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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33221

FusionGeneSummary for SEPHS1_PTER

check button Fusion gene summary
Fusion gene informationFusion gene name: SEPHS1_PTER
Fusion gene ID: 33221
HgeneTgene
Gene symbol

SEPHS1

PTER

Gene ID

22929

9317

Gene nameselenophosphate synthetase 1phosphotriesterase related
SynonymsSELD|SPS|SPS1HPHRP|RPR-1
Cytomap

10p13

10p13

Type of geneprotein-codingprotein-coding
Descriptionselenide, water dikinase 1selenium donor protein 1selenophosphate synthase 1selenophosphate synthetase 1 +E9selenophosphate synthetase 1 +E9aselenophosphate synthetase 1 delta E2selenophosphate synthetase 1 delta E8selenophosphate synthetase 1 majophosphotriesterase-related proteinparathion hydrolase-related proteinresiniferatoxin-binding, phosphotriesterase-related
Modification date2018052320180523
UniProtAcc

P49903

Q96BW5

Ensembl transtripts involved in fusion geneENST00000327347, ENST00000378614, 
ENST00000545675, ENST00000537130, 
ENST00000494329, 		ENST00000535784, 
ENST00000423462, ENST00000378000, 
ENST00000298942, ENST00000485788, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: SEPHS1 [Title/Abstract] AND PTER [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCHOLTCGA-3X-AAVE-01ASEPHS1chr10

13386758

-PTERchr10

16547019

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000327347ENST00000535784SEPHS1chr10

13386758

-PTERchr10

16547019

+
5CDS-intronENST00000327347ENST00000423462SEPHS1chr10

13386758

-PTERchr10

16547019

+
5CDS-intronENST00000327347ENST00000378000SEPHS1chr10

13386758

-PTERchr10

16547019

+
5CDS-intronENST00000327347ENST00000298942SEPHS1chr10

13386758

-PTERchr10

16547019

+
5CDS-intronENST00000327347ENST00000485788SEPHS1chr10

13386758

-PTERchr10

16547019

+
Frame-shitENST00000378614ENST00000535784SEPHS1chr10

13386758

-PTERchr10

16547019

+
5CDS-intronENST00000378614ENST00000423462SEPHS1chr10

13386758

-PTERchr10

16547019

+
5CDS-intronENST00000378614ENST00000378000SEPHS1chr10

13386758

-PTERchr10

16547019

+
5CDS-intronENST00000378614ENST00000298942SEPHS1chr10

13386758

-PTERchr10

16547019

+
5CDS-intronENST00000378614ENST00000485788SEPHS1chr10

13386758

-PTERchr10

16547019

+
Frame-shitENST00000545675ENST00000535784SEPHS1chr10

13386758

-PTERchr10

16547019

+
5CDS-intronENST00000545675ENST00000423462SEPHS1chr10

13386758

-PTERchr10

16547019

+
5CDS-intronENST00000545675ENST00000378000SEPHS1chr10

13386758

-PTERchr10

16547019

+
5CDS-intronENST00000545675ENST00000298942SEPHS1chr10

13386758

-PTERchr10

16547019

+
5CDS-intronENST00000545675ENST00000485788SEPHS1chr10

13386758

-PTERchr10

16547019

+
intron-3CDSENST00000537130ENST00000535784SEPHS1chr10

13386758

-PTERchr10

16547019

+
intron-intronENST00000537130ENST00000423462SEPHS1chr10

13386758

-PTERchr10

16547019

+
intron-intronENST00000537130ENST00000378000SEPHS1chr10

13386758

-PTERchr10

16547019

+
intron-intronENST00000537130ENST00000298942SEPHS1chr10

13386758

-PTERchr10

16547019

+
intron-intronENST00000537130ENST00000485788SEPHS1chr10

13386758

-PTERchr10

16547019

+
5UTR-3CDSENST00000494329ENST00000535784SEPHS1chr10

13386758

-PTERchr10

16547019

+
5UTR-intronENST00000494329ENST00000423462SEPHS1chr10

13386758

-PTERchr10

16547019

+
5UTR-intronENST00000494329ENST00000378000SEPHS1chr10

13386758

-PTERchr10

16547019

+
5UTR-intronENST00000494329ENST00000298942SEPHS1chr10

13386758

-PTERchr10

16547019

+
5UTR-intronENST00000494329ENST00000485788SEPHS1chr10

13386758

-PTERchr10

16547019

+

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FusionProtFeatures for SEPHS1_PTER


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEPHS1

P49903

PTER

Q96BW5

Synthesizes selenophosphate from selenide and ATP.{ECO:0000269|PubMed:7665581}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEPHS1_PTER


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEPHS1_PTER


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEPHS1SEPHS1, C9orf9, GBP2, SAT1, SLC35F6, IGSF21, UNC119, C14orf1, CRMP1, ELAVL1, CUL3, PPIL3, XPO7, PFAS, AHCYL1, GART, PIPSL, HYPK, COPS2, PUM1, TPD52, WDR12, ZBTB25, QRICH1, SOX2, TAS2R41, CCDC130, ACADS, CRKL, DDX19A, G6PD, HSPB1, MCFD2, PDCD6, RTCB, SEC13, CLIC1, CLIC4, DIS3, ECH1, FDPS, MAT2B, PTPRF, REXO2, UMPS, XPO1, SUGT1, TUFM, CDCA4, DEPDC7, HLXPTERPRKDC, XRCC5, TMEM51, NPDC1, TEKT2, LIPH, ABCE1, MCM2, KHDRBS2, HYAL3, S1PR2, RNMTL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEPHS1_PTER


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEPHS1_PTER


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTERC0023893Liver Cirrhosis, Experimental1CTD_human
TgenePTERC0023903Liver neoplasms1CTD_human
TgenePTERC0025202melanoma1CTD_human