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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 332

FusionGeneSummary for ACAD11_ABCE1

check button Fusion gene summary
Fusion gene informationFusion gene name: ACAD11_ABCE1
Fusion gene ID: 332
HgeneTgene
Gene symbol

ACAD11

ABCE1

Gene ID

84129

6059

Gene nameacyl-CoA dehydrogenase family member 11ATP binding cassette subfamily E member 1
SynonymsACAD-11ABC38|OABP|RLI|RLI1|RNASEL1|RNASELI|RNS4I
Cytomap

3q22.1

4q31.21

Type of geneprotein-codingprotein-coding
Descriptionacyl-CoA dehydrogenase family member 11acyl-Coenzyme A dehydrogenase family, member 11ATP-binding cassette sub-family E member 12'-5'-oligoadenylate-binding proteinATP-binding cassette, sub-family E (OABP), member 1RNase L inhibitor 1huHP68ribonuclease 4 inhibitorribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) inhibitor
Modification date2018051920180523
UniProtAcc

Q709F0

P61221

Ensembl transtripts involved in fusion geneENST00000355458, ENST00000264990, 
ENST00000545291, ENST00000481970, 
ENST00000489991, 
ENST00000296577, 
ENST00000502803, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 1 X 2=4
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: ACAD11 [Title/Abstract] AND ABCE1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACAD11

GO:0033539

fatty acid beta-oxidation using acyl-CoA dehydrogenase

21237683

TgeneABCE1

GO:0060702

negative regulation of endoribonuclease activity

7539425


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A3UA-01AACAD11chr3

132360816

-ABCE1chr4

146025538

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000355458ENST00000296577ACAD11chr3

132360816

-ABCE1chr4

146025538

+
5CDS-3UTRENST00000355458ENST00000502803ACAD11chr3

132360816

-ABCE1chr4

146025538

+
5CDS-5UTRENST00000264990ENST00000296577ACAD11chr3

132360816

-ABCE1chr4

146025538

+
5CDS-3UTRENST00000264990ENST00000502803ACAD11chr3

132360816

-ABCE1chr4

146025538

+
5UTR-5UTRENST00000545291ENST00000296577ACAD11chr3

132360816

-ABCE1chr4

146025538

+
5UTR-3UTRENST00000545291ENST00000502803ACAD11chr3

132360816

-ABCE1chr4

146025538

+
5CDS-5UTRENST00000481970ENST00000296577ACAD11chr3

132360816

-ABCE1chr4

146025538

+
5CDS-3UTRENST00000481970ENST00000502803ACAD11chr3

132360816

-ABCE1chr4

146025538

+
intron-5UTRENST00000489991ENST00000296577ACAD11chr3

132360816

-ABCE1chr4

146025538

+
intron-3UTRENST00000489991ENST00000502803ACAD11chr3

132360816

-ABCE1chr4

146025538

+

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FusionProtFeatures for ACAD11_ABCE1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACAD11

Q709F0

ABCE1

P61221

Acyl-CoA dehydrogenase, that exhibits maximal activitytowards saturated C22-CoA. {ECO:0000269|PubMed:21237683}. Antagonizes the binding of 2-5A (5'-phosphorylated2',5'-linked oligoadenylates) by RNase L through directinteraction with RNase L and therefore inhibits itsendoribonuclease activity. May play a central role in theregulation of mRNA turnover. Antagonizes the anti-viral effect ofthe interferon-regulated 2-5A/RNase L pathway. May act as achaperone for post-translational events during HIV-1 capsidassembly. {ECO:0000269|PubMed:11585831,ECO:0000269|PubMed:9660177, ECO:0000269|PubMed:9847332}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ACAD11_ABCE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ACAD11_ABCE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ACAD11TBKBP1, APP, PEX5, PPP6R1, PPP6R3, TTC4, DUSP19, PDYN, TRAK2, KCTD17, ZMYM5, SDF4, FAM9A, STK25, FAM64A, MIER2, TCL1B, AMOT, GTSE1, UBXN7, NSFL1C, MTMR4, CD2BP2, TRIM44, C7orf60, PPP6R2, ASAP3, NR4A1, TINAG, SART3, TMEM194A, HSPB8, IL17RA, DCAF8, TRAFD1, POLR3E, GPR156, GPBP1L1, SDHB, LZTS2, CDH5, TMOD4, CNTN5, KHDRBS2, PTPN14, PTPN7, SLC7A6OSABCE1RNASEL, EIF3H, EIF3F, USP50, UBASH3A, SIRT7, CUL3, ITGA4, MMS19, FBXO6, PARK2, AP1B1, DIABLO, PDIA3, ILK, DCP2, STAU1, FAM96B, CIAO1, RNF2, ABCF1, FUBP3, CBX3, PDHA1, ABLIM1, CNIH4, NAA10, PSMD4, CORO1C, MAPK1, SRP9, TIMM21, SNAP23, HIST1H1C, EPB41L3, CUL4A, ZNF207, PRCP, TTC29, WDR1, EIF3D, EWSR1, PAK3, TIMM23, PFDN2, H3F3C, HIST2H2BF, FLNB, SAE1, PTGES3, PSMD13, STRAP, WDR77, TPP1, GNS, PPP2R2A, CD44, ATP6V1A, ISYNA1, ETF1, CCNY, IMMT, C16orf96, RRP1B, RFC4, RPL32, PEBP1, TFAM, TCEB1, FLOT2, SSFA2, GSPT1, NAT10, AARS, MAP4, MYO6, FLNA, RAVER1, RBBP7, ASNS, FDPS, RRP12, KARS, EPB41, HMGB1P1, SFXN4, TSN, RPRD1B, CD59, ORAOV1, SRRM2, SMARCA5, POLR1B, SAFB, RAB35, SUCLG2, MED23, VDAC3, PPM1G, MFGE8, DDX18, HAX1, NDUFA4, PSMD14, PPP6C, SURF4, ARPC5, EPB41L2, DKC1, PSIP1, RP2, CBR3, FLOT1, UFL1, AIFM1, PNP, LMNA, CSTB, TP53, FYN, HEXB, LYN, VIM, PTPRF, CTSA, RALA, IGF2R, SLC25A4, SRC, PRKAR2A, JUP, GLB1, PRKACA, PFKL, RPL35A, GNAZ, SRM, LMNB1, SDHB, FBL, ACAT1, RPS12, PSMA2, MSN, APEX1, PSMA5, GNA11, KIF5B, DUT, PSMC2, PPP1CC, EIF4A3, TMPO, RPS27, VDAC2, CBX5, RPL21, MAP1B, IQGAP1, PSMD8, PSMB3, GNAQ, CACNA2D1, AK2, S100A10, ABCE1, RAP2B, HSPE1, PPP1CB, RPS29, SNRPF, RPS25, GNB1, DYNLL1, GNG5, ANK2, LMNB2, YWHAH, TWF1, DSG2, SMC1A, NUMA1, EBP, TOMM20, SF3A1, MAPRE1, NDUFA5, C14orf166, AIF1L, ULBP3, TTC37, DDX46, DCXR, DNAJC7, PEG10, GAS2L3, GADD45GIP1, KIAA1524, HM13, C2orf47, ATXN2L, USP7, MACF1, PSMD1, SDF4, TBCD, CPVL, GNB4, EXOSC4, YAE1D1, SMC4, MDN1, FANCI, TECR, CISD1, NDUFAF4, NDUFA13, STARD9, ATXN10, CPSF3, RPL36, SUPT16H, PTER, RPL7, RPS3A, VAPA, VAPB, RPL4, NTRK1, POC5, TMEM17, TMEM216, CENPJ, XPO1, XRCC5, MCM2, DNM1L


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ACAD11_ABCE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ACAD11_ABCE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneABCE1C0009404Colorectal Neoplasms1CTD_human