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Fusion gene ID: 33140 |
FusionGeneSummary for SEMA3D_RBM28 |
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Fusion gene information | Fusion gene name: SEMA3D_RBM28 | Fusion gene ID: 33140 | Hgene | Tgene | Gene symbol | SEMA3D | RBM28 | Gene ID | 223117 | 55131 |
Gene name | semaphorin 3D | RNA binding motif protein 28 | |
Synonyms | Sema-Z2|coll-2 | ANES | |
Cytomap | 7q21.11 | 7q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | semaphorin-3Dcollapsin 2sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | RNA-binding protein 282810480G15Rik | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O95025 | Q9NW13 | |
Ensembl transtripts involved in fusion gene | ENST00000284136, ENST00000444867, ENST00000484038, | ENST00000223073, ENST00000481788, ENST00000415472, | |
Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 3 X 3 X 3=27 |
# samples | 2 | 3 | |
** MAII score | log2(2/12*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SEMA3D [Title/Abstract] AND RBM28 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-CH-5788-01A | SEMA3D | chr7 | 84782924 | - | RBM28 | chr7 | 127979845 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000284136 | ENST00000223073 | SEMA3D | chr7 | 84782924 | - | RBM28 | chr7 | 127979845 | - |
intron-intron | ENST00000284136 | ENST00000481788 | SEMA3D | chr7 | 84782924 | - | RBM28 | chr7 | 127979845 | - |
intron-intron | ENST00000284136 | ENST00000415472 | SEMA3D | chr7 | 84782924 | - | RBM28 | chr7 | 127979845 | - |
5UTR-3CDS | ENST00000444867 | ENST00000223073 | SEMA3D | chr7 | 84782924 | - | RBM28 | chr7 | 127979845 | - |
5UTR-intron | ENST00000444867 | ENST00000481788 | SEMA3D | chr7 | 84782924 | - | RBM28 | chr7 | 127979845 | - |
5UTR-intron | ENST00000444867 | ENST00000415472 | SEMA3D | chr7 | 84782924 | - | RBM28 | chr7 | 127979845 | - |
intron-3CDS | ENST00000484038 | ENST00000223073 | SEMA3D | chr7 | 84782924 | - | RBM28 | chr7 | 127979845 | - |
intron-intron | ENST00000484038 | ENST00000481788 | SEMA3D | chr7 | 84782924 | - | RBM28 | chr7 | 127979845 | - |
intron-intron | ENST00000484038 | ENST00000415472 | SEMA3D | chr7 | 84782924 | - | RBM28 | chr7 | 127979845 | - |
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FusionProtFeatures for SEMA3D_RBM28 |
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Hgene | Tgene |
SEMA3D | RBM28 |
Induces the collapse and paralysis of neuronal growthcones. Could potentially act as repulsive cues toward specificneuronal populations. Binds to neuropilin (By similarity).{ECO:0000250}. | Nucleolar component of the spliceosomalribonucleoprotein complexes. {ECO:0000269|PubMed:17081119}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SEMA3D_RBM28 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SEMA3D_RBM28 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SEMA3D | RBM28 | NOP56, SIRT7, CUL3, CUL1, CAND1, RPL5, RPS17, RRP12, DKC1, CTPS1, POLR3F, POLR3G, ZNF622, ESR1, HDAC11, HECW2, LIN28A, TARBP2, BRCA1, OBSL1, EED, RNF2, NOL12, RPL14, RPL8, DHX8, NIFK, NPM1, ZC3H3, PRR11, ILF2, NTRK1, NOP2, PES1, DDX18, NIP7, RRP15, SDAD1, TOP1, IFI16, HNRNPU, KIF11, RPL10, SORT1, FBXW7, ZNF746, RPL30, ZC3HAV1, ZNF2, RPL18, H2AFY2, KIAA0020, KNOP1, GPATCH4, RPL18A, RRP8, WDR46, RPS14, RPL37A, RBM4, PRDM5, MAK16, STAU1, DGCR8, GLTSCR2, ZBTB48, SART3, PDGFB, MECP2, HIST1H1E, SRP68, RBM34, RPL28, CNBP, MTF1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SEMA3D_RBM28 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEMA3D_RBM28 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SEMA3D | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | RBM28 | C2677535 | Alopecia, Neurologic Defects, and Endocrinopathy Syndrome | 1 | CTD_human;ORPHANET;UNIPROT |