	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
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Fusion gene ID: 33162

FusionGeneSummary for SEMA4D_SEMA4D

Fusion gene summary

Fusion gene information	Fusion gene name: SEMA4D_SEMA4D
	Fusion gene ID: 33162
		Hgene	Tgene
	Gene symbol	SEMA4D	SEMA4D
	Gene ID	10507	10507
	Gene name	semaphorin 4D	semaphorin 4D
	Synonyms	C9orf164\|CD100\|COLL4\|M-sema-G\|SEMAJ\|coll-4	C9orf164\|CD100\|COLL4\|M-sema-G\|SEMAJ\|coll-4
	Cytomap	9q22.2	9q22.2
	Type of gene	protein-coding	protein-coding
	Description	semaphorin-4DA8BB18GR3sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D	semaphorin-4DA8BB18GR3sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D
	Modification date	20180527	20180527
	UniProtAcc	Q92854	Q92854
	Ensembl transtripts involved in fusion gene	ENST00000339861, ENST00000420987, ENST00000455551, ENST00000343780, ENST00000450295, ENST00000438547, ENST00000356444, ENST00000422704, ENST00000420101, ENST00000469653,	ENST00000339861, ENST00000420987, ENST00000455551, ENST00000343780, ENST00000450295, ENST00000438547, ENST00000356444, ENST00000422704, ENST00000420101, ENST00000469653,
Fusion gene scores	* DoF score	2 X 3 X 2=12	3 X 4 X 2=24
	# samples	3	4
	** MAII score	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SEMA4D [Title/Abstract] AND SEMA4D [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SEMA4D	GO:0001934	positive regulation of protein phosphorylation	16055703
Hgene	SEMA4D	GO:0007162	negative regulation of cell adhesion	15218527
Hgene	SEMA4D	GO:0030335	positive regulation of cell migration	16055703
Hgene	SEMA4D	GO:0071526	semaphorin-plexin signaling pathway	15218527
Tgene	SEMA4D	GO:0001934	positive regulation of protein phosphorylation	16055703
Tgene	SEMA4D	GO:0007162	negative regulation of cell adhesion	15218527
Tgene	SEMA4D	GO:0030335	positive regulation of cell migration	16055703
Tgene	SEMA4D	GO:0071526	semaphorin-plexin signaling pathway	15218527

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BE938931	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
ChiTaRS3.1			EB360774	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000339861	ENST00000339861	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000339861	ENST00000420987	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000339861	ENST00000455551	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000339861	ENST00000343780	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000339861	ENST00000450295	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000339861	ENST00000438547	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000339861	ENST00000356444	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000339861	ENST00000422704	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000339861	ENST00000420101	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000339861	ENST00000469653	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420987	ENST00000339861	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420987	ENST00000420987	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420987	ENST00000455551	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420987	ENST00000343780	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420987	ENST00000450295	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420987	ENST00000438547	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420987	ENST00000356444	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420987	ENST00000422704	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420987	ENST00000420101	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420987	ENST00000469653	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000455551	ENST00000339861	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000455551	ENST00000420987	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000455551	ENST00000455551	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000455551	ENST00000343780	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000455551	ENST00000450295	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000455551	ENST00000438547	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000455551	ENST00000356444	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000455551	ENST00000422704	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000455551	ENST00000420101	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000455551	ENST00000469653	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000343780	ENST00000339861	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000343780	ENST00000420987	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000343780	ENST00000455551	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000343780	ENST00000343780	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000343780	ENST00000450295	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000343780	ENST00000438547	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000343780	ENST00000356444	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000343780	ENST00000422704	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000343780	ENST00000420101	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000343780	ENST00000469653	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000450295	ENST00000339861	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000450295	ENST00000420987	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000450295	ENST00000455551	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000450295	ENST00000343780	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000450295	ENST00000450295	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000450295	ENST00000438547	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000450295	ENST00000356444	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000450295	ENST00000422704	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000450295	ENST00000420101	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000450295	ENST00000469653	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000438547	ENST00000339861	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000438547	ENST00000420987	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000438547	ENST00000455551	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000438547	ENST00000343780	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000438547	ENST00000450295	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000438547	ENST00000438547	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000438547	ENST00000356444	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000438547	ENST00000422704	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000438547	ENST00000420101	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000438547	ENST00000469653	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000356444	ENST00000339861	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000356444	ENST00000420987	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000356444	ENST00000455551	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000356444	ENST00000343780	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000356444	ENST00000450295	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000356444	ENST00000438547	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000356444	ENST00000356444	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000356444	ENST00000422704	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000356444	ENST00000420101	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000356444	ENST00000469653	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000422704	ENST00000339861	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000422704	ENST00000420987	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000422704	ENST00000455551	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000422704	ENST00000343780	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000422704	ENST00000450295	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000422704	ENST00000438547	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000422704	ENST00000356444	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000422704	ENST00000422704	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000422704	ENST00000420101	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000422704	ENST00000469653	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420101	ENST00000339861	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420101	ENST00000420987	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420101	ENST00000455551	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420101	ENST00000343780	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420101	ENST00000450295	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420101	ENST00000438547	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420101	ENST00000356444	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420101	ENST00000422704	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420101	ENST00000420101	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000420101	ENST00000469653	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000469653	ENST00000339861	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000469653	ENST00000420987	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000469653	ENST00000455551	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000469653	ENST00000343780	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000469653	ENST00000450295	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000469653	ENST00000438547	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000469653	ENST00000356444	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000469653	ENST00000422704	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000469653	ENST00000420101	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000469653	ENST00000469653	SEMA4D	chr9	91993333	-	SEMA4D	chr9	91994107	-
intron-intron	ENST00000339861	ENST00000339861	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000339861	ENST00000420987	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000339861	ENST00000455551	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000339861	ENST00000343780	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000339861	ENST00000450295	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000339861	ENST00000438547	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000339861	ENST00000356444	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000339861	ENST00000422704	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000339861	ENST00000420101	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000339861	ENST00000469653	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420987	ENST00000339861	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420987	ENST00000420987	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420987	ENST00000455551	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420987	ENST00000343780	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420987	ENST00000450295	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420987	ENST00000438547	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420987	ENST00000356444	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420987	ENST00000422704	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420987	ENST00000420101	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420987	ENST00000469653	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000455551	ENST00000339861	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000455551	ENST00000420987	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000455551	ENST00000455551	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000455551	ENST00000343780	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000455551	ENST00000450295	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000455551	ENST00000438547	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000455551	ENST00000356444	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000455551	ENST00000422704	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000455551	ENST00000420101	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000455551	ENST00000469653	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000343780	ENST00000339861	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000343780	ENST00000420987	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000343780	ENST00000455551	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000343780	ENST00000343780	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000343780	ENST00000450295	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000343780	ENST00000438547	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000343780	ENST00000356444	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000343780	ENST00000422704	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000343780	ENST00000420101	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000343780	ENST00000469653	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000450295	ENST00000339861	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000450295	ENST00000420987	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000450295	ENST00000455551	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000450295	ENST00000343780	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000450295	ENST00000450295	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000450295	ENST00000438547	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000450295	ENST00000356444	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000450295	ENST00000422704	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000450295	ENST00000420101	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000450295	ENST00000469653	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000438547	ENST00000339861	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000438547	ENST00000420987	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000438547	ENST00000455551	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000438547	ENST00000343780	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000438547	ENST00000450295	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000438547	ENST00000438547	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000438547	ENST00000356444	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000438547	ENST00000422704	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000438547	ENST00000420101	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000438547	ENST00000469653	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000356444	ENST00000339861	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000356444	ENST00000420987	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000356444	ENST00000455551	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000356444	ENST00000343780	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000356444	ENST00000450295	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000356444	ENST00000438547	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000356444	ENST00000356444	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000356444	ENST00000422704	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000356444	ENST00000420101	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000356444	ENST00000469653	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000422704	ENST00000339861	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000422704	ENST00000420987	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000422704	ENST00000455551	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000422704	ENST00000343780	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000422704	ENST00000450295	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000422704	ENST00000438547	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000422704	ENST00000356444	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000422704	ENST00000422704	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000422704	ENST00000420101	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000422704	ENST00000469653	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420101	ENST00000339861	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420101	ENST00000420987	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420101	ENST00000455551	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420101	ENST00000343780	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420101	ENST00000450295	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420101	ENST00000438547	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420101	ENST00000356444	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420101	ENST00000422704	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420101	ENST00000420101	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000420101	ENST00000469653	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000469653	ENST00000339861	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000469653	ENST00000420987	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000469653	ENST00000455551	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000469653	ENST00000343780	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000469653	ENST00000450295	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000469653	ENST00000438547	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000469653	ENST00000356444	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000469653	ENST00000422704	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000469653	ENST00000420101	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+
intron-intron	ENST00000469653	ENST00000469653	SEMA4D	chr9	92046799	+	SEMA4D	chr9	92046267	+

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FusionProtFeatures for SEMA4D_SEMA4D

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SEMA4D Q92854	SEMA4D Q92854
Cell surface receptor for PLXN1B and PLXNB2 that playsan important role in cell-cell signaling. Promotes reorganizationof the actin cytoskeleton and plays a role in axonal growth coneguidance in the developing central nervous system. Regulatesdendrite and axon branching and morphogenesis. Promotes themigration of cerebellar granule cells and of endothelial cells.Plays a role in the immune system; induces B-cells to aggregateand improves their viability (in vitro). Promotes signaling viaSRC and PTK2B/PYK2, which then mediates activation ofphosphatidylinositol 3-kinase and of the AKT1 signaling cascade.Interaction with PLXNB1 mediates activation of RHOA.{ECO:0000269\|PubMed:16055703, ECO:0000269\|PubMed:19788569,ECO:0000269\|PubMed:20877282, ECO:0000269\|PubMed:8876214}.	Cell surface receptor for PLXN1B and PLXNB2 that playsan important role in cell-cell signaling. Promotes reorganizationof the actin cytoskeleton and plays a role in axonal growth coneguidance in the developing central nervous system. Regulatesdendrite and axon branching and morphogenesis. Promotes themigration of cerebellar granule cells and of endothelial cells.Plays a role in the immune system; induces B-cells to aggregateand improves their viability (in vitro). Promotes signaling viaSRC and PTK2B/PYK2, which then mediates activation ofphosphatidylinositol 3-kinase and of the AKT1 signaling cascade.Interaction with PLXNB1 mediates activation of RHOA.{ECO:0000269\|PubMed:16055703, ECO:0000269\|PubMed:19788569,ECO:0000269\|PubMed:20877282, ECO:0000269\|PubMed:8876214}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for SEMA4D_SEMA4D

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEMA4D_SEMA4D

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for SEMA4D_SEMA4D

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SEMA4D_SEMA4D

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Home

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Statistics

Examples

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Fusion gene ID: 33162

FusionGeneSummary for SEMA4D_SEMA4D

FusionProtFeatures for SEMA4D_SEMA4D

FusionGeneSequence for SEMA4D_SEMA4D

FusionGenePPI for SEMA4D_SEMA4D

RelatedDrugs for SEMA4D_SEMA4D

RelatedDiseases for SEMA4D_SEMA4D