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Fusion gene ID: 33221 |
FusionGeneSummary for SEPHS1_PTER |
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Fusion gene information | Fusion gene name: SEPHS1_PTER | Fusion gene ID: 33221 | Hgene | Tgene | Gene symbol | SEPHS1 | PTER | Gene ID | 22929 | 9317 |
Gene name | selenophosphate synthetase 1 | phosphotriesterase related | |
Synonyms | SELD|SPS|SPS1 | HPHRP|RPR-1 | |
Cytomap | 10p13 | 10p13 | |
Type of gene | protein-coding | protein-coding | |
Description | selenide, water dikinase 1selenium donor protein 1selenophosphate synthase 1selenophosphate synthetase 1 +E9selenophosphate synthetase 1 +E9aselenophosphate synthetase 1 delta E2selenophosphate synthetase 1 delta E8selenophosphate synthetase 1 majo | phosphotriesterase-related proteinparathion hydrolase-related proteinresiniferatoxin-binding, phosphotriesterase-related | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P49903 | Q96BW5 | |
Ensembl transtripts involved in fusion gene | ENST00000327347, ENST00000378614, ENST00000545675, ENST00000537130, ENST00000494329, | ENST00000535784, ENST00000423462, ENST00000378000, ENST00000298942, ENST00000485788, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
# samples | 1 | 2 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: SEPHS1 [Title/Abstract] AND PTER [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | CHOL | TCGA-3X-AAVE-01A | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000327347 | ENST00000535784 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5CDS-intron | ENST00000327347 | ENST00000423462 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5CDS-intron | ENST00000327347 | ENST00000378000 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5CDS-intron | ENST00000327347 | ENST00000298942 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5CDS-intron | ENST00000327347 | ENST00000485788 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
Frame-shift | ENST00000378614 | ENST00000535784 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5CDS-intron | ENST00000378614 | ENST00000423462 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5CDS-intron | ENST00000378614 | ENST00000378000 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5CDS-intron | ENST00000378614 | ENST00000298942 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5CDS-intron | ENST00000378614 | ENST00000485788 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
Frame-shift | ENST00000545675 | ENST00000535784 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5CDS-intron | ENST00000545675 | ENST00000423462 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5CDS-intron | ENST00000545675 | ENST00000378000 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5CDS-intron | ENST00000545675 | ENST00000298942 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5CDS-intron | ENST00000545675 | ENST00000485788 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
intron-3CDS | ENST00000537130 | ENST00000535784 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
intron-intron | ENST00000537130 | ENST00000423462 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
intron-intron | ENST00000537130 | ENST00000378000 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
intron-intron | ENST00000537130 | ENST00000298942 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
intron-intron | ENST00000537130 | ENST00000485788 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5UTR-3CDS | ENST00000494329 | ENST00000535784 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5UTR-intron | ENST00000494329 | ENST00000423462 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5UTR-intron | ENST00000494329 | ENST00000378000 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5UTR-intron | ENST00000494329 | ENST00000298942 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
5UTR-intron | ENST00000494329 | ENST00000485788 | SEPHS1 | chr10 | 13386758 | - | PTER | chr10 | 16547019 | + |
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FusionProtFeatures for SEPHS1_PTER |
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Hgene | Tgene |
SEPHS1 | PTER |
Synthesizes selenophosphate from selenide and ATP.{ECO:0000269|PubMed:7665581}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SEPHS1_PTER |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SEPHS1_PTER |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SEPHS1 | SEPHS1, C9orf9, GBP2, SAT1, SLC35F6, IGSF21, UNC119, C14orf1, CRMP1, ELAVL1, CUL3, PPIL3, XPO7, PFAS, AHCYL1, GART, PIPSL, HYPK, COPS2, PUM1, TPD52, WDR12, ZBTB25, QRICH1, SOX2, TAS2R41, CCDC130, ACADS, CRKL, DDX19A, G6PD, HSPB1, MCFD2, PDCD6, RTCB, SEC13, CLIC1, CLIC4, DIS3, ECH1, FDPS, MAT2B, PTPRF, REXO2, UMPS, XPO1, SUGT1, TUFM, CDCA4, DEPDC7, HLX | PTER | PRKDC, XRCC5, TMEM51, NPDC1, TEKT2, LIPH, ABCE1, MCM2, KHDRBS2, HYAL3, S1PR2, RNMTL1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SEPHS1_PTER |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEPHS1_PTER |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PTER | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | PTER | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | PTER | C0025202 | melanoma | 1 | CTD_human |