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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33174

FusionGeneSummary for SEMA6A_DOCK10

check button Fusion gene summary
Fusion gene informationFusion gene name: SEMA6A_DOCK10
Fusion gene ID: 33174
HgeneTgene
Gene symbol

SEMA6A

DOCK10

Gene ID

57556

55619

Gene namesemaphorin 6Adedicator of cytokinesis 10
SynonymsHT018|SEMA|SEMA6A1|SEMAQ|VIADRIP2|Nbla10300|ZIZ3
Cytomap

5q23.1

2q36.2

Type of geneprotein-codingprotein-coding
Descriptionsemaphorin-6ASEMA6A-1sema VIasema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Asemaphorin 6A-1semaphorin VIAdedicator of cytokinesis protein 10dopamine receptor interacting protein 2zizimin3
Modification date2018052320180526
UniProtAcc

Q9H2E6

Q96BY6

Ensembl transtripts involved in fusion geneENST00000343348, ENST00000257414, 
ENST00000510263, ENST00000513137, 
ENST00000282394, ENST00000503865, 
ENST00000503962, 
ENST00000409592, 
ENST00000258390, ENST00000474102, 
Fusion gene scores* DoF score6 X 6 X 2=722 X 2 X 2=8
# samples 112
** MAII scorelog2(11/72*10)=0.611434712082347
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: SEMA6A [Title/Abstract] AND DOCK10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSEMA6A

GO:1903671

negative regulation of sprouting angiogenesis

22184411

TgeneDOCK10

GO:0030334

regulation of cell migration

18835169


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM974321SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000343348ENST00000409592SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000343348ENST00000258390SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000343348ENST00000474102SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000257414ENST00000409592SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000257414ENST00000258390SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000257414ENST00000474102SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000510263ENST00000409592SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000510263ENST00000258390SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000510263ENST00000474102SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000513137ENST00000409592SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000513137ENST00000258390SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000513137ENST00000474102SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000282394ENST00000409592SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000282394ENST00000258390SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000282394ENST00000474102SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000503865ENST00000409592SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000503865ENST00000258390SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000503865ENST00000474102SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000503962ENST00000409592SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000503962ENST00000258390SEMA6Achr5

115785676

-DOCK10chr2

225699395

+
intron-intronENST00000503962ENST00000474102SEMA6Achr5

115785676

-DOCK10chr2

225699395

+

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FusionProtFeatures for SEMA6A_DOCK10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEMA6A

Q9H2E6

DOCK10

Q96BY6

Cell surface receptor for PLXNA2 that plays an importantrole in cell-cell signaling. Required for normal granule cellmigration in the developing cerebellum. Promotes reorganization ofthe actin cytoskeleton and plays an important role in axonguidance in the developing central nervous system. Can act asrepulsive axon guidance cue. Has repulsive action towardsmigrating granular neurons. May play a role in channelingsympathetic axons into the sympathetic chains and controlling thetemporal sequence of sympathetic target innervation (Bysimilarity). {ECO:0000250}. Guanine nucleotide-exchange factor (GEF) that activatesCDC42 and RAC1 by exchanging bound GDP for free GTP. Essential fordendritic spine morphogenesis in Purkinje cells and in hippocampalneurons, via a CDC42-mediated pathway. Sustains B-celllymphopoiesis in secondary lymphoid tissues and regulatesFCER2/CD23 expression. {ECO:0000250|UniProtKB:Q8BZN6}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEMA6A_DOCK10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEMA6A_DOCK10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEMA6A_DOCK10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEMA6A_DOCK10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneDOCK10C0023893Liver Cirrhosis, Experimental1CTD_human