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Fusion gene ID: 332 |
FusionGeneSummary for ACAD11_ABCE1 |
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Fusion gene information | Fusion gene name: ACAD11_ABCE1 | Fusion gene ID: 332 | Hgene | Tgene | Gene symbol | ACAD11 | ABCE1 | Gene ID | 84129 | 6059 |
Gene name | acyl-CoA dehydrogenase family member 11 | ATP binding cassette subfamily E member 1 | |
Synonyms | ACAD-11 | ABC38|OABP|RLI|RLI1|RNASEL1|RNASELI|RNS4I | |
Cytomap | 3q22.1 | 4q31.21 | |
Type of gene | protein-coding | protein-coding | |
Description | acyl-CoA dehydrogenase family member 11acyl-Coenzyme A dehydrogenase family, member 11 | ATP-binding cassette sub-family E member 12'-5'-oligoadenylate-binding proteinATP-binding cassette, sub-family E (OABP), member 1RNase L inhibitor 1huHP68ribonuclease 4 inhibitorribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q709F0 | P61221 | |
Ensembl transtripts involved in fusion gene | ENST00000355458, ENST00000264990, ENST00000545291, ENST00000481970, ENST00000489991, | ENST00000296577, ENST00000502803, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 1 X 2=4 |
# samples | 2 | 2 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: ACAD11 [Title/Abstract] AND ABCE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ACAD11 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase | 21237683 |
Tgene | ABCE1 | GO:0060702 | negative regulation of endoribonuclease activity | 7539425 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-A3UA-01A | ACAD11 | chr3 | 132360816 | - | ABCE1 | chr4 | 146025538 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000355458 | ENST00000296577 | ACAD11 | chr3 | 132360816 | - | ABCE1 | chr4 | 146025538 | + |
5CDS-3UTR | ENST00000355458 | ENST00000502803 | ACAD11 | chr3 | 132360816 | - | ABCE1 | chr4 | 146025538 | + |
5CDS-5UTR | ENST00000264990 | ENST00000296577 | ACAD11 | chr3 | 132360816 | - | ABCE1 | chr4 | 146025538 | + |
5CDS-3UTR | ENST00000264990 | ENST00000502803 | ACAD11 | chr3 | 132360816 | - | ABCE1 | chr4 | 146025538 | + |
5UTR-5UTR | ENST00000545291 | ENST00000296577 | ACAD11 | chr3 | 132360816 | - | ABCE1 | chr4 | 146025538 | + |
5UTR-3UTR | ENST00000545291 | ENST00000502803 | ACAD11 | chr3 | 132360816 | - | ABCE1 | chr4 | 146025538 | + |
5CDS-5UTR | ENST00000481970 | ENST00000296577 | ACAD11 | chr3 | 132360816 | - | ABCE1 | chr4 | 146025538 | + |
5CDS-3UTR | ENST00000481970 | ENST00000502803 | ACAD11 | chr3 | 132360816 | - | ABCE1 | chr4 | 146025538 | + |
intron-5UTR | ENST00000489991 | ENST00000296577 | ACAD11 | chr3 | 132360816 | - | ABCE1 | chr4 | 146025538 | + |
intron-3UTR | ENST00000489991 | ENST00000502803 | ACAD11 | chr3 | 132360816 | - | ABCE1 | chr4 | 146025538 | + |
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FusionProtFeatures for ACAD11_ABCE1 |
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Hgene | Tgene |
ACAD11 | ABCE1 |
Acyl-CoA dehydrogenase, that exhibits maximal activitytowards saturated C22-CoA. {ECO:0000269|PubMed:21237683}. | Antagonizes the binding of 2-5A (5'-phosphorylated2',5'-linked oligoadenylates) by RNase L through directinteraction with RNase L and therefore inhibits itsendoribonuclease activity. May play a central role in theregulation of mRNA turnover. Antagonizes the anti-viral effect ofthe interferon-regulated 2-5A/RNase L pathway. May act as achaperone for post-translational events during HIV-1 capsidassembly. {ECO:0000269|PubMed:11585831,ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ACAD11_ABCE1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACAD11_ABCE1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ACAD11 | TBKBP1, APP, PEX5, PPP6R1, PPP6R3, TTC4, DUSP19, PDYN, TRAK2, KCTD17, ZMYM5, SDF4, FAM9A, STK25, FAM64A, MIER2, TCL1B, AMOT, GTSE1, UBXN7, NSFL1C, MTMR4, CD2BP2, TRIM44, C7orf60, PPP6R2, ASAP3, NR4A1, TINAG, SART3, TMEM194A, HSPB8, IL17RA, DCAF8, TRAFD1, POLR3E, GPR156, GPBP1L1, SDHB, LZTS2, CDH5, TMOD4, CNTN5, KHDRBS2, PTPN14, PTPN7, SLC7A6OS | ABCE1 | RNASEL, EIF3H, EIF3F, USP50, UBASH3A, SIRT7, CUL3, ITGA4, MMS19, FBXO6, PARK2, AP1B1, DIABLO, PDIA3, ILK, DCP2, STAU1, FAM96B, CIAO1, RNF2, ABCF1, FUBP3, CBX3, PDHA1, ABLIM1, CNIH4, NAA10, PSMD4, CORO1C, MAPK1, SRP9, TIMM21, SNAP23, HIST1H1C, EPB41L3, CUL4A, ZNF207, PRCP, TTC29, WDR1, EIF3D, EWSR1, PAK3, TIMM23, PFDN2, H3F3C, HIST2H2BF, FLNB, SAE1, PTGES3, PSMD13, STRAP, WDR77, TPP1, GNS, PPP2R2A, CD44, ATP6V1A, ISYNA1, ETF1, CCNY, IMMT, C16orf96, RRP1B, RFC4, RPL32, PEBP1, TFAM, TCEB1, FLOT2, SSFA2, GSPT1, NAT10, AARS, MAP4, MYO6, FLNA, RAVER1, RBBP7, ASNS, FDPS, RRP12, KARS, EPB41, HMGB1P1, SFXN4, TSN, RPRD1B, CD59, ORAOV1, SRRM2, SMARCA5, POLR1B, SAFB, RAB35, SUCLG2, MED23, VDAC3, PPM1G, MFGE8, DDX18, HAX1, NDUFA4, PSMD14, PPP6C, SURF4, ARPC5, EPB41L2, DKC1, PSIP1, RP2, CBR3, FLOT1, UFL1, AIFM1, PNP, LMNA, CSTB, TP53, FYN, HEXB, LYN, VIM, PTPRF, CTSA, RALA, IGF2R, SLC25A4, SRC, PRKAR2A, JUP, GLB1, PRKACA, PFKL, RPL35A, GNAZ, SRM, LMNB1, SDHB, FBL, ACAT1, RPS12, PSMA2, MSN, APEX1, PSMA5, GNA11, KIF5B, DUT, PSMC2, PPP1CC, EIF4A3, TMPO, RPS27, VDAC2, CBX5, RPL21, MAP1B, IQGAP1, PSMD8, PSMB3, GNAQ, CACNA2D1, AK2, S100A10, ABCE1, RAP2B, HSPE1, PPP1CB, RPS29, SNRPF, RPS25, GNB1, DYNLL1, GNG5, ANK2, LMNB2, YWHAH, TWF1, DSG2, SMC1A, NUMA1, EBP, TOMM20, SF3A1, MAPRE1, NDUFA5, C14orf166, AIF1L, ULBP3, TTC37, DDX46, DCXR, DNAJC7, PEG10, GAS2L3, GADD45GIP1, KIAA1524, HM13, C2orf47, ATXN2L, USP7, MACF1, PSMD1, SDF4, TBCD, CPVL, GNB4, EXOSC4, YAE1D1, SMC4, MDN1, FANCI, TECR, CISD1, NDUFAF4, NDUFA13, STARD9, ATXN10, CPSF3, RPL36, SUPT16H, PTER, RPL7, RPS3A, VAPA, VAPB, RPL4, NTRK1, POC5, TMEM17, TMEM216, CENPJ, XPO1, XRCC5, MCM2, DNM1L |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACAD11_ABCE1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACAD11_ABCE1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ABCE1 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |