGCACACTGATCCCGTCCCTGACCCACGAGCTGTCAACCAAGATAAAAAGAACATGCTGTTTTCT
GGTACAAACATTGCTGCTGGGAAAGCTATGGGAGTGGTGGTAGCAACTGGAGTTAACACCGAAATTGGCAAGATCCGGGATGAAATGGTG
GCAACAGAACAGGAGAGAACACCCCTTCAGCAAAAACTAGATGAATTTGGGGAACAGCTTTCCAAAGTCATCTCCCTTATTTGCATTGCA
GTCTGGATCATAAATATTGGGCACTTCAATGACCCGGTTCATGGAGGGTCCTGGATCAGAGGTGCTATTTACTACTTTAAAATTGCAGTG
GCCCTGGCTGTAGCAGCCATTCCTGAAGGTCTGCCTGCAGTCATCACCACCTGCCTGGCTCTTGGAACTCGCAGAATGGCAAAGAAAAAT
GCCATTGTTCGAAGCCTCCCGTCTGTGGAAACCCTTGGTTGTACTTCTGTTATCTGCTCAGACAAGACTGGTACACTTACAACAAACCAG
ATGTCAGTCTGCAGGATGTTCATTCTGGACAGAGTGGAAGGTGATACTTGTTCCCTTAATGAGTTTACCATAACTGGATCAACTTATGCA
CCTATTGGAGAAGTGCATAAAGATGATAAACCAGTGAATTGTCACCAGTATGATGGTCTGGTAGAATTAGCAACAATTTGTGCTCTTTGT
AATGACTCTGCTTTGGATTACAATGAGGCAAAGGGTGTGTATGAAAAAGTTGGAGAAGCTACAGAGACTGCTCTCACTTGCCTAGTAGAG
AAGATGAATGTATTTGATACCGAATTGAAGGGTCTTTCTAAAATAGAACGTGCAAATGCCTGCAACTCAGTCATTAAACAGCTGATGAAA
AAGGAATTCACTCTAGAGTTTTCACGTGACAGAAAGTCAATGTCGGTTTACTGTACACCAAATAAACCAAGCAGGACATCAATGAGCAAG
ATGTTTGTGAAGGGTGCTCCTGAAGGTGTCATTGACAGGTGCACCCACATTCGAGTTGGAAGTACTAAGGTTCCTATGACCTCTGGAGTC
AAACAGAAGATCATGTCTGTCATTCGAGAGTGGGGTAGTGGCAGCGACACACTGCGATGCCTGGCCCTGGCCACTCATGACAACCCACTG
AGAAGAGAAGAAATGCACCTTGAGGACTCTGCCAACTTTATTAAATATGAGACCAATCTGACCTTCGTTGGCTGCGTGGGCATGCTGGAT
CCTCCGAGAATCGAGGTGGCCTCCTCCGTGAAGCTGTGCCGGCAAGCAGGCATCCGGGTCATCATGATCACTGGGGACAACAAGGGCACT
GCTGTGGCCATCTGTCGCCGCATCGGCATCTTCGGGCAGGATGAGGACGTGACGTCAAAAGCTTTCACAGGCCGGGAGTTTGATGAACTC
AACCCCTCCGCCCAGCGAGACGCCTGCCTGAACGCCCGCTGTTTTGCTCGAGTTGAACCCTCCCACAAGTCTAAAATCGTAGAATTTCTT
CAGTCTTTTGATGAGATTACAGCTATGACTGGCGATGGCGTGAACGATGCTCCTGCTCTGAAGAAAGCCGAGATTGGCATTGCTATGGGC
TCTGGCACTGCGGTGGCTAAAACCGCCTCTGAGATGGTCCTGGCGGATGACAACTTCTCCACCATTGTGGCTGCCGTTGAGGAGGGGCGG
GCAATCTACAACAACATGAAACAGTTCATCCGCTACCTCATCTCGTCCAACGTCGGGGAAGTTGTCTGTATTTTCCTGACAGCAGCCCTT
GGATTTCCCGAGGCTTTGATTCCTGTTCAGCTGCTCTGGGTCAATCTGGTGACAGATGGCCTGCCTGCCACTGCACTGGGGTTCAACCCT
CCTGATCTGGACATCATGAATAAACCTCCCCGGAACCCAAAGGAACCATTGATCAGCGGGTGGCTCTTTTTCCGTTACTTGGCTATTGGC
TGTGGTTTTACGCACGACGAGCTGCTGAAGGTGTGGAAAGGACTGTTTTATTGCATGTGGATGCAGGACAAGCCACTCCTCCAGGAAGAA
TTAGGAAGGACTATTTCCCAGCTCGTTCATGCTTTTCAGACCACGGAGGCGCAGCACCTGTTCCTTCAGGCCTTCTGGCAGACCATGAAT
CGCGAGTGGACGGGCATTGACAGGCTGCGCCTGGATAAATTCTACATGCTCATGCGGATGGTCCTGAACGAGTCCTTGAAGGTTCTGAAG
ATGCAAGGCTGGGAAGAAAGACAGATCGAGGAGCTGCTAGAGCTGCTGATGACTGAGATCCTGCACCCCAGCAGCCAGGCCCCCAACGGT
GTGAAGAGCCACTTCATCGAGATCTTCCTGGAGGAGCTGACCAAAGTGGGCGCCGAGGAGCTTACGGCAGACCAGAACCTGAAGTTCATC
GACCCCTTCTGCAGAATTGCTGCCCGGACCAAGGATTCCTTGGTTTTGAACAACATCACTCGAGGCATCTTTGAGACGATTGTGGAGCAG
GCCCCGCTTGCCATTGAAGACCTCCTGAATGAACTGGACACACAGGATGAGGAGGTGGCGTCGGACAGTGATGAGTCCTCTGAGGGTGGT
GAGCGTGGAGACGCGCTGTCCCAGAAGAGGTCTGAGAAGCCGCCCGCAGGCTCCATCTGCAGGGCTGAACCTGAGGCTGGTGAGGAGCAG
GCAGGTGACGACAGGGACAGTGGCGGCCCCGTTCTCCAGTTTGACTACGAGGCAGTTGCTAACAGACTGTTTGAAATGGCCAGCCGCCAG
AGCACCCCTTCTCAGAACAGAAAGCGTCTCTACAAAGTGATCCGGAAGCTGCAGGACCTGGCAGGAGGCATTTTCCCTGAAGATGAGATC
CCAGAGAAGGCCTGCAGGCGCCTGCTTGAAGGGAGGCGGCAGAAGAAGACGAAGAAGCAGAAGCGTCTGCTCAGGTTGCAGCAGGAGAGA
GGGAAAGGTGAGAAGGAGCCCCCGAGCCCGGGCATGGAGAGGAAGAGGAGCAGGAGGAGGGGTGTAGGGGCCGACCCCGAGGCGCGGGCA
GAGGCTGGTGAGCAGCCAGGCACAGCTGAGCGGGCCCTGCTCCGAGATCAGCCCAGGGGCCGTGGCCAGAGAGGGGCTCGCCAGAGAAGG

>In-frame_ATP2A2_ENST00000395494_chr12_110781239_+_RRP1_ENST00000497547_chr21_45211231_+_3693nt
ATGGAGAACGCGCACACCAAGACGGTGGAGGAGGTGCTGGGCCACTTCGGCGTCAACGAGAGTACGGGGCTGAGCCTGGAACAGGTCAAG
AAGCTTAAGGAGAGATGGGGCTCCAACGAGTTACCGGCTGAAGAAGGAAAAACCTTGCTGGAACTTGTGATTGAGCAGTTTGAAGACTTG
CTAGTTAGGATTTTATTACTGGCAGCATGTATATCTTTTGTTTTGGCTTGGTTTGAAGAAGGTGAAGAAACAATTACAGCCTTTGTAGAA
CCTTTTGTAATTTTACTCATATTAGTAGCCAATGCAATTGTGGGTGTATGGCAGGAAAGAAATGCTGAAAATGCCATCGAAGCCCTTAAG
GAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGAGTGTGCAGCGGATTAAAGCTAAAGACATAGTTCCTGGTGATATT
GTAGAAATTGCTGGTGAATCTGTCTCTGTCATCAAGCACACTGATCCCGTCCCTGACCCACGAGCTGTCAACCAAGATAAAAAGAACATG
CTGTTTTCTGGTACAAACATTGCTGCTGGGAAAGCTATGGGAGTGGTGGTAGCAACTGGAGTTAACACCGAAATTGGCAAGATCCGGGAT
GAAATGGTGGCAACAGAACAGGAGAGAACACCCCTTCAGCAAAAACTAGATGAATTTGGGGAACAGCTTTCCAAAGTCATCTCCCTTATT
TGCATTGCAGTCTGGATCATAAATATTGGGCACTTCAATGACCCGGTTCATGGAGGGTCCTGGATCAGAGGTGCTATTTACTACTTTAAA
ATTGCAGTGGCCCTGGCTGTAGCAGCCATTCCTGAAGGTCTGCCTGCAGTCATCACCACCTGCCTGGCTCTTGGAACTCGCAGAATGGCA
AAGAAAAATGCCATTGTTCGAAGCCTCCCGTCTGTGGAAACCCTTGGTTGTACTTCTGTTATCTGCTCAGACAAGACTGGTACACTTACA
ACAAACCAGATGTCAGTCTGCAGGATGTTCATTCTGGACAGAGTGGAAGGTGATACTTGTTCCCTTAATGAGTTTACCATAACTGGATCA
ACTTATGCACCTATTGGAGAAGTGCATAAAGATGATAAACCAGTGAATTGTCACCAGTATGATGGTCTGGTAGAATTAGCAACAATTTGT
GCTCTTTGTAATGACTCTGCTTTGGATTACAATGAGGCAAAGGGTGTGTATGAAAAAGTTGGAGAAGCTACAGAGACTGCTCTCACTTGC
CTAGTAGAGAAGATGAATGTATTTGATACCGAATTGAAGGGTCTTTCTAAAATAGAACGTGCAAATGCCTGCAACTCAGTCATTAAACAG
CTGATGAAAAAGGAATTCACTCTAGAGTTTTCACGTGACAGAAAGTCAATGTCGGTTTACTGTACACCAAATAAACCAAGCAGGACATCA
ATGAGCAAGATGTTTGTGAAGGGTGCTCCTGAAGGTGTCATTGACAGGTGCACCCACATTCGAGTTGGAAGTACTAAGGTTCCTATGACC
TCTGGAGTCAAACAGAAGATCATGTCTGTCATTCGAGAGTGGGGTAGTGGCAGCGACACACTGCGATGCCTGGCCCTGGCCACTCATGAC
AACCCACTGAGAAGAGAAGAAATGCACCTTGAGGACTCTGCCAACTTTATTAAATATGAGACCAATCTGACCTTCGTTGGCTGCGTGGGC
ATGCTGGATCCTCCGAGAATCGAGGTGGCCTCCTCCGTGAAGCTGTGCCGGCAAGCAGGCATCCGGGTCATCATGATCACTGGGGACAAC
AAGGGCACTGCTGTGGCCATCTGTCGCCGCATCGGCATCTTCGGGCAGGATGAGGACGTGACGTCAAAAGCTTTCACAGGCCGGGAGTTT
GATGAACTCAACCCCTCCGCCCAGCGAGACGCCTGCCTGAACGCCCGCTGTTTTGCTCGAGTTGAACCCTCCCACAAGTCTAAAATCGTA
GAATTTCTTCAGTCTTTTGATGAGATTACAGCTATGACTGGCGATGGCGTGAACGATGCTCCTGCTCTGAAGAAAGCCGAGATTGGCATT
GCTATGGGCTCTGGCACTGCGGTGGCTAAAACCGCCTCTGAGATGGTCCTGGCGGATGACAACTTCTCCACCATTGTGGCTGCCGTTGAG
GAGGGGCGGGCAATCTACAACAACATGAAACAGTTCATCCGCTACCTCATCTCGTCCAACGTCGGGGAAGTTGTCTGTATTTTCCTGACA
GCAGCCCTTGGATTTCCCGAGGCTTTGATTCCTGTTCAGCTGCTCTGGGTCAATCTGGTGACAGATGGCCTGCCTGCCACTGCACTGGGG
TTCAACCCTCCTGATCTGGACATCATGAATAAACCTCCCCGGAACCCAAAGGAACCATTGATCAGCGGGTGGCTCTTTTTCCGTTACTTG
GCTATTGGCTGTGGTTTTACGCACGACGAGCTGCTGAAGGTGTGGAAAGGACTGTTTTATTGCATGTGGATGCAGGACAAGCCACTCCTC
CAGGAAGAATTAGGAAGGACTATTTCCCAGCTCGTTCATGCTTTTCAGACCACGGAGGCGCAGCACCTGTTCCTTCAGGCCTTCTGGCAG
ACCATGAATCGCGAGTGGACGGGCATTGACAGGCTGCGCCTGGATAAATTCTACATGCTCATGCGGATGGTCCTGAACGAGTCCTTGAAG
GTTCTGAAGATGCAAGGCTGGGAAGAAAGACAGATCGAGGAGCTGCTAGAGCTGCTGATGACTGAGATCCTGCACCCCAGCAGCCAGGCC
CCCAACGGTGTGAAGAGCCACTTCATCGAGATCTTCCTGGAGGAGCTGACCAAAGTGGGCGCCGAGGAGCTTACGGCAGACCAGAACCTG
AAGTTCATCGACCCCTTCTGCAGAATTGCTGCCCGGACCAAGGATTCCTTGGTTTTGAACAACATCACTCGAGGCATCTTTGAGACGATT
GTGGAGCAGGCCCCGCTTGCCATTGAAGACCTCCTGAATGAACTGGACACACAGGATGAGGAGGTGGCGTCGGACAGTGATGAGTCCTCT
GAGGGTGGTGAGCGTGGAGACGCGCTGTCCCAGAAGAGGTCTGAGAAGCCGCCCGCAGGCTCCATCTGCAGGGCTGAACCTGAGGCTGGT
GAGGAGCAGGCAGGTGACGACAGGGACAGTGGCGGCCCCGTTCTCCAGTTTGACTACGAGGCAGTTGCTAACAGACTGTTTGAAATGGCC
AGCCGCCAGAGCACCCCTTCTCAGAACAGAAAGCGTCTCTACAAAGTGATCCGGAAGCTGCAGGACCTGGCAGGAGGCATTTTCCCTGAA
GATGAGATCCCAGAGAAGGCCTGCAGGCGCCTGCTTGAAGGGAGGCGGCAGAAGAAGACGAAGAAGCAGAAGCGTCTGCTCAGGTTGCAG
CAGGAGAGAGGGAAAGGTGAGAAGGAGCCCCCGAGCCCGGGCATGGAGAGGAAGAGGAGCAGGAGGAGGGGTGTAGGGGCCGACCCCGAG
GCGCGGGCAGAGGCTGGTGAGCAGCCAGGCACAGCTGAGCGGGCCCTGCTCCGAGATCAGCCCAGGGGCCGTGGCCAGAGAGGGGCTCGC
CAGAGAAGGAGGACACCTCGGCCCCTGACCAGTGCCCGAGCAAAGGCGGCCAATGTCCAGGAGCCGGAGAAGAAGAAGAAACGCAGGGAG

>In-frame_ATP2A2_ENST00000539276_chr12_110781239_+_RRP1_ENST00000497547_chr21_45211231_+_3774nt
ATGGAGAACGCGCACACCAAGACGGTGGAGGAGGTGCTGGGCCACTTCGGCGTCAACGAGAGTACGGGGCTGAGCCTGGAACAGGTCAAG
AAGCTTAAGGAGAGATGGGGCTCCAACGAGTTACCGGCTGAAGAAGGAAAAACCTTGCTGGAACTTGTGATTGAGCAGTTTGAAGACTTG
CTAGTTAGGATTTTATTACTGGCAGCATGTATATCTTTTGTTTTGGCTTGGTTTGAAGAAGGTGAAGAAACAATTACAGCCTTTGTAGAA
CCTTTTGTAATTTTACTCATATTAGTAGCCAATGCAATTGTGGGTGTATGGCAGGAAAGAAATGCTGAAAATGCCATCGAAGCCCTTAAG
GAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGAGTGTGCAGCGGATTAAAGCTAAAGACATAGTTCCTGGTGATATT
GTAGAAATTGCTGTTGGTGACAAAGTTCCTGCTGATATAAGGTTAACTTCCATCAAATCTACCACACTAAGAGTTGACCAGTCAATTCTC
ACAGGTGAATCTGTCTCTGTCATCAAGCACACTGATCCCGTCCCTGACCCACGAGCTGTCAACCAAGATAAAAAGAACATGCTGTTTTCT
GGTACAAACATTGCTGCTGGGAAAGCTATGGGAGTGGTGGTAGCAACTGGAGTTAACACCGAAATTGGCAAGATCCGGGATGAAATGGTG
GCAACAGAACAGGAGAGAACACCCCTTCAGCAAAAACTAGATGAATTTGGGGAACAGCTTTCCAAAGTCATCTCCCTTATTTGCATTGCA
GTCTGGATCATAAATATTGGGCACTTCAATGACCCGGTTCATGGAGGGTCCTGGATCAGAGGTGCTATTTACTACTTTAAAATTGCAGTG
GCCCTGGCTGTAGCAGCCATTCCTGAAGGTCTGCCTGCAGTCATCACCACCTGCCTGGCTCTTGGAACTCGCAGAATGGCAAAGAAAAAT
GCCATTGTTCGAAGCCTCCCGTCTGTGGAAACCCTTGGTTGTACTTCTGTTATCTGCTCAGACAAGACTGGTACACTTACAACAAACCAG
ATGTCAGTCTGCAGGATGTTCATTCTGGACAGAGTGGAAGGTGATACTTGTTCCCTTAATGAGTTTACCATAACTGGATCAACTTATGCA
CCTATTGGAGAAGTGCATAAAGATGATAAACCAGTGAATTGTCACCAGTATGATGGTCTGGTAGAATTAGCAACAATTTGTGCTCTTTGT
AATGACTCTGCTTTGGATTACAATGAGGCAAAGGGTGTGTATGAAAAAGTTGGAGAAGCTACAGAGACTGCTCTCACTTGCCTAGTAGAG
AAGATGAATGTATTTGATACCGAATTGAAGGGTCTTTCTAAAATAGAACGTGCAAATGCCTGCAACTCAGTCATTAAACAGCTGATGAAA
AAGGAATTCACTCTAGAGTTTTCACGTGACAGAAAGTCAATGTCGGTTTACTGTACACCAAATAAACCAAGCAGGACATCAATGAGCAAG
ATGTTTGTGAAGGGTGCTCCTGAAGGTGTCATTGACAGGTGCACCCACATTCGAGTTGGAAGTACTAAGGTTCCTATGACCTCTGGAGTC
AAACAGAAGATCATGTCTGTCATTCGAGAGTGGGGTAGTGGCAGCGACACACTGCGATGCCTGGCCCTGGCCACTCATGACAACCCACTG
AGAAGAGAAGAAATGCACCTTGAGGACTCTGCCAACTTTATTAAATATGAGACCAATCTGACCTTCGTTGGCTGCGTGGGCATGCTGGAT
CCTCCGAGAATCGAGGTGGCCTCCTCCGTGAAGCTGTGCCGGCAAGCAGGCATCCGGGTCATCATGATCACTGGGGACAACAAGGGCACT
GCTGTGGCCATCTGTCGCCGCATCGGCATCTTCGGGCAGGATGAGGACGTGACGTCAAAAGCTTTCACAGGCCGGGAGTTTGATGAACTC
AACCCCTCCGCCCAGCGAGACGCCTGCCTGAACGCCCGCTGTTTTGCTCGAGTTGAACCCTCCCACAAGTCTAAAATCGTAGAATTTCTT
CAGTCTTTTGATGAGATTACAGCTATGACTGGCGATGGCGTGAACGATGCTCCTGCTCTGAAGAAAGCCGAGATTGGCATTGCTATGGGC
TCTGGCACTGCGGTGGCTAAAACCGCCTCTGAGATGGTCCTGGCGGATGACAACTTCTCCACCATTGTGGCTGCCGTTGAGGAGGGGCGG
GCAATCTACAACAACATGAAACAGTTCATCCGCTACCTCATCTCGTCCAACGTCGGGGAAGTTGTCTGTATTTTCCTGACAGCAGCCCTT
GGATTTCCCGAGGCTTTGATTCCTGTTCAGCTGCTCTGGGTCAATCTGGTGACAGATGGCCTGCCTGCCACTGCACTGGGGTTCAACCCT
CCTGATCTGGACATCATGAATAAACCTCCCCGGAACCCAAAGGAACCATTGATCAGCGGGTGGCTCTTTTTCCGTTACTTGGCTATTGGC
TGTGGTTTTACGCACGACGAGCTGCTGAAGGTGTGGAAAGGACTGTTTTATTGCATGTGGATGCAGGACAAGCCACTCCTCCAGGAAGAA
TTAGGAAGGACTATTTCCCAGCTCGTTCATGCTTTTCAGACCACGGAGGCGCAGCACCTGTTCCTTCAGGCCTTCTGGCAGACCATGAAT
CGCGAGTGGACGGGCATTGACAGGCTGCGCCTGGATAAATTCTACATGCTCATGCGGATGGTCCTGAACGAGTCCTTGAAGGTTCTGAAG
ATGCAAGGCTGGGAAGAAAGACAGATCGAGGAGCTGCTAGAGCTGCTGATGACTGAGATCCTGCACCCCAGCAGCCAGGCCCCCAACGGT
GTGAAGAGCCACTTCATCGAGATCTTCCTGGAGGAGCTGACCAAAGTGGGCGCCGAGGAGCTTACGGCAGACCAGAACCTGAAGTTCATC
GACCCCTTCTGCAGAATTGCTGCCCGGACCAAGGATTCCTTGGTTTTGAACAACATCACTCGAGGCATCTTTGAGACGATTGTGGAGCAG
GCCCCGCTTGCCATTGAAGACCTCCTGAATGAACTGGACACACAGGATGAGGAGGTGGCGTCGGACAGTGATGAGTCCTCTGAGGGTGGT
GAGCGTGGAGACGCGCTGTCCCAGAAGAGGTCTGAGAAGCCGCCCGCAGGCTCCATCTGCAGGGCTGAACCTGAGGCTGGTGAGGAGCAG
GCAGGTGACGACAGGGACAGTGGCGGCCCCGTTCTCCAGTTTGACTACGAGGCAGTTGCTAACAGACTGTTTGAAATGGCCAGCCGCCAG
AGCACCCCTTCTCAGAACAGAAAGCGTCTCTACAAAGTGATCCGGAAGCTGCAGGACCTGGCAGGAGGCATTTTCCCTGAAGATGAGATC
CCAGAGAAGGCCTGCAGGCGCCTGCTTGAAGGGAGGCGGCAGAAGAAGACGAAGAAGCAGAAGCGTCTGCTCAGGTTGCAGCAGGAGAGA
GGGAAAGGTGAGAAGGAGCCCCCGAGCCCGGGCATGGAGAGGAAGAGGAGCAGGAGGAGGGGTGTAGGGGCCGACCCCGAGGCGCGGGCA
GAGGCTGGTGAGCAGCCAGGCACAGCTGAGCGGGCCCTGCTCCGAGATCAGCCCAGGGGCCGTGGCCAGAGAGGGGCTCGCCAGAGAAGG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ATP2A2_ENST00000308664_chr12_110781239_+_RRP1_ENST00000497547_chr21_45211231_+_5967nt
GCGCGGGAGGAGGGAGCCGGGAGGAGGGGGCGGGGCCGCGCCGCCCGCGCCGCGCTGGGCGCTCTCGGCCAATGAGCGGCGTCCACATGC
CGCGGCGGCGGCGAAAGGGGAGGCAGCGGCCGATAAATGCTATTAGAGCAGCCGCCGCGGAGCCGTCCCCGACGCCACCTCCTTTTCCTT
CGCCGCAGTTTCCTCCGCCGCTGTCGGGCGTGCGGCGCTGAGGGACCCGGGCGAGCGCGCCGCGCACCGCCCCGCCGGCTCGCCTCCCTC
GCCGCGTTCCGCCCTCAGTGGTCTGCCGGGCGCCCCCTCCTCCGGCCCGGGCGGGGCCTCTGATCGCCTCAAGAGAGCGGGGAGGGGGCT
CGGGGGCCGCGGCCTGCCCTCCCGGCGGGCGGCTGAGGGCGAGGGAGGCCCTCCCTTCTGGCGAGGGGAGGGAGGGTGGGTCAGGAGCCC
CCAACCCGCCCTGCGGAGCTCGGGGCCGCGCGAGGGGCGGTTGTCTGGGGGAGGGGGCGCGGGGTGATTCAGCGCCCGGCGAGGCGGAAG
CGGCCGCAAGAGGAGGAGGGGAGAGCCCGTCCGCGCCTGGGCTCCCGGGGTGGCACGAGCCCGCGGCCGGAGTGCGAGGCGGAGGCGAGG
AGGCCGCGGGGACGGGAGGCGAGGCCGGCCGGGCCCCCGAAGCCATGGAGAACGCGCACACCAAGACGGTGGAGGAGGTGCTGGGCCACT
TCGGCGTCAACGAGAGTACGGGGCTGAGCCTGGAACAGGTCAAGAAGCTTAAGGAGAGATGGGGCTCCAACGAGTTACCGGCTGAAGAAG
GAAAAACCTTGCTGGAACTTGTGATTGAGCAGTTTGAAGACTTGCTAGTTAGGATTTTATTACTGGCAGCATGTATATCTTTTGTTTTGG
CTTGGTTTGAAGAAGGTGAAGAAACAATTACAGCCTTTGTAGAACCTTTTGTAATTTTACTCATATTAGTAGCCAATGCAATTGTGGGTG
TATGGCAGGAAAGAAATGCTGAAAATGCCATCGAAGCCCTTAAGGAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGA
GTGTGCAGCGGATTAAAGCTAAAGACATAGTTCCTGGTGATATTGTAGAAATTGCTGTTGGTGACAAAGTTCCTGCTGATATAAGGTTAA
CTTCCATCAAATCTACCACACTAAGAGTTGACCAGTCAATTCTCACAGGTGAATCTGTCTCTGTCATCAAGCACACTGATCCCGTCCCTG
ACCCACGAGCTGTCAACCAAGATAAAAAGAACATGCTGTTTTCTGGTACAAACATTGCTGCTGGGAAAGCTATGGGAGTGGTGGTAGCAA
CTGGAGTTAACACCGAAATTGGCAAGATCCGGGATGAAATGGTGGCAACAGAACAGGAGAGAACACCCCTTCAGCAAAAACTAGATGAAT
TTGGGGAACAGCTTTCCAAAGTCATCTCCCTTATTTGCATTGCAGTCTGGATCATAAATATTGGGCACTTCAATGACCCGGTTCATGGAG
GGTCCTGGATCAGAGGTGCTATTTACTACTTTAAAATTGCAGTGGCCCTGGCTGTAGCAGCCATTCCTGAAGGTCTGCCTGCAGTCATCA
CCACCTGCCTGGCTCTTGGAACTCGCAGAATGGCAAAGAAAAATGCCATTGTTCGAAGCCTCCCGTCTGTGGAAACCCTTGGTTGTACTT
CTGTTATCTGCTCAGACAAGACTGGTACACTTACAACAAACCAGATGTCAGTCTGCAGGATGTTCATTCTGGACAGAGTGGAAGGTGATA
CTTGTTCCCTTAATGAGTTTACCATAACTGGATCAACTTATGCACCTATTGGAGAAGTGCATAAAGATGATAAACCAGTGAATTGTCACC
AGTATGATGGTCTGGTAGAATTAGCAACAATTTGTGCTCTTTGTAATGACTCTGCTTTGGATTACAATGAGGCAAAGGGTGTGTATGAAA
AAGTTGGAGAAGCTACAGAGACTGCTCTCACTTGCCTAGTAGAGAAGATGAATGTATTTGATACCGAATTGAAGGGTCTTTCTAAAATAG
AACGTGCAAATGCCTGCAACTCAGTCATTAAACAGCTGATGAAAAAGGAATTCACTCTAGAGTTTTCACGTGACAGAAAGTCAATGTCGG
TTTACTGTACACCAAATAAACCAAGCAGGACATCAATGAGCAAGATGTTTGTGAAGGGTGCTCCTGAAGGTGTCATTGACAGGTGCACCC
ACATTCGAGTTGGAAGTACTAAGGTTCCTATGACCTCTGGAGTCAAACAGAAGATCATGTCTGTCATTCGAGAGTGGGGTAGTGGCAGCG
ACACACTGCGATGCCTGGCCCTGGCCACTCATGACAACCCACTGAGAAGAGAAGAAATGCACCTTGAGGACTCTGCCAACTTTATTAAAT
ATGAGACCAATCTGACCTTCGTTGGCTGCGTGGGCATGCTGGATCCTCCGAGAATCGAGGTGGCCTCCTCCGTGAAGCTGTGCCGGCAAG
CAGGCATCCGGGTCATCATGATCACTGGGGACAACAAGGGCACTGCTGTGGCCATCTGTCGCCGCATCGGCATCTTCGGGCAGGATGAGG
ACGTGACGTCAAAAGCTTTCACAGGCCGGGAGTTTGATGAACTCAACCCCTCCGCCCAGCGAGACGCCTGCCTGAACGCCCGCTGTTTTG
CTCGAGTTGAACCCTCCCACAAGTCTAAAATCGTAGAATTTCTTCAGTCTTTTGATGAGATTACAGCTATGACTGGCGATGGCGTGAACG
ATGCTCCTGCTCTGAAGAAAGCCGAGATTGGCATTGCTATGGGCTCTGGCACTGCGGTGGCTAAAACCGCCTCTGAGATGGTCCTGGCGG
ATGACAACTTCTCCACCATTGTGGCTGCCGTTGAGGAGGGGCGGGCAATCTACAACAACATGAAACAGTTCATCCGCTACCTCATCTCGT
CCAACGTCGGGGAAGTTGTCTGTATTTTCCTGACAGCAGCCCTTGGATTTCCCGAGGCTTTGATTCCTGTTCAGCTGCTCTGGGTCAATC
TGGTGACAGATGGCCTGCCTGCCACTGCACTGGGGTTCAACCCTCCTGATCTGGACATCATGAATAAACCTCCCCGGAACCCAAAGGAAC
CATTGATCAGCGGGTGGCTCTTTTTCCGTTACTTGGCTATTGGCTGTGGTTTTACGCACGACGAGCTGCTGAAGGTGTGGAAAGGACTGT
TTTATTGCATGTGGATGCAGGACAAGCCACTCCTCCAGGAAGAATTAGGAAGGACTATTTCCCAGCTCGTTCATGCTTTTCAGACCACGG
AGGCGCAGCACCTGTTCCTTCAGGCCTTCTGGCAGACCATGAATCGCGAGTGGACGGGCATTGACAGGCTGCGCCTGGATAAATTCTACA
TGCTCATGCGGATGGTCCTGAACGAGTCCTTGAAGGTTCTGAAGATGCAAGGCTGGGAAGAAAGACAGATCGAGGAGCTGCTAGAGCTGC
TGATGACTGAGATCCTGCACCCCAGCAGCCAGGCCCCCAACGGTGTGAAGAGCCACTTCATCGAGATCTTCCTGGAGGAGCTGACCAAAG
TGGGCGCCGAGGAGCTTACGGCAGACCAGAACCTGAAGTTCATCGACCCCTTCTGCAGAATTGCTGCCCGGACCAAGGATTCCTTGGTTT
TGAACAACATCACTCGAGGCATCTTTGAGACGATTGTGGAGCAGGCCCCGCTTGCCATTGAAGACCTCCTGAATGAACTGGACACACAGG
ATGAGGAGGTGGCGTCGGACAGTGATGAGTCCTCTGAGGGTGGTGAGCGTGGAGACGCGCTGTCCCAGAAGAGGTCTGAGAAGCCGCCCG
CAGGCTCCATCTGCAGGGCTGAACCTGAGGCTGGTGAGGAGCAGGCAGGTGACGACAGGGACAGTGGCGGCCCCGTTCTCCAGTTTGACT
ACGAGGCAGTTGCTAACAGACTGTTTGAAATGGCCAGCCGCCAGAGCACCCCTTCTCAGAACAGAAAGCGTCTCTACAAAGTGATCCGGA
AGCTGCAGGACCTGGCAGGAGGCATTTTCCCTGAAGATGAGATCCCAGAGAAGGCCTGCAGGCGCCTGCTTGAAGGGAGGCGGCAGAAGA
AGACGAAGAAGCAGAAGCGTCTGCTCAGGTTGCAGCAGGAGAGAGGGAAAGGTGAGAAGGAGCCCCCGAGCCCGGGCATGGAGAGGAAGA
GGAGCAGGAGGAGGGGTGTAGGGGCCGACCCCGAGGCGCGGGCAGAGGCTGGTGAGCAGCCAGGCACAGCTGAGCGGGCCCTGCTCCGAG
ATCAGCCCAGGGGCCGTGGCCAGAGAGGGGCTCGCCAGAGAAGGAGGACACCTCGGCCCCTGACCAGTGCCCGAGCAAAGGCGGCCAATG
TCCAGGAGCCGGAGAAGAAGAAGAAACGCAGGGAGTGATGTGGCCGGGCCAAGGACAGGCAGGGAGGGAGGCCAGGCCTCGCTTGCACCG
CGGGACGAGGCTGACCGGGCTGTTCTGTAGACTCAGGACCGTGGCTCCAGAACTCCTGTGCCAGGCGGGAGGGAAGGGCGGCACTGGAGA
GATGGGCCCATCATTAGGGGCCAGCATCCCAGGAACTGGACCTTTCCCCAGAGCCTCCGCCTGTGGCTGTGATGACCTTGGGCCAGAAGG
TCAAACTCCGAAGACTGAAACTCTGCCTGCAGCAGGACTGGCCGCCCCTGCTGTGGGGGGTTCAGAAAATAAAATGCCGCGCAGCCCTTG
CCAGGGGAAGTGTCGCTTCAGGTGTGTCCTACGGACGTGTGGGAGGTGGCAGGCGCCAGCCTCCGAGCAGTGTGGTGGTTTATATTCATG
TTTGTGGAAAAATCTTGCAAGACATTTCTCCTTTCACAGAACTGCCCAGGTGTTAACAGGGCTGTCTGGACGGGGCTCTTTTGCTTCCCC
CTCAATCTGGGGTCTAGAGTTGTGCAAGGAATTCAGCTCCAGTAAGGCCTGGATTGCCCGGGGTGAGCGTGTGTGTGGTGGGAAGACCTG
GCTTCCGCGAGAGCCTTGTTCCTGGAGGCAGGAGCGCCCCGCCATCCTGGGTACCCGCGGGTCCGCAGGCTGCGCACCTCTTTCCCTCAG
CCAGGTCACCCTCAGCGTCCTCCCTGCCCCTCTCCCCTTCACACCTGCTGGAGCCTGTGAGGGAGGTGGCGGGTCCCCACTGTGGCGACG
GAGAGCTGACAGTAGCCCAGGGCTTTCCACCTGCATGGAACAAGGGCCTGTCTGCCGCCAGCGCTGTGGCCACAGCCTGCATAGGTGACA
AGGGGCCGCTGCGTTGGGTTTTGCCCGCATCTTCTGTTCCATGGGTGCCCAGCCAGCCAGGCCGTGTGGGATCCAGCGAGAGGCCAGGGC
TTGGAGTGGGCCTGGGACCAGGAAGGACCTCTAGGCTGTGGCTGGCCTTGTGCAGACCCTGGACTGCATCCGGTTCCCCAAAGCCCTGCT
GCATTCGAGTGTCCCCCAACCCCGGGCAGGTGGCACCTGGTGACACCTCCTTCAGTCCCACTCAGCTGGGCGGCCGGGGCAGGCTTAGGG
CACAGTTAGGGGCCAAGGAGAGGGAAGGCCAGGGCCCCTGTTCTAGGGGTTAGGGTTCTTTCCCCAAAGGAACTTAAAAAGACAAGCGTG
GCCAGGCACAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGCCAGATCACCTGAGGTCAGGAGTTTGAGACCAGACT
GACCAACATGGAGAAACCCCATCTCTACTAAAATACAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAATCCCAGCTACTCGGGAGGCT
GAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGTGGTGAGCTAAGATCACGCCATTGCACTCCAGCCTGGGCAACGAGAGGGAA

>In-frame_ATP2A2_ENST00000395494_chr12_110781239_+_RRP1_ENST00000497547_chr21_45211231_+_5775nt
GGCAGCGGCCGATAAATGCTATTAGAGCAGCCGCCGCGGAGCCGTCCCCGACGCCACCTCCTTTTCCTTCGCCGCAGTTTCCTCCGCCGC
TGTCGGGCGTGCGGCGCTGAGGGACCCGGGCGAGCGCGCCGCGCACCGCCCCGCCGGCTCGCCTCCCTCGCCGCGTTCCGCCCTCAGTGG
TCTGCCGGGCGCCCCCTCCTCCGGCCCGGGCGGGGCCTCTGATCGCCTCAAGAGAGCGGGGAGGGGGCTCGGGGGCCGCGGCCTGCCCTC
CCGGCGGGCGGCTGAGGGCGAGGGAGGCCCTCCCTTCTGGCGAGGGGAGGGAGGGTGGGTCAGGAGCCCCCAACCCGCCCTGCGGAGCTC
GGGGCCGCGCGAGGGGCGGTTGTCTGGGGGAGGGGGCGCGGGGTGATTCAGCGCCCGGCGAGGCGGAAGCGGCCGCAAGAGGAGGAGGGG
AGAGCCCGTCCGCGCCTGGGCTCCCGGGGTGGCACGAGCCCGCGGCCGGAGTGCGAGGCGGAGGCGAGGAGGCCGCGGGGACGGGAGGCG
AGGCCGGCCGGGCCCCCGAAGCCATGGAGAACGCGCACACCAAGACGGTGGAGGAGGTGCTGGGCCACTTCGGCGTCAACGAGAGTACGG
GGCTGAGCCTGGAACAGGTCAAGAAGCTTAAGGAGAGATGGGGCTCCAACGAGTTACCGGCTGAAGAAGGAAAAACCTTGCTGGAACTTG
TGATTGAGCAGTTTGAAGACTTGCTAGTTAGGATTTTATTACTGGCAGCATGTATATCTTTTGTTTTGGCTTGGTTTGAAGAAGGTGAAG
AAACAATTACAGCCTTTGTAGAACCTTTTGTAATTTTACTCATATTAGTAGCCAATGCAATTGTGGGTGTATGGCAGGAAAGAAATGCTG
AAAATGCCATCGAAGCCCTTAAGGAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGAGTGTGCAGCGGATTAAAGCTA
AAGACATAGTTCCTGGTGATATTGTAGAAATTGCTGGTGAATCTGTCTCTGTCATCAAGCACACTGATCCCGTCCCTGACCCACGAGCTG
TCAACCAAGATAAAAAGAACATGCTGTTTTCTGGTACAAACATTGCTGCTGGGAAAGCTATGGGAGTGGTGGTAGCAACTGGAGTTAACA
CCGAAATTGGCAAGATCCGGGATGAAATGGTGGCAACAGAACAGGAGAGAACACCCCTTCAGCAAAAACTAGATGAATTTGGGGAACAGC
TTTCCAAAGTCATCTCCCTTATTTGCATTGCAGTCTGGATCATAAATATTGGGCACTTCAATGACCCGGTTCATGGAGGGTCCTGGATCA
GAGGTGCTATTTACTACTTTAAAATTGCAGTGGCCCTGGCTGTAGCAGCCATTCCTGAAGGTCTGCCTGCAGTCATCACCACCTGCCTGG
CTCTTGGAACTCGCAGAATGGCAAAGAAAAATGCCATTGTTCGAAGCCTCCCGTCTGTGGAAACCCTTGGTTGTACTTCTGTTATCTGCT
CAGACAAGACTGGTACACTTACAACAAACCAGATGTCAGTCTGCAGGATGTTCATTCTGGACAGAGTGGAAGGTGATACTTGTTCCCTTA
ATGAGTTTACCATAACTGGATCAACTTATGCACCTATTGGAGAAGTGCATAAAGATGATAAACCAGTGAATTGTCACCAGTATGATGGTC
TGGTAGAATTAGCAACAATTTGTGCTCTTTGTAATGACTCTGCTTTGGATTACAATGAGGCAAAGGGTGTGTATGAAAAAGTTGGAGAAG
CTACAGAGACTGCTCTCACTTGCCTAGTAGAGAAGATGAATGTATTTGATACCGAATTGAAGGGTCTTTCTAAAATAGAACGTGCAAATG
CCTGCAACTCAGTCATTAAACAGCTGATGAAAAAGGAATTCACTCTAGAGTTTTCACGTGACAGAAAGTCAATGTCGGTTTACTGTACAC
CAAATAAACCAAGCAGGACATCAATGAGCAAGATGTTTGTGAAGGGTGCTCCTGAAGGTGTCATTGACAGGTGCACCCACATTCGAGTTG
GAAGTACTAAGGTTCCTATGACCTCTGGAGTCAAACAGAAGATCATGTCTGTCATTCGAGAGTGGGGTAGTGGCAGCGACACACTGCGAT
GCCTGGCCCTGGCCACTCATGACAACCCACTGAGAAGAGAAGAAATGCACCTTGAGGACTCTGCCAACTTTATTAAATATGAGACCAATC
TGACCTTCGTTGGCTGCGTGGGCATGCTGGATCCTCCGAGAATCGAGGTGGCCTCCTCCGTGAAGCTGTGCCGGCAAGCAGGCATCCGGG
TCATCATGATCACTGGGGACAACAAGGGCACTGCTGTGGCCATCTGTCGCCGCATCGGCATCTTCGGGCAGGATGAGGACGTGACGTCAA
AAGCTTTCACAGGCCGGGAGTTTGATGAACTCAACCCCTCCGCCCAGCGAGACGCCTGCCTGAACGCCCGCTGTTTTGCTCGAGTTGAAC
CCTCCCACAAGTCTAAAATCGTAGAATTTCTTCAGTCTTTTGATGAGATTACAGCTATGACTGGCGATGGCGTGAACGATGCTCCTGCTC
TGAAGAAAGCCGAGATTGGCATTGCTATGGGCTCTGGCACTGCGGTGGCTAAAACCGCCTCTGAGATGGTCCTGGCGGATGACAACTTCT
CCACCATTGTGGCTGCCGTTGAGGAGGGGCGGGCAATCTACAACAACATGAAACAGTTCATCCGCTACCTCATCTCGTCCAACGTCGGGG
AAGTTGTCTGTATTTTCCTGACAGCAGCCCTTGGATTTCCCGAGGCTTTGATTCCTGTTCAGCTGCTCTGGGTCAATCTGGTGACAGATG
GCCTGCCTGCCACTGCACTGGGGTTCAACCCTCCTGATCTGGACATCATGAATAAACCTCCCCGGAACCCAAAGGAACCATTGATCAGCG
GGTGGCTCTTTTTCCGTTACTTGGCTATTGGCTGTGGTTTTACGCACGACGAGCTGCTGAAGGTGTGGAAAGGACTGTTTTATTGCATGT
GGATGCAGGACAAGCCACTCCTCCAGGAAGAATTAGGAAGGACTATTTCCCAGCTCGTTCATGCTTTTCAGACCACGGAGGCGCAGCACC
TGTTCCTTCAGGCCTTCTGGCAGACCATGAATCGCGAGTGGACGGGCATTGACAGGCTGCGCCTGGATAAATTCTACATGCTCATGCGGA
TGGTCCTGAACGAGTCCTTGAAGGTTCTGAAGATGCAAGGCTGGGAAGAAAGACAGATCGAGGAGCTGCTAGAGCTGCTGATGACTGAGA
TCCTGCACCCCAGCAGCCAGGCCCCCAACGGTGTGAAGAGCCACTTCATCGAGATCTTCCTGGAGGAGCTGACCAAAGTGGGCGCCGAGG
AGCTTACGGCAGACCAGAACCTGAAGTTCATCGACCCCTTCTGCAGAATTGCTGCCCGGACCAAGGATTCCTTGGTTTTGAACAACATCA
CTCGAGGCATCTTTGAGACGATTGTGGAGCAGGCCCCGCTTGCCATTGAAGACCTCCTGAATGAACTGGACACACAGGATGAGGAGGTGG
CGTCGGACAGTGATGAGTCCTCTGAGGGTGGTGAGCGTGGAGACGCGCTGTCCCAGAAGAGGTCTGAGAAGCCGCCCGCAGGCTCCATCT
GCAGGGCTGAACCTGAGGCTGGTGAGGAGCAGGCAGGTGACGACAGGGACAGTGGCGGCCCCGTTCTCCAGTTTGACTACGAGGCAGTTG
CTAACAGACTGTTTGAAATGGCCAGCCGCCAGAGCACCCCTTCTCAGAACAGAAAGCGTCTCTACAAAGTGATCCGGAAGCTGCAGGACC
TGGCAGGAGGCATTTTCCCTGAAGATGAGATCCCAGAGAAGGCCTGCAGGCGCCTGCTTGAAGGGAGGCGGCAGAAGAAGACGAAGAAGC
AGAAGCGTCTGCTCAGGTTGCAGCAGGAGAGAGGGAAAGGTGAGAAGGAGCCCCCGAGCCCGGGCATGGAGAGGAAGAGGAGCAGGAGGA
GGGGTGTAGGGGCCGACCCCGAGGCGCGGGCAGAGGCTGGTGAGCAGCCAGGCACAGCTGAGCGGGCCCTGCTCCGAGATCAGCCCAGGG
GCCGTGGCCAGAGAGGGGCTCGCCAGAGAAGGAGGACACCTCGGCCCCTGACCAGTGCCCGAGCAAAGGCGGCCAATGTCCAGGAGCCGG
AGAAGAAGAAGAAACGCAGGGAGTGATGTGGCCGGGCCAAGGACAGGCAGGGAGGGAGGCCAGGCCTCGCTTGCACCGCGGGACGAGGCT
GACCGGGCTGTTCTGTAGACTCAGGACCGTGGCTCCAGAACTCCTGTGCCAGGCGGGAGGGAAGGGCGGCACTGGAGAGATGGGCCCATC
ATTAGGGGCCAGCATCCCAGGAACTGGACCTTTCCCCAGAGCCTCCGCCTGTGGCTGTGATGACCTTGGGCCAGAAGGTCAAACTCCGAA
GACTGAAACTCTGCCTGCAGCAGGACTGGCCGCCCCTGCTGTGGGGGGTTCAGAAAATAAAATGCCGCGCAGCCCTTGCCAGGGGAAGTG
TCGCTTCAGGTGTGTCCTACGGACGTGTGGGAGGTGGCAGGCGCCAGCCTCCGAGCAGTGTGGTGGTTTATATTCATGTTTGTGGAAAAA
TCTTGCAAGACATTTCTCCTTTCACAGAACTGCCCAGGTGTTAACAGGGCTGTCTGGACGGGGCTCTTTTGCTTCCCCCTCAATCTGGGG
TCTAGAGTTGTGCAAGGAATTCAGCTCCAGTAAGGCCTGGATTGCCCGGGGTGAGCGTGTGTGTGGTGGGAAGACCTGGCTTCCGCGAGA
GCCTTGTTCCTGGAGGCAGGAGCGCCCCGCCATCCTGGGTACCCGCGGGTCCGCAGGCTGCGCACCTCTTTCCCTCAGCCAGGTCACCCT
CAGCGTCCTCCCTGCCCCTCTCCCCTTCACACCTGCTGGAGCCTGTGAGGGAGGTGGCGGGTCCCCACTGTGGCGACGGAGAGCTGACAG
TAGCCCAGGGCTTTCCACCTGCATGGAACAAGGGCCTGTCTGCCGCCAGCGCTGTGGCCACAGCCTGCATAGGTGACAAGGGGCCGCTGC
GTTGGGTTTTGCCCGCATCTTCTGTTCCATGGGTGCCCAGCCAGCCAGGCCGTGTGGGATCCAGCGAGAGGCCAGGGCTTGGAGTGGGCC
TGGGACCAGGAAGGACCTCTAGGCTGTGGCTGGCCTTGTGCAGACCCTGGACTGCATCCGGTTCCCCAAAGCCCTGCTGCATTCGAGTGT
CCCCCAACCCCGGGCAGGTGGCACCTGGTGACACCTCCTTCAGTCCCACTCAGCTGGGCGGCCGGGGCAGGCTTAGGGCACAGTTAGGGG
CCAAGGAGAGGGAAGGCCAGGGCCCCTGTTCTAGGGGTTAGGGTTCTTTCCCCAAAGGAACTTAAAAAGACAAGCGTGGCCAGGCACAGT
GGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGCCAGATCACCTGAGGTCAGGAGTTTGAGACCAGACTGACCAACATGGA
GAAACCCCATCTCTACTAAAATACAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAA
TTGCTTGAACCTGGGAGGCAGAGGTTGTGGTGAGCTAAGATCACGCCATTGCACTCCAGCCTGGGCAACGAGAGGGAAACTCTGTTTCAA

>In-frame_ATP2A2_ENST00000539276_chr12_110781239_+_RRP1_ENST00000497547_chr21_45211231_+_5402nt
CCCGTCCGCGCCTGGGCTCCCGGGGTGGCACGAGCCCGCGGCCGGAGTGCGAGGCGGAGGCGAGGAGGCCGCGGGGACGGGAGGCGAGGC
CGGCCGGGCCCCCGAAGCCATGGAGAACGCGCACACCAAGACGGTGGAGGAGGTGCTGGGCCACTTCGGCGTCAACGAGAGTACGGGGCT
GAGCCTGGAACAGGTCAAGAAGCTTAAGGAGAGATGGGGCTCCAACGAGTTACCGGCTGAAGAAGGAAAAACCTTGCTGGAACTTGTGAT
TGAGCAGTTTGAAGACTTGCTAGTTAGGATTTTATTACTGGCAGCATGTATATCTTTTGTTTTGGCTTGGTTTGAAGAAGGTGAAGAAAC
AATTACAGCCTTTGTAGAACCTTTTGTAATTTTACTCATATTAGTAGCCAATGCAATTGTGGGTGTATGGCAGGAAAGAAATGCTGAAAA
TGCCATCGAAGCCCTTAAGGAATATGAGCCTGAAATGGGCAAAGTGTATCGACAGGACAGAAAGAGTGTGCAGCGGATTAAAGCTAAAGA
CATAGTTCCTGGTGATATTGTAGAAATTGCTGTTGGTGACAAAGTTCCTGCTGATATAAGGTTAACTTCCATCAAATCTACCACACTAAG
AGTTGACCAGTCAATTCTCACAGGTGAATCTGTCTCTGTCATCAAGCACACTGATCCCGTCCCTGACCCACGAGCTGTCAACCAAGATAA
AAAGAACATGCTGTTTTCTGGTACAAACATTGCTGCTGGGAAAGCTATGGGAGTGGTGGTAGCAACTGGAGTTAACACCGAAATTGGCAA
GATCCGGGATGAAATGGTGGCAACAGAACAGGAGAGAACACCCCTTCAGCAAAAACTAGATGAATTTGGGGAACAGCTTTCCAAAGTCAT
CTCCCTTATTTGCATTGCAGTCTGGATCATAAATATTGGGCACTTCAATGACCCGGTTCATGGAGGGTCCTGGATCAGAGGTGCTATTTA
CTACTTTAAAATTGCAGTGGCCCTGGCTGTAGCAGCCATTCCTGAAGGTCTGCCTGCAGTCATCACCACCTGCCTGGCTCTTGGAACTCG
CAGAATGGCAAAGAAAAATGCCATTGTTCGAAGCCTCCCGTCTGTGGAAACCCTTGGTTGTACTTCTGTTATCTGCTCAGACAAGACTGG
TACACTTACAACAAACCAGATGTCAGTCTGCAGGATGTTCATTCTGGACAGAGTGGAAGGTGATACTTGTTCCCTTAATGAGTTTACCAT
AACTGGATCAACTTATGCACCTATTGGAGAAGTGCATAAAGATGATAAACCAGTGAATTGTCACCAGTATGATGGTCTGGTAGAATTAGC
AACAATTTGTGCTCTTTGTAATGACTCTGCTTTGGATTACAATGAGGCAAAGGGTGTGTATGAAAAAGTTGGAGAAGCTACAGAGACTGC
TCTCACTTGCCTAGTAGAGAAGATGAATGTATTTGATACCGAATTGAAGGGTCTTTCTAAAATAGAACGTGCAAATGCCTGCAACTCAGT
CATTAAACAGCTGATGAAAAAGGAATTCACTCTAGAGTTTTCACGTGACAGAAAGTCAATGTCGGTTTACTGTACACCAAATAAACCAAG
CAGGACATCAATGAGCAAGATGTTTGTGAAGGGTGCTCCTGAAGGTGTCATTGACAGGTGCACCCACATTCGAGTTGGAAGTACTAAGGT
TCCTATGACCTCTGGAGTCAAACAGAAGATCATGTCTGTCATTCGAGAGTGGGGTAGTGGCAGCGACACACTGCGATGCCTGGCCCTGGC
CACTCATGACAACCCACTGAGAAGAGAAGAAATGCACCTTGAGGACTCTGCCAACTTTATTAAATATGAGACCAATCTGACCTTCGTTGG
CTGCGTGGGCATGCTGGATCCTCCGAGAATCGAGGTGGCCTCCTCCGTGAAGCTGTGCCGGCAAGCAGGCATCCGGGTCATCATGATCAC
TGGGGACAACAAGGGCACTGCTGTGGCCATCTGTCGCCGCATCGGCATCTTCGGGCAGGATGAGGACGTGACGTCAAAAGCTTTCACAGG
CCGGGAGTTTGATGAACTCAACCCCTCCGCCCAGCGAGACGCCTGCCTGAACGCCCGCTGTTTTGCTCGAGTTGAACCCTCCCACAAGTC
TAAAATCGTAGAATTTCTTCAGTCTTTTGATGAGATTACAGCTATGACTGGCGATGGCGTGAACGATGCTCCTGCTCTGAAGAAAGCCGA
GATTGGCATTGCTATGGGCTCTGGCACTGCGGTGGCTAAAACCGCCTCTGAGATGGTCCTGGCGGATGACAACTTCTCCACCATTGTGGC
TGCCGTTGAGGAGGGGCGGGCAATCTACAACAACATGAAACAGTTCATCCGCTACCTCATCTCGTCCAACGTCGGGGAAGTTGTCTGTAT
TTTCCTGACAGCAGCCCTTGGATTTCCCGAGGCTTTGATTCCTGTTCAGCTGCTCTGGGTCAATCTGGTGACAGATGGCCTGCCTGCCAC
TGCACTGGGGTTCAACCCTCCTGATCTGGACATCATGAATAAACCTCCCCGGAACCCAAAGGAACCATTGATCAGCGGGTGGCTCTTTTT
CCGTTACTTGGCTATTGGCTGTGGTTTTACGCACGACGAGCTGCTGAAGGTGTGGAAAGGACTGTTTTATTGCATGTGGATGCAGGACAA
GCCACTCCTCCAGGAAGAATTAGGAAGGACTATTTCCCAGCTCGTTCATGCTTTTCAGACCACGGAGGCGCAGCACCTGTTCCTTCAGGC
CTTCTGGCAGACCATGAATCGCGAGTGGACGGGCATTGACAGGCTGCGCCTGGATAAATTCTACATGCTCATGCGGATGGTCCTGAACGA
GTCCTTGAAGGTTCTGAAGATGCAAGGCTGGGAAGAAAGACAGATCGAGGAGCTGCTAGAGCTGCTGATGACTGAGATCCTGCACCCCAG
CAGCCAGGCCCCCAACGGTGTGAAGAGCCACTTCATCGAGATCTTCCTGGAGGAGCTGACCAAAGTGGGCGCCGAGGAGCTTACGGCAGA
CCAGAACCTGAAGTTCATCGACCCCTTCTGCAGAATTGCTGCCCGGACCAAGGATTCCTTGGTTTTGAACAACATCACTCGAGGCATCTT
TGAGACGATTGTGGAGCAGGCCCCGCTTGCCATTGAAGACCTCCTGAATGAACTGGACACACAGGATGAGGAGGTGGCGTCGGACAGTGA
TGAGTCCTCTGAGGGTGGTGAGCGTGGAGACGCGCTGTCCCAGAAGAGGTCTGAGAAGCCGCCCGCAGGCTCCATCTGCAGGGCTGAACC
TGAGGCTGGTGAGGAGCAGGCAGGTGACGACAGGGACAGTGGCGGCCCCGTTCTCCAGTTTGACTACGAGGCAGTTGCTAACAGACTGTT
TGAAATGGCCAGCCGCCAGAGCACCCCTTCTCAGAACAGAAAGCGTCTCTACAAAGTGATCCGGAAGCTGCAGGACCTGGCAGGAGGCAT
TTTCCCTGAAGATGAGATCCCAGAGAAGGCCTGCAGGCGCCTGCTTGAAGGGAGGCGGCAGAAGAAGACGAAGAAGCAGAAGCGTCTGCT
CAGGTTGCAGCAGGAGAGAGGGAAAGGTGAGAAGGAGCCCCCGAGCCCGGGCATGGAGAGGAAGAGGAGCAGGAGGAGGGGTGTAGGGGC
CGACCCCGAGGCGCGGGCAGAGGCTGGTGAGCAGCCAGGCACAGCTGAGCGGGCCCTGCTCCGAGATCAGCCCAGGGGCCGTGGCCAGAG
AGGGGCTCGCCAGAGAAGGAGGACACCTCGGCCCCTGACCAGTGCCCGAGCAAAGGCGGCCAATGTCCAGGAGCCGGAGAAGAAGAAGAA
ACGCAGGGAGTGATGTGGCCGGGCCAAGGACAGGCAGGGAGGGAGGCCAGGCCTCGCTTGCACCGCGGGACGAGGCTGACCGGGCTGTTC
TGTAGACTCAGGACCGTGGCTCCAGAACTCCTGTGCCAGGCGGGAGGGAAGGGCGGCACTGGAGAGATGGGCCCATCATTAGGGGCCAGC
ATCCCAGGAACTGGACCTTTCCCCAGAGCCTCCGCCTGTGGCTGTGATGACCTTGGGCCAGAAGGTCAAACTCCGAAGACTGAAACTCTG
CCTGCAGCAGGACTGGCCGCCCCTGCTGTGGGGGGTTCAGAAAATAAAATGCCGCGCAGCCCTTGCCAGGGGAAGTGTCGCTTCAGGTGT
GTCCTACGGACGTGTGGGAGGTGGCAGGCGCCAGCCTCCGAGCAGTGTGGTGGTTTATATTCATGTTTGTGGAAAAATCTTGCAAGACAT
TTCTCCTTTCACAGAACTGCCCAGGTGTTAACAGGGCTGTCTGGACGGGGCTCTTTTGCTTCCCCCTCAATCTGGGGTCTAGAGTTGTGC
AAGGAATTCAGCTCCAGTAAGGCCTGGATTGCCCGGGGTGAGCGTGTGTGTGGTGGGAAGACCTGGCTTCCGCGAGAGCCTTGTTCCTGG
AGGCAGGAGCGCCCCGCCATCCTGGGTACCCGCGGGTCCGCAGGCTGCGCACCTCTTTCCCTCAGCCAGGTCACCCTCAGCGTCCTCCCT
GCCCCTCTCCCCTTCACACCTGCTGGAGCCTGTGAGGGAGGTGGCGGGTCCCCACTGTGGCGACGGAGAGCTGACAGTAGCCCAGGGCTT
TCCACCTGCATGGAACAAGGGCCTGTCTGCCGCCAGCGCTGTGGCCACAGCCTGCATAGGTGACAAGGGGCCGCTGCGTTGGGTTTTGCC
CGCATCTTCTGTTCCATGGGTGCCCAGCCAGCCAGGCCGTGTGGGATCCAGCGAGAGGCCAGGGCTTGGAGTGGGCCTGGGACCAGGAAG
GACCTCTAGGCTGTGGCTGGCCTTGTGCAGACCCTGGACTGCATCCGGTTCCCCAAAGCCCTGCTGCATTCGAGTGTCCCCCAACCCCGG
GCAGGTGGCACCTGGTGACACCTCCTTCAGTCCCACTCAGCTGGGCGGCCGGGGCAGGCTTAGGGCACAGTTAGGGGCCAAGGAGAGGGA
AGGCCAGGGCCCCTGTTCTAGGGGTTAGGGTTCTTTCCCCAAAGGAACTTAAAAAGACAAGCGTGGCCAGGCACAGTGGCTCACACCTGT
AATCCCAGCACTTTGGGAGGCCGAGGTGGCCAGATCACCTGAGGTCAGGAGTTTGAGACCAGACTGACCAACATGGAGAAACCCCATCTC
TACTAAAATACAAAATTAGCCAGGCGTGGTGGCACATGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTG
GGAGGCAGAGGTTGTGGTGAGCTAAGATCACGCCATTGCACTCCAGCCTGGGCAACGAGAGGGAAACTCTGTTTCAAAAAAAAAAAAAAA


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FusionGenePPI for ATP2A2_RRP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP2A2PTP4A3, S100A1, PLN, SLN, HGS, HDAC5, AMFR, ELAVL1, SIRT7, SPP1, FBXO25, TRIM13, CUL3, ITPR3, SLC3A2, ECT2, MDC1, ATF2, NOS2, CFTR, CLN3, CLN5, ADRB2, EGFR, ASB1, ASB5, ASB14, ASB17, LGR4, ILK, PTPLAD1, SPRTN, ERLIN2, CUL7, CCDC8, EZH2, SUZ12, RNF2, RIC3, UNK, ATP1B1, LMAN1, MTCH2, UQCRQ, VAPA, NDUFS4, NOTCH2, NTRK1, MDM2, TCTN2, TCTN3, CDK1, PKN2, XRCC3, RAB7A, SLC33A1, KIF23, NCSTN, GOLT1B, TMEM63B, TUBA1C, MBOAT1, SKI, RNF126, ESRRB, C3orf17, DERL1, ZNF746, CTDNEP1, PPEF2, PTPMT1, PTPRK, PTPRT, TPTE, PDHA1, TRIM25RRP1SIRT7, BARD1, PAN2, OBSL1, RNF2, CA14, PNKD, CHST8, SCN2B, PVRL4, SCARNA22, IFI16, MED4, MED20, SRPK2, MDM2, VSIG1, MAK16, TNFRSF13B, EPHA1, NEUROG3, VTN, CLEC3A, KIAA1467, TMEM206, RPL18, CLMP, CDH5, NCL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621575_594840998HAX1
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519575_5948131016HAX1
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620575_5948401043HAX1
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621370_400840998phospholamban 1
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519370_4008131016phospholamban 1
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620370_4008401043phospholamban 1
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621787_807840998phospholamban 2
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519787_8078131016phospholamban 2
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620787_8078401043phospholamban 2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneATP2A2chr12:110781239chr21:45211231ENST00000308664+1621788_1042840998TMEM64 and PDIA3
HgeneATP2A2chr12:110781239chr21:45211231ENST00000395494+1519788_10428131016TMEM64 and PDIA3
HgeneATP2A2chr12:110781239chr21:45211231ENST00000539276+1620788_10428401043TMEM64 and PDIA3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP2A2_RRP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP2A2_RRP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATP2A2C0022595Keratosis Follicularis4CTD_human;ORPHANET;UNIPROT
HgeneATP2A2C0011570Mental Depression2PSYGENET
HgeneATP2A2C0011581Depressive disorder2PSYGENET
HgeneATP2A2C0525045Mood Disorders2PSYGENET
HgeneATP2A2C0005586Bipolar Disorder1HPO;PSYGENET
HgeneATP2A2C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneATP2A2C0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgeneATP2A2C0018799Heart Diseases1CTD_human
HgeneATP2A2C0018800Cardiomegaly1CTD_human
HgeneATP2A2C0018801Heart failure1CTD_human
HgeneATP2A2C0027055Myocardial Reperfusion Injury1CTD_human
HgeneATP2A2C0036341Schizophrenia1HPO;PSYGENET
HgeneATP2A2C0038220Status Epilepticus1CTD_human
HgeneATP2A2C0206146Myocardial Stunning1CTD_human
HgeneATP2A2C0242698Ventricular Dysfunction, Left1CTD_human
HgeneATP2A2C0265971Acrokeratosis Verruciformis of Hopf1ORPHANET;UNIPROT
HgeneATP2A2C0853897Diabetic Cardiomyopathies1CTD_human