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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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RelatedDiseases

Fusion gene ID: 33135

FusionGeneSummary for SEMA3C_CD36

check button Fusion gene summary
Fusion gene informationFusion gene name: SEMA3C_CD36
Fusion gene ID: 33135
HgeneTgene
Gene symbol

SEMA3C

CD36

Gene ID

10512

948

Gene namesemaphorin 3CCD36 molecule
SynonymsSEMAE|SemEBDPLT10|CHDS7|FAT|GP3B|GP4|GPIV|PASIV|SCARB3
Cytomap

7q21.11

7q21.11

Type of geneprotein-codingprotein-coding
Descriptionsemaphorin-3Csema Esema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Csemaphorin Eplatelet glycoprotein 4CD36 antigen (collagen type I receptor, thrombospondin receptor)CD36 molecule (thrombospondin receptor)GPIIIBPAS IVPAS-4 proteincluster determinant 36fatty acid translocaseglycoprotein IIIbleukocyte differentiation antigen
Modification date2018052320180520
UniProtAcc

Q99985

P16671

Ensembl transtripts involved in fusion geneENST00000265361, ENST00000544525, 
ENST00000419255, ENST00000536800, 
ENST00000487621, 		ENST00000435819, 
ENST00000309881, ENST00000534394, 
ENST00000441109, ENST00000394788, 
ENST00000447544, ENST00000432207, 
ENST00000544133, ENST00000538969, 
ENST00000433696, 
Fusion gene scores* DoF score6 X 4 X 5=1203 X 4 X 4=48
# samples 74
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEMA3C [Title/Abstract] AND CD36 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCD36

GO:0001954

positive regulation of cell-matrix adhesion

17416590

TgeneCD36

GO:0007263

nitric oxide mediated signal transduction

17416590

TgeneCD36

GO:0019934

cGMP-mediated signaling

17416590

TgeneCD36

GO:0044539

long-chain fatty acid import

17416590|22022213

TgeneCD36

GO:0071726

cellular response to diacyl bacterial lipopeptide

16880211


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-GV-A3QF-01ASEMA3Cchr7

80545995

-CD36chr7

80293722

+
TCGARVLUSCTCGA-22-5492-01ASEMA3Cchr7

80545995

-CD36chr7

80115783

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265361ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80293722

+
In-frameENST00000265361ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80293722

+
In-frameENST00000265361ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000265361ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000265361ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000265361ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000265361ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000265361ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000265361ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000265361ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000544525ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000544525ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000544525ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000544525ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000544525ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000544525ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000544525ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000544525ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000544525ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000544525ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000419255ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000419255ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000419255ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000419255ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000419255ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000419255ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000419255ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000419255ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000419255ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000419255ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000536800ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000536800ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80293722

+
Frame-shiftENST00000536800ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000536800ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000536800ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000536800ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000536800ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000536800ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000536800ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-intronENST00000536800ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-3CDSENST00000487621ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-3CDSENST00000487621ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-3CDSENST00000487621ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-intronENST00000487621ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-intronENST00000487621ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-intronENST00000487621ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-intronENST00000487621ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-intronENST00000487621ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-intronENST00000487621ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5UTR-intronENST00000487621ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80293722

+
5CDS-5UTRENST00000265361ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000265361ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-5UTRENST00000544525ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000544525ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-5UTRENST00000419255ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000419255ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-5UTRENST00000536800ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5CDS-intronENST00000536800ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-5UTRENST00000487621ENST00000435819SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000309881SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000534394SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000441109SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000394788SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000447544SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000432207SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000544133SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000538969SEMA3Cchr7

80545995

-CD36chr7

80115783

+
5UTR-intronENST00000487621ENST00000433696SEMA3Cchr7

80545995

-CD36chr7

80115783

+

Top

FusionProtFeatures for SEMA3C_CD36


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEMA3C

Q99985

CD36

P16671

Binds to plexin family members and plays an importantrole in the regulation of developmental processes. Required fornormal cardiovascular development during embryogenesis. Functionsas attractant for growing axons, and thereby plays an importantrole in axon growth and axon guidance (By similarity).{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCD36chr7:80545995chr7:80293722ENST00000309881+514440_461203473TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST00000394788+514440_461203473TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST00000432207+413440_461203473TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST00000435819+817440_461203473TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST00000447544+515440_461203657TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEMA3Cchr7:80545995chr7:80293722ENST00000265361-218724_74534752Compositional biasNote=Arg/Lys-rich (basic)
HgeneSEMA3Cchr7:80545995chr7:80293722ENST00000419255-218724_74534752Compositional biasNote=Arg/Lys-rich (basic)
HgeneSEMA3Cchr7:80545995chr7:80293722ENST00000265361-21828_51134752DomainSema
HgeneSEMA3Cchr7:80545995chr7:80293722ENST00000265361-218571_65534752DomainNote=Ig-like C2-type
HgeneSEMA3Cchr7:80545995chr7:80293722ENST00000419255-21828_51134752DomainSema
HgeneSEMA3Cchr7:80545995chr7:80293722ENST00000419255-218571_65534752DomainNote=Ig-like C2-type
TgeneCD36chr7:80545995chr7:80293722ENST00000309881+5142_7203473Topological domainCytoplasmic
TgeneCD36chr7:80545995chr7:80293722ENST00000309881+51430_439203473Topological domainExtracellular
TgeneCD36chr7:80545995chr7:80293722ENST00000394788+5142_7203473Topological domainCytoplasmic
TgeneCD36chr7:80545995chr7:80293722ENST00000394788+51430_439203473Topological domainExtracellular
TgeneCD36chr7:80545995chr7:80293722ENST00000432207+4132_7203473Topological domainCytoplasmic
TgeneCD36chr7:80545995chr7:80293722ENST00000432207+41330_439203473Topological domainExtracellular
TgeneCD36chr7:80545995chr7:80293722ENST00000435819+8172_7203473Topological domainCytoplasmic
TgeneCD36chr7:80545995chr7:80293722ENST00000435819+81730_439203473Topological domainExtracellular
TgeneCD36chr7:80545995chr7:80293722ENST00000447544+5152_7203657Topological domainCytoplasmic
TgeneCD36chr7:80545995chr7:80293722ENST00000447544+51530_439203657Topological domainExtracellular
TgeneCD36chr7:80545995chr7:80293722ENST00000309881+5148_29203473TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST00000394788+5148_29203473TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST00000432207+4138_29203473TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST00000435819+8178_29203473TransmembraneHelical
TgeneCD36chr7:80545995chr7:80293722ENST00000447544+5158_29203657TransmembraneHelical


Top

FusionGeneSequence for SEMA3C_CD36


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SEMA3C_ENST00000265361_chr7_80545995_-_CD36_ENST00000435819_chr7_80293722_+_304aa
MAFRTICVLVGVFICSICVKGSSQPQARVYLTFDVQQYCRWSLXSFQWKRXHKXSCHNRHIXRXKESVLLGKSLRHDXWYRCSLISTFCX
EKPGIAVLFFXYLQVNLCCIXIRRXSERNPCVXICSSIQGLCLSSXKPRQLLFLHRKNYLKKLYIIWCARHQQMQRRETCVHFTSSFSVC
KSXCFRTYXWIKPKXRRTXDILGYXTYNWIHFTICKTAAGQPIGQAIRKNSSIKESEEELYCAYSLAXXDWDHWXXEGKHVQKSSNWKNK

>In-frame_SEMA3C_ENST00000265361_chr7_80545995_-_CD36_ENST00000309881_chr7_80293722_+_304aa
MAFRTICVLVGVFICSICVKGSSQPQARVYLTFDVQQYCRWSLXSFQWKRXHKXSCHNRHIXRXKESVLLGKSLRHDXWYRCSLISTFCX
EKPGIAVLFFXYLQVNLCCIXIRRXSERNPCVXICSSIQGLCLSSXKPRQLLFLHRKNYLKKLYIIWCARHQQMQRRETCVHFTSSFSVC
KSXCFRTYXWIKPKXRRTXDILGYXTYNWIHFTICKTAAGQPIGQAIRKNSSIKESEEELYCAYSLAXXDWDHWXXEGKHVQKSSNWKNK

>In-frame_SEMA3C_ENST00000265361_chr7_80545995_-_CD36_ENST00000534394_chr7_80293722_+_304aa
MAFRTICVLVGVFICSICVKGSSQPQARVYLTFDVQQYCRWSLXSFQWKRXHKXSCHNRHIXRXKESVLLGKSLRHDXWYRCSLISTFCX
EKPGIAVLFFXYLQVNLCCIXIRRXSERNPCVXICSSIQGLCLSSXKPRQLLFLHRKNYLKKLYIIWCARHQQMQRRETCVHFTSSFSVC
KSXCFRTYXWIKPKXRRTXDILGYXTYNWIHFTICKTAAGQPIGQAIRKNSSIKESEEELYCAYSLAXXDWDHWXXEGKHVQKSSNWKNK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SEMA3C_ENST00000265361_chr7_80545995_-_CD36_ENST00000435819_chr7_80293722_+_913nt
ATGGCATTCCGGACAATTTGCGTGTTGGTTGGAGTATTTATTTGTTCTATCTGTGTGAAAGGATCTTCCCAGCCCCAAGCAAGAGTTTAT
TTAACATTTGATGTACAACAATACTGCAGATGGAGTTTATAAAGTTTTCAATGGAAAAGATAACATAAGTAAAGTTGCCATAATCGACAC
ATATAAAGGTAAAAGGAATCTGTCCTATTGGGAAAGTCACTGCGACATGATTAATGGTACAGATGCAGCCTCATTTCCACCTTTTGTTGA
GAAAAGCCAGGTATTGCAGTTCTTTTCTTCTGATATTTGCAGGTCAATCTATGCTGTATTTGAATCCGACGTTAATCTGAAAGGAATCCC
TGTGTATAGATTTGTTCTTCCATCCAAGGCCTTTGCCTCTCCAGTTGAAAACCCAGACAACTATTGTTTCTGCACAGAAAAAATTATCTC
AAAAAATTGTACATCATATGGTGTGCTAGACATCAGCAAATGCAAAGAAGGGAGACCTGTGTACATTTCACTTCCTCATTTTCTGTATGC
AAGTCCTGATGTTTCAGAACCTATTGATGGATTAAACCCAAATGAAGAAGAACATAGGACATACTTGGATATTGAACCTATAACTGGATT
CACTTTACAATTTGCAAAACGGCTGCAGGTCAACCTATTGGTCAAGCCATCAGAAAAAATTCAAGTATTAAAGAATCTGAAGAGGAACTA
TATTGTGCCTATTCTTTGGCTTAATGAGACTGGGACCATTGGTGATGAGAAGGCAAACATGTTCAGAAGTCAAGTAACTGGAAAAATAAA
CCTCCTTGGCCTGATAGAAATGATCTTACTCAGTGTTGGTGTGGTGATGTTTGTTGCTTTTATGATTTCATATTGTGCATGCAGATCGAA

>In-frame_SEMA3C_ENST00000265361_chr7_80545995_-_CD36_ENST00000309881_chr7_80293722_+_913nt
ATGGCATTCCGGACAATTTGCGTGTTGGTTGGAGTATTTATTTGTTCTATCTGTGTGAAAGGATCTTCCCAGCCCCAAGCAAGAGTTTAT
TTAACATTTGATGTACAACAATACTGCAGATGGAGTTTATAAAGTTTTCAATGGAAAAGATAACATAAGTAAAGTTGCCATAATCGACAC
ATATAAAGGTAAAAGGAATCTGTCCTATTGGGAAAGTCACTGCGACATGATTAATGGTACAGATGCAGCCTCATTTCCACCTTTTGTTGA
GAAAAGCCAGGTATTGCAGTTCTTTTCTTCTGATATTTGCAGGTCAATCTATGCTGTATTTGAATCCGACGTTAATCTGAAAGGAATCCC
TGTGTATAGATTTGTTCTTCCATCCAAGGCCTTTGCCTCTCCAGTTGAAAACCCAGACAACTATTGTTTCTGCACAGAAAAAATTATCTC
AAAAAATTGTACATCATATGGTGTGCTAGACATCAGCAAATGCAAAGAAGGGAGACCTGTGTACATTTCACTTCCTCATTTTCTGTATGC
AAGTCCTGATGTTTCAGAACCTATTGATGGATTAAACCCAAATGAAGAAGAACATAGGACATACTTGGATATTGAACCTATAACTGGATT
CACTTTACAATTTGCAAAACGGCTGCAGGTCAACCTATTGGTCAAGCCATCAGAAAAAATTCAAGTATTAAAGAATCTGAAGAGGAACTA
TATTGTGCCTATTCTTTGGCTTAATGAGACTGGGACCATTGGTGATGAGAAGGCAAACATGTTCAGAAGTCAAGTAACTGGAAAAATAAA
CCTCCTTGGCCTGATAGAAATGATCTTACTCAGTGTTGGTGTGGTGATGTTTGTTGCTTTTATGATTTCATATTGTGCATGCAGATCGAA

>In-frame_SEMA3C_ENST00000265361_chr7_80545995_-_CD36_ENST00000534394_chr7_80293722_+_913nt
ATGGCATTCCGGACAATTTGCGTGTTGGTTGGAGTATTTATTTGTTCTATCTGTGTGAAAGGATCTTCCCAGCCCCAAGCAAGAGTTTAT
TTAACATTTGATGTACAACAATACTGCAGATGGAGTTTATAAAGTTTTCAATGGAAAAGATAACATAAGTAAAGTTGCCATAATCGACAC
ATATAAAGGTAAAAGGAATCTGTCCTATTGGGAAAGTCACTGCGACATGATTAATGGTACAGATGCAGCCTCATTTCCACCTTTTGTTGA
GAAAAGCCAGGTATTGCAGTTCTTTTCTTCTGATATTTGCAGGTCAATCTATGCTGTATTTGAATCCGACGTTAATCTGAAAGGAATCCC
TGTGTATAGATTTGTTCTTCCATCCAAGGCCTTTGCCTCTCCAGTTGAAAACCCAGACAACTATTGTTTCTGCACAGAAAAAATTATCTC
AAAAAATTGTACATCATATGGTGTGCTAGACATCAGCAAATGCAAAGAAGGGAGACCTGTGTACATTTCACTTCCTCATTTTCTGTATGC
AAGTCCTGATGTTTCAGAACCTATTGATGGATTAAACCCAAATGAAGAAGAACATAGGACATACTTGGATATTGAACCTATAACTGGATT
CACTTTACAATTTGCAAAACGGCTGCAGGTCAACCTATTGGTCAAGCCATCAGAAAAAATTCAAGTATTAAAGAATCTGAAGAGGAACTA
TATTGTGCCTATTCTTTGGCTTAATGAGACTGGGACCATTGGTGATGAGAAGGCAAACATGTTCAGAAGTCAAGTAACTGGAAAAATAAA
CCTCCTTGGCCTGATAGAAATGATCTTACTCAGTGTTGGTGTGGTGATGTTTGTTGCTTTTATGATTTCATATTGTGCATGCAGATCGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_SEMA3C_ENST00000265361_chr7_80545995_-_CD36_ENST00000435819_chr7_80293722_+_1737nt
GGACTGCGAAAGGAGCAGGGTTGCGGAGCTAGGGCTCCAGCCTGCGGCCGCGCATTCTTGCGTCTGGCCAGCCGCGAGCTCTAAGGGTCG
GCCCCGCCCGGTCCGCCCCCGCGGCTCCCTGCCAGGCTCTCGCGGGCGCGCTCGGGGTGGGGCCTCGCGGCTGGCGGAGATGCGGCCGGG
GCTGCGCGGTGGTGATGCGAGCCTGCAGGGCGGCGCGCCGGGGCAGCCGGAGCCGCGCGCCGCGGCGCTGTAATCGGACACCAAGAGCGC
TCGCCCCCGGCCTCCGGCCACTTTCCATTCACTCCGAGGTGCTTGATTGAGCGACGCGGAGAAGAGCTCCGGGTGCCGCGGCACTGCAGC
GCTGAGATTCCTTTACAAAGAAACTCAGAGGACCGGGAAGAAAGAATTTCACCTTTGCGACGTGCTAGAAAATAAGGTCGTCTGGGAAAA
GGACTGGAGACACAAGCGCATCCAACCCCGGTAGCAAACTGATGACTTTTCCGTGCTGATTTCTTTCAACCTCGGTATTTTCCCTTGGAT
ATTAACTTGCATATCTGAAGAAATGGCATTCCGGACAATTTGCGTGTTGGTTGGAGTATTTATTTGTTCTATCTGTGTGAAAGGATCTTC
CCAGCCCCAAGCAAGAGTTTATTTAACATTTGATGTACAACAATACTGCAGATGGAGTTTATAAAGTTTTCAATGGAAAAGATAACATAA
GTAAAGTTGCCATAATCGACACATATAAAGGTAAAAGGAATCTGTCCTATTGGGAAAGTCACTGCGACATGATTAATGGTACAGATGCAG
CCTCATTTCCACCTTTTGTTGAGAAAAGCCAGGTATTGCAGTTCTTTTCTTCTGATATTTGCAGGTCAATCTATGCTGTATTTGAATCCG
ACGTTAATCTGAAAGGAATCCCTGTGTATAGATTTGTTCTTCCATCCAAGGCCTTTGCCTCTCCAGTTGAAAACCCAGACAACTATTGTT
TCTGCACAGAAAAAATTATCTCAAAAAATTGTACATCATATGGTGTGCTAGACATCAGCAAATGCAAAGAAGGGAGACCTGTGTACATTT
CACTTCCTCATTTTCTGTATGCAAGTCCTGATGTTTCAGAACCTATTGATGGATTAAACCCAAATGAAGAAGAACATAGGACATACTTGG
ATATTGAACCTATAACTGGATTCACTTTACAATTTGCAAAACGGCTGCAGGTCAACCTATTGGTCAAGCCATCAGAAAAAATTCAAGTAT
TAAAGAATCTGAAGAGGAACTATATTGTGCCTATTCTTTGGCTTAATGAGACTGGGACCATTGGTGATGAGAAGGCAAACATGTTCAGAA
GTCAAGTAACTGGAAAAATAAACCTCCTTGGCCTGATAGAAATGATCTTACTCAGTGTTGGTGTGGTGATGTTTGTTGCTTTTATGATTT
CATATTGTGCATGCAGATCGAAAACAATAAAATAAGTAAGTATGTACCAAAAAATATTGCTTCAATAATATTAGCTTATATATTACTTGT
TTTCACTTTATCAAAGAGAAGTTACATATTAGGCCATATATATTTCTAGACATGTCTAGCCACTGATCATTTTTAAATATAGGTAAATAA
ACCTATAAATATTATCACGCAGATCACTAAAGTATATCTTTAATTCTGGGAGAAATGAGATAAAAGATGTACTTGTGACCATTGTAACAA

>In-frame_SEMA3C_ENST00000265361_chr7_80545995_-_CD36_ENST00000309881_chr7_80293722_+_1737nt
GGACTGCGAAAGGAGCAGGGTTGCGGAGCTAGGGCTCCAGCCTGCGGCCGCGCATTCTTGCGTCTGGCCAGCCGCGAGCTCTAAGGGTCG
GCCCCGCCCGGTCCGCCCCCGCGGCTCCCTGCCAGGCTCTCGCGGGCGCGCTCGGGGTGGGGCCTCGCGGCTGGCGGAGATGCGGCCGGG
GCTGCGCGGTGGTGATGCGAGCCTGCAGGGCGGCGCGCCGGGGCAGCCGGAGCCGCGCGCCGCGGCGCTGTAATCGGACACCAAGAGCGC
TCGCCCCCGGCCTCCGGCCACTTTCCATTCACTCCGAGGTGCTTGATTGAGCGACGCGGAGAAGAGCTCCGGGTGCCGCGGCACTGCAGC
GCTGAGATTCCTTTACAAAGAAACTCAGAGGACCGGGAAGAAAGAATTTCACCTTTGCGACGTGCTAGAAAATAAGGTCGTCTGGGAAAA
GGACTGGAGACACAAGCGCATCCAACCCCGGTAGCAAACTGATGACTTTTCCGTGCTGATTTCTTTCAACCTCGGTATTTTCCCTTGGAT
ATTAACTTGCATATCTGAAGAAATGGCATTCCGGACAATTTGCGTGTTGGTTGGAGTATTTATTTGTTCTATCTGTGTGAAAGGATCTTC
CCAGCCCCAAGCAAGAGTTTATTTAACATTTGATGTACAACAATACTGCAGATGGAGTTTATAAAGTTTTCAATGGAAAAGATAACATAA
GTAAAGTTGCCATAATCGACACATATAAAGGTAAAAGGAATCTGTCCTATTGGGAAAGTCACTGCGACATGATTAATGGTACAGATGCAG
CCTCATTTCCACCTTTTGTTGAGAAAAGCCAGGTATTGCAGTTCTTTTCTTCTGATATTTGCAGGTCAATCTATGCTGTATTTGAATCCG
ACGTTAATCTGAAAGGAATCCCTGTGTATAGATTTGTTCTTCCATCCAAGGCCTTTGCCTCTCCAGTTGAAAACCCAGACAACTATTGTT
TCTGCACAGAAAAAATTATCTCAAAAAATTGTACATCATATGGTGTGCTAGACATCAGCAAATGCAAAGAAGGGAGACCTGTGTACATTT
CACTTCCTCATTTTCTGTATGCAAGTCCTGATGTTTCAGAACCTATTGATGGATTAAACCCAAATGAAGAAGAACATAGGACATACTTGG
ATATTGAACCTATAACTGGATTCACTTTACAATTTGCAAAACGGCTGCAGGTCAACCTATTGGTCAAGCCATCAGAAAAAATTCAAGTAT
TAAAGAATCTGAAGAGGAACTATATTGTGCCTATTCTTTGGCTTAATGAGACTGGGACCATTGGTGATGAGAAGGCAAACATGTTCAGAA
GTCAAGTAACTGGAAAAATAAACCTCCTTGGCCTGATAGAAATGATCTTACTCAGTGTTGGTGTGGTGATGTTTGTTGCTTTTATGATTT
CATATTGTGCATGCAGATCGAAAACAATAAAATAAGTAAGTATGTACCAAAAAATATTGCTTCAATAATATTAGCTTATATATTACTTGT
TTTCACTTTATCAAAGAGAAGTTACATATTAGGCCATATATATTTCTAGACATGTCTAGCCACTGATCATTTTTAAATATAGGTAAATAA
ACCTATAAATATTATCACGCAGATCACTAAAGTATATCTTTAATTCTGGGAGAAATGAGATAAAAGATGTACTTGTGACCATTGTAACAA

>In-frame_SEMA3C_ENST00000265361_chr7_80545995_-_CD36_ENST00000534394_chr7_80293722_+_1744nt
GGACTGCGAAAGGAGCAGGGTTGCGGAGCTAGGGCTCCAGCCTGCGGCCGCGCATTCTTGCGTCTGGCCAGCCGCGAGCTCTAAGGGTCG
GCCCCGCCCGGTCCGCCCCCGCGGCTCCCTGCCAGGCTCTCGCGGGCGCGCTCGGGGTGGGGCCTCGCGGCTGGCGGAGATGCGGCCGGG
GCTGCGCGGTGGTGATGCGAGCCTGCAGGGCGGCGCGCCGGGGCAGCCGGAGCCGCGCGCCGCGGCGCTGTAATCGGACACCAAGAGCGC
TCGCCCCCGGCCTCCGGCCACTTTCCATTCACTCCGAGGTGCTTGATTGAGCGACGCGGAGAAGAGCTCCGGGTGCCGCGGCACTGCAGC
GCTGAGATTCCTTTACAAAGAAACTCAGAGGACCGGGAAGAAAGAATTTCACCTTTGCGACGTGCTAGAAAATAAGGTCGTCTGGGAAAA
GGACTGGAGACACAAGCGCATCCAACCCCGGTAGCAAACTGATGACTTTTCCGTGCTGATTTCTTTCAACCTCGGTATTTTCCCTTGGAT
ATTAACTTGCATATCTGAAGAAATGGCATTCCGGACAATTTGCGTGTTGGTTGGAGTATTTATTTGTTCTATCTGTGTGAAAGGATCTTC
CCAGCCCCAAGCAAGAGTTTATTTAACATTTGATGTACAACAATACTGCAGATGGAGTTTATAAAGTTTTCAATGGAAAAGATAACATAA
GTAAAGTTGCCATAATCGACACATATAAAGGTAAAAGGAATCTGTCCTATTGGGAAAGTCACTGCGACATGATTAATGGTACAGATGCAG
CCTCATTTCCACCTTTTGTTGAGAAAAGCCAGGTATTGCAGTTCTTTTCTTCTGATATTTGCAGGTCAATCTATGCTGTATTTGAATCCG
ACGTTAATCTGAAAGGAATCCCTGTGTATAGATTTGTTCTTCCATCCAAGGCCTTTGCCTCTCCAGTTGAAAACCCAGACAACTATTGTT
TCTGCACAGAAAAAATTATCTCAAAAAATTGTACATCATATGGTGTGCTAGACATCAGCAAATGCAAAGAAGGGAGACCTGTGTACATTT
CACTTCCTCATTTTCTGTATGCAAGTCCTGATGTTTCAGAACCTATTGATGGATTAAACCCAAATGAAGAAGAACATAGGACATACTTGG
ATATTGAACCTATAACTGGATTCACTTTACAATTTGCAAAACGGCTGCAGGTCAACCTATTGGTCAAGCCATCAGAAAAAATTCAAGTAT
TAAAGAATCTGAAGAGGAACTATATTGTGCCTATTCTTTGGCTTAATGAGACTGGGACCATTGGTGATGAGAAGGCAAACATGTTCAGAA
GTCAAGTAACTGGAAAAATAAACCTCCTTGGCCTGATAGAAATGATCTTACTCAGTGTTGGTGTGGTGATGTTTGTTGCTTTTATGATTT
CATATTGTGCATGCAGATCGAAAACAATAAAATAAGTAAGTATGTACCAAAAAATATTGCTTCAATAATATTAGCTTATATATTACTTGT
TTTCACTTTATCAAAGAGAAGTTACATATTAGGCCATATATATTTCTAGACATGTCTAGCCACTGATCATTTTTAAATATAGGTAAATAA
ACCTATAAATATTATCACGCAGATCACTAAAGTATATCTTTAATTCTGGGAGAAATGAGATAAAAGATGTACTTGTGACCATTGTAACAA


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FusionGenePPI for SEMA3C_CD36


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEMA3CSCGB2A2, SDC2CD36HSD11B1, LDLR, VLDLR, FYN, LYN, YES1, MATK, ITGA2B, ITGB3, ITGA6, CD9, ITGB1, CAND1, APP, CHRD, CROT, C3orf52, MBOAT7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCD36chr7:80545995chr7:80293722ENST00000309881+514460_472203473PTK2%2C PXN and LYN
TgeneCD36chr7:80545995chr7:80293722ENST00000394788+514460_472203473PTK2%2C PXN and LYN
TgeneCD36chr7:80545995chr7:80293722ENST00000432207+413460_472203473PTK2%2C PXN and LYN
TgeneCD36chr7:80545995chr7:80293722ENST00000435819+817460_472203473PTK2%2C PXN and LYN
TgeneCD36chr7:80545995chr7:80293722ENST00000447544+515460_472203657PTK2%2C PXN and LYN


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEMA3C_CD36


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEMA3C_CD36


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSEMA3CC0041207Truncus Arteriosus, Persistent1CTD_human
TgeneCD36C0007193Cardiomyopathy, Dilated1CTD_human
TgeneCD36C0020538Hypertensive disease1CTD_human
TgeneCD36C0021051Immunologic Deficiency Syndromes1CTD_human
TgeneCD36C0021655Insulin Resistance1CTD_human
TgeneCD36C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCD36C0035126Reperfusion Injury1CTD_human
TgeneCD36C0038160Staphylococcal Infections1CTD_human
TgeneCD36C0043094Weight Gain1CTD_human
TgeneCD36C0151744Myocardial Ischemia1CTD_human
TgeneCD36C0162820Dermatitis, Allergic Contact1CTD_human
TgeneCD36C0271650Impaired glucose tolerance1CTD_human
TgeneCD36C1842090Platelet Glycoprotein IV Deficiency1CTD_human;UNIPROT