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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33320

FusionGeneSummary for SERPINF1_WDR1

check button Fusion gene summary
Fusion gene informationFusion gene name: SERPINF1_WDR1
Fusion gene ID: 33320
HgeneTgene
Gene symbol

SERPINF1

WDR1

Gene ID

5176

9948

Gene nameserpin family F member 1WD repeat domain 1
SynonymsEPC-1|OI12|OI6|PEDF|PIG35AIP1|HEL-S-52|NORI-1
Cytomap

17p13.3

4p16.1

Type of geneprotein-codingprotein-coding
Descriptionpigment epithelium-derived factoralpha-2 antiplasmincell proliferation-inducing gene 35 proteinserine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1serpin peptidase inhibitor, clade F (alWD repeat-containing protein 1actin-interacting protein 1epididymis secretory protein Li 52
Modification date2018052720180523
UniProtAcc

P36955

O75083

Ensembl transtripts involved in fusion geneENST00000254722, ENST00000571870, 
ENST00000499869, ENST00000382451, 
ENST00000382452, ENST00000515743, 
ENST00000502702, 
Fusion gene scores* DoF score4 X 4 X 1=163 X 6 X 2=36
# samples 46
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/36*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SERPINF1 [Title/Abstract] AND WDR1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSERPINF1

GO:0016525

negative regulation of angiogenesis

11562499

HgeneSERPINF1

GO:0050769

positive regulation of neurogenesis

8226833

TgeneWDR1

GO:0030834

regulation of actin filament depolymerization

15629458

TgeneWDR1

GO:0043297

apical junction assembly

25792565

TgeneWDR1

GO:0045199

maintenance of epithelial cell apical/basal polarity

25792565


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA864346SERPINF1chr17

1679946

+WDR1chr4

10090365

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000254722ENST00000499869SERPINF1chr17

1679946

+WDR1chr4

10090365

-
Frame-shiftENST00000254722ENST00000382451SERPINF1chr17

1679946

+WDR1chr4

10090365

-
Frame-shiftENST00000254722ENST00000382452SERPINF1chr17

1679946

+WDR1chr4

10090365

-
5CDS-5UTRENST00000254722ENST00000515743SERPINF1chr17

1679946

+WDR1chr4

10090365

-
5CDS-5UTRENST00000254722ENST00000502702SERPINF1chr17

1679946

+WDR1chr4

10090365

-
intron-3CDSENST00000571870ENST00000499869SERPINF1chr17

1679946

+WDR1chr4

10090365

-
intron-3CDSENST00000571870ENST00000382451SERPINF1chr17

1679946

+WDR1chr4

10090365

-
intron-3CDSENST00000571870ENST00000382452SERPINF1chr17

1679946

+WDR1chr4

10090365

-
intron-5UTRENST00000571870ENST00000515743SERPINF1chr17

1679946

+WDR1chr4

10090365

-
intron-5UTRENST00000571870ENST00000502702SERPINF1chr17

1679946

+WDR1chr4

10090365

-

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FusionProtFeatures for SERPINF1_WDR1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SERPINF1

P36955

WDR1

O75083

Neurotrophic protein; induces extensive neuronaldifferentiation in retinoblastoma cells. Potent inhibitor ofangiogenesis. As it does not undergo the S (stressed) to R(relaxed) conformational transition characteristic of activeserpins, it exhibits no serine protease inhibitory activity.{ECO:0000269|PubMed:7592790, ECO:0000269|PubMed:8226833}. Induces disassembly of actin filaments in conjunctionwith ADF/cofilin family proteins (PubMed:15629458). Enhancescofilin-mediated actin severing (By similarity). Involved incytokinesis. Involved in chemotactic cell migration by restrictinglamellipodial membrane protrusions (PubMed:18494608). Involved inmyocardium sarcomere organization. Required for cardiomyocytegrowth and maintenance (By similarity). Involved in megakaryocytematuration and platelet shedding. Required for the establishmentof planar cell polarity (PCP) during follicular epitheliumdevelopment and for cell shape changes during PCP; the functionseems to implicate cooperation with CFL1 and/or DSTN/ADF. Involvedin the generation/maintenance of cortical tension (By similarity).Involved in assembly and maintenance of epithelial apical celljunctions and plays a role in the organization of theperijunctional actomyosin belt (PubMed:25792565).{ECO:0000250|UniProtKB:O88342, ECO:0000250|UniProtKB:Q9W7F2,ECO:0000269|PubMed:15629458, ECO:0000269|PubMed:18494608,ECO:0000269|PubMed:25792565}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SERPINF1_WDR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SERPINF1_WDR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SERPINF1_WDR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SERPINF1_WDR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSERPINF1C0010043Corneal Ulcer1CTD_human
HgeneSERPINF1C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneSERPINF1C0011875Diabetic Angiopathies1CTD_human
HgeneSERPINF1C0022548Keloid1CTD_human
HgeneSERPINF1C0033578Prostatic Neoplasms1CTD_human
HgeneSERPINF1C0036095Salivary Gland Neoplasms1CTD_human
HgeneSERPINF1C0042164Uveitis1CTD_human
TgeneWDR1C0021368Inflammation1CTD_human
TgeneWDR1C0029456Osteoporosis1CTD_human
TgeneWDR1C0040034Thrombocytopenia1CTD_human