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Fusion gene ID: 33176 |
FusionGeneSummary for SEMA6A_ELOF1 |
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Fusion gene information | Fusion gene name: SEMA6A_ELOF1 | Fusion gene ID: 33176 | Hgene | Tgene | Gene symbol | SEMA6A | ELOF1 | Gene ID | 57556 | 84337 |
Gene name | semaphorin 6A | elongation factor 1 homolog | |
Synonyms | HT018|SEMA|SEMA6A1|SEMAQ|VIA | ELF1 | |
Cytomap | 5q23.1 | 19p13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | semaphorin-6ASEMA6A-1sema VIasema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Asemaphorin 6A-1semaphorin VIA | transcription elongation factor 1 homologELF1 homolog, elongation factor 1elongation factor 1 homolog (ELF1, S. cerevisiae) | |
Modification date | 20180523 | 20180529 | |
UniProtAcc | Q9H2E6 | P60002 | |
Ensembl transtripts involved in fusion gene | ENST00000343348, ENST00000257414, ENST00000510263, ENST00000513137, ENST00000282394, ENST00000503865, ENST00000503962, | ENST00000586683, ENST00000252445, ENST00000587806, ENST00000589171, ENST00000591674, ENST00000586120, ENST00000590700, ENST00000591912, | |
Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 7 X 3 X 5=105 |
# samples | 11 | 7 | |
** MAII score | log2(11/72*10)=0.611434712082347 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/105*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SEMA6A [Title/Abstract] AND ELOF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SEMA6A | GO:1903671 | negative regulation of sprouting angiogenesis | 22184411 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI652447 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + | ||
ChiTaRS3.1 | AI650814 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000343348 | ENST00000586683 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000343348 | ENST00000252445 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000343348 | ENST00000587806 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000343348 | ENST00000589171 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000343348 | ENST00000591674 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000343348 | ENST00000586120 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000343348 | ENST00000590700 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000343348 | ENST00000591912 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-intron | ENST00000257414 | ENST00000586683 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000257414 | ENST00000252445 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000257414 | ENST00000587806 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000257414 | ENST00000589171 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000257414 | ENST00000591674 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000257414 | ENST00000586120 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000257414 | ENST00000590700 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000257414 | ENST00000591912 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-intron | ENST00000510263 | ENST00000586683 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000510263 | ENST00000252445 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000510263 | ENST00000587806 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000510263 | ENST00000589171 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000510263 | ENST00000591674 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000510263 | ENST00000586120 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000510263 | ENST00000590700 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000510263 | ENST00000591912 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-intron | ENST00000513137 | ENST00000586683 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000513137 | ENST00000252445 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000513137 | ENST00000587806 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000513137 | ENST00000589171 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000513137 | ENST00000591674 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000513137 | ENST00000586120 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000513137 | ENST00000590700 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000513137 | ENST00000591912 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-intron | ENST00000282394 | ENST00000586683 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000282394 | ENST00000252445 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000282394 | ENST00000587806 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000282394 | ENST00000589171 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000282394 | ENST00000591674 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000282394 | ENST00000586120 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000282394 | ENST00000590700 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000282394 | ENST00000591912 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-intron | ENST00000503865 | ENST00000586683 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000503865 | ENST00000252445 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000503865 | ENST00000587806 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000503865 | ENST00000589171 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000503865 | ENST00000591674 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000503865 | ENST00000586120 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000503865 | ENST00000590700 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000503865 | ENST00000591912 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-intron | ENST00000503962 | ENST00000586683 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000503962 | ENST00000252445 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000503962 | ENST00000587806 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000503962 | ENST00000589171 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000503962 | ENST00000591674 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000503962 | ENST00000586120 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000503962 | ENST00000590700 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
intron-3UTR | ENST00000503962 | ENST00000591912 | SEMA6A | chr5 | 115781956 | + | ELOF1 | chr19 | 11664451 | + |
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FusionProtFeatures for SEMA6A_ELOF1 |
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Hgene | Tgene |
SEMA6A | ELOF1 |
Cell surface receptor for PLXNA2 that plays an importantrole in cell-cell signaling. Required for normal granule cellmigration in the developing cerebellum. Promotes reorganization ofthe actin cytoskeleton and plays an important role in axonguidance in the developing central nervous system. Can act asrepulsive axon guidance cue. Has repulsive action towardsmigrating granular neurons. May play a role in channelingsympathetic axons into the sympathetic chains and controlling thetemporal sequence of sympathetic target innervation (Bysimilarity). {ECO:0000250}. | Transcription elongation factor implicated in themaintenance of proper chromatin structure in actively transcribedregions. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SEMA6A_ELOF1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SEMA6A_ELOF1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SEMA6A_ELOF1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEMA6A_ELOF1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |