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Fusion gene ID: 33141 |
FusionGeneSummary for SEMA3E_CEP41 |
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Fusion gene information | Fusion gene name: SEMA3E_CEP41 | Fusion gene ID: 33141 | Hgene | Tgene | Gene symbol | SEMA3E | CEP41 | Gene ID | 9723 | 95681 |
Gene name | semaphorin 3E | centrosomal protein 41 | |
Synonyms | M-SEMAH|M-SemaK|SEMAH|coll-5 | JBTS15|TSGA14 | |
Cytomap | 7q21.11 | 7q32.2 | |
Type of gene | protein-coding | protein-coding | |
Description | semaphorin-3Esema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | centrosomal protein of 41 kDacentrosomal protein 41 kDacentrosomal protein 41kDatestis specific protein A14testis specific, 14testis-specific gene A14 protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O15041 | Q9BYV8 | |
Ensembl transtripts involved in fusion gene | ENST00000307792, ENST00000427262, | ENST00000223208, ENST00000541543, ENST00000343969, ENST00000489512, ENST00000495702, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 4=64 |
# samples | 2 | 4 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SEMA3E [Title/Abstract] AND CEP41 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SKCM | TCGA-FS-A1ZB-06A | SEMA3E | chr7 | 83277744 | - | CEP41 | chr7 | 130056807 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000307792 | ENST00000223208 | SEMA3E | chr7 | 83277744 | - | CEP41 | chr7 | 130056807 | - |
5CDS-intron | ENST00000307792 | ENST00000541543 | SEMA3E | chr7 | 83277744 | - | CEP41 | chr7 | 130056807 | - |
5CDS-intron | ENST00000307792 | ENST00000343969 | SEMA3E | chr7 | 83277744 | - | CEP41 | chr7 | 130056807 | - |
5CDS-intron | ENST00000307792 | ENST00000489512 | SEMA3E | chr7 | 83277744 | - | CEP41 | chr7 | 130056807 | - |
5CDS-intron | ENST00000307792 | ENST00000495702 | SEMA3E | chr7 | 83277744 | - | CEP41 | chr7 | 130056807 | - |
intron-3CDS | ENST00000427262 | ENST00000223208 | SEMA3E | chr7 | 83277744 | - | CEP41 | chr7 | 130056807 | - |
intron-intron | ENST00000427262 | ENST00000541543 | SEMA3E | chr7 | 83277744 | - | CEP41 | chr7 | 130056807 | - |
intron-intron | ENST00000427262 | ENST00000343969 | SEMA3E | chr7 | 83277744 | - | CEP41 | chr7 | 130056807 | - |
intron-intron | ENST00000427262 | ENST00000489512 | SEMA3E | chr7 | 83277744 | - | CEP41 | chr7 | 130056807 | - |
intron-intron | ENST00000427262 | ENST00000495702 | SEMA3E | chr7 | 83277744 | - | CEP41 | chr7 | 130056807 | - |
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FusionProtFeatures for SEMA3E_CEP41 |
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Hgene | Tgene |
SEMA3E | CEP41 |
Plays an important role in signaling via the cellsurface receptor PLXND1. Mediates reorganization of the actincytoskeleton, leading to the retraction of cell projections.Promotes focal adhesion disassembly and inhibits adhesion ofendothelial cells to the extracellular matrix. Regulatesangiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascularpatterning during embryogenesis. Plays an important role inensuring the specificity of synapse formation (By similarity).{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SEMA3E_CEP41 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SEMA3E_CEP41 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SEMA3E | CEP41 | HIP1R, MVB12A, WARS, DCTN1, XPO1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SEMA3E_CEP41 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEMA3E_CEP41 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CEP41 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |