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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 33250

FusionGeneSummary for SERINC2_YY1

check button Fusion gene summary
Fusion gene informationFusion gene name: SERINC2_YY1
Fusion gene ID: 33250
HgeneTgene
Gene symbol

SERINC2

YY1

Gene ID

347735

7528

Gene nameserine incorporator 2YY1 transcription factor
SynonymsFKSG84|PRO0899|TDE2|TDE2LDELTA|GADEVS|INO80S|NF-E1|UCRBP|YIN-YANG-1
Cytomap

1p35.2

14q32.2

Type of geneprotein-codingprotein-coding
Descriptionserine incorporator 2tumor differentially expressed protein 2transcriptional repressor protein YY1INO80 complex subunit SYY-1Yin and Yang 1 proteindelta transcription factor
Modification date2018052320180527
UniProtAcc

Q96SA4

P25490

Ensembl transtripts involved in fusion geneENST00000373710, ENST00000536859, 
ENST00000373709, ENST00000536384, 
ENST00000491976, 		ENST00000262238, 
Fusion gene scores* DoF score9 X 7 X 5=3156 X 4 X 5=120
# samples 117
** MAII scorelog2(11/315*10)=-1.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SERINC2 [Title/Abstract] AND YY1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneYY1

GO:0000122

negative regulation of transcription by RNA polymerase II

9857059|16260628

TgeneYY1

GO:0032688

negative regulation of interferon-beta production

16260628


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-E7-A677-01ASERINC2chr1

31907524

+YY1chr14

100728641

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000373710ENST00000262238SERINC2chr1

31907524

+YY1chr14

100728641

+
intron-3CDSENST00000536859ENST00000262238SERINC2chr1

31907524

+YY1chr14

100728641

+
Frame-shiftENST00000373709ENST00000262238SERINC2chr1

31907524

+YY1chr14

100728641

+
In-frameENST00000536384ENST00000262238SERINC2chr1

31907524

+YY1chr14

100728641

+
Frame-shiftENST00000491976ENST00000262238SERINC2chr1

31907524

+YY1chr14

100728641

+

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FusionProtFeatures for SERINC2_YY1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SERINC2

Q96SA4

YY1

P25490

Multifunctional transcription factor that exhibitspositive and negative control on a large number of cellular andviral genes by binding to sites overlapping the transcriptionstart site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; somegenes have been shown to contain a longer binding motif allowingenhanced binding; the initial CG dinucleotide can be methylatedgreatly reducing the binding affinity. The effect on transcriptionregulation is depending upon the context in which it binds anddiverse mechanisms of action include direct activation orrepression, indirect activation or repression via cofactorrecruitment, or activation or repression by disruption of bindingsites or conformational DNA changes. Its activity is regulated bytranscription factors and cytoplasmic proteins that have beenshown to abrogate or completely inhibit YY1-mediated activation orrepression. For example, it acts as a repressor in absence ofadenovirus E1A protein but as an activator in its presence. Actssynergistically with the SMAD1 and SMAD4 in bone morphogeneticprotein (BMP)-mediated cardiac-specific gene expression(PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiacactivating regions. May play an important role in development anddifferentiation. Proposed to recruit the PRC2/EED-EZH2 complex totarget genes that are transcriptional repressed. Involved in DNArepair. In vitro, binds to DNA recombination intermediatestructures (Holliday junctions). Plays a role in regulatingenhancer activation (PubMed:28575647).{ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:24326773,ECO:0000269|PubMed:25787250, ECO:0000269|PubMed:28575647}. Proposed core component of the chromatin remodelingINO80 complex which is involved in transcriptional regulation, DNAreplication and probably DNA repair; proposed to target the INO80complex to YY1-responsive elements. {ECO:0000269|PubMed:17721549,ECO:0000269|PubMed:18026119}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373709+1010131_150615456TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373709+1010160_182615456TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373709+1010202_224615456TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373709+1010239_256615456TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373709+1010268_290615456TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373709+1010317_339615456TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373709+1010385_407615456TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373709+101040_57615456TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373709+1010422_444615456TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373709+10105_27615456TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373709+101096_118615456TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373710+1111131_150624465TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373710+1111160_182624465TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373710+1111202_224624465TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373710+1111239_256624465TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373710+1111268_290624465TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373710+1111317_339624465TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373710+1111385_407624465TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373710+111140_57624465TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373710+1111422_444624465TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373710+11115_27624465TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000373710+111196_118624465TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536384+1010131_150618460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536384+1010160_182618460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536384+1010202_224618460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536384+1010239_256618460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536384+1010268_290618460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536384+1010317_339618460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536384+1010385_407618460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536384+101040_57618460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536384+1010422_444618460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536384+10105_27618460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536384+101096_118618460TransmembraneHelical
TgeneYY1chr1:31907524chr14:100728641ENST00000262238+05257_341226415RegionNote=Involved in nuclear matrix association
TgeneYY1chr1:31907524chr14:100728641ENST00000262238+05295_414226415RegionNote=Binding to DNA
TgeneYY1chr1:31907524chr14:100728641ENST00000262238+05333_371226415RegionNote=Involved in repression of activated transcription
TgeneYY1chr1:31907524chr14:100728641ENST00000262238+05371_397226415RegionNote=Involved in masking transactivation domain
TgeneYY1chr1:31907524chr14:100728641ENST00000262238+05296_320226415Zinc fingerC2H2-type 1
TgeneYY1chr1:31907524chr14:100728641ENST00000262238+05325_347226415Zinc fingerC2H2-type 2
TgeneYY1chr1:31907524chr14:100728641ENST00000262238+05353_377226415Zinc fingerC2H2-type 3
TgeneYY1chr1:31907524chr14:100728641ENST00000262238+05383_407226415Zinc fingerC2H2-type 4

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536859+110131_150-62460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536859+110160_182-62460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536859+110202_224-62460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536859+110239_256-62460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536859+110268_290-62460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536859+110317_339-62460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536859+110385_407-62460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536859+11040_57-62460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536859+110422_444-62460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536859+1105_27-62460TransmembraneHelical
HgeneSERINC2chr1:31907524chr14:100728641ENST00000536859+11096_118-62460TransmembraneHelical
TgeneYY1chr1:31907524chr14:100728641ENST00000262238+05159_170226415Compositional biasNote=Gly/Ser-rich
TgeneYY1chr1:31907524chr14:100728641ENST00000262238+0543_53226415Compositional biasNote=Asp/Glu-rich (acidic)
TgeneYY1chr1:31907524chr14:100728641ENST00000262238+0554_69226415Compositional biasNote=Gly-rich
TgeneYY1chr1:31907524chr14:100728641ENST00000262238+0570_80226415Compositional biasNote=Poly-His


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FusionGeneSequence for SERINC2_YY1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SERINC2_ENST00000373710_chr1_31907524_+_YY1_ENST00000262238_chr14_100728641_+_813aa
MDGRMMRSMRLREEESPGPSHTASCLCGSAPCILCSCCPASRNSTVSRLIFTFFLFLGVLVSIIMLSPGVESQLYKLPWVCEEGAGIPTV
LQGHIDCGSLLGYRAVYRMCFATAAFFFFFTLLMLCVSSSRDPRAAIQNGFWFFKFLILVGLTVGAFYIPDGSFTNIWFYFGVVGSFLFI
LIQLVLLIDFAHSWNQRWLGKAEECDSRAWYAGLFFFTLLFYLLSIAAVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAVLPKVQD
AQPNSGLLQASVITLYTMFVTWSALSSIPEQKCNPHLPTQLGNETVVAGPEGYETQWWDAPSIVGLIIFLLCTLFISLRSSDHRQVNSLM
QTEECPPMLDATQQQQQVAACEGRAFDNEQDGVTYSYSFFHFCLVLASLHVMMTLTNWYKPGETRKMISTWTAVWVKICASWAGLLLYLW
TLVAPLLLRNRDFSXGSLTACHLVPPATWCLSAQXQPTCPLPTPISQAEPPPLPQLQDLPLSRAFXSXCLQGPRSIRLLQSPIPPPHPHG
GAASSFPSSLLPILSISDERAPLSSGSTGAGLLERAGNSHHSGASGTEALVFLVTSPRGPCPLPGLRALLSLXDFFXXTSQCVYHEKKDI
DHETVVEEQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGP
RVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKN

>In-frame_SERINC2_ENST00000536384_chr1_31907524_+_YY1_ENST00000262238_chr14_100728641_+_807aa
MGAEGAPDFLSCPRVRRASCLCGSAPCILCSCCPASRNSTVSRLIFTFFLFLGVLVSIIMLSPGVESQLYKLPWVCEEGAGIPTVLQGHI
DCGSLLGYRAVYRMCFATAAFFFFFTLLMLCVSSSRDPRAAIQNGFWFFKFLILVGLTVGAFYIPDGSFTNIWFYFGVVGSFLFILIQLV
LLIDFAHSWNQRWLGKAEECDSRAWYAGLFFFTLLFYLLSIAAVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAVLPKVQDAQPNS
GLLQASVITLYTMFVTWSALSSIPEQKCNPHLPTQLGNETVVAGPEGYETQWWDAPSIVGLIIFLLCTLFISLRSSDHRQVNSLMQTEEC
PPMLDATQQQQQVAACEGRAFDNEQDGVTYSYSFFHFCLVLASLHVMMTLTNWYKPGETRKMISTWTAVWVKICASWAGLLLYLWTLVAP
LLLRNRDFSXGSLTACHLVPPATWCLSAQXQPTCPLPTPISQAEPPPLPQLQDLPLSRAFXSXCLQGPRSIRLLQSPIPPPHPHGGAASS
FPSSLLPILSISDERAPLSSGSTGAGLLERAGNSHHSGASGTEALVFLVTSPRGPCPLPGLRALLSLXDFFXXTSQCVYEKKDIDHETVV
EEQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SERINC2_ENST00000373710_chr1_31907524_+_YY1_ENST00000262238_chr14_100728641_+_2439nt
ATGGACGGGAGGATGATGAGAAGCATGAGGCTGAGAGAGGAGGAGTCACCCGGACCCAGCCACACAGCGTCCTGCCTCTGCGGCTCTGCC
CCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTCCTCTTCCTGGGGGTGCTG
GTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGGGCCGGGATCCCCACCGTC
CTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCGGCCTTCTTCTTCTTTTTC
ACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTTAAGTTCCTGATCCTGGTG
GGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTGGGCTCCTTCCTCTTCATC
CTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAGTGCGATTCCCGTGCCTGG
TACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATGTACTACACTGAGCCCAGC
GGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTCCTGCCCAAGGTCCAGGAC
GCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCCCTATCCAGTATCCCTGAA
CAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAGACCCAGTGGTGGGATGCC
CCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGGCAGGTGAACAGCCTGATG
CAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGGGCCTTTGACAACGAGCAG
GACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACGCTCACCAACTGGTACAAG
CCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGGCTGCTCCTCTACCTGTGG
ACCCTGGTAGCCCCACTCCTCCTGCGCAACCGCGACTTCAGCTGAGGCAGCCTCACAGCCTGCCATCTGGTGCCTCCTGCCACCTGGTGC
CTCTCGGCTCAGTGACAGCCAACCTGCCCCCTCCCCACACCAATCAGCCAGGCTGAGCCCCCACCCCTGCCCCAGCTCCAGGACCTGCCC
CTGAGCCGGGCCTTCTAGTCGTAGTGCCTTCAGGGTCCGAGGAGCATCAGGCTCCTGCAGAGCCCCATCCCCCCGCCACACCCACACGGT
GGAGCTGCCTCTTCCTTCCCCTCCTCCCTGTTGCCCATACTCAGCATCTCGGATGAAAGGGCTCCCTTGTCCTCAGGCTCCACGGGAGCG
GGGCTGCTGGAGAGAGCGGGGAACTCCCACCACAGTGGGGCATCCGGCACTGAAGCCCTGGTGTTCCTGGTCACGTCCCCCAGGGGACCC
TGCCCACTTCCTGGACTTCGTGCCTTACTGAGTCTCTAAGACTTTTTCTAATAAACAAGCCAGTGCGTGTACCATGAAAAAAAAGATATT
GACCATGAGACAGTGGTTGAAGAACAGATCATTGGAGAGAACTCACCTCCTGATTATTCAGAATATATGACAGGAAAGAAACTTCCTCCT
GGAGGAATACCTGGCATTGACCTCTCAGATCCCAAACAACTGGCAGAATTTGCTAGAATGAAGCCAAGAAAAATTAAAGAAGATGATGCT
CCAAGAACAATAGCTTGCCCTCATAAAGGCTGCACAAAGATGTTCAGGGATAACTCGGCCATGAGAAAACATCTGCACACCCACGGTCCC
AGAGTCCACGTCTGTGCAGAATGTGGCAAAGCTTTTGTTGAGAGTTCAAAACTAAAACGACACCAACTGGTTCATACTGGAGAGAAGCCC
TTTCAGTGCACGTTCGAAGGCTGTGGGAAACGCTTTTCACTGGACTTCAATTTGCGCACACATGTGCGAATCCATACCGGAGACAGGCCC
TATGTGTGCCCCTTCGATGGTTGTAATAAGAAGTTTGCTCAGTCAACTAACCTGAAATCTCACATCTTAACACATGCTAAGGCCAAAAAC

>In-frame_SERINC2_ENST00000536384_chr1_31907524_+_YY1_ENST00000262238_chr14_100728641_+_2421nt
ATGGGAGCGGAGGGAGCCCCGGACTTTCTTAGCTGCCCTCGAGTGAGGCGGGCGTCCTGCCTCTGCGGCTCTGCCCCCTGCATCCTGTGC
AGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTCCTCTTCCTGGGGGTGCTGGTGTCCATCATTATG
CTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGGGCCGGGATCCCCACCGTCCTGCAGGGCCACATC
GACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCGGCCTTCTTCTTCTTTTTCACCCTGCTCATGCTC
TGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTTAAGTTCCTGATCCTGGTGGGCCTCACCGTGGGT
GCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTGGGCTCCTTCCTCTTCATCCTCATCCAGCTGGTG
CTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAGTGCGATTCCCGTGCCTGGTACGCAGGCCTCTTC
TTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATGTACTACACTGAGCCCAGCGGCTGCCACGAGGGC
AAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTCCTGCCCAAGGTCCAGGACGCCCAGCCCAACTCG
GGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCCCTATCCAGTATCCCTGAACAGAAATGCAACCCC
CATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAGACCCAGTGGTGGGATGCCCCGAGCATTGTGGGC
CTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGGCAGGTGAACAGCCTGATGCAGACCGAGGAGTGC
CCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGGGCCTTTGACAACGAGCAGGACGGCGTCACCTAC
AGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACGCTCACCAACTGGTACAAGCCCGGTGAGACCCGG
AAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGGCTGCTCCTCTACCTGTGGACCCTGGTAGCCCCA
CTCCTCCTGCGCAACCGCGACTTCAGCTGAGGCAGCCTCACAGCCTGCCATCTGGTGCCTCCTGCCACCTGGTGCCTCTCGGCTCAGTGA
CAGCCAACCTGCCCCCTCCCCACACCAATCAGCCAGGCTGAGCCCCCACCCCTGCCCCAGCTCCAGGACCTGCCCCTGAGCCGGGCCTTC
TAGTCGTAGTGCCTTCAGGGTCCGAGGAGCATCAGGCTCCTGCAGAGCCCCATCCCCCCGCCACACCCACACGGTGGAGCTGCCTCTTCC
TTCCCCTCCTCCCTGTTGCCCATACTCAGCATCTCGGATGAAAGGGCTCCCTTGTCCTCAGGCTCCACGGGAGCGGGGCTGCTGGAGAGA
GCGGGGAACTCCCACCACAGTGGGGCATCCGGCACTGAAGCCCTGGTGTTCCTGGTCACGTCCCCCAGGGGACCCTGCCCACTTCCTGGA
CTTCGTGCCTTACTGAGTCTCTAAGACTTTTTCTAATAAACAAGCCAGTGCGTGTATGAAAAAAAAGATATTGACCATGAGACAGTGGTT
GAAGAACAGATCATTGGAGAGAACTCACCTCCTGATTATTCAGAATATATGACAGGAAAGAAACTTCCTCCTGGAGGAATACCTGGCATT
GACCTCTCAGATCCCAAACAACTGGCAGAATTTGCTAGAATGAAGCCAAGAAAAATTAAAGAAGATGATGCTCCAAGAACAATAGCTTGC
CCTCATAAAGGCTGCACAAAGATGTTCAGGGATAACTCGGCCATGAGAAAACATCTGCACACCCACGGTCCCAGAGTCCACGTCTGTGCA
GAATGTGGCAAAGCTTTTGTTGAGAGTTCAAAACTAAAACGACACCAACTGGTTCATACTGGAGAGAAGCCCTTTCAGTGCACGTTCGAA
GGCTGTGGGAAACGCTTTTCACTGGACTTCAATTTGCGCACACATGTGCGAATCCATACCGGAGACAGGCCCTATGTGTGCCCCTTCGAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_SERINC2_ENST00000373710_chr1_31907524_+_YY1_ENST00000262238_chr14_100728641_+_7904nt
TACTTTAGCCTTTGCTCTGAAATCCCATGCACGCTTTGTGAGGAAGGACAGCCTTGGTTGGGGGGTGTTTATGGGGAGAGCAGAGTGGAT
GGTGCGTATGTGAATACCTCTCCCCAGATGCTCCCCCAATCCCAAGCTCTCATTATCTTATATGCATATTCATAAGGGATGGCCCTGCTC
TGTAAATGGGTCAGAAGCAGGAAATAGAGGCCAGTACAGACAGCGAAGCCCAAGGGATAGGAGGGCTCAAAGCCGGCACACATCTGAGTC
CTCATGGACGGGAGGATGATGAGAAGCATGAGGCTGAGAGAGGAGGAGTCACCCGGACCCAGCCACACAGCGTCCTGCCTCTGCGGCTCT
GCCCCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTCCTCTTCCTGGGGGTG
CTGGTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGGGCCGGGATCCCCACC
GTCCTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCGGCCTTCTTCTTCTTT
TTCACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTTAAGTTCCTGATCCTG
GTGGGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTGGGCTCCTTCCTCTTC
ATCCTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAGTGCGATTCCCGTGCC
TGGTACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATGTACTACACTGAGCCC
AGCGGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTCCTGCCCAAGGTCCAG
GACGCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCCCTATCCAGTATCCCT
GAACAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAGACCCAGTGGTGGGAT
GCCCCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGGCAGGTGAACAGCCTG
ATGCAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGGGCCTTTGACAACGAG
CAGGACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACGCTCACCAACTGGTAC
AAGCCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGGCTGCTCCTCTACCTG
TGGACCCTGGTAGCCCCACTCCTCCTGCGCAACCGCGACTTCAGCTGAGGCAGCCTCACAGCCTGCCATCTGGTGCCTCCTGCCACCTGG
TGCCTCTCGGCTCAGTGACAGCCAACCTGCCCCCTCCCCACACCAATCAGCCAGGCTGAGCCCCCACCCCTGCCCCAGCTCCAGGACCTG
CCCCTGAGCCGGGCCTTCTAGTCGTAGTGCCTTCAGGGTCCGAGGAGCATCAGGCTCCTGCAGAGCCCCATCCCCCCGCCACACCCACAC
GGTGGAGCTGCCTCTTCCTTCCCCTCCTCCCTGTTGCCCATACTCAGCATCTCGGATGAAAGGGCTCCCTTGTCCTCAGGCTCCACGGGA
GCGGGGCTGCTGGAGAGAGCGGGGAACTCCCACCACAGTGGGGCATCCGGCACTGAAGCCCTGGTGTTCCTGGTCACGTCCCCCAGGGGA
CCCTGCCCACTTCCTGGACTTCGTGCCTTACTGAGTCTCTAAGACTTTTTCTAATAAACAAGCCAGTGCGTGTACCATGAAAAAAAAGAT
ATTGACCATGAGACAGTGGTTGAAGAACAGATCATTGGAGAGAACTCACCTCCTGATTATTCAGAATATATGACAGGAAAGAAACTTCCT
CCTGGAGGAATACCTGGCATTGACCTCTCAGATCCCAAACAACTGGCAGAATTTGCTAGAATGAAGCCAAGAAAAATTAAAGAAGATGAT
GCTCCAAGAACAATAGCTTGCCCTCATAAAGGCTGCACAAAGATGTTCAGGGATAACTCGGCCATGAGAAAACATCTGCACACCCACGGT
CCCAGAGTCCACGTCTGTGCAGAATGTGGCAAAGCTTTTGTTGAGAGTTCAAAACTAAAACGACACCAACTGGTTCATACTGGAGAGAAG
CCCTTTCAGTGCACGTTCGAAGGCTGTGGGAAACGCTTTTCACTGGACTTCAATTTGCGCACACATGTGCGAATCCATACCGGAGACAGG
CCCTATGTGTGCCCCTTCGATGGTTGTAATAAGAAGTTTGCTCAGTCAACTAACCTGAAATCTCACATCTTAACACATGCTAAGGCCAAA
AACAACCAGTGAAAAGAAGAGAGAAGACCCTTCTCGACCACGGGAAGCATCTTCCAGAAGTGTGATTGGGAATAAATATGCCTCTCCTTT
GTATATTATTTCTAGGAAGAATTTTAAAAATGAATCCTACACACCTAAGGGACATGTTTTGATAAAGTAGTAAAAATTAAAAAAAAAAAA
CTTTACTAAGATGACATTGCTAAGATGCTCTATCTTGCTCTGTAATCTCGTTTCAAAAACACAGTGTTTTTGTAAAGTGTGGTCCCAACA
GGAGGACAATTCATGAACTTCGCATCAAAAGACAATTCTTTATACAACAGTGCTAAAAATGGGACTTCTTTTCACATTCTTATAAATATG
AAGCTCACCTGTTGCTTACAATTTTTTTAATTTTGTATTTTCCAAGTGTGCATATTGTACACTTTTTTGGGGATATGCTTAGTAATGCTA
CGTGTGATTTTTCTGGAGGTTGATAACTTTGCTTGCAGTAGATTTTCTTTAAAAGAATGGGCAGTTACATGCATACTTCAAAAGTATTTT
CCTGTAAAAAAAAAAAAGTTATATAGGTTTTGTTTGCTATCTTAATTTTGGTTGTATTCTTTGATGTTAACACATTTTGTATAATTGTAT
CGTATAGCTGTATTGAATCATGTAGTATCAAATATTAGATGTGATTTAATAGTGTTAATCAATTTAAACCCATTTTAGTCACTTTTTTTT
TCCAAAAAAATACTGCCAGATGCTGATGTTCAGTGTAATTTCTTTGCCTGTTCAGTTACAGAAAGTGGTGCTCAGTTGTAGAATGTATTG
TACCTTTTAACACCTGATGTGTACATCCCATGTAACAGAAAGGGCAACAATAAAATAGCAATCCTAAAGCAAGAATATGGCAGAACAAGA
TCTGTAAGCACAGTCTTATTTTCTTTTGTTGTCCAGAATACTTATAATTCTTGAGCCTCCCAGAAATTGGAAGCTAAATAAAGCAACTCA
AGTTTCCTTTATTTTGCACTCAATTACAGTGATTATTGATGAAAGCGATGCATGGATATTTTAATACTTCCTACATGTCCTGACTTCTGA
AAGAGAGTAGGTAACAGGCATCCCGAGTTCAGGAACTACCTCAGAACACCCCAGGCCAGGTTGGTCATAGGCTGTGATTTTAGCCCCCGG
CAAGTGTGAGTGAAGCATCTGTACCACCGCGCAGGCTGAGCGCCTGCGCAGGGTAAGGTGCCACCTGGCAGTGGGGCACACAGAGGGAAG
ACCAGGCCTGTCCATCAGCCGGCTGCCTTCAGAGGCAGCTCCAGCAGGACCTTGGCTTGTCTGACAGGAAATGCTTGTGGTCGTTGGTTA
TTTGGTTTGAGAGCCCTTGTTCCTCCATCTAGTGGAGTCCTTATTAAATGCTAGCAATGTGGCAATTGAGTGCCAGTAGCTTAATTTCAT
GTTTCTAAATGGACACTGGGTGCAAATCGGCAAGGTGATTAGATTATTAGAAAATTCTGCTCAATGAGTACCTCTCACATTGTAACCTCT
TAAATGTACGATTATAATGTTGGATCTTAGGTCAAATAACAGACTTGAGAATACTTTATAAACTGCCATGATACAGCAAAATCTCATTTA
TTCAAAGTGCAAACATACTGTGTGTCTTTCTGTTTTGTGTATGCTTGACTGCAAGATAAATGACAAACTAGCTAATATCCGAGATTTATT
TACAAATGGCCAGGGACCCCATCAGGTGAAACACATAGCCCATTGTCTTAGAGCTTCTCCATCGGTCCTGTACAGGAGGATTGGTGACCT
ACTAACAGTGACCCTGTGGCTCTGTGGAATTTTGAAGTGCCTTTTGTGAATCATGAATGAAACATTTAACTTGAGACCCTTTAAAAAATT
CATCCAGAATCTGTTACCCCTTGGGTAGTTTGATGGAACTGAGTTAAGCAGAAGACCCCAGCTGTTTTCTGGGTAAGCCAGGCTTTGCTG
TATCTGGCAGTCAGGAGAGAGGTCAGCCCATGGTGGAGGTCTTCAGTGCCGAGGGCTCGGATGAGAACGTGTAGTTCTTTGACTTGGACC
TGGGCAGCGTCTTCTATGGATGCCTGCCTTGTGAGCACCCACACCTTCCCTCCCCACTGTCGGGTTGAGTAGCCCCAGCGTGGCTGTGTT
AGGAGTCCTTTGCCCAACATTGTGCTGCACTGGAGCCTGGCCCTGGCACTGTCCTCAGGACCCTGCCCAAGGGCCCACCGCAGAGCACAC
CTATGCTATGGGGAGCCCTGCTGGCAGCCCCGAGAGCCATGCCATGGCCTGCAGGAGCCAGGCTCCTGTGTGGATGAAGTCCCTCTTCCT
CTGTGCCTTGATCCCTTGGGGGTGCCTTTGGTCATCTCTTCTGTCCTTTCCTGTCTCTGAAATAGTCATCACTCCCCTTGACTCTCTCTG
TTCACGTCTTCTCAGTCTGCAGAGTTAACTTCTGTAAGGAGTTTAATCTGGGGTTCCAAGAAAACAAGTTCCTTGTTAACATAGCACTGA
CTTTGCAACAATAGAAAACTAACAAATGAGCAACAATATAAAGAGTAGAGGTAGTTCTCATTGGGTGTAACTTCAACCCATTCTGCTTGT
GGTTAGAATTTATAATTTTGCTAACGATGTAATTTACTAAGGTTTGAAATGGTATTCTAACAGTGAGTCCATTGTCTTGAGGATTAATCT
GATTTATAAGTAATACTGATAGACATATTTTCGTACATCTGAGCAGAAATAAATGCATGTTTCTAGCATATGTAATATAAAAACTCCAGA
GGATAAGTTTACACTTAACAAGATGTTGTTTTCTATTTTTGAATTTCTTATTATTTCCCCCTTTTTGGTAGTGGAGTTGAGAGGGGGAGC
ATACTATTTGTATAAAGAACTGTCACCCCAGAGTGACATTTATTTTCCAAGATGACCCTGAACTCATGCTGTTGGTTTCATATGGTGTTT
GTGTGCTTTGCCTAGATTCAAGGCCTGAGGATTTGAGGAAAATCGGGATTTTTTTTTTCCTATTTGGTTTTCATGTAAAAGTTCTAAATG
TCACTTATTTTGCTAAATAAGACCCTTTCACAGGATAGTGTGCGCAATACCTGTCCGTGTTTCCAAGCAGAGTTCAAGTTCATGTCTTCA
CAAGTAGATGAGAGTCACTTCCAGTCGGGGGAAGCCCGCCTGAGCAGTGTTTTGAGAGTGCGTACATTGGAGGACTGCCCCACGTCCGTT
TGCACTCTGCCTTGCAAAACTTACTGTGGAGACGTGTCCCAGACTGGTCTCAGACCAGAGTTTGTGGCACAGGAAAACCTGGCCCCCTAA
AAAGAAGTTTTGGAATTGGAAGCCTGATAATTTCGGGAGGCTGAGGCAGGAGAACGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCC
GAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCCCAAAAAAAAAAAAAAAAAAAAAAAAAAGGAAACCTGAC
AATTCTACCCACCTCCCCCCACCCCCGACTATAGGCAAAGAGAGTTGATCACTTCCAGGGTCTCTGACTTCTGTGACCTGGAAATCAGCC
TGGCTTGGGAAATTCATGTTGTTGATCTTTAATTATTTAATTATTCTTTAATAATCCTTCTATTTTCTTGACATCTGACCCCCAGCAAGA
GTAAGGATCCCAGAGGTCAAAACAGTGGTGAGAGCCAAGCTGCTCACAGACACCCACTTGATGCCACAGCCATGCCATGAGGCTTCCTCC
CAGCTGCTCTGCTGGCTTGCTGAAGCCAGCTCTGAGTCACAGGGTTGCCTTGGACCCTCGGCTGTAGGGGGCACCTGTCTGGCTCCGGGC
CCTTTGTCCTGGATACACTGACAGTAATGTGAGCGCAGCACTTCAGAGTTCAGGCCCAGCAGGTCCTGGCAAGTGCATTCCACCCGAACT
TTTAACCCAAGCGGTGGGGAAGGAAGCCAAAACTCCAAGCTGCACTTTCTTGGGGTTCTGGCCATGCACTTCTTAGCCTTCTCTCTGACT
TTACAGGACAAAAGGTACCCCACGCCTTCAGAATCATGCTTACCTGCACGGCAGCATCTGACTGGATGGCTGGCTAGGTCTCATCCACCC
CAAATTACTGACCCTTGATTTATGTTGTTACTGCTCAGGTTATGCTCAGATGCCCTGGTTGCCTGAAGATGGTTTAAGTGCAGGCCCTTC
AGACAAGTCACGTCAGGCAAGAGAGGGCTGGCCTCTGACCCACAAGAGGGCAGATTTGTGGCCAAGAGGCTTCCTGGCATCCACCCCCAG
GCCCAAGGGATCAGTGTGGTGCCAGAGAGGATCTTTAAGCTGGGACTGTACTGAGGCTTGATGGGAAGTATGGGCAGCATGTACTTGACA
CGTTATCACCCAGTCCCCTTGTAAAATCTGGAATGGAGCGTTTAAGCTGAGCGTTAGCATCAGGTCAGCAGGCAAAGCAAACCTCCCACA
AACTGGGTGCCGTAAGGTGGGAGGTGACACATGGAGAGCTTCGTCCTGGCCGAGCAGGCACCCAGCCCCATGTCCCCCGCCAGCATTCTG
GATGTCAGAGGAGGGTGCGTGTGATGGCGTCACATTCATCTGAAGCACACTGATTGATTTTCCACAAGGTGGCAAGTTTGATCAAATTGA
CCGCTTTTCATGAGACACCCAGATGCTGTAAAAAAAAAAAACAGCACTGGGATGTGTTGAGGAGGGGGCAGTTTGCTGTGCTCTGTTCTG
TCTGCTGCTCTCTCTGGGGGCCGCACAATGTCCGCACACATCACGGAGGGGAGAAAGGCATCAGTACCAAACGGAACAACCTCTTTTTTC
TACATTGTCCATACCCGGACATGTGAGGCTCTATTATCAACAGGTGGTGAGAAAAATTATGTTTTTATTCGCTTTCTGGTAACTTCTGTA
GGCCCTGGCTCAAGGACTTAGCATTTCGTCTCATGTACATCTTTTTCTTAAGTGTTCTTTGCCATTTCTGGAATTGTCCTTGGTTTTTCC
TTAGCTCATAGGTCATAGATGCAGAAATATAGTATTTAAGGCATCCGCATCCAGCATCAGATGGCTTTGCATCCAGAAAAACATTGATAA

>In-frame_SERINC2_ENST00000536384_chr1_31907524_+_YY1_ENST00000262238_chr14_100728641_+_7814nt
GTATTTGTCTGGTTCCTGTCTGTGTCCGTCGTTCGTCCGACTGTCTTTGTCCGTCTGCTGTCTTCTGTCCGTCTGCCCGTCCGCCCGTCC
GTCCCTCAGTCTCTCTGCGGTCCCTTTACCGTCCTCAGTCTGGCTCGCGCTGCCTCTCAGGCACTTCCCCAGCTCGCCCCGGATCATCTG
GGCCCCAGCGCGGAGACTGGGATGGGAGCGGAGGGAGCCCCGGACTTTCTTAGCTGCCCTCGAGTGAGGCGGGCGTCCTGCCTCTGCGGC
TCTGCCCCCTGCATCCTGTGCAGCTGCTGCCCCGCCAGCCGCAACTCCACCGTGAGCCGCCTCATCTTCACGTTCTTCCTCTTCCTGGGG
GTGCTGGTGTCCATCATTATGCTGAGCCCGGGCGTGGAGAGTCAGCTCTACAAGCTGCCCTGGGTGTGTGAGGAGGGGGCCGGGATCCCC
ACCGTCCTGCAGGGCCACATCGACTGTGGCTCCCTGCTTGGCTACCGCGCTGTCTACCGCATGTGCTTCGCCACGGCGGCCTTCTTCTTC
TTTTTCACCCTGCTCATGCTCTGCGTGAGCAGCAGCCGGGACCCCCGGGCTGCCATCCAGAATGGGTTTTGGTTCTTTAAGTTCCTGATC
CTGGTGGGCCTCACCGTGGGTGCCTTCTACATTCCTGACGGCTCCTTCACCAACATCTGGTTCTACTTCGGCGTCGTGGGCTCCTTCCTC
TTCATCCTCATCCAGCTGGTGCTGCTCATCGACTTTGCGCACTCCTGGAACCAGCGGTGGCTGGGCAAGGCCGAGGAGTGCGATTCCCGT
GCCTGGTACGCAGGCCTCTTCTTCTTCACTCTCCTCTTCTACTTGCTGTCGATCGCGGCCGTGGCGCTGATGTTCATGTACTACACTGAG
CCCAGCGGCTGCCACGAGGGCAAGGTCTTCATCAGCCTCAACCTCACCTTCTGTGTCTGCGTGTCCATCGCTGCTGTCCTGCCCAAGGTC
CAGGACGCCCAGCCCAACTCGGGTCTGCTGCAGGCCTCGGTCATCACCCTCTACACCATGTTTGTCACCTGGTCAGCCCTATCCAGTATC
CCTGAACAGAAATGCAACCCCCATTTGCCAACCCAGCTGGGCAACGAGACAGTTGTGGCAGGCCCCGAGGGCTATGAGACCCAGTGGTGG
GATGCCCCGAGCATTGTGGGCCTCATCATCTTCCTCCTGTGCACCCTCTTCATCAGTCTGCGCTCCTCAGACCACCGGCAGGTGAACAGC
CTGATGCAGACCGAGGAGTGCCCACCTATGCTAGACGCCACACAGCAGCAGCAGCAGGTGGCAGCCTGTGAGGGCCGGGCCTTTGACAAC
GAGCAGGACGGCGTCACCTACAGCTACTCCTTCTTCCACTTCTGCCTGGTGCTGGCCTCACTGCACGTCATGATGACGCTCACCAACTGG
TACAAGCCCGGTGAGACCCGGAAGATGATCAGCACGTGGACCGCCGTGTGGGTGAAGATCTGTGCCAGCTGGGCAGGGCTGCTCCTCTAC
CTGTGGACCCTGGTAGCCCCACTCCTCCTGCGCAACCGCGACTTCAGCTGAGGCAGCCTCACAGCCTGCCATCTGGTGCCTCCTGCCACC
TGGTGCCTCTCGGCTCAGTGACAGCCAACCTGCCCCCTCCCCACACCAATCAGCCAGGCTGAGCCCCCACCCCTGCCCCAGCTCCAGGAC
CTGCCCCTGAGCCGGGCCTTCTAGTCGTAGTGCCTTCAGGGTCCGAGGAGCATCAGGCTCCTGCAGAGCCCCATCCCCCCGCCACACCCA
CACGGTGGAGCTGCCTCTTCCTTCCCCTCCTCCCTGTTGCCCATACTCAGCATCTCGGATGAAAGGGCTCCCTTGTCCTCAGGCTCCACG
GGAGCGGGGCTGCTGGAGAGAGCGGGGAACTCCCACCACAGTGGGGCATCCGGCACTGAAGCCCTGGTGTTCCTGGTCACGTCCCCCAGG
GGACCCTGCCCACTTCCTGGACTTCGTGCCTTACTGAGTCTCTAAGACTTTTTCTAATAAACAAGCCAGTGCGTGTATGAAAAAAAAGAT
ATTGACCATGAGACAGTGGTTGAAGAACAGATCATTGGAGAGAACTCACCTCCTGATTATTCAGAATATATGACAGGAAAGAAACTTCCT
CCTGGAGGAATACCTGGCATTGACCTCTCAGATCCCAAACAACTGGCAGAATTTGCTAGAATGAAGCCAAGAAAAATTAAAGAAGATGAT
GCTCCAAGAACAATAGCTTGCCCTCATAAAGGCTGCACAAAGATGTTCAGGGATAACTCGGCCATGAGAAAACATCTGCACACCCACGGT
CCCAGAGTCCACGTCTGTGCAGAATGTGGCAAAGCTTTTGTTGAGAGTTCAAAACTAAAACGACACCAACTGGTTCATACTGGAGAGAAG
CCCTTTCAGTGCACGTTCGAAGGCTGTGGGAAACGCTTTTCACTGGACTTCAATTTGCGCACACATGTGCGAATCCATACCGGAGACAGG
CCCTATGTGTGCCCCTTCGATGGTTGTAATAAGAAGTTTGCTCAGTCAACTAACCTGAAATCTCACATCTTAACACATGCTAAGGCCAAA
AACAACCAGTGAAAAGAAGAGAGAAGACCCTTCTCGACCACGGGAAGCATCTTCCAGAAGTGTGATTGGGAATAAATATGCCTCTCCTTT
GTATATTATTTCTAGGAAGAATTTTAAAAATGAATCCTACACACCTAAGGGACATGTTTTGATAAAGTAGTAAAAATTAAAAAAAAAAAA
CTTTACTAAGATGACATTGCTAAGATGCTCTATCTTGCTCTGTAATCTCGTTTCAAAAACACAGTGTTTTTGTAAAGTGTGGTCCCAACA
GGAGGACAATTCATGAACTTCGCATCAAAAGACAATTCTTTATACAACAGTGCTAAAAATGGGACTTCTTTTCACATTCTTATAAATATG
AAGCTCACCTGTTGCTTACAATTTTTTTAATTTTGTATTTTCCAAGTGTGCATATTGTACACTTTTTTGGGGATATGCTTAGTAATGCTA
CGTGTGATTTTTCTGGAGGTTGATAACTTTGCTTGCAGTAGATTTTCTTTAAAAGAATGGGCAGTTACATGCATACTTCAAAAGTATTTT
CCTGTAAAAAAAAAAAAGTTATATAGGTTTTGTTTGCTATCTTAATTTTGGTTGTATTCTTTGATGTTAACACATTTTGTATAATTGTAT
CGTATAGCTGTATTGAATCATGTAGTATCAAATATTAGATGTGATTTAATAGTGTTAATCAATTTAAACCCATTTTAGTCACTTTTTTTT
TCCAAAAAAATACTGCCAGATGCTGATGTTCAGTGTAATTTCTTTGCCTGTTCAGTTACAGAAAGTGGTGCTCAGTTGTAGAATGTATTG
TACCTTTTAACACCTGATGTGTACATCCCATGTAACAGAAAGGGCAACAATAAAATAGCAATCCTAAAGCAAGAATATGGCAGAACAAGA
TCTGTAAGCACAGTCTTATTTTCTTTTGTTGTCCAGAATACTTATAATTCTTGAGCCTCCCAGAAATTGGAAGCTAAATAAAGCAACTCA
AGTTTCCTTTATTTTGCACTCAATTACAGTGATTATTGATGAAAGCGATGCATGGATATTTTAATACTTCCTACATGTCCTGACTTCTGA
AAGAGAGTAGGTAACAGGCATCCCGAGTTCAGGAACTACCTCAGAACACCCCAGGCCAGGTTGGTCATAGGCTGTGATTTTAGCCCCCGG
CAAGTGTGAGTGAAGCATCTGTACCACCGCGCAGGCTGAGCGCCTGCGCAGGGTAAGGTGCCACCTGGCAGTGGGGCACACAGAGGGAAG
ACCAGGCCTGTCCATCAGCCGGCTGCCTTCAGAGGCAGCTCCAGCAGGACCTTGGCTTGTCTGACAGGAAATGCTTGTGGTCGTTGGTTA
TTTGGTTTGAGAGCCCTTGTTCCTCCATCTAGTGGAGTCCTTATTAAATGCTAGCAATGTGGCAATTGAGTGCCAGTAGCTTAATTTCAT
GTTTCTAAATGGACACTGGGTGCAAATCGGCAAGGTGATTAGATTATTAGAAAATTCTGCTCAATGAGTACCTCTCACATTGTAACCTCT
TAAATGTACGATTATAATGTTGGATCTTAGGTCAAATAACAGACTTGAGAATACTTTATAAACTGCCATGATACAGCAAAATCTCATTTA
TTCAAAGTGCAAACATACTGTGTGTCTTTCTGTTTTGTGTATGCTTGACTGCAAGATAAATGACAAACTAGCTAATATCCGAGATTTATT
TACAAATGGCCAGGGACCCCATCAGGTGAAACACATAGCCCATTGTCTTAGAGCTTCTCCATCGGTCCTGTACAGGAGGATTGGTGACCT
ACTAACAGTGACCCTGTGGCTCTGTGGAATTTTGAAGTGCCTTTTGTGAATCATGAATGAAACATTTAACTTGAGACCCTTTAAAAAATT
CATCCAGAATCTGTTACCCCTTGGGTAGTTTGATGGAACTGAGTTAAGCAGAAGACCCCAGCTGTTTTCTGGGTAAGCCAGGCTTTGCTG
TATCTGGCAGTCAGGAGAGAGGTCAGCCCATGGTGGAGGTCTTCAGTGCCGAGGGCTCGGATGAGAACGTGTAGTTCTTTGACTTGGACC
TGGGCAGCGTCTTCTATGGATGCCTGCCTTGTGAGCACCCACACCTTCCCTCCCCACTGTCGGGTTGAGTAGCCCCAGCGTGGCTGTGTT
AGGAGTCCTTTGCCCAACATTGTGCTGCACTGGAGCCTGGCCCTGGCACTGTCCTCAGGACCCTGCCCAAGGGCCCACCGCAGAGCACAC
CTATGCTATGGGGAGCCCTGCTGGCAGCCCCGAGAGCCATGCCATGGCCTGCAGGAGCCAGGCTCCTGTGTGGATGAAGTCCCTCTTCCT
CTGTGCCTTGATCCCTTGGGGGTGCCTTTGGTCATCTCTTCTGTCCTTTCCTGTCTCTGAAATAGTCATCACTCCCCTTGACTCTCTCTG
TTCACGTCTTCTCAGTCTGCAGAGTTAACTTCTGTAAGGAGTTTAATCTGGGGTTCCAAGAAAACAAGTTCCTTGTTAACATAGCACTGA
CTTTGCAACAATAGAAAACTAACAAATGAGCAACAATATAAAGAGTAGAGGTAGTTCTCATTGGGTGTAACTTCAACCCATTCTGCTTGT
GGTTAGAATTTATAATTTTGCTAACGATGTAATTTACTAAGGTTTGAAATGGTATTCTAACAGTGAGTCCATTGTCTTGAGGATTAATCT
GATTTATAAGTAATACTGATAGACATATTTTCGTACATCTGAGCAGAAATAAATGCATGTTTCTAGCATATGTAATATAAAAACTCCAGA
GGATAAGTTTACACTTAACAAGATGTTGTTTTCTATTTTTGAATTTCTTATTATTTCCCCCTTTTTGGTAGTGGAGTTGAGAGGGGGAGC
ATACTATTTGTATAAAGAACTGTCACCCCAGAGTGACATTTATTTTCCAAGATGACCCTGAACTCATGCTGTTGGTTTCATATGGTGTTT
GTGTGCTTTGCCTAGATTCAAGGCCTGAGGATTTGAGGAAAATCGGGATTTTTTTTTTCCTATTTGGTTTTCATGTAAAAGTTCTAAATG
TCACTTATTTTGCTAAATAAGACCCTTTCACAGGATAGTGTGCGCAATACCTGTCCGTGTTTCCAAGCAGAGTTCAAGTTCATGTCTTCA
CAAGTAGATGAGAGTCACTTCCAGTCGGGGGAAGCCCGCCTGAGCAGTGTTTTGAGAGTGCGTACATTGGAGGACTGCCCCACGTCCGTT
TGCACTCTGCCTTGCAAAACTTACTGTGGAGACGTGTCCCAGACTGGTCTCAGACCAGAGTTTGTGGCACAGGAAAACCTGGCCCCCTAA
AAAGAAGTTTTGGAATTGGAAGCCTGATAATTTCGGGAGGCTGAGGCAGGAGAACGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCC
GAGATCGCACCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCCCAAAAAAAAAAAAAAAAAAAAAAAAAAGGAAACCTGAC
AATTCTACCCACCTCCCCCCACCCCCGACTATAGGCAAAGAGAGTTGATCACTTCCAGGGTCTCTGACTTCTGTGACCTGGAAATCAGCC
TGGCTTGGGAAATTCATGTTGTTGATCTTTAATTATTTAATTATTCTTTAATAATCCTTCTATTTTCTTGACATCTGACCCCCAGCAAGA
GTAAGGATCCCAGAGGTCAAAACAGTGGTGAGAGCCAAGCTGCTCACAGACACCCACTTGATGCCACAGCCATGCCATGAGGCTTCCTCC
CAGCTGCTCTGCTGGCTTGCTGAAGCCAGCTCTGAGTCACAGGGTTGCCTTGGACCCTCGGCTGTAGGGGGCACCTGTCTGGCTCCGGGC
CCTTTGTCCTGGATACACTGACAGTAATGTGAGCGCAGCACTTCAGAGTTCAGGCCCAGCAGGTCCTGGCAAGTGCATTCCACCCGAACT
TTTAACCCAAGCGGTGGGGAAGGAAGCCAAAACTCCAAGCTGCACTTTCTTGGGGTTCTGGCCATGCACTTCTTAGCCTTCTCTCTGACT
TTACAGGACAAAAGGTACCCCACGCCTTCAGAATCATGCTTACCTGCACGGCAGCATCTGACTGGATGGCTGGCTAGGTCTCATCCACCC
CAAATTACTGACCCTTGATTTATGTTGTTACTGCTCAGGTTATGCTCAGATGCCCTGGTTGCCTGAAGATGGTTTAAGTGCAGGCCCTTC
AGACAAGTCACGTCAGGCAAGAGAGGGCTGGCCTCTGACCCACAAGAGGGCAGATTTGTGGCCAAGAGGCTTCCTGGCATCCACCCCCAG
GCCCAAGGGATCAGTGTGGTGCCAGAGAGGATCTTTAAGCTGGGACTGTACTGAGGCTTGATGGGAAGTATGGGCAGCATGTACTTGACA
CGTTATCACCCAGTCCCCTTGTAAAATCTGGAATGGAGCGTTTAAGCTGAGCGTTAGCATCAGGTCAGCAGGCAAAGCAAACCTCCCACA
AACTGGGTGCCGTAAGGTGGGAGGTGACACATGGAGAGCTTCGTCCTGGCCGAGCAGGCACCCAGCCCCATGTCCCCCGCCAGCATTCTG
GATGTCAGAGGAGGGTGCGTGTGATGGCGTCACATTCATCTGAAGCACACTGATTGATTTTCCACAAGGTGGCAAGTTTGATCAAATTGA
CCGCTTTTCATGAGACACCCAGATGCTGTAAAAAAAAAAAACAGCACTGGGATGTGTTGAGGAGGGGGCAGTTTGCTGTGCTCTGTTCTG
TCTGCTGCTCTCTCTGGGGGCCGCACAATGTCCGCACACATCACGGAGGGGAGAAAGGCATCAGTACCAAACGGAACAACCTCTTTTTTC
TACATTGTCCATACCCGGACATGTGAGGCTCTATTATCAACAGGTGGTGAGAAAAATTATGTTTTTATTCGCTTTCTGGTAACTTCTGTA
GGCCCTGGCTCAAGGACTTAGCATTTCGTCTCATGTACATCTTTTTCTTAAGTGTTCTTTGCCATTTCTGGAATTGTCCTTGGTTTTTCC
TTAGCTCATAGGTCATAGATGCAGAAATATAGTATTTAAGGCATCCGCATCCAGCATCAGATGGCTTTGCATCCAGAAAAACATTGATAA


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FusionGenePPI for SERINC2_YY1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SERINC2ATP6V0A2, ATP6V0A1, GHITM, ATP6V0D1, STOM, TMBIM6, LGALS3, GPR89BYY1FKBP1A, YAF2, MTA2, NOTCH1, SAP30, HDAC1, HDAC2, HDAC3, KAT2B, EP300, FKBP3, RYBP, SP1, SREBF1, MYC, ATF6, PPIA, CTCF, HDAC4, ATF2, ZNF232, HOXA11, MAX, CREBBP, HDAC5, TP53, MDM2, CDKN2A, SMAD4, SMAD1, SMAD2, SMAD3, PRMT1, ILF3, NPM1, TFAP2A, EZH2, INO80, TFCP2, PRKDC, ACTR8, HSPA4, ACTR5, ACTL6A, RUVBL1, RUVBL2, RELB, YY1, JUNB, JUND, RB1, NFE2L2, MECP2, TERF1, TERF2, INO80C, INO80E, NFRKB, TCF3, INO80B, UCHL5, INO80D, MCRS1, TFPT, HSPA5, BCL6, NEDD4, UHRF2, CREB1, ATF7, BAP1, HCFC1, NEDD4L, XRCC6, XRCC5, SMARCAD1, DDX5, DDX3X, SP3, PSMD9, SKP2, ELAVL1, EED, APP, ZNF830, NHP2L1, ZNF638, NCL, WDHD1, ZNF24, ARRB1, RING1, RNF2, PCGF2, LAMC2, GABPB1, GABPA, SLC39A7, CRKL, GRN, NFKB1, RAF1, TESK1, NR1H2, SPRY1, SHFM1, SMURF2, SUZ12, BMI1, TWIST1, PPP1R3B, TMEM150A, TRPV5, CEP164, BAX, FOXB1, FOXJ2, FOXL1, FOXN1, KMT2E, DNMT3L, AURKA, ID2, F9, TRIM25, AGO2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneYY1chr1:31907524chr14:100728641ENST00000262238+051_170226415the SMAD1/SMAD4 complex


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SERINC2_YY1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SERINC2_YY1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSERINC2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneYY1C0007873Uterine Cervical Neoplasm1CTD_human
TgeneYY1C0019693HIV Infections1CTD_human
TgeneYY1C3714756Intellectual Disability1CTD_human