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Fusion gene ID: 33146 |
FusionGeneSummary for SEMA3F_SLC9A9 |
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Fusion gene information | Fusion gene name: SEMA3F_SLC9A9 | Fusion gene ID: 33146 | Hgene | Tgene | Gene symbol | SEMA3F | SLC9A9 | Gene ID | 6405 | 285195 |
Gene name | semaphorin 3F | solute carrier family 9 member A9 | |
Synonyms | SEMA-IV|SEMA4|SEMAK | AUTS16|NHE9 | |
Cytomap | 3p21.31 | 3q24 | |
Type of gene | protein-coding | protein-coding | |
Description | semaphorin-3Fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fsema domain, immunoglobulin domain (Ig), short basic domain, secreted, 3Fsemaphorin III/Fsemaphorin IV | sodium/hydrogen exchanger 9Na(+)/H(+) exchanger 9putative protein product of Nbla00118sodium/proton exchanger NHE9solute carrier family 9 (sodium/hydrogen exchanger)solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q13275 | Q8IVB4 | |
Ensembl transtripts involved in fusion gene | ENST00000413852, ENST00000002829, ENST00000434342, | ENST00000316549, ENST00000498717, | |
Fusion gene scores | * DoF score | 4 X 5 X 5=100 | 7 X 7 X 5=245 |
# samples | 6 | 7 | |
** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SEMA3F [Title/Abstract] AND SLC9A9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SEMA3F | GO:0007411 | axon guidance | 15814794 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-95-7039-01A | SEMA3F | chr3 | 50192580 | + | SLC9A9 | chr3 | 143186032 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000413852 | ENST00000316549 | SEMA3F | chr3 | 50192580 | + | SLC9A9 | chr3 | 143186032 | - |
5UTR-intron | ENST00000413852 | ENST00000498717 | SEMA3F | chr3 | 50192580 | + | SLC9A9 | chr3 | 143186032 | - |
5UTR-3CDS | ENST00000002829 | ENST00000316549 | SEMA3F | chr3 | 50192580 | + | SLC9A9 | chr3 | 143186032 | - |
5UTR-intron | ENST00000002829 | ENST00000498717 | SEMA3F | chr3 | 50192580 | + | SLC9A9 | chr3 | 143186032 | - |
intron-3CDS | ENST00000434342 | ENST00000316549 | SEMA3F | chr3 | 50192580 | + | SLC9A9 | chr3 | 143186032 | - |
intron-intron | ENST00000434342 | ENST00000498717 | SEMA3F | chr3 | 50192580 | + | SLC9A9 | chr3 | 143186032 | - |
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FusionProtFeatures for SEMA3F_SLC9A9 |
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Hgene | Tgene |
SEMA3F | SLC9A9 |
May play a role in cell motility and cell adhesion. | May act in electroneutral exchange of protons for Na(+)across membranes. Involved in the effusion of Golgi luminal H(+)in exchange for cytosolic cations. Involved in organelle ionhomeostasis by contributing to the maintenance of the uniqueacidic pH values of the Golgi and post-Golgi compartments in thecell. {ECO:0000269|PubMed:15522866}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SEMA3F_SLC9A9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SEMA3F_SLC9A9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SEMA3F | SHBG, UBC, MOV10, NXF1 | SLC9A9 | ZDHHC17, TP53 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SEMA3F_SLC9A9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEMA3F_SLC9A9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SEMA3F | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Tgene | SLC9A9 | C0004352 | Autistic Disorder | 1 | CTD_human |