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Fusion gene ID: 33173 |
FusionGeneSummary for SEMA6A_DLG5 |
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Fusion gene information | Fusion gene name: SEMA6A_DLG5 | Fusion gene ID: 33173 | Hgene | Tgene | Gene symbol | SEMA6A | DLG5 | Gene ID | 57556 | 9231 |
Gene name | semaphorin 6A | discs large MAGUK scaffold protein 5 | |
Synonyms | HT018|SEMA|SEMA6A1|SEMAQ|VIA | LP-DLG|P-DLG5|PDLG | |
Cytomap | 5q23.1 | 10q22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | semaphorin-6ASEMA6A-1sema VIasema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Asemaphorin 6A-1semaphorin VIA | disks large homolog 5discs large protein LP-DLGdiscs large protein P-dlgdiscs, large homolog 5large type of P-DLGplacenta and prostate DLG | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9H2E6 | Q8TDM6 | |
Ensembl transtripts involved in fusion gene | ENST00000343348, ENST00000257414, ENST00000510263, ENST00000513137, ENST00000282394, ENST00000503865, ENST00000503962, | ENST00000372391, ENST00000372388, ENST00000459739, | |
Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 4 X 4 X 2=32 |
# samples | 11 | 8 | |
** MAII score | log2(11/72*10)=0.611434712082347 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/32*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SEMA6A [Title/Abstract] AND DLG5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SEMA6A | GO:1903671 | negative regulation of sprouting angiogenesis | 22184411 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BF990536 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + | ||
ChiTaRS3.1 | BF990530 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + | ||
ChiTaRS3.1 | BF990533 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + | ||
ChiTaRS3.1 | BF990526 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + | ||
ChiTaRS3.1 | BF990529 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000343348 | ENST00000372391 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000343348 | ENST00000372388 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000343348 | ENST00000459739 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000257414 | ENST00000372391 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000257414 | ENST00000372388 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000257414 | ENST00000459739 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000510263 | ENST00000372391 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000510263 | ENST00000372388 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000510263 | ENST00000459739 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000513137 | ENST00000372391 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000513137 | ENST00000372388 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000513137 | ENST00000459739 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000282394 | ENST00000372391 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000282394 | ENST00000372388 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000282394 | ENST00000459739 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000503865 | ENST00000372391 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000503865 | ENST00000372388 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000503865 | ENST00000459739 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000503962 | ENST00000372391 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000503962 | ENST00000372388 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
intron-intron | ENST00000503962 | ENST00000459739 | SEMA6A | chr5 | 115781980 | - | DLG5 | chr10 | 79572329 | + |
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FusionProtFeatures for SEMA6A_DLG5 |
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Hgene | Tgene |
SEMA6A | DLG5 |
Cell surface receptor for PLXNA2 that plays an importantrole in cell-cell signaling. Required for normal granule cellmigration in the developing cerebellum. Promotes reorganization ofthe actin cytoskeleton and plays an important role in axonguidance in the developing central nervous system. Can act asrepulsive axon guidance cue. Has repulsive action towardsmigrating granular neurons. May play a role in channelingsympathetic axons into the sympathetic chains and controlling thetemporal sequence of sympathetic target innervation (Bysimilarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SEMA6A_DLG5 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SEMA6A_DLG5 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SEMA6A_DLG5 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEMA6A_DLG5 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |