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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33187

FusionGeneSummary for SENP2_ABR

check button Fusion gene summary
Fusion gene informationFusion gene name: SENP2_ABR
Fusion gene ID: 33187
HgeneTgene
Gene symbol

SENP2

ABR

Gene ID

59343

29

Gene nameSUMO specific peptidase 2ABR, RhoGEF and GTPase activating protein
SynonymsAXAM2|SMT3IP2MDB
Cytomap

3q27.2

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionsentrin-specific protease 2SMT3-specific isopeptidase 2SUMO1/sentrin/SMT3 specific peptidase 2SUMO1/sentrin/SMT3 specific protease 2sentrin (SUMO1) specific peptidase 2sentrin/SUMO-specific protease SENP2active breakpoint cluster region-related proteinactive BCR-related
Modification date2018052320180523
UniProtAcc

Q9HC62

Q12979

Ensembl transtripts involved in fusion geneENST00000545472, ENST00000296257, 
ENST00000427465, ENST00000465201, 
ENST00000302538, ENST00000544583, 
ENST00000572441, ENST00000574437, 
ENST00000291107, ENST00000543210, 
ENST00000536794, ENST00000573895, 
Fusion gene scores* DoF score8 X 6 X 8=38414 X 13 X 8=1456
# samples 918
** MAII scorelog2(9/384*10)=-2.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1456*10)=-3.01594154386902
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SENP2 [Title/Abstract] AND ABR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSENP2

GO:0016926

protein desumoylation

20194620

HgeneSENP2

GO:0031397

negative regulation of protein ubiquitination

22028379


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-DK-A6B2-01ASENP2chr3

185307957

+ABRchr17

915225

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000545472ENST00000302538SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000545472ENST00000544583SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000545472ENST00000572441SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000545472ENST00000574437SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000545472ENST00000291107SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000545472ENST00000543210SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000545472ENST00000536794SENP2chr3

185307957

+ABRchr17

915225

-
5CDS-intronENST00000545472ENST00000573895SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000296257ENST00000302538SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000296257ENST00000544583SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000296257ENST00000572441SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000296257ENST00000574437SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000296257ENST00000291107SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000296257ENST00000543210SENP2chr3

185307957

+ABRchr17

915225

-
Frame-shiftENST00000296257ENST00000536794SENP2chr3

185307957

+ABRchr17

915225

-
5CDS-intronENST00000296257ENST00000573895SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-3CDSENST00000427465ENST00000302538SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-3CDSENST00000427465ENST00000544583SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-3CDSENST00000427465ENST00000572441SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-3CDSENST00000427465ENST00000574437SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-3CDSENST00000427465ENST00000291107SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-3CDSENST00000427465ENST00000543210SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-3CDSENST00000427465ENST00000536794SENP2chr3

185307957

+ABRchr17

915225

-
5UTR-intronENST00000427465ENST00000573895SENP2chr3

185307957

+ABRchr17

915225

-
3UTR-3CDSENST00000465201ENST00000302538SENP2chr3

185307957

+ABRchr17

915225

-
3UTR-3CDSENST00000465201ENST00000544583SENP2chr3

185307957

+ABRchr17

915225

-
3UTR-3CDSENST00000465201ENST00000572441SENP2chr3

185307957

+ABRchr17

915225

-
3UTR-3CDSENST00000465201ENST00000574437SENP2chr3

185307957

+ABRchr17

915225

-
3UTR-3CDSENST00000465201ENST00000291107SENP2chr3

185307957

+ABRchr17

915225

-
3UTR-3CDSENST00000465201ENST00000543210SENP2chr3

185307957

+ABRchr17

915225

-
3UTR-3CDSENST00000465201ENST00000536794SENP2chr3

185307957

+ABRchr17

915225

-
3UTR-intronENST00000465201ENST00000573895SENP2chr3

185307957

+ABRchr17

915225

-

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FusionProtFeatures for SENP2_ABR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SENP2

Q9HC62

ABR

Q12979

Protease that catalyzes two essential functions in theSUMO pathway. The first is the hydrolysis of an alpha-linkedpeptide bond at the C-terminal end of the small ubiquitin-likemodifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to themature form of the proteins. The second is the deconjugation ofSUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving anepsilon-linked peptide bond between the C-terminal glycine of themature SUMO and the lysine epsilon-amino group of the targetprotein. May down-regulate CTNNB1 levels and thereby modulate theWnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role inadipogenesis by desumoylating and promoting the stabilization ofCEBPB (PubMed:20194620). {ECO:0000250|UniProtKB:Q91ZX6,ECO:0000250|UniProtKB:Q9EQE1, ECO:0000269|PubMed:11896061,ECO:0000269|PubMed:12192048, ECO:0000269|PubMed:20194620,ECO:0000269|PubMed:21965678}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SENP2_ABR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SENP2_ABR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SENP2CDK5RAP2, NUP153, SUMO1, SUMO3, IKBKG, NEDD4L, ELAVL1, HIPK2, DAXX, TRIM63, APP, HNRNPK, TPD52, CDCA5, RANGAP1, SUMO2, ARL6IP1, AGTRAP, FUNDC1, CCDC155, SYNE4, TMEM239, FZR1, NUP43, NUP107, NUP133, TMEM17, TMEM216, NACC1, BCOR, MYC, CTDNEP1, USP28, PGK2, KPNA1, KPNB1, LMNAABRLNX1, APP, ECT2, ERBB2IP, AURKB, CDKN1A, CEP250, CEP57, CEP76, TP53, MOV10, NXF1, HERC2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SENP2_ABR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SENP2_ABR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneABRC0033578Prostatic Neoplasms1CTD_human