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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33338

FusionGeneSummary for SESN1_AIM1

check button Fusion gene summary
Fusion gene informationFusion gene name: SESN1_AIM1
Fusion gene ID: 33338
HgeneTgene
Gene symbol

SESN1

AIM1

Gene ID

27244

51151

Gene namesestrin 1solute carrier family 45 member 2
SynonymsPA26|SEST11A1|AIM1|MATP|OCA4|SHEP5
Cytomap

6q21

5p13.2

Type of geneprotein-codingprotein-coding
Descriptionsestrin-1p53 activated gene 26p53 regulated PA26 nuclear proteinmembrane-associated transporter proteinmelanoma antigen AIM1protein AIM-1underwhite
Modification date2018052320180519
UniProtAcc

Q9Y6P5

Ensembl transtripts involved in fusion geneENST00000436639, ENST00000302071, 
ENST00000356644, ENST00000517548, 
ENST00000369066, ENST00000535438, 
ENST00000487681, 
Fusion gene scores* DoF score8 X 3 X 7=1687 X 7 X 4=196
# samples 87
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SESN1 [Title/Abstract] AND AIM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E2-A155-01ASESN1chr6

109414998

-AIM1chr6

106899569

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000436639ENST00000369066SESN1chr6

109414998

-AIM1chr6

106899569

+
5CDS-intronENST00000436639ENST00000535438SESN1chr6

109414998

-AIM1chr6

106899569

+
5CDS-intronENST00000436639ENST00000487681SESN1chr6

109414998

-AIM1chr6

106899569

+
intron-intronENST00000302071ENST00000369066SESN1chr6

109414998

-AIM1chr6

106899569

+
intron-intronENST00000302071ENST00000535438SESN1chr6

109414998

-AIM1chr6

106899569

+
intron-intronENST00000302071ENST00000487681SESN1chr6

109414998

-AIM1chr6

106899569

+
intron-intronENST00000356644ENST00000369066SESN1chr6

109414998

-AIM1chr6

106899569

+
intron-intronENST00000356644ENST00000535438SESN1chr6

109414998

-AIM1chr6

106899569

+
intron-intronENST00000356644ENST00000487681SESN1chr6

109414998

-AIM1chr6

106899569

+
5UTR-intronENST00000517548ENST00000369066SESN1chr6

109414998

-AIM1chr6

106899569

+
5UTR-intronENST00000517548ENST00000535438SESN1chr6

109414998

-AIM1chr6

106899569

+
5UTR-intronENST00000517548ENST00000487681SESN1chr6

109414998

-AIM1chr6

106899569

+

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FusionProtFeatures for SESN1_AIM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SESN1

Q9Y6P5

AIM1

Functions as an intracellular leucine sensor thatnegatively regulates the TORC1 signaling pathway through the GATORcomplex. In absence of leucine, binds the GATOR subcomplex GATOR2and prevents TORC1 signaling. Binding of leucine to SESN2 disruptsits interaction with GATOR2 thereby activating the TORC1 signalingpathway (PubMed:25263562, PubMed:26449471). This stress-induciblemetabolic regulator may also play a role in protection againstoxidative and genotoxic stresses (By similarity). May positivelyregulate the transcription by NFE2L2 of genes involved in theresponse to oxidative stress by facilitating the SQSTM1-mediatedautophagic degradation of KEAP1 (PubMed:23274085). May have analkylhydroperoxide reductase activity born by the N-terminaldomain of the protein (By similarity). Was originally reported tocontribute to oxidative stress resistance by reducing PRDX1(PubMed:15105503). However, this could not be confirmed (Bysimilarity). {ECO:0000250|UniProtKB:P58004,ECO:0000269|PubMed:15105503, ECO:0000269|PubMed:23274085,ECO:0000269|PubMed:25263562, ECO:0000269|PubMed:26449471}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SESN1_AIM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SESN1_AIM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SESN1PRDX1, SQSTM1, RBX1, KEAP1, NXF1AIM1CUL3, ZNF829, PYHIN1, XPO1, CD44, GSK3A, KIFAP3, CDH1, FBXL4, IL31RA, MRPL38, TBC1D22B, CDK15


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SESN1_AIM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SESN1_AIM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource