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Fusion gene ID: 33188 |
FusionGeneSummary for SENP2_ANKRD27 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SENP2_ANKRD27 | Fusion gene ID: 33188 | Hgene | Tgene | Gene symbol | SENP2 | ANKRD27 | Gene ID | 59343 | 84079 |
| Gene name | SUMO specific peptidase 2 | ankyrin repeat domain 27 | |
| Synonyms | AXAM2|SMT3IP2 | PP12899|VARP | |
| Cytomap | 3q27.2 | 19q13.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sentrin-specific protease 2SMT3-specific isopeptidase 2SUMO1/sentrin/SMT3 specific peptidase 2SUMO1/sentrin/SMT3 specific protease 2sentrin (SUMO1) specific peptidase 2sentrin/SUMO-specific protease SENP2 | ankyrin repeat domain-containing protein 27VPS9 domain-containing proteinVPS9-ankyrin-repeat proteinVps9 domain and ankyrin-repeat-containing proteinankyrin repeat domain 27 (VPS9 domain) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9HC62 | Q96NW4 | |
| Ensembl transtripts involved in fusion gene | ENST00000545472, ENST00000296257, ENST00000427465, ENST00000465201, | ENST00000306065, ENST00000587352, | |
| Fusion gene scores | * DoF score | 8 X 6 X 8=384 | 4 X 5 X 3=60 |
| # samples | 9 | 7 | |
| ** MAII score | log2(9/384*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/60*10)=0.222392421336448 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SENP2 [Title/Abstract] AND ANKRD27 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SENP2 | GO:0016926 | protein desumoylation | 20194620 |
| Hgene | SENP2 | GO:0031397 | negative regulation of protein ubiquitination | 22028379 |
| Tgene | ANKRD27 | GO:0035544 | negative regulation of SNARE complex assembly | 24856514 |
| Tgene | ANKRD27 | GO:0045022 | early endosome to late endosome transport | 16525121 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-21-1071-01A | SENP2 | chr3 | 185304302 | + | ANKRD27 | chr19 | 33133051 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000545472 | ENST00000306065 | SENP2 | chr3 | 185304302 | + | ANKRD27 | chr19 | 33133051 | - |
| intron-3CDS | ENST00000545472 | ENST00000587352 | SENP2 | chr3 | 185304302 | + | ANKRD27 | chr19 | 33133051 | - |
| In-frame | ENST00000296257 | ENST00000306065 | SENP2 | chr3 | 185304302 | + | ANKRD27 | chr19 | 33133051 | - |
| In-frame | ENST00000296257 | ENST00000587352 | SENP2 | chr3 | 185304302 | + | ANKRD27 | chr19 | 33133051 | - |
| 5UTR-3CDS | ENST00000427465 | ENST00000306065 | SENP2 | chr3 | 185304302 | + | ANKRD27 | chr19 | 33133051 | - |
| 5UTR-3CDS | ENST00000427465 | ENST00000587352 | SENP2 | chr3 | 185304302 | + | ANKRD27 | chr19 | 33133051 | - |
| intron-3CDS | ENST00000465201 | ENST00000306065 | SENP2 | chr3 | 185304302 | + | ANKRD27 | chr19 | 33133051 | - |
| intron-3CDS | ENST00000465201 | ENST00000587352 | SENP2 | chr3 | 185304302 | + | ANKRD27 | chr19 | 33133051 | - |
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FusionProtFeatures for SENP2_ANKRD27 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SENP2 | ANKRD27 |
| Protease that catalyzes two essential functions in theSUMO pathway. The first is the hydrolysis of an alpha-linkedpeptide bond at the C-terminal end of the small ubiquitin-likemodifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to themature form of the proteins. The second is the deconjugation ofSUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving anepsilon-linked peptide bond between the C-terminal glycine of themature SUMO and the lysine epsilon-amino group of the targetprotein. May down-regulate CTNNB1 levels and thereby modulate theWnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role inadipogenesis by desumoylating and promoting the stabilization ofCEBPB (PubMed:20194620). {ECO:0000250|UniProtKB:Q91ZX6,ECO:0000250|UniProtKB:Q9EQE1, ECO:0000269|PubMed:11896061,ECO:0000269|PubMed:12192048, ECO:0000269|PubMed:20194620,ECO:0000269|PubMed:21965678}. | May be a guanine exchange factor (GEF) for Rab21, Rab32and Rab38 and regulate endosome dynamics (PubMed:16525121,PubMed:18477474). May regulate the participation of VAMP7 inmembrane fusion events; in vitro inhibits VAMP7-mediated SNAREcomplex formation by trapping VAMP7 in a closed, fusogenicallyinactive conformation (PubMed:23104059). Involved in peripheralmelanosomal distribution of TYRP1 in melanocytes; the function,which probably is implicating vesicle-trafficking, includescooperation with Rab32, Rab38 and VAMP7 (By similarity). Involvedin the regulation of neurite growth; the function seems to requireits GEF activity, probably towards Rab21, and VAMP7 but notRab32/38 (By similarity). Proposed to be involved in Golgi sortingof VAMP7 and transport of VAMP7 vesicles to the cell surface; thefunction seems to implicate kinesin heavy chain isoform 5proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required forthe colocalization of VAMP7 and Rab21, probably on TGN sites(PubMed:19745841). Involved in GLUT1 endosome-to-plasma membranetrafficking; the function is dependent of association with VPS29(PubMed:24856514). Regulates the proper trafficking of melanogenicenzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (Bysimilarity). {ECO:0000250|UniProtKB:Q3UMR0,ECO:0000269|PubMed:23104059, ECO:0000269|PubMed:24856514,ECO:0000305|PubMed:16525121, ECO:0000305|PubMed:18477474,ECO:0000305|PubMed:22705394}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SENP2_ANKRD27 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SENP2_ENST00000296257_chr3_185304302_+_ANKRD27_ENST00000306065_chr19_33133051_-_824aa MYRWLVRILGTIFRFCDRSVPPARALLKRRRSDSFNIPRAKRELAQLNKCTSPQQKLVCLRKVVQLITQSPSQRVNLETMCADDLLSVLL YLLVKTEIPNWMANLSYIKNFRFSSLAKDELGYCLTSFEAAIEYIRQGSLSAKPPESEGFGDRLFLKQRMSLLSQMTSSPTDCLFKHIAS GNQKEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVAAVCGQASLIDLLVSKGAMVNATDYHGA TPLHLACQKGYQSVTLLLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQN GASTEIQNRLKETPLKCALNSKILSVMEAYHLSFERRQKSSEAPVQSPQRSVDSISQESSTSSFSSMSASSRQEETKKDYREVEKLLRAV ADGDLEMVRYLLEWTEEDLEDAEDTVSAADPEFCHPLCQCPKCAPAQKRLAKVPASGLGVNVTSQDGSSPLHVAALHGRADLIPLLLKHG ANAGARNADQAVPLHLACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIYACSGGHHELVALLLQHGASINASNNKGNTALHEAVIEKHVF VVELLLLHGASVQVLNKRQRTAVDCAEQNSKIMELLQVVPSCVASLDDVAETDRKEYVTVKIRKKWNSKLYDLPDEPFTRQFYFVHSAGQ FKGKTSREIMARDRSVPNLTEGSLHEPGRQSVTLRQNNLPAQSGSHAAEKGNSDWPERPGLTQTGPGHRRMLRRHTVEDAVVSQGPEAAG >In-frame_SENP2_ENST00000296257_chr3_185304302_+_ANKRD27_ENST00000587352_chr19_33133051_-_163aa MYRWLVRILGTIFRFCDRSVPPARALLKRRRSDSFNIPRAKRELAQLNKCTSPQQKLVCLRKVVQLITQSPSQRVNLETMCADDLLSVLL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SENP2_ENST00000296257_chr3_185304302_+_ANKRD27_ENST00000306065_chr19_33133051_-_2472nt ATGTACAGATGGCTGGTTAGGATTCTCGGCACCATTTTCCGTTTCTGCGACCGGTCGGTGCCCCCTGCCCGGGCCCTCCTGAAGAGGCGG CGCTCAGACAGCTTTAACATACCTCGTGCCAAAAGAGAGCTGGCTCAGCTGAACAAATGCACCTCCCCACAGCAGAAGCTTGTCTGCTTG CGAAAAGTGGTGCAGCTCATTACACAGTCTCCAAGCCAGAGAGTGAACCTGGAGACCATGTGTGCTGATGATCTGCTATCAGTCCTGTTA TACTTGCTTGTGAAAACGGAGATCCCTAATTGGATGGCAAATTTGAGTTACATCAAAAACTTCAGGTTTAGCAGCTTGGCAAAGGATGAA CTGGGATACTGCCTGACCTCATTCGAAGCTGCCATTGAATATATTCGGCAAGGAAGCCTCTCTGCTAAACCCCCTGAGTCTGAGGGATTT GGAGACAGGCTGTTCCTTAAGCAGAGAATGAGCTTACTCTCTCAGATGACTTCGTCTCCCACCGACTGCCTGTTTAAGCACATTGCATCA GGTAACCAGAAAGAAGTGGAGAGACTTCTGAGCCAAGAGGACCATGATAAAGATACCGTCCAAAAGATGTGTCACCCTCTCTGCTTCTGC GATGACTGTGAGAAACTCGTCTCTGGGAGGTTGAATGATCCCTCAGTTGTCACTCCATTCTCCAGAGACGACAGGGGGCACACCCCTCTC CATGTGGCTGCTGTCTGTGGGCAGGCATCCCTCATCGACCTCCTGGTTTCCAAGGGCGCCATGGTAAATGCCACAGACTACCATGGAGCC ACTCCGCTCCACCTGGCCTGTCAGAAGGGCTACCAGAGCGTGACGCTGCTGCTGCTGCACTACAAGGCCAGCGCGGAAGTGCAGGACAAC AATGGGAATACGCCACTCCACCTGGCCTGCACCTACGGCCACGAGGACTGTGTGAAGGCTCTGGTTTACTACGACGTGGAGTCGTGCAGA CTTGACATTGGCAATGAGAAAGGAGACACCCCTCTACACATTGCTGCCCGCTGGGGCTACCAAGGCGTCATAGAGACATTGCTGCAGAAC GGAGCGTCCACCGAGATCCAGAACAGACTGAAGGAGACGCCCCTCAAGTGTGCATTAAACTCAAAGATTCTGTCTGTAATGGAAGCCTAT CACCTGTCCTTCGAGAGGAGGCAGAAGTCGTCCGAGGCCCCTGTGCAGTCCCCGCAGCGCTCCGTGGACTCCATCAGCCAAGAGTCCTCC ACTTCCAGCTTCTCCTCCATGTCAGCCAGCTCAAGGCAGGAGGAGACCAAGAAGGACTACAGAGAGGTAGAAAAACTTTTGAGAGCAGTT GCTGATGGAGATCTAGAAATGGTGCGTTACCTGTTGGAATGGACAGAGGAGGACCTGGAGGATGCGGAGGACACTGTCAGTGCAGCGGAC CCCGAATTCTGTCACCCGTTGTGCCAGTGCCCCAAGTGTGCCCCAGCTCAGAAGAGGCTGGCGAAGGTTCCTGCCAGTGGGCTTGGTGTG AACGTGACCAGCCAGGACGGCTCCTCCCCGCTGCATGTCGCCGCCCTGCACGGCCGGGCGGACCTCATCCCCCTCCTGCTGAAGCACGGG GCCAACGCAGGTGCCAGGAACGCAGACCAAGCCGTCCCGCTCCACCTGGCCTGCCAGCAGGGCCACTTTCAGGTGGTGAAGTGTCTGTTA GATTCGAATGCAAAACCCAATAAGAAGGACCTCAGTGGAAACACGCCCCTCATTTACGCCTGCTCCGGTGGCCATCACGAGCTTGTGGCA CTGCTGCTACAGCACGGGGCCTCCATTAACGCTTCTAACAATAAGGGCAACACAGCGCTGCACGAGGCTGTGATTGAAAAGCACGTCTTC GTGGTAGAGCTGCTTCTGCTCCACGGAGCGTCAGTTCAGGTGCTGAACAAGCGGCAGCGCACGGCTGTAGACTGTGCTGAACAGAATTCA AAAATAATGGAATTGCTTCAGGTGGTACCAAGCTGTGTTGCTTCATTAGATGATGTGGCTGAAACTGACCGCAAGGAGTATGTCACTGTT AAGATCAGGAAAAAATGGAACTCAAAACTGTATGATCTACCAGATGAGCCTTTTACAAGACAGTTTTACTTTGTCCACTCAGCTGGTCAG TTTAAGGGAAAGACTTCAAGGGAGATTATGGCAAGAGATAGAAGTGTCCCTAATTTAACCGAAGGTTCTTTGCATGAGCCAGGGAGGCAA AGTGTCACACTGAGACAGAATAACCTGCCAGCTCAGAGTGGATCTCATGCTGCTGAGAAAGGCAACAGCGACTGGCCAGAGAGGCCTGGA CTGACACAGACTGGCCCTGGACACAGACGGATGCTGCGGAGACACACGGTAGAGGATGCGGTCGTGTCCCAGGGCCCGGAGGCTGCTGGC >In-frame_SENP2_ENST00000296257_chr3_185304302_+_ANKRD27_ENST00000587352_chr19_33133051_-_489nt ATGTACAGATGGCTGGTTAGGATTCTCGGCACCATTTTCCGTTTCTGCGACCGGTCGGTGCCCCCTGCCCGGGCCCTCCTGAAGAGGCGG CGCTCAGACAGCTTTAACATACCTCGTGCCAAAAGAGAGCTGGCTCAGCTGAACAAATGCACCTCCCCACAGCAGAAGCTTGTCTGCTTG CGAAAAGTGGTGCAGCTCATTACACAGTCTCCAAGCCAGAGAGTGAACCTGGAGACCATGTGTGCTGATGATCTGCTATCAGTCCTGTTA TACTTGCTTGTGAAAACGGAGATCCCTAATTGGATGGCAAATTTGAGTTACATCAAAAACTTCAGGTTTAGCAGCTTGGCAAAGGATGAA CTGGGATACTGCCTGACCTCATTCGAAGCTGCCATTGAATATATTCGGCAAGGAAGCCTCTCTGCTAAACCCCCTGTAAGATCTCACCCC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SENP2_ENST00000296257_chr3_185304302_+_ANKRD27_ENST00000306065_chr19_33133051_-_3850nt GTGCGCAGATTGAGAATGGAGCTTTCCGGTCGGGCGGGAGGAGGTGACGTCAGGAGTGGTGGCGGGCGGGGGCCTCTGGTAGCCCTGGGG ACGCTGTATCTGTGGGCTCTTGAATCGCGTCACAAATCAGCGACCGAACTCTGGCGGTGGTGGTTAAGACGGCGAAGGCGGCAGCGGCGG CGACAGCTCTGGGGTTTGCGTCTCGGGGTGTGTCGGCCGCCGCTGCTGCTTGGGCCTGGTATGTACAGATGGCTGGTTAGGATTCTCGGC ACCATTTTCCGTTTCTGCGACCGGTCGGTGCCCCCTGCCCGGGCCCTCCTGAAGAGGCGGCGCTCAGACAGCTTTAACATACCTCGTGCC AAAAGAGAGCTGGCTCAGCTGAACAAATGCACCTCCCCACAGCAGAAGCTTGTCTGCTTGCGAAAAGTGGTGCAGCTCATTACACAGTCT CCAAGCCAGAGAGTGAACCTGGAGACCATGTGTGCTGATGATCTGCTATCAGTCCTGTTATACTTGCTTGTGAAAACGGAGATCCCTAAT TGGATGGCAAATTTGAGTTACATCAAAAACTTCAGGTTTAGCAGCTTGGCAAAGGATGAACTGGGATACTGCCTGACCTCATTCGAAGCT GCCATTGAATATATTCGGCAAGGAAGCCTCTCTGCTAAACCCCCTGAGTCTGAGGGATTTGGAGACAGGCTGTTCCTTAAGCAGAGAATG AGCTTACTCTCTCAGATGACTTCGTCTCCCACCGACTGCCTGTTTAAGCACATTGCATCAGGTAACCAGAAAGAAGTGGAGAGACTTCTG AGCCAAGAGGACCATGATAAAGATACCGTCCAAAAGATGTGTCACCCTCTCTGCTTCTGCGATGACTGTGAGAAACTCGTCTCTGGGAGG TTGAATGATCCCTCAGTTGTCACTCCATTCTCCAGAGACGACAGGGGGCACACCCCTCTCCATGTGGCTGCTGTCTGTGGGCAGGCATCC CTCATCGACCTCCTGGTTTCCAAGGGCGCCATGGTAAATGCCACAGACTACCATGGAGCCACTCCGCTCCACCTGGCCTGTCAGAAGGGC TACCAGAGCGTGACGCTGCTGCTGCTGCACTACAAGGCCAGCGCGGAAGTGCAGGACAACAATGGGAATACGCCACTCCACCTGGCCTGC ACCTACGGCCACGAGGACTGTGTGAAGGCTCTGGTTTACTACGACGTGGAGTCGTGCAGACTTGACATTGGCAATGAGAAAGGAGACACC CCTCTACACATTGCTGCCCGCTGGGGCTACCAAGGCGTCATAGAGACATTGCTGCAGAACGGAGCGTCCACCGAGATCCAGAACAGACTG AAGGAGACGCCCCTCAAGTGTGCATTAAACTCAAAGATTCTGTCTGTAATGGAAGCCTATCACCTGTCCTTCGAGAGGAGGCAGAAGTCG TCCGAGGCCCCTGTGCAGTCCCCGCAGCGCTCCGTGGACTCCATCAGCCAAGAGTCCTCCACTTCCAGCTTCTCCTCCATGTCAGCCAGC TCAAGGCAGGAGGAGACCAAGAAGGACTACAGAGAGGTAGAAAAACTTTTGAGAGCAGTTGCTGATGGAGATCTAGAAATGGTGCGTTAC CTGTTGGAATGGACAGAGGAGGACCTGGAGGATGCGGAGGACACTGTCAGTGCAGCGGACCCCGAATTCTGTCACCCGTTGTGCCAGTGC CCCAAGTGTGCCCCAGCTCAGAAGAGGCTGGCGAAGGTTCCTGCCAGTGGGCTTGGTGTGAACGTGACCAGCCAGGACGGCTCCTCCCCG CTGCATGTCGCCGCCCTGCACGGCCGGGCGGACCTCATCCCCCTCCTGCTGAAGCACGGGGCCAACGCAGGTGCCAGGAACGCAGACCAA GCCGTCCCGCTCCACCTGGCCTGCCAGCAGGGCCACTTTCAGGTGGTGAAGTGTCTGTTAGATTCGAATGCAAAACCCAATAAGAAGGAC CTCAGTGGAAACACGCCCCTCATTTACGCCTGCTCCGGTGGCCATCACGAGCTTGTGGCACTGCTGCTACAGCACGGGGCCTCCATTAAC GCTTCTAACAATAAGGGCAACACAGCGCTGCACGAGGCTGTGATTGAAAAGCACGTCTTCGTGGTAGAGCTGCTTCTGCTCCACGGAGCG TCAGTTCAGGTGCTGAACAAGCGGCAGCGCACGGCTGTAGACTGTGCTGAACAGAATTCAAAAATAATGGAATTGCTTCAGGTGGTACCA AGCTGTGTTGCTTCATTAGATGATGTGGCTGAAACTGACCGCAAGGAGTATGTCACTGTTAAGATCAGGAAAAAATGGAACTCAAAACTG TATGATCTACCAGATGAGCCTTTTACAAGACAGTTTTACTTTGTCCACTCAGCTGGTCAGTTTAAGGGAAAGACTTCAAGGGAGATTATG GCAAGAGATAGAAGTGTCCCTAATTTAACCGAAGGTTCTTTGCATGAGCCAGGGAGGCAAAGTGTCACACTGAGACAGAATAACCTGCCA GCTCAGAGTGGATCTCATGCTGCTGAGAAAGGCAACAGCGACTGGCCAGAGAGGCCTGGACTGACACAGACTGGCCCTGGACACAGACGG ATGCTGCGGAGACACACGGTAGAGGATGCGGTCGTGTCCCAGGGCCCGGAGGCTGCTGGCCCCCTCTCCACTCCCCAAGAGGTTAGTGCT TCCCGGTCCTAACAGGAATGAGGAGTTGTTGAACCCACTGCTAGGAAGCAAGGATGCAACAAGATGATGCTGAGCGTGAACACATCTGAG AACTAAATGTGCTTCCATGAGACTGGCTTGAGAAGTCTTCAGCACCAAGTTCCTGAAAGCTTTTCTGTGGCAGGAAAGAATGCAACAAAA AAGTTAACCACCACCATCTCTCTCCTCTTCAAAGCTAATGAATACAATTGAAACAGACAAAAATTCCAGTAGCATCCAGATCCTTAAGCC AGAGGTGCATGCTTCTTTTTAAGTATGAGGGTTTGTTGGTCACAGTGGGAGAGGTTTCACCACCGCATTCTGACCTCCTCCTCCCAAAAG GTGCTAAACCTCTCTGACCTGTGTACATTCACAAACCACAGCTAGAATTCCTCCACCTAGGATTAAGCTGGAGAGAAGTAAGTAATTTAG GTTTCATGGTACTGTAGAGGCCAGGCTGAAATGTCATATCTGAAGGAAGAAAGCAGCAGCTGGACAATGTTTCTTTGCAAAGCAACACTC GAACCAAAAGATGCCTCAATCCCATTTTGATATTCATTTTAGTGAAAGGATGCATCAGACCTGTTCCACATCATGCACATGGGAAAGGGT GGTTATCATTTTCCTTCTAACAAGTAGGTACAGATATTCGGTTACTACACGTGCACCTGTAGCAGTATTTCTAGAAACATCCCTTTTTGT TGAGAACCTCCCTTGAATGTCTGTCACACTCACACCTGACGGGATGGTTACTGGATTAGAGAGTAGATTTGGCACATCTTTTCTTAGTCT TTTGATTCAAATTCAAAACTTAACAGCACAAACCAGGTCAGAGTTACTTTCGGTTAGAATTTATTGCCATTTATTCCTTTTTATAAATTT CTATAGATTATACTGTTATTTTTATGTTATTGGCCTAGAGCTACACGTATATGGGTTTGTCCTGAGTCCGTTTTCAAATGACCTTGTGAT AGGGAAATGGTTTTGTCCATGTTCTTGGAAATACTTGTGTATGTACAGAAGGAAGGGAGGGATTATTTTTCTACAAAGTAATTTATGATT >In-frame_SENP2_ENST00000296257_chr3_185304302_+_ANKRD27_ENST00000587352_chr19_33133051_-_2731nt GTGCGCAGATTGAGAATGGAGCTTTCCGGTCGGGCGGGAGGAGGTGACGTCAGGAGTGGTGGCGGGCGGGGGCCTCTGGTAGCCCTGGGG ACGCTGTATCTGTGGGCTCTTGAATCGCGTCACAAATCAGCGACCGAACTCTGGCGGTGGTGGTTAAGACGGCGAAGGCGGCAGCGGCGG CGACAGCTCTGGGGTTTGCGTCTCGGGGTGTGTCGGCCGCCGCTGCTGCTTGGGCCTGGTATGTACAGATGGCTGGTTAGGATTCTCGGC ACCATTTTCCGTTTCTGCGACCGGTCGGTGCCCCCTGCCCGGGCCCTCCTGAAGAGGCGGCGCTCAGACAGCTTTAACATACCTCGTGCC AAAAGAGAGCTGGCTCAGCTGAACAAATGCACCTCCCCACAGCAGAAGCTTGTCTGCTTGCGAAAAGTGGTGCAGCTCATTACACAGTCT CCAAGCCAGAGAGTGAACCTGGAGACCATGTGTGCTGATGATCTGCTATCAGTCCTGTTATACTTGCTTGTGAAAACGGAGATCCCTAAT TGGATGGCAAATTTGAGTTACATCAAAAACTTCAGGTTTAGCAGCTTGGCAAAGGATGAACTGGGATACTGCCTGACCTCATTCGAAGCT GCCATTGAATATATTCGGCAAGGAAGCCTCTCTGCTAAACCCCCTGTAAGATCTCACCCCTGCCCTGGCCTTCCTTTGTGGGCATCATGG TTCCCTTGATAGGGTGCTGGGGTTGGTATGTGGGCAGACGGATTCTTAAATTGCCTCCCAGGAATGGGGCCTCAGCTGTTTGAGGGCTGT GAGTCTTAAAAATCACTCAGTGAAGAGAACACCAAGCCCTCAATTGGTGGTAAAAATTGGTGGGTTATCATTGGGATTTACATTGTTAAT ATCCTACTTCATTAGTCCCCATCCTCTCCAAAGACATGTGGGTGCAAAGGGAAGCCAGAAGTAGGGAATTTGGATTTCTTGACCTTGATA GTCAAGAAGTGATGTCACGGGATCCCTGGACTGTCGCTTTTCCAGCCGGAAACCTCTGTGGCTGGTGGCTCCTTTGCCTGAGTTTTGTTC GGGCCTGCTGGGCTCATTTCACGCTCTTGGCCTGGCAGGCTGCGCTCGGCTTGTGCTACTGGCCTGGATCCCATGCCTGCCAAGGGCGAG CCAGGTGTGGAGTGGCGAGGGGTATGTGAGCAAGTGCAGGGTCTGGCCACTGCACACAACCAGGTGTGCCGACTGAGGTGGGGTGGGCAG CTCCAAGTTGCTTGTACAGGGTCCTGCTCCATGCAAGGCTGCAGCTAGAGCAGGCGTACTGTAGGCCGCTTCCACGGTGGGCACTGGGGA ACACAGTGGGGCCTGGAAGCTTGGAGACACCAGGAACTGCAGAGCCCCAAAGAGGGTGTCATAGCCCTGGCTCGGGGAACTCCTAGGTTG GGCTCCCTGAAGGGCCAGAGCTCTTCTCTCCTCTCGTCACCTGCAATGTAGTGAGTCGGGAGCATGTTTTAGCTCTCTTTATGTTACAGC TCTTTCAGTCCTGCCATTTGGTGGGTCCCGAGTTCTTGTCCCATGTCGAGGAAGAATGAGGTACGTAGACTAGTGGAGGGTGAGCAAGGC AGAGAGGAGCTTTACTGAACGGCAGAATAGCTCTCAGGAGACCCACAGTGGGCAGCTTCTTTCCACAGGCAGGTCGTCCTGACGAGTTAA AGAGGCCTGACGTAGGTAGCTCCTTCCTGCAGTTGGTAGTCCCGACATCTGTCTGAGTCTGGCTGAGTCCGGGGTTTTTTATGGCTCAGA AGGGAGGGAGTATGTGCTGATTGGTCCATAGGTGGGCCTGGAGAAAGCACCATGAGTTCTCAGTCTGGGTCGTGGACTCCACTTGGGACT GACAGCCCGGCCCCCAGGCTTTAGGCTGTCCCTGTCTTGAAGGTGGGGCTTCACTGGGCACCTGCACCTTTCCACCCAGAAGCGTGTCTG CCTTCTGCCACCATCAACATGCTGGCCAGTGCATCCAGGCTGTTTGTGCCAAGGGGCATCTGCAGGCCTGCACTGAGCTGCCCTCAGCCC CTACCTTGACTACTCTCCCATGCTCATCAGCGCCCAAAATCTTGGAGGGGTCTGAGGCATCAGGAGGCTGGTGTGTCAGTGTCACACCAA GCATGTGCACACATGGCTGGGTTGCAACAGTACCCGGGCTTGGCCTCAGCTTTGCTCTGAAATTGAAGTCGGTGCCAGGAGTGGGGAGGA GCGGGAGCAGGCACTTACGAGCCTGCGGCGGCAGGGATGCTTCCTGGGCCCCTGAGAGTGCAGAGATTCCTGGATCCAGAGCTGCGGCTG GGCGGCTGCAGCTGCGCCTGGGAGTGCAGGGCTCCCGCCCTGCCAGCTCAGTAGGAGATGGGGGCTCCTGCCTGTTCCTGGCTCCTGTTG GCCCTGCAGAGTGCACAAACCTGGCCGCGCTTCCTCCACTGCAGCTTACGTCTTTGCAGCAGCCACTCCCGATGGGCTGCCACTGCCATC TGTGAGACCATTAATGTGTGCAATTTGAGGACTCAGTGGCCTTGCCATTGTTTCCTTGGTTTTTATTGAGCATTGGCTGGGGTCGGCGAG GGGATGTGATTATATTTCTATGTGAATCGTGAGAATCTTGAACCATGGTTGTCCTGCTGGCCTGTTTTACTACATACCAATGAGTAAAAT |
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FusionGenePPI for SENP2_ANKRD27 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SENP2 | CDK5RAP2, NUP153, SUMO1, SUMO3, IKBKG, NEDD4L, ELAVL1, HIPK2, DAXX, TRIM63, APP, HNRNPK, TPD52, CDCA5, RANGAP1, SUMO2, ARL6IP1, AGTRAP, FUNDC1, CCDC155, SYNE4, TMEM239, FZR1, NUP43, NUP107, NUP133, TMEM17, TMEM216, NACC1, BCOR, MYC, CTDNEP1, USP28, PGK2, KPNA1, KPNB1, LMNA | ANKRD27 | VAMP7, SMAD1, NFKBIA, DLK1, RAB40A, RAB40B, RAB40C, VPS26A, VPS26B, VPS29, HIF1AN, TPCN2, ZNF669, IKZF1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SENP2_ANKRD27 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SENP2_ANKRD27 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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