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Fusion gene ID: 33116 |
FusionGeneSummary for SEL1L_ANGEL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SEL1L_ANGEL1 | Fusion gene ID: 33116 | Hgene | Tgene | Gene symbol | SEL1L | ANGEL1 | Gene ID | 6400 | 23357 |
| Gene name | SEL1L, ERAD E3 ligase adaptor subunit | angel homolog 1 | |
| Synonyms | PRO1063|SEL1-LIKE|SEL1L1 | Ccr4e|KIAA0759 | |
| Cytomap | 14q31.1 | 14q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein sel-1 homolog 1Suppressor of lin 12 (sel-1), C. elegans, homolog ofsel-1 suppressor of lin-12-like 1suppressor of lin-12-like protein 1 | protein angel homolog 1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9UBV2 | Q9UNK9 | |
| Ensembl transtripts involved in fusion gene | ENST00000336735, ENST00000555824, | ENST00000251089, ENST00000557179, ENST00000554941, | |
| Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SEL1L [Title/Abstract] AND ANGEL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-J4-AATZ-01A | SEL1L | chr14 | 81952016 | - | ANGEL1 | chr14 | 77275986 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000336735 | ENST00000251089 | SEL1L | chr14 | 81952016 | - | ANGEL1 | chr14 | 77275986 | - |
| 5CDS-intron | ENST00000336735 | ENST00000557179 | SEL1L | chr14 | 81952016 | - | ANGEL1 | chr14 | 77275986 | - |
| 5CDS-5UTR | ENST00000336735 | ENST00000554941 | SEL1L | chr14 | 81952016 | - | ANGEL1 | chr14 | 77275986 | - |
| intron-3CDS | ENST00000555824 | ENST00000251089 | SEL1L | chr14 | 81952016 | - | ANGEL1 | chr14 | 77275986 | - |
| intron-intron | ENST00000555824 | ENST00000557179 | SEL1L | chr14 | 81952016 | - | ANGEL1 | chr14 | 77275986 | - |
| intron-5UTR | ENST00000555824 | ENST00000554941 | SEL1L | chr14 | 81952016 | - | ANGEL1 | chr14 | 77275986 | - |
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FusionProtFeatures for SEL1L_ANGEL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SEL1L | ANGEL1 |
| Plays a role in the endoplasmic reticulum qualitycontrol (ERQC) system also called ER-associated degradation (ERAD)involved in ubiquitin-dependent degradation of misfoldedendoplasmic reticulum proteins (PubMed:16186509). Enhances SYVN1stability. Plays a role in LPL maturation and secretion. Requiredfor normal differentiation of the pancreas epithelium, and fornormal exocrine function and survival of pancreatic cells. Mayplay a role in Notch signaling. {ECO:0000250|UniProtKB:Q9Z2G6,ECO:0000269|PubMed:16186509}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 122_170 | 624 | 795 | Domain | Fibronectin type-II |
| Hgene | SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 352_537 | 624 | 795 | Region | Important for homodimerization and oligomerization |
| Hgene | SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 183_218 | 624 | 795 | Repeat | Note=Sel1-like 1 |
| Hgene | SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 219_254 | 624 | 795 | Repeat | Note=Sel1-like 2 |
| Hgene | SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 255_290 | 624 | 795 | Repeat | Note=Sel1-like 3 |
| Hgene | SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 291_326 | 624 | 795 | Repeat | Note=Sel1-like 4 |
| Hgene | SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 373_409 | 624 | 795 | Repeat | Note=Sel1-like 5 |
| Hgene | SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 410_446 | 624 | 795 | Repeat | Note=Sel1-like 6 |
| Hgene | SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 447_482 | 624 | 795 | Repeat | Note=Sel1-like 7 |
| Hgene | SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 483_518 | 624 | 795 | Repeat | Note=Sel1-like 8 |
| Hgene | SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 519_554 | 624 | 795 | Repeat | Note=Sel1-like 9 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 770_793 | 624 | 795 | Compositional bias | Note=Pro-rich |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 770_793 | -30 | 302 | Compositional bias | Note=Pro-rich |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 122_170 | -30 | 302 | Domain | Fibronectin type-II |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 738_794 | 624 | 795 | Region | Note=Mediates retention in the endoplasmic reticulum |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 352_537 | -30 | 302 | Region | Important for homodimerization and oligomerization |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 738_794 | -30 | 302 | Region | Note=Mediates retention in the endoplasmic reticulum |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 627_662 | 624 | 795 | Repeat | Note=Sel1-like 10 |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 664_699 | 624 | 795 | Repeat | Note=Sel1-like 11 |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 183_218 | -30 | 302 | Repeat | Note=Sel1-like 1 |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 219_254 | -30 | 302 | Repeat | Note=Sel1-like 2 |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 255_290 | -30 | 302 | Repeat | Note=Sel1-like 3 |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 291_326 | -30 | 302 | Repeat | Note=Sel1-like 4 |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 373_409 | -30 | 302 | Repeat | Note=Sel1-like 5 |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 410_446 | -30 | 302 | Repeat | Note=Sel1-like 6 |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 447_482 | -30 | 302 | Repeat | Note=Sel1-like 7 |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 483_518 | -30 | 302 | Repeat | Note=Sel1-like 8 |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 519_554 | -30 | 302 | Repeat | Note=Sel1-like 9 |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 627_662 | -30 | 302 | Repeat | Note=Sel1-like 10 |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 664_699 | -30 | 302 | Repeat | Note=Sel1-like 11 |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 22_738 | 624 | 795 | Topological domain | Lumenal |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 760_794 | 624 | 795 | Topological domain | Cytoplasmic |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 22_738 | -30 | 302 | Topological domain | Lumenal |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 760_794 | -30 | 302 | Topological domain | Cytoplasmic |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 739_759 | 624 | 795 | Transmembrane | Helical |
| Hgene | >SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 739_759 | -30 | 302 | Transmembrane | Helical |
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FusionGeneSequence for SEL1L_ANGEL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SEL1L_ENST00000336735_chr14_81952016_-_ANGEL1_ENST00000251089_chr14_77275986_-_1274aa MRVRIGLTLLLCAVLLSLASASSDEEGSQDESLDSKTTLTSDESVKDHTTAGRVVAGQIFLDSEESELESSIQEEEDSLKSQEGESVTED ISFLESPNPENKDYEEPKKVRKPALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQM QEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLPQNIQAAREMFEKLTEEGSPKGQTALGFLYASGLG VNSSQAKALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDL IQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQ SGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCH TAVELFKNVCERGRWSERLMTAYNSYKDGDYNAAVIQYLLLAEQGYEVAQSNAAFILDQREASIVGENETYPRALLHWNRAASQDAFFTC RKNVLLANSSSPQVEGDFAMAPRGPEQEECEGLLQQWREEGLSQVLSTASEGPLIDKGLAQSSLALLMDNPGEENAASEDRWSSRQLSDL RAAENLDEPFPEMLGEEPLLEVEGVEGSMWAAIPMQSEPQYADCAALPVGALATEQWEEDPAVLAWSIAPEPVPQEEASIWPFEGLGQLQ PPAVEIPYHEILWREWEDFSTQPDAQGLKAGDGPQFQFTLMSYNILAQDLMQQSSELYLHCHPDILNWNYRFVNLMQEFQHWDPDILCLQ EVQEDHYWEQLEPSLRMMGFTCFYKRRTGCKTDGCAVCYKPTRFRLLCASPVEYFRPGLELLNRDNVGLVLLLQPLVPEGLGQVSVAPLC VANTHILYNPRRGDVKLAQMAILLAEVDKVARLSDGSHCPIILCGDLNSVPDSPLYNFIRDGELQYHGMPAWKVSGQEDFSHQLYQRKLQ APLWPSSLGITDCCQYVTSCHPKRSERRKYGRDFLLRFRFCSIACQRPVGLVLMEGVTDTKPERPAGWAESVLEEDASELEPAFSRTVGT IQHCLHLTSVYTHFLPQRGRPEVTTMPLGLGMTVDYIFFSAESCENGNRTDHRLYRDGTLKLLGRLSLLSEEILWAANGLPNPFCSSDHL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SEL1L_ENST00000336735_chr14_81952016_-_ANGEL1_ENST00000251089_chr14_77275986_-_3822nt ATGCGGGTCCGGATAGGGCTGACGCTGCTGCTGTGTGCGGTGCTGCTGAGCTTGGCCTCGGCGTCCTCGGATGAAGAAGGCAGCCAGGAT GAATCCTTAGATTCCAAGACTACTTTGACATCAGATGAGTCAGTAAAGGACCATACTACTGCAGGCAGAGTAGTTGCTGGTCAAATATTT CTTGATTCAGAAGAATCTGAATTAGAATCCTCTATTCAAGAAGAGGAAGACAGCCTCAAGAGCCAAGAGGGGGAAAGTGTCACAGAAGAT ATCAGCTTTCTAGAGTCTCCAAATCCAGAAAACAAGGACTATGAAGAGCCAAAGAAAGTACGGAAACCAGCTTTGACCGCCATTGAAGGC ACAGCACATGGGGAGCCCTGCCACTTCCCTTTTCTTTTCCTAGATAAGGAGTATGATGAATGTACATCAGATGGGAGGGAAGATGGCAGA CTGTGGTGTGCTACAACCTATGACTACAAAGCAGATGAAAAGTGGGGCTTTTGTGAAACTGAAGAAGAGGCTGCTAAGAGACGGCAGATG CAGGAAGCAGAAATGATGTATCAAACTGGAATGAAAATCCTTAATGGAAGCAATAAGAAAAGCCAAAAAAGAGAAGCATATCGGTATCTC CAAAAGGCAGCAAGCATGAACCATACCAAAGCCCTGGAGAGAGTGTCATATGCTCTTTTATTTGGTGATTACTTGCCACAGAATATCCAG GCAGCGAGAGAGATGTTTGAGAAGCTGACTGAGGAAGGCTCTCCCAAGGGACAGACTGCTCTTGGCTTTCTGTATGCCTCTGGACTTGGT GTTAATTCAAGTCAGGCAAAGGCTCTTGTATATTATACATTTGGAGCTCTTGGGGGCAATCTAATAGCCCACATGGTTTTGGGTTACAGA TACTGGGCTGGCATCGGCGTCCTCCAGAGTTGTGAATCTGCCCTGACTCACTATCGTCTTGTTGCCAATCATGTTGCTAGTGATATCTCG CTAACAGGAGGCTCAGTAGTACAGAGAATACGGCTGCCTGATGAAGTGGAAAATCCAGGAATGAACAGTGGAATGCTAGAAGAAGATTTG ATTCAATATTACCAGTTCCTAGCTGAAAAAGGTGATGTACAAGCACAGGTTGGTCTTGGACAACTGCACCTGCACGGAGGGCGTGGAGTA GAACAGAATCATCAGAGAGCATTTGACTACTTCAATTTAGCAGCAAATGCTGGCAATTCACATGCCATGGCCTTTTTGGGAAAGATGTAT TCGGAAGGAAGTGACATTGTACCTCAGAGTAATGAGACAGCTCTCCACTACTTTAAGAAAGCTGCTGACATGGGCAACCCAGTTGGACAG AGTGGGCTTGGAATGGCCTACCTCTATGGGAGAGGAGTTCAAGTTAATTATGATCTAGCCCTTAAGTATTTCCAGAAAGCTGCTGAACAA GGCTGGGTGGATGGGCAGCTACAGCTTGGTTCCATGTACTATAATGGCATTGGAGTCAAGAGAGATTATAAACAGGCCTTGAAGTATTTT AATTTAGCTTCTCAGGGAGGCCATATCTTGGCTTTCTATAACCTAGCTCAGATGCATGCCAGTGGCACCGGCGTGATGCGATCATGTCAC ACTGCAGTGGAGTTGTTTAAGAATGTATGTGAACGAGGCCGTTGGTCTGAAAGGCTTATGACTGCCTATAACAGCTATAAAGATGGCGAT TACAATGCTGCAGTGATCCAGTACCTCCTCCTGGCTGAACAGGGCTATGAAGTGGCACAAAGCAATGCAGCCTTTATTCTTGATCAGAGA GAAGCAAGCATTGTAGGTGAGAATGAAACTTATCCCAGAGCTTTGCTACATTGGAACAGGGCCGCCTCTCAAGATGCTTTCTTCACATGT CGAAAAAATGTCCTTCTGGCGAACAGCTCATCCCCCCAGGTAGAGGGCGACTTTGCCATGGCCCCTCGGGGCCCTGAGCAGGAGGAATGT GAGGGCCTGCTGCAGCAGTGGCGAGAAGAAGGGTTGAGCCAGGTGCTCTCAACTGCAAGTGAGGGGCCCCTTATAGATAAAGGACTAGCC CAGAGCAGCCTGGCACTTCTGATGGATAATCCTGGAGAAGAGAATGCTGCTTCAGAGGACAGGTGGTCCAGCAGGCAGCTGAGTGACCTT CGGGCTGCAGAGAACCTGGATGAGCCTTTCCCTGAGATGCTAGGAGAGGAGCCACTGCTGGAGGTGGAGGGGGTGGAGGGCTCCATGTGG GCAGCTATCCCCATGCAGTCGGAGCCCCAGTATGCAGACTGTGCTGCCCTCCCAGTGGGTGCCCTGGCCACAGAGCAGTGGGAAGAGGAC CCAGCGGTGTTGGCCTGGAGCATAGCACCTGAGCCTGTGCCCCAGGAAGAGGCTTCCATCTGGCCCTTTGAGGGCCTGGGGCAGTTGCAG CCTCCCGCAGTGGAAATACCATATCATGAAATTTTGTGGCGAGAATGGGAGGATTTCTCCACCCAGCCAGATGCTCAGGGCCTGAAGGCA GGAGATGGCCCTCAGTTCCAGTTCACTCTGATGTCTTATAACATCCTGGCTCAGGACCTGATGCAGCAGAGCTCAGAGCTCTATCTACAT TGCCATCCAGACATCCTCAATTGGAACTATCGCTTCGTGAACCTCATGCAGGAATTCCAGCACTGGGACCCTGATATCCTGTGTCTCCAG GAAGTCCAGGAAGATCATTACTGGGAGCAGCTGGAACCCTCTCTGCGAATGATGGGCTTTACCTGTTTCTACAAGAGGAGGACTGGGTGT AAAACCGATGGCTGTGCTGTCTGCTACAAGCCTACCAGATTCCGCCTGCTCTGTGCTAGCCCTGTGGAGTACTTCCGGCCTGGCTTGGAG CTACTTAATCGGGATAATGTGGGCTTAGTGTTGCTACTGCAACCACTCGTCCCAGAAGGCCTGGGACAAGTCTCGGTGGCCCCGCTGTGT GTGGCAAATACCCATATCCTTTACAACCCACGCCGGGGCGATGTCAAGCTGGCCCAGATGGCCATTCTCCTGGCGGAAGTGGACAAGGTG GCCAGACTGTCAGATGGCAGCCACTGCCCCATCATCTTGTGCGGGGACCTAAATTCTGTCCCTGATTCACCTCTCTACAACTTCATCAGG GATGGAGAGCTCCAGTACCATGGGATGCCAGCCTGGAAGGTATCTGGACAGGAAGACTTCTCCCATCAGCTTTACCAGAGGAAGCTGCAG GCCCCACTGTGGCCCAGCTCCCTGGGCATCACTGATTGCTGTCAGTATGTCACCTCCTGTCACCCCAAGAGATCAGAGAGACGCAAGTAT GGCCGAGACTTCCTGCTACGTTTCCGCTTCTGCAGCATCGCTTGTCAGCGACCAGTAGGACTGGTCCTTATGGAAGGAGTGACAGATACT AAGCCAGAGCGACCTGCGGGTTGGGCTGAGTCTGTCCTTGAGGAAGATGCATCGGAGCTTGAGCCTGCCTTCTCCAGGACTGTAGGTACC ATCCAGCACTGCCTCCACCTGACGTCAGTATATACCCACTTCCTGCCCCAGCGTGGCCGCCCAGAGGTCACTACAATGCCATTGGGTCTT GGAATGACAGTAGATTACATCTTCTTCTCAGCTGAGTCCTGTGAGAATGGGAACAGAACTGATCACAGGCTGTATCGAGATGGAACTCTC AAGCTCCTGGGTCGTCTCTCCCTTCTCTCTGAAGAGATACTCTGGGCTGCCAATGGCTTACCCAACCCCTTCTGCTCTTCAGACCACCTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SEL1L_ENST00000336735_chr14_81952016_-_ANGEL1_ENST00000251089_chr14_77275986_-_5922nt GCGGAGGAAGGAGACTAGAGCAGGAAGAGCAGCGGCGAGGCGGCGGTGGTGGCTGAGTCCGTGGTGGCAGAGGCGAAGGCGACAGCTCTA GGGGTTGGCACCGGCCCCGAGAGGAGGATGCGGGTCCGGATAGGGCTGACGCTGCTGCTGTGTGCGGTGCTGCTGAGCTTGGCCTCGGCG TCCTCGGATGAAGAAGGCAGCCAGGATGAATCCTTAGATTCCAAGACTACTTTGACATCAGATGAGTCAGTAAAGGACCATACTACTGCA GGCAGAGTAGTTGCTGGTCAAATATTTCTTGATTCAGAAGAATCTGAATTAGAATCCTCTATTCAAGAAGAGGAAGACAGCCTCAAGAGC CAAGAGGGGGAAAGTGTCACAGAAGATATCAGCTTTCTAGAGTCTCCAAATCCAGAAAACAAGGACTATGAAGAGCCAAAGAAAGTACGG AAACCAGCTTTGACCGCCATTGAAGGCACAGCACATGGGGAGCCCTGCCACTTCCCTTTTCTTTTCCTAGATAAGGAGTATGATGAATGT ACATCAGATGGGAGGGAAGATGGCAGACTGTGGTGTGCTACAACCTATGACTACAAAGCAGATGAAAAGTGGGGCTTTTGTGAAACTGAA GAAGAGGCTGCTAAGAGACGGCAGATGCAGGAAGCAGAAATGATGTATCAAACTGGAATGAAAATCCTTAATGGAAGCAATAAGAAAAGC CAAAAAAGAGAAGCATATCGGTATCTCCAAAAGGCAGCAAGCATGAACCATACCAAAGCCCTGGAGAGAGTGTCATATGCTCTTTTATTT GGTGATTACTTGCCACAGAATATCCAGGCAGCGAGAGAGATGTTTGAGAAGCTGACTGAGGAAGGCTCTCCCAAGGGACAGACTGCTCTT GGCTTTCTGTATGCCTCTGGACTTGGTGTTAATTCAAGTCAGGCAAAGGCTCTTGTATATTATACATTTGGAGCTCTTGGGGGCAATCTA ATAGCCCACATGGTTTTGGGTTACAGATACTGGGCTGGCATCGGCGTCCTCCAGAGTTGTGAATCTGCCCTGACTCACTATCGTCTTGTT GCCAATCATGTTGCTAGTGATATCTCGCTAACAGGAGGCTCAGTAGTACAGAGAATACGGCTGCCTGATGAAGTGGAAAATCCAGGAATG AACAGTGGAATGCTAGAAGAAGATTTGATTCAATATTACCAGTTCCTAGCTGAAAAAGGTGATGTACAAGCACAGGTTGGTCTTGGACAA CTGCACCTGCACGGAGGGCGTGGAGTAGAACAGAATCATCAGAGAGCATTTGACTACTTCAATTTAGCAGCAAATGCTGGCAATTCACAT GCCATGGCCTTTTTGGGAAAGATGTATTCGGAAGGAAGTGACATTGTACCTCAGAGTAATGAGACAGCTCTCCACTACTTTAAGAAAGCT GCTGACATGGGCAACCCAGTTGGACAGAGTGGGCTTGGAATGGCCTACCTCTATGGGAGAGGAGTTCAAGTTAATTATGATCTAGCCCTT AAGTATTTCCAGAAAGCTGCTGAACAAGGCTGGGTGGATGGGCAGCTACAGCTTGGTTCCATGTACTATAATGGCATTGGAGTCAAGAGA GATTATAAACAGGCCTTGAAGTATTTTAATTTAGCTTCTCAGGGAGGCCATATCTTGGCTTTCTATAACCTAGCTCAGATGCATGCCAGT GGCACCGGCGTGATGCGATCATGTCACACTGCAGTGGAGTTGTTTAAGAATGTATGTGAACGAGGCCGTTGGTCTGAAAGGCTTATGACT GCCTATAACAGCTATAAAGATGGCGATTACAATGCTGCAGTGATCCAGTACCTCCTCCTGGCTGAACAGGGCTATGAAGTGGCACAAAGC AATGCAGCCTTTATTCTTGATCAGAGAGAAGCAAGCATTGTAGGTGAGAATGAAACTTATCCCAGAGCTTTGCTACATTGGAACAGGGCC GCCTCTCAAGATGCTTTCTTCACATGTCGAAAAAATGTCCTTCTGGCGAACAGCTCATCCCCCCAGGTAGAGGGCGACTTTGCCATGGCC CCTCGGGGCCCTGAGCAGGAGGAATGTGAGGGCCTGCTGCAGCAGTGGCGAGAAGAAGGGTTGAGCCAGGTGCTCTCAACTGCAAGTGAG GGGCCCCTTATAGATAAAGGACTAGCCCAGAGCAGCCTGGCACTTCTGATGGATAATCCTGGAGAAGAGAATGCTGCTTCAGAGGACAGG TGGTCCAGCAGGCAGCTGAGTGACCTTCGGGCTGCAGAGAACCTGGATGAGCCTTTCCCTGAGATGCTAGGAGAGGAGCCACTGCTGGAG GTGGAGGGGGTGGAGGGCTCCATGTGGGCAGCTATCCCCATGCAGTCGGAGCCCCAGTATGCAGACTGTGCTGCCCTCCCAGTGGGTGCC CTGGCCACAGAGCAGTGGGAAGAGGACCCAGCGGTGTTGGCCTGGAGCATAGCACCTGAGCCTGTGCCCCAGGAAGAGGCTTCCATCTGG CCCTTTGAGGGCCTGGGGCAGTTGCAGCCTCCCGCAGTGGAAATACCATATCATGAAATTTTGTGGCGAGAATGGGAGGATTTCTCCACC CAGCCAGATGCTCAGGGCCTGAAGGCAGGAGATGGCCCTCAGTTCCAGTTCACTCTGATGTCTTATAACATCCTGGCTCAGGACCTGATG CAGCAGAGCTCAGAGCTCTATCTACATTGCCATCCAGACATCCTCAATTGGAACTATCGCTTCGTGAACCTCATGCAGGAATTCCAGCAC TGGGACCCTGATATCCTGTGTCTCCAGGAAGTCCAGGAAGATCATTACTGGGAGCAGCTGGAACCCTCTCTGCGAATGATGGGCTTTACC TGTTTCTACAAGAGGAGGACTGGGTGTAAAACCGATGGCTGTGCTGTCTGCTACAAGCCTACCAGATTCCGCCTGCTCTGTGCTAGCCCT GTGGAGTACTTCCGGCCTGGCTTGGAGCTACTTAATCGGGATAATGTGGGCTTAGTGTTGCTACTGCAACCACTCGTCCCAGAAGGCCTG GGACAAGTCTCGGTGGCCCCGCTGTGTGTGGCAAATACCCATATCCTTTACAACCCACGCCGGGGCGATGTCAAGCTGGCCCAGATGGCC ATTCTCCTGGCGGAAGTGGACAAGGTGGCCAGACTGTCAGATGGCAGCCACTGCCCCATCATCTTGTGCGGGGACCTAAATTCTGTCCCT GATTCACCTCTCTACAACTTCATCAGGGATGGAGAGCTCCAGTACCATGGGATGCCAGCCTGGAAGGTATCTGGACAGGAAGACTTCTCC CATCAGCTTTACCAGAGGAAGCTGCAGGCCCCACTGTGGCCCAGCTCCCTGGGCATCACTGATTGCTGTCAGTATGTCACCTCCTGTCAC CCCAAGAGATCAGAGAGACGCAAGTATGGCCGAGACTTCCTGCTACGTTTCCGCTTCTGCAGCATCGCTTGTCAGCGACCAGTAGGACTG GTCCTTATGGAAGGAGTGACAGATACTAAGCCAGAGCGACCTGCGGGTTGGGCTGAGTCTGTCCTTGAGGAAGATGCATCGGAGCTTGAG CCTGCCTTCTCCAGGACTGTAGGTACCATCCAGCACTGCCTCCACCTGACGTCAGTATATACCCACTTCCTGCCCCAGCGTGGCCGCCCA GAGGTCACTACAATGCCATTGGGTCTTGGAATGACAGTAGATTACATCTTCTTCTCAGCTGAGTCCTGTGAGAATGGGAACAGAACTGAT CACAGGCTGTATCGAGATGGAACTCTCAAGCTCCTGGGTCGTCTCTCCCTTCTCTCTGAAGAGATACTCTGGGCTGCCAATGGCTTACCC AACCCCTTCTGCTCTTCAGACCACCTCTGCCTGCTAGCCAGCTTCGGGATGGAAGTCACCGCCCCATGACAGGGCTCCCAGGGGAAGAGA GCTTCTCTTCCAGAAGAGCTCACTGGATCAGAGACTGTGGAAAAATCCCATGCATCTAGAAACTTAGATCCAAGAAACTTACATCCCCTC CCTTCCCCCTCCTCGTTCCCTTTTTCCCACGGTTAGACTTTCTCCAGGCCTGGCTGCGTTCTCTGCCTGTGGTCCTTGCCCCACCCCAGC CTCTTCCTAATCCTGTGCCACACACTCAGTGGCCCTGGGAGAGGCAGAAGGGGGGCTCCCCCTTCCTTCCATGTATCCAGCGCTCCCCCT TGATTTTTAATTACCAGGGTTATGGGAGTTCTTGATTTCATTGGTTATTTGCTTTCAGGCCGTTTCTTGATGTACCTTCTGACCTGACCT TTTCCCTGCCTTCAGGACTTCTGGGCCCAGCCCTCTTGCCAGGCATGCATATGTGAGATATGCATATCATGTATGTGTCCTCTTGGGGTG AGACTTCTGCACAGCCATGCCTGCCTCTGACCAGTCCACTTTTCATGTTGGGGCTGTAGGCCTGGGGCAGGTTCAGAGTCTACCCAAGTA CCTATGTATGAGCAGGCAGCAGCAGGGCATGGCCCCATCTCTCCTTTTAGCCTCTGTGTTTCATTAGGCATTCATCCTGCCAACCAGGGC AGGCCCGGCGTCTGGGCTCTGGGAACAAATGGGGCCCACATCCTGGAGTGGCAAATTTTGGGGGATGCGCTACCTGTCCCAGCTGGCCCT GTGCCTCCAACCCAGAGCTCCCCACAGACCTGGTGTAATTTCACAAGGGCCATCCCTTTCCCCAGGCTTCCCTGAGGGAGGCGGAAGTTT GAACCCTTATGTGGGGTTCATTGGGCTAGGGTAGTGGTATGAGGTTTAAAACTATTTAAGGATTAGGAGGAGAAAGAGTCTTCAGGAAAC TCTTGTTTCACTGGACTCTGCAGCCTGCAGAACTGGGGCAAGGGTAGGAGTTCCAGTAGGGGAAGGAGCAGGTAGACTCTTCAGCTGCCT CAGCTGGGACTGAAGACCTAAGCTGATTCTCTTTCCTCTCCACTCCTAAGAAGCAATTTTCTGTTCCTCTCCTTCCACCACTTTTTACTT TCTGCTATCTCCCATCTCCCGCTTCCCTTCCATTTCCTTTCTAGAAAACCCTGGTATTTAGCTCAGGCCAAACTGCCTCAGCAGAAAGGT GGCCTTGGACAAAACTGGTCCAAGAATTTGAAGTGGCAGTACTTGCGGATTGGCTCTGTCCAGCAAGGCCTCAGCTGCTTGTTGCGTCTG CTTTCCCTCCCCTAACAGAAGGGTACCCTGGCTTATTCAGGGGACTCCTTAGTCCACACTGTGTCACCTGCATGCCTTAATCTTTCATTG CTGGGGTGTGGCCTTGGGAGATCCTGGGCCAGCCCCTCCACACATCTCCCTAAGTCAGAGTGGCTGCTGGCCCTGGTAGATTTGACTTGC TCTTGCCTCACTCGACCTCCAAAGTGGGACTGAAGACAGTGGTCAAGAGACTTGAGTTCGGGACAGTAAGCCAGGGGTTAAGGTTCTTTC CTTTTTTTGAAAGCCAAAGACCCAGTTTGCATTGTGCTGCTGCATTCATGGTTAGAAGCTTTCCATGCCTAGGTTCTAGGGAATTTATTT TTCTATGTGTATATATTTTCAAACTTTGTTTCCTGGGTACTGGGCATGTGCCTGTCTGAGCCCCAGGTCTGTCTACACCCCACCATTCAT TCTGTCTGTCTGTTCCCTGGACACTGCCTAAAAGGGTCTCAAGACAGTGCCCTGTGGGTTCCTAGGACTAGGGCCCATCACTGTTCTCTT CTGCTGGGAAATGCAGCTTTAAAATGGCTAACCACAGCAGAGGGCAGATGCTTGATAGATTATCTTTTCCTTGCTTTCTTGTTTCTGTTT |
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FusionGenePPI for SEL1L_ANGEL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SEL1L | IGHM, TRA, DERL2, SYVN1, DERL1, EDEM1, FOXRED2, RPN1, UNC93B1, FAM8A1, SARAF, OS9, AUP1, UBXN4, FAF2, UBE2J1, ERN1, ERLEC1, FLOT1, MYH9, SYNJ2BP, BSG, CLN5, EGFR, RPL6, FBXO6, USP19, HEY2, HEY1, SHH, ITGB1, ITGA5, ITGB4, TMEM129, HYOU1, NTRK1, TCTN1, HSP90B1, METTL3, AMFR, EDEM2, EDEM3, HSPA5, ACP5, AMIGO3, SLAMF1, TMEM5, CHST12, CPA5, TPSB2, SMPD1, PSG8, ZPBP2, PTPRE, PTPRO, TRIM25 | ANGEL1 | EIF4E, ZNF414, ARHGAP25, APOBEC3D, KIAA1683, FGFRL1, SCNN1D, MICU1, HTR2C, SSH3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 22_737 | 624 | 795 | ERLEC1%2C OS9 and SYVN1 |
| Hgene | SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 22_737 | -30 | 302 | ERLEC1%2C OS9 and SYVN1 |
| Hgene | SEL1L | chr14:81952016 | chr14:77275986 | ENST00000336735 | - | 18 | 21 | 643_723 | 624 | 795 | SYVN1 |
| Hgene | SEL1L | chr14:81952016 | chr14:77275986 | ENST00000555824 | - | 1 | 8 | 643_723 | -30 | 302 | SYVN1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SEL1L_ANGEL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEL1L_ANGEL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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