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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33231

FusionGeneSummary for SERF1B_RNF111

check button Fusion gene summary
Fusion gene informationFusion gene name: SERF1B_RNF111
Fusion gene ID: 33231
HgeneTgene
Gene symbol

SERF1B

RNF111

Gene ID

728492

54778

Gene namesmall EDRK-rich factor 1Bring finger protein 111
SynonymsFAM2B|H4F5C|h4F5ARK|hRNF111
Cytomap

5q13.2

15q22.1-q22.2

Type of geneprotein-codingprotein-coding
Descriptionsmall EDRK-rich factor 1SMA modifier 1protein 4F5small EDRK-rich factor 1B (centromeric)E3 ubiquitin-protein ligase ArkadiaArkadiaRING-type E3 ubiquitin transferase Arkadia
Modification date2018032920180523
UniProtAcc

O75920

Q6ZNA4

Ensembl transtripts involved in fusion geneENST00000380750, ENST00000506542, 
ENST00000515588, ENST00000380751, 
ENST00000503931, ENST00000514285, 
ENST00000348370, ENST00000434298, 
ENST00000559209, ENST00000557998, 
ENST00000561186, ENST00000560080, 
Fusion gene scores* DoF score2 X 1 X 1=27 X 6 X 5=210
# samples 27
** MAII scorelog2(2/2*10)=3.32192809488736log2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SERF1B [Title/Abstract] AND RNF111 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-BF-A5EQ-01ASERF1Bchr5

69322342

+RNF111chr15

59358963

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000380750ENST00000348370SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000380750ENST00000434298SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000380750ENST00000559209SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000380750ENST00000557998SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000380750ENST00000561186SERF1Bchr5

69322342

+RNF111chr15

59358963

+
5CDS-intronENST00000380750ENST00000560080SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000506542ENST00000348370SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000506542ENST00000434298SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000506542ENST00000559209SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000506542ENST00000557998SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000506542ENST00000561186SERF1Bchr5

69322342

+RNF111chr15

59358963

+
5CDS-intronENST00000506542ENST00000560080SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000515588ENST00000348370SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000515588ENST00000434298SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000515588ENST00000559209SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000515588ENST00000557998SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000515588ENST00000561186SERF1Bchr5

69322342

+RNF111chr15

59358963

+
5CDS-intronENST00000515588ENST00000560080SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000380751ENST00000348370SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000380751ENST00000434298SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000380751ENST00000559209SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000380751ENST00000557998SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000380751ENST00000561186SERF1Bchr5

69322342

+RNF111chr15

59358963

+
5CDS-intronENST00000380751ENST00000560080SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000503931ENST00000348370SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000503931ENST00000434298SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000503931ENST00000559209SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000503931ENST00000557998SERF1Bchr5

69322342

+RNF111chr15

59358963

+
Frame-shiftENST00000503931ENST00000561186SERF1Bchr5

69322342

+RNF111chr15

59358963

+
5CDS-intronENST00000503931ENST00000560080SERF1Bchr5

69322342

+RNF111chr15

59358963

+
3UTR-3CDSENST00000514285ENST00000348370SERF1Bchr5

69322342

+RNF111chr15

59358963

+
3UTR-3CDSENST00000514285ENST00000434298SERF1Bchr5

69322342

+RNF111chr15

59358963

+
3UTR-3CDSENST00000514285ENST00000559209SERF1Bchr5

69322342

+RNF111chr15

59358963

+
3UTR-3CDSENST00000514285ENST00000557998SERF1Bchr5

69322342

+RNF111chr15

59358963

+
3UTR-3CDSENST00000514285ENST00000561186SERF1Bchr5

69322342

+RNF111chr15

59358963

+
3UTR-intronENST00000514285ENST00000560080SERF1Bchr5

69322342

+RNF111chr15

59358963

+

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FusionProtFeatures for SERF1B_RNF111


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SERF1B

O75920

RNF111

Q6ZNA4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SERF1B_RNF111


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SERF1B_RNF111


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SERF1BRNF111SMAD3, SMAD6, SMAD7, SKIL, SMAD2, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E3, UBE2G2, UBE2W, UBE2I, UBE2M, UBE2V1, UBE2K, UBE2E2, UBE2Q2, TSG101, CREB1, SKI, RB1CC1, SUMO2, SUMO1, FHL2, RNF111, HSP90AA1, SMURF2, PML, UBE2N, XPC, DTX3L, TRIM21, ANAPC11, LRSAM1, MARCH7, PHF7, TRIM8, TRAF5, CSNK2A2, CTBP1, MVP, ACTN3, CSNK2A1, KRTAP5-9, EDARADD, LCE4A, SUMO3, NR4A1, AXIN2, UBC, ESRP2, ESRP1, SETD7, FAM189B, UBXN7, TPX2, DCUN1D5, TTC9C, SUGP1, CGGBP1, RBM27, GNAQ, ADD3, C21orf59, SPAST


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SERF1B_RNF111


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SERF1B_RNF111


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource