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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 33136

FusionGeneSummary for SEMA3C_CNTNAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: SEMA3C_CNTNAP2
Fusion gene ID: 33136
HgeneTgene
Gene symbol

SEMA3C

CNTNAP2

Gene ID

10512

26047

Gene namesemaphorin 3Ccontactin associated protein like 2
SynonymsSEMAE|SemEAUTS15|CASPR2|CDFE|NRXN4|PTHSL1
Cytomap

7q21.11

7q35-q36.1

Type of geneprotein-codingprotein-coding
Descriptionsemaphorin-3Csema Esema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Csemaphorin Econtactin-associated protein-like 2cell recognition molecule Caspr2homolog of Drosophila neurexin IV
Modification date2018052320180519
UniProtAcc

Q99985

Q9UHC6

Ensembl transtripts involved in fusion geneENST00000265361, ENST00000544525, 
ENST00000419255, ENST00000536800, 
ENST00000487621, 		ENST00000361727, 
ENST00000538075, ENST00000463592, 
Fusion gene scores* DoF score6 X 4 X 5=1208 X 8 X 7=448
# samples 79
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/448*10)=-2.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEMA3C [Title/Abstract] AND CNTNAP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E2-A1LL-01ASEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265361ENST00000361727SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
In-frameENST00000265361ENST00000538075SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
5CDS-3UTRENST00000265361ENST00000463592SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
Frame-shiftENST00000544525ENST00000361727SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
Frame-shiftENST00000544525ENST00000538075SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
5CDS-3UTRENST00000544525ENST00000463592SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
Frame-shiftENST00000419255ENST00000361727SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
Frame-shiftENST00000419255ENST00000538075SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
5CDS-3UTRENST00000419255ENST00000463592SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
Frame-shiftENST00000536800ENST00000361727SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
Frame-shiftENST00000536800ENST00000538075SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
5CDS-3UTRENST00000536800ENST00000463592SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
5UTR-3CDSENST00000487621ENST00000361727SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
5UTR-3CDSENST00000487621ENST00000538075SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+
5UTR-3UTRENST00000487621ENST00000463592SEMA3Cchr7

80545995

-CNTNAP2chr7

148112509

+

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FusionProtFeatures for SEMA3C_CNTNAP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEMA3C

Q99985

CNTNAP2

Q9UHC6

Binds to plexin family members and plays an importantrole in the regulation of developmental processes. Required fornormal cardiovascular development during embryogenesis. Functionsas attractant for growing axons, and thereby plays an importantrole in axon growth and axon guidance (By similarity).{ECO:0000250}. Required, with CNTNAP1, for radial and longitudinalorganization of myelinated axons. Plays a role in the formation offunctional distinct domains critical for saltatory conduction ofnerve impulses in myelinated nerve fibers. Demarcates thejuxtaparanodal region of the axo-glial junction.{ECO:0000250|UniProtKB:Q9CPW0}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCNTNAP2chr7:80545995chr7:148112509ENST00000361727+22241284_133112651332Topological domainCytoplasmic
TgeneCNTNAP2chr7:80545995chr7:148112509ENST00000361727+22241263_128312651332TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEMA3Cchr7:80545995chr7:148112509ENST00000265361-218724_74534752Compositional biasNote=Arg/Lys-rich (basic)
HgeneSEMA3Cchr7:80545995chr7:148112509ENST00000419255-218724_74534752Compositional biasNote=Arg/Lys-rich (basic)
HgeneSEMA3Cchr7:80545995chr7:148112509ENST00000265361-21828_51134752DomainSema
HgeneSEMA3Cchr7:80545995chr7:148112509ENST00000265361-218571_65534752DomainNote=Ig-like C2-type
HgeneSEMA3Cchr7:80545995chr7:148112509ENST00000419255-21828_51134752DomainSema
HgeneSEMA3Cchr7:80545995chr7:148112509ENST00000419255-218571_65534752DomainNote=Ig-like C2-type
TgeneCNTNAP2chr7:80545995chr7:148112509ENST00000361727+22241055_121412651332DomainLaminin G-like 4
TgeneCNTNAP2chr7:80545995chr7:148112509ENST00000361727+2224216_36812651332DomainLaminin G-like 1
TgeneCNTNAP2chr7:80545995chr7:148112509ENST00000361727+2224401_55212651332DomainLaminin G-like 2
TgeneCNTNAP2chr7:80545995chr7:148112509ENST00000361727+2224554_59112651332DomainEGF-like 1
TgeneCNTNAP2chr7:80545995chr7:148112509ENST00000361727+2224592_79812651332DomainFibrinogen C-terminal
TgeneCNTNAP2chr7:80545995chr7:148112509ENST00000361727+2224799_96312651332DomainLaminin G-like 3
TgeneCNTNAP2chr7:80545995chr7:148112509ENST00000361727+2224963_100212651332DomainEGF-like 2
TgeneCNTNAP2chr7:80545995chr7:148112509ENST00000361727+222428_126212651332Topological domainExtracellular


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FusionGeneSequence for SEMA3C_CNTNAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SEMA3C_ENST00000265361_chr7_80545995_-_CNTNAP2_ENST00000361727_chr7_148112509_+_101aa
MAFRTICVLVGVFICSICVKGSSQPQARVYLTFDGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAESAESADAAIMNNDPNFTET

>In-frame_SEMA3C_ENST00000265361_chr7_80545995_-_CNTNAP2_ENST00000538075_chr7_148112509_+_101aa
MAFRTICVLVGVFICSICVKGSSQPQARVYLTFDGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAESAESADAAIMNNDPNFTET


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SEMA3C_ENST00000265361_chr7_80545995_-_CNTNAP2_ENST00000361727_chr7_148112509_+_303nt
ATGGCATTCCGGACAATTTGCGTGTTGGTTGGAGTATTTATTTGTTCTATCTGTGTGAAAGGATCTTCCCAGCCCCAAGCAAGAGTTTAT
TTAACATTTGATGGCGTCATTGCTGTGGTGATTTTCACCATCCTGTGCACCCTGGTCTTCCTGATCCGGTACATGTTCCGCCACAAGGGC
ACCTACCATACCAACGAAGCAAAGGGGGCGGAGTCGGCAGAGAGCGCGGACGCCGCCATCATGAACAACGACCCCAACTTCACAGAGACC

>In-frame_SEMA3C_ENST00000265361_chr7_80545995_-_CNTNAP2_ENST00000538075_chr7_148112509_+_303nt
ATGGCATTCCGGACAATTTGCGTGTTGGTTGGAGTATTTATTTGTTCTATCTGTGTGAAAGGATCTTCCCAGCCCCAAGCAAGAGTTTAT
TTAACATTTGATGGCGTCATTGCTGTGGTGATTTTCACCATCCTGTGCACCCTGGTCTTCCTGATCCGGTACATGTTCCGCCACAAGGGC
ACCTACCATACCAACGAAGCAAAGGGGGCGGAGTCGGCAGAGAGCGCGGACGCCGCCATCATGAACAACGACCCCAACTTCACAGAGACC


* Fusion transcript sequences (Full-length transcript).
>In-frame_SEMA3C_ENST00000265361_chr7_80545995_-_CNTNAP2_ENST00000361727_chr7_148112509_+_6247nt
GGACTGCGAAAGGAGCAGGGTTGCGGAGCTAGGGCTCCAGCCTGCGGCCGCGCATTCTTGCGTCTGGCCAGCCGCGAGCTCTAAGGGTCG
GCCCCGCCCGGTCCGCCCCCGCGGCTCCCTGCCAGGCTCTCGCGGGCGCGCTCGGGGTGGGGCCTCGCGGCTGGCGGAGATGCGGCCGGG
GCTGCGCGGTGGTGATGCGAGCCTGCAGGGCGGCGCGCCGGGGCAGCCGGAGCCGCGCGCCGCGGCGCTGTAATCGGACACCAAGAGCGC
TCGCCCCCGGCCTCCGGCCACTTTCCATTCACTCCGAGGTGCTTGATTGAGCGACGCGGAGAAGAGCTCCGGGTGCCGCGGCACTGCAGC
GCTGAGATTCCTTTACAAAGAAACTCAGAGGACCGGGAAGAAAGAATTTCACCTTTGCGACGTGCTAGAAAATAAGGTCGTCTGGGAAAA
GGACTGGAGACACAAGCGCATCCAACCCCGGTAGCAAACTGATGACTTTTCCGTGCTGATTTCTTTCAACCTCGGTATTTTCCCTTGGAT
ATTAACTTGCATATCTGAAGAAATGGCATTCCGGACAATTTGCGTGTTGGTTGGAGTATTTATTTGTTCTATCTGTGTGAAAGGATCTTC
CCAGCCCCAAGCAAGAGTTTATTTAACATTTGATGGCGTCATTGCTGTGGTGATTTTCACCATCCTGTGCACCCTGGTCTTCCTGATCCG
GTACATGTTCCGCCACAAGGGCACCTACCATACCAACGAAGCAAAGGGGGCGGAGTCGGCAGAGAGCGCGGACGCCGCCATCATGAACAA
CGACCCCAACTTCACAGAGACCATTGATGAAAGCAAAAAGGAATGGCTCATTTGAGGGGTGGCTACTTGGCTATGGGATAGGGAGGAGGG
AATTACTAGGGAGGAGAGAAAGGGACAAAAGCACCCTGCTTCATACTCTTGAGCACATCCTTAAAATATCAGCACAAGTTGGGGGAGGCA
GGCAATGGAATATAATGGAATATTCTTGAGACTGATCACAAAAAAAAAAACCTTTTTAATATTTCTTTATAGCTGAGTTTTCCCTTCTGT
ATCAAAACAAAATAATACAAAAAATGCTTTTAGAGTTTAAGCAATGGTTGAAATTTGTAGGTACTATCTGTCTTATTTTGTGTGTGTTTA
GAGGTGTTCTAAAGACCCGTGGTAACAGGGCAAGTTTTCTACGTTTTTAAGAGCCCTTAGAACGTGGGTATTTTTTTTCTTGAGAAAAGC
TAATGCACCTACAGATGGCCCCCAACATTCTCTTCCTTTTGCTTCTAGTCAACCTTAATGGGCTGTTACAGAAACTAGTTCGTGTTTATA
TACTATTTCCTTTGATGTCCTATAAGTCGGAAAAGAAAGGGGCAAAGAGAACCTATTATTTGCCAGTTTTTAAGCAGAGCTCAATCTATG
CCAGCTCTCTGGCATCTGGGGTTCCTGACTGATACCAGCAGTTGAAGGAAGAGAGTGCATGGCACCTGGTGTGTAACGACACAATCAGCA
CAACTGGAGAGAGGCATTAAAGAACCAGGGAAGGTAGTTTGATTTTTCATTGAATTCTACAAGCTAATATTGTTCCACGTATGTAGTCTT
AGACCAATAGCTGTAACTATCAGCTGCAATACCATGGTGACCAGCTGTTACAAAAGATTTTTTCCTGTTTTATCTGAAACATACTGGATT
TATATATGTATAAGCGCCTCAATGGGGAATTAGAGCCAGATGTTATGATTTGTTTGCTCTTTTTCTTTTATAGTTTAGTTATAGCAAAAA
TATGGATAATTTCTAGTGAATGCATAAATTAGGTTGCGTTTCTTATTTTGCTTTAAATCTCTGGTAGTTTTTCCACCCCTGTGACACAAT
CCTAATAGACAGTGTCCTGTAAATGGACACAACACAATAAAGTCAAGTTATTATTGCTGTTACTCTGGATGATATGGAAAACACTGCCAT
ATTTTAAATCAACTACTCCACGTGTTTTTCCATCCAATCACACTGCTGTGATTCAGGGATCTTTCTTCTAAGACGGACACATTTGAACCT
CAGGTTCATCACAAACCTGGTACCTGTTGCTTCCCAGAGGATGGAGAAGTGTAGTTAATCACACCTCTTAGTTTAATCTGAAATCTTGAC
CCAGTTATTTAACAAATAAATACCTCATTGATTATATTTAAAAGTAATACACTTCCTGTAAACAAATGGGGACAATGCATCCAAAAAATC
TTTTTAAACAGATTACACAAAAATTATTTCCAGAAAGGCTACCATTTATCATCATTATATTTCAAGCCTCTTATACTTAATAAGCACTTT
CTAAAAAGTCTTGAGATCCCACCATTCTGAGGAATTCAATATGATCACTTTTTCCTTCTTTGCCTGGGAGAGGTTAAGAGGAGGTTTCGA
AGGTATAGATGCTATTGTTCTGATGGCCCGGCTGAATAAAATGGAAATTCTAGTTTGTTAGAATTATGCATTCTTTTTCAAGATTCTCAG
TGTGCCTAACTTATTGGAGCACATCAGTTTCTTGGGTAATGGAAAACATTACCTAGAGTTGCCAGTGGCACATTACACCAGTACAGAGCA
CATTCCAAAGGAGACATTGGACCAGTTAATTCCCATACAAGTCAAGGTAACAGAACAAAAGGGAATCCTGATGCCCTTTTACCATTGCTG
GTTGAGCTCAGGCACTGTCATGGACACCCTTAATTTTAAAAGGTTTTAATCATTCTTCTATAAAATACATTTAAAATGGAAAAATACTTA
ATATCACTAAATATCAGAACAATGTAACATTTACAAATGACATATTGAAAGCAAAGGCTGTTTTATTTAGCCAAGATGATTACCATTAGG
AGTTACTTTATGTATTGTTGAAAGCAAATTTTAAACATGATGTTTTAGAAGTGTTTCTGATTTTTAAACCTGGTTTACAGGTATTACTTC
TGCACTTACCAAATAATGCCAGATGGAAATTTATTATTTCTTGCAATTCCCATGATAGCTCTGTTCTTTATGCATTGTCTCAACACTTTC
CCTTTTTTCCCAAAATGAGTAGAGAATTAAAGCCACCCAAAACAGCTTCTGCTACTAAAATGTTCTCATCCTTTCTCCTCCCTCTCCTTT
TCCTGCCACAAAAGGTGAAAAATGAGATCCAATCCTCTCACCAAAATTTCAAACCTAGGACACTGGAATGACTGCAGGGATCAGTGGTTC
TCCCATATCACCATCAATTAAGACATATAGGACACTGTCTTCCTTCAAGAGGGTTACAATGTGGCCATCAGACAGGAAACCAAACGGTGG
ATAAAGTATTAAGTAACTAAGTGCCAAATAAATGCTGGAAATCTTGACCTCTCCTTGGGATTATGGGTGTAACAAAAATCCCTACATCTG
TTTATGAAGGCCATATTCAGTACATTTTAAATGGTAAATAATCTGTTTATGTGAAGAAAAAGAATTAAGTCTTTCTTCCAACTCTCTCCT
TGGATAGCCTAGCACAGTGCAGCCTCCATAACCATGACATTCCCGCCCAAGCTCTCAGTGCCTAATCCTGCTTTGTCATTCACATCTCAC
AAAATCTTGACATCTTACATTCCAATACATTATCAAGCAAGCACAAGTATGCTGGTAGTAGCCTCTTTAAATAATATGTATAGACAACAA
CAACGACAAAAAATAGACTGTTTTAAAGTTTCAGGGAAAGTTGGTGGCTGATTTAAAGTTGTGCAGGAAACATCTTCTGTGTATGAAGCA
AATGTCGATGTTTTGAAAAAAGCTAGGAGATGACTTTGAATGAATGCAAGGTTAGTGAGATCCTAAGCTCTCAAAATAGCATATTCCCTA
GAGCTCAAGAAAGCTGGTCCAGGAGGTTGAAAAAGCTATTTTGTTGTTAAATTATTTTCTGGCCCTTCTTAATATTTAAAAATGTATTTC
CCCTTGTGGCTTTCAACCACCTGCTCAAAAAAAGAGACTTGTTACATGAAAGTTTTCATTAAAGAGCTGAAAACAAGAATTTAGAGAGCC
ATTCCTAGAAAATGTCCTACTGCCCTGCATTTGACAAACAAGCATCCTTTACTAACAAGAGCAGGAATTCAGAGGCACAAGAAAAAGCAT
TGGCATGAGCCAAAGAGTCTGTCTTAATGTTACTTTTGAAAATCTGCTGAGCGGCCACCATATGCAGGCTGAGAGCTGGGCACAGGCGAA
GCCATTGGAAGCACTTCAGGAACAAGCACACAGCTGTGGGACTTGAACATGCAAGTGTTCAGGTTGTGTCAAGAAGCTTTTCTTTCCTTC
TATGATGGAATCTGTTCTTTTCTATCCTACTTTTTTCTCTCTTCCTCTCCTCACCACATTATACCCTGCTCTTACGCAGTAAACGTTTTA
ATGGCCCGTTTATGTCTCATGCCTCCAAACAACACTGAATTTGAAACCCCCCATTTTTTCTTTTCACCACCCTGTTGAGCAATTTTCCCA
AAAAAAGGGCAGCAATTATTAAATTGAATTCAAGTAAGCCAGCCAAAGATAGGTCCTAAATTGCTAGTCCCAGTAGAACCACCTGATCCT
AAACCAGTGCGAAACAAACAGTAACAATGTCCCCAGCTGACTTCAGCTAAGAACCAATGGCTCCTACCCCCGCCCCGCTTTTTTTTGTTG
TTTTTTGTTTTGTTTTGAGACGGAGTCTTGCTCTGTCCCCCAGGCTGGAGTGCACTGGCGCAATCTCGGGCTCACTGCAACCTCCTCCTC
CTCCCACATTGAGGCGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCGCCATCACACCCAGCTAATTTTTTTTTTT
TTTTGTATTATTAGTAGAAGCCAGGTTTCACCATGTTGGCCAGGGTGGTCTCGAACTCCTGACCTCAAGTGATCCGTCCACCTCGGCCTT
GCAAATTGCTGGGATTACAGGTGTGAGCCACCGTGCCGAGCCAGCCCCATTTTTTAAATGATGTTTTGGTTAAGAGTGGACCATGAGAAT
TAGCTGACAGCATCCCCTTTCTCTCTCCCTGCCTTGGTGGGACCCTCCCTGTGTGACCTTGGTCAAGTCCTCGAACTTTTGTCCCGTATT
TAAGATGGAGCTGTTTTACCTACTTCATAAGACAGTTGCGAGGTGCCATTGATTCTTGACTGCAAAATACCTTGAAACCCTTATATAAAG
ACTGAAGTCAACGGAGCCTAGTGAAAGACTTACTTTGTGGCTTGTGGTTGAAAGTCACATCAAAAGACAAATGTGGCCACGTTCAGGAAT
TGGAGACTTACTGGCATGGCTCTACAGCTGCTCAGTTATTAATCATGCAGACTAACCTGTCAACACTGGGAGATGCAACATAGCAAAAGG
ACAGAGAAATTAGAATTTTTTGTGCAGAAAGCCCTAAATTCCCACCTGAATGTAACTTACAGCTCCCTTACCTACTCTCACACATGCCCT
CAAACATGCTAGATTGGCTTATACATAGGCCAACACAAAATACAAACGTGACGTGTTCATGTAGCCTAGTGGCTATATGCCTATTCTCCA
TGTACCCTGCATGGTAGTGCTGCAAACTTTAAAGTACATTTCTTTCACAGCAGTATTTTTTTTCATAAGTGGCATATAAATGTCATTCAA
TGAAATGGGGAAATCACGTTGAGAAGTTGGTCTGTCATCTCCCATTGAGCAAAGACTGGCAGGAGATAATAAAAATAAATATGGGCACAC
ATGTATTAATATACAGCACGCATTTACAAGTTTATTTTCCAGATAAAATTGTGCTATAAGAACAGCTCTACCAAGACAGTCTGCACCATT
TCCAAGTCTCAGTTAATTTACAGCAACTGCTGCTTTCGGAGATGGCTGTGAAAATATGGAAGTTCCTCTCAAGTAGGCCAAGAAACAGTT
CTAGATTTTACTAAGTTTTATTTTGTCAGGTTTTTTAAATTTTTTCAGTGAGCGTGGTGACTGCAGAGGTTAGTGCTGTGAAAAGCTGGG
CTAAATATTCTTTCTGTAAAGTCAAACAGGATTCCATCCCCTGTGAAATAACACAAAATTTCACTCTCTAAAAGCAACAGCATGTAAACT
AGAATGAAAGAAGGAAATTATGTACGTATGCCTAATATTCTTTGTGAATGTCTTTCATTTAACTAAAATTATATTAGAAACCAGATTGAT

>In-frame_SEMA3C_ENST00000265361_chr7_80545995_-_CNTNAP2_ENST00000538075_chr7_148112509_+_1189nt
GGACTGCGAAAGGAGCAGGGTTGCGGAGCTAGGGCTCCAGCCTGCGGCCGCGCATTCTTGCGTCTGGCCAGCCGCGAGCTCTAAGGGTCG
GCCCCGCCCGGTCCGCCCCCGCGGCTCCCTGCCAGGCTCTCGCGGGCGCGCTCGGGGTGGGGCCTCGCGGCTGGCGGAGATGCGGCCGGG
GCTGCGCGGTGGTGATGCGAGCCTGCAGGGCGGCGCGCCGGGGCAGCCGGAGCCGCGCGCCGCGGCGCTGTAATCGGACACCAAGAGCGC
TCGCCCCCGGCCTCCGGCCACTTTCCATTCACTCCGAGGTGCTTGATTGAGCGACGCGGAGAAGAGCTCCGGGTGCCGCGGCACTGCAGC
GCTGAGATTCCTTTACAAAGAAACTCAGAGGACCGGGAAGAAAGAATTTCACCTTTGCGACGTGCTAGAAAATAAGGTCGTCTGGGAAAA
GGACTGGAGACACAAGCGCATCCAACCCCGGTAGCAAACTGATGACTTTTCCGTGCTGATTTCTTTCAACCTCGGTATTTTCCCTTGGAT
ATTAACTTGCATATCTGAAGAAATGGCATTCCGGACAATTTGCGTGTTGGTTGGAGTATTTATTTGTTCTATCTGTGTGAAAGGATCTTC
CCAGCCCCAAGCAAGAGTTTATTTAACATTTGATGGCGTCATTGCTGTGGTGATTTTCACCATCCTGTGCACCCTGGTCTTCCTGATCCG
GTACATGTTCCGCCACAAGGGCACCTACCATACCAACGAAGCAAAGGGGGCGGAGTCGGCAGAGAGCGCGGACGCCGCCATCATGAACAA
CGACCCCAACTTCACAGAGACCATTGATGAAAGCAAAAAGGAATGGCTCATTTGAGGGGTGGCTACTTGGCTATGGGATAGGGAGGAGGG
AATTACTAGGGAGGAGAGAAAGGGACAAAAGCACCCTGCTTCATACTCTTGAGCACATCCTTAAAATATCAGCACAAGTTGGGGGAGGCA
GGCAATGGAATATAATGGAATATTCTTGAGACTGATCACAAAAAAAAAAACCTTTTTAATATTTCTTTATAGCTGAGTTTTCCCTTCTGT
ATCAAAACAAAATAATACAAAAAATGCTTTTAGAGTTTAAGCAATGGTTGAAATTTGTAGGTACTATCTGTCTTATTTTGTGTGTGTTTA


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FusionGenePPI for SEMA3C_CNTNAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEMA3CSCGB2A2, SDC2CNTNAP2CNTN2, EPB41L3, CASK, CTR9, ZMIZ1, MACF1, IQCB1, MEOX2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEMA3C_CNTNAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEMA3C_CNTNAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSEMA3CC0041207Truncus Arteriosus, Persistent1CTD_human
TgeneCNTNAP2C0004352Autistic Disorder4CTD_human
TgeneCNTNAP2C1510586Autism Spectrum Disorders4CTD_human
TgeneCNTNAP2C0023014Language Development Disorders3CTD_human
TgeneCNTNAP2C0014544Epilepsy2CTD_human;HPO
TgeneCNTNAP2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneCNTNAP2C0005586Bipolar Disorder1PSYGENET
TgeneCNTNAP2C0036341Schizophrenia1CTD_human
TgeneCNTNAP2C0038506Stuttering1CTD_human
TgeneCNTNAP2C0041696Unipolar Depression1PSYGENET
TgeneCNTNAP2C0149925Small cell carcinoma of lung1CTD_human
TgeneCNTNAP2C0424295Hyperactive behavior1CTD_human;HPO
TgeneCNTNAP2C1269683Major Depressive Disorder1PSYGENET
TgeneCNTNAP2C1970431PITT-HOPKINS SYNDROME1CTD_human