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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 33116

FusionGeneSummary for SEL1L_ANGEL1

check button Fusion gene summary
Fusion gene informationFusion gene name: SEL1L_ANGEL1
Fusion gene ID: 33116
HgeneTgene
Gene symbol

SEL1L

ANGEL1

Gene ID

6400

23357

Gene nameSEL1L, ERAD E3 ligase adaptor subunitangel homolog 1
SynonymsPRO1063|SEL1-LIKE|SEL1L1Ccr4e|KIAA0759
Cytomap

14q31.1

14q24.3

Type of geneprotein-codingprotein-coding
Descriptionprotein sel-1 homolog 1Suppressor of lin 12 (sel-1), C. elegans, homolog ofsel-1 suppressor of lin-12-like 1suppressor of lin-12-like protein 1protein angel homolog 1
Modification date2018051920180519
UniProtAcc

Q9UBV2

Q9UNK9

Ensembl transtripts involved in fusion geneENST00000336735, ENST00000555824, 
ENST00000251089, ENST00000557179, 
ENST00000554941, 
Fusion gene scores* DoF score6 X 6 X 5=1801 X 1 X 1=1
# samples 61
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: SEL1L [Title/Abstract] AND ANGEL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-J4-AATZ-01ASEL1Lchr14

81952016

-ANGEL1chr14

77275986

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000336735ENST00000251089SEL1Lchr14

81952016

-ANGEL1chr14

77275986

-
5CDS-intronENST00000336735ENST00000557179SEL1Lchr14

81952016

-ANGEL1chr14

77275986

-
5CDS-5UTRENST00000336735ENST00000554941SEL1Lchr14

81952016

-ANGEL1chr14

77275986

-
intron-3CDSENST00000555824ENST00000251089SEL1Lchr14

81952016

-ANGEL1chr14

77275986

-
intron-intronENST00000555824ENST00000557179SEL1Lchr14

81952016

-ANGEL1chr14

77275986

-
intron-5UTRENST00000555824ENST00000554941SEL1Lchr14

81952016

-ANGEL1chr14

77275986

-

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FusionProtFeatures for SEL1L_ANGEL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEL1L

Q9UBV2

ANGEL1

Q9UNK9

Plays a role in the endoplasmic reticulum qualitycontrol (ERQC) system also called ER-associated degradation (ERAD)involved in ubiquitin-dependent degradation of misfoldedendoplasmic reticulum proteins (PubMed:16186509). Enhances SYVN1stability. Plays a role in LPL maturation and secretion. Requiredfor normal differentiation of the pancreas epithelium, and fornormal exocrine function and survival of pancreatic cells. Mayplay a role in Notch signaling. {ECO:0000250|UniProtKB:Q9Z2G6,ECO:0000269|PubMed:16186509}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821122_170624795DomainFibronectin type-II
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821352_537624795RegionImportant for homodimerization and oligomerization
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821183_218624795RepeatNote=Sel1-like 1
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821219_254624795RepeatNote=Sel1-like 2
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821255_290624795RepeatNote=Sel1-like 3
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821291_326624795RepeatNote=Sel1-like 4
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821373_409624795RepeatNote=Sel1-like 5
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821410_446624795RepeatNote=Sel1-like 6
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821447_482624795RepeatNote=Sel1-like 7
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821483_518624795RepeatNote=Sel1-like 8
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821519_554624795RepeatNote=Sel1-like 9

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821770_793624795Compositional biasNote=Pro-rich
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18770_793-30302Compositional biasNote=Pro-rich
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18122_170-30302DomainFibronectin type-II
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821738_794624795RegionNote=Mediates retention in the endoplasmic reticulum
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18352_537-30302RegionImportant for homodimerization and oligomerization
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18738_794-30302RegionNote=Mediates retention in the endoplasmic reticulum
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821627_662624795RepeatNote=Sel1-like 10
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821664_699624795RepeatNote=Sel1-like 11
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18183_218-30302RepeatNote=Sel1-like 1
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18219_254-30302RepeatNote=Sel1-like 2
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18255_290-30302RepeatNote=Sel1-like 3
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18291_326-30302RepeatNote=Sel1-like 4
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18373_409-30302RepeatNote=Sel1-like 5
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18410_446-30302RepeatNote=Sel1-like 6
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18447_482-30302RepeatNote=Sel1-like 7
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18483_518-30302RepeatNote=Sel1-like 8
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18519_554-30302RepeatNote=Sel1-like 9
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18627_662-30302RepeatNote=Sel1-like 10
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18664_699-30302RepeatNote=Sel1-like 11
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-182122_738624795Topological domainLumenal
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821760_794624795Topological domainCytoplasmic
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-1822_738-30302Topological domainLumenal
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18760_794-30302Topological domainCytoplasmic
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821739_759624795TransmembraneHelical
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18739_759-30302TransmembraneHelical


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FusionGeneSequence for SEL1L_ANGEL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SEL1L_ENST00000336735_chr14_81952016_-_ANGEL1_ENST00000251089_chr14_77275986_-_1274aa
MRVRIGLTLLLCAVLLSLASASSDEEGSQDESLDSKTTLTSDESVKDHTTAGRVVAGQIFLDSEESELESSIQEEEDSLKSQEGESVTED
ISFLESPNPENKDYEEPKKVRKPALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQM
QEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLPQNIQAAREMFEKLTEEGSPKGQTALGFLYASGLG
VNSSQAKALVYYTFGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDL
IQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQ
SGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCH
TAVELFKNVCERGRWSERLMTAYNSYKDGDYNAAVIQYLLLAEQGYEVAQSNAAFILDQREASIVGENETYPRALLHWNRAASQDAFFTC
RKNVLLANSSSPQVEGDFAMAPRGPEQEECEGLLQQWREEGLSQVLSTASEGPLIDKGLAQSSLALLMDNPGEENAASEDRWSSRQLSDL
RAAENLDEPFPEMLGEEPLLEVEGVEGSMWAAIPMQSEPQYADCAALPVGALATEQWEEDPAVLAWSIAPEPVPQEEASIWPFEGLGQLQ
PPAVEIPYHEILWREWEDFSTQPDAQGLKAGDGPQFQFTLMSYNILAQDLMQQSSELYLHCHPDILNWNYRFVNLMQEFQHWDPDILCLQ
EVQEDHYWEQLEPSLRMMGFTCFYKRRTGCKTDGCAVCYKPTRFRLLCASPVEYFRPGLELLNRDNVGLVLLLQPLVPEGLGQVSVAPLC
VANTHILYNPRRGDVKLAQMAILLAEVDKVARLSDGSHCPIILCGDLNSVPDSPLYNFIRDGELQYHGMPAWKVSGQEDFSHQLYQRKLQ
APLWPSSLGITDCCQYVTSCHPKRSERRKYGRDFLLRFRFCSIACQRPVGLVLMEGVTDTKPERPAGWAESVLEEDASELEPAFSRTVGT
IQHCLHLTSVYTHFLPQRGRPEVTTMPLGLGMTVDYIFFSAESCENGNRTDHRLYRDGTLKLLGRLSLLSEEILWAANGLPNPFCSSDHL


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SEL1L_ENST00000336735_chr14_81952016_-_ANGEL1_ENST00000251089_chr14_77275986_-_3822nt
ATGCGGGTCCGGATAGGGCTGACGCTGCTGCTGTGTGCGGTGCTGCTGAGCTTGGCCTCGGCGTCCTCGGATGAAGAAGGCAGCCAGGAT
GAATCCTTAGATTCCAAGACTACTTTGACATCAGATGAGTCAGTAAAGGACCATACTACTGCAGGCAGAGTAGTTGCTGGTCAAATATTT
CTTGATTCAGAAGAATCTGAATTAGAATCCTCTATTCAAGAAGAGGAAGACAGCCTCAAGAGCCAAGAGGGGGAAAGTGTCACAGAAGAT
ATCAGCTTTCTAGAGTCTCCAAATCCAGAAAACAAGGACTATGAAGAGCCAAAGAAAGTACGGAAACCAGCTTTGACCGCCATTGAAGGC
ACAGCACATGGGGAGCCCTGCCACTTCCCTTTTCTTTTCCTAGATAAGGAGTATGATGAATGTACATCAGATGGGAGGGAAGATGGCAGA
CTGTGGTGTGCTACAACCTATGACTACAAAGCAGATGAAAAGTGGGGCTTTTGTGAAACTGAAGAAGAGGCTGCTAAGAGACGGCAGATG
CAGGAAGCAGAAATGATGTATCAAACTGGAATGAAAATCCTTAATGGAAGCAATAAGAAAAGCCAAAAAAGAGAAGCATATCGGTATCTC
CAAAAGGCAGCAAGCATGAACCATACCAAAGCCCTGGAGAGAGTGTCATATGCTCTTTTATTTGGTGATTACTTGCCACAGAATATCCAG
GCAGCGAGAGAGATGTTTGAGAAGCTGACTGAGGAAGGCTCTCCCAAGGGACAGACTGCTCTTGGCTTTCTGTATGCCTCTGGACTTGGT
GTTAATTCAAGTCAGGCAAAGGCTCTTGTATATTATACATTTGGAGCTCTTGGGGGCAATCTAATAGCCCACATGGTTTTGGGTTACAGA
TACTGGGCTGGCATCGGCGTCCTCCAGAGTTGTGAATCTGCCCTGACTCACTATCGTCTTGTTGCCAATCATGTTGCTAGTGATATCTCG
CTAACAGGAGGCTCAGTAGTACAGAGAATACGGCTGCCTGATGAAGTGGAAAATCCAGGAATGAACAGTGGAATGCTAGAAGAAGATTTG
ATTCAATATTACCAGTTCCTAGCTGAAAAAGGTGATGTACAAGCACAGGTTGGTCTTGGACAACTGCACCTGCACGGAGGGCGTGGAGTA
GAACAGAATCATCAGAGAGCATTTGACTACTTCAATTTAGCAGCAAATGCTGGCAATTCACATGCCATGGCCTTTTTGGGAAAGATGTAT
TCGGAAGGAAGTGACATTGTACCTCAGAGTAATGAGACAGCTCTCCACTACTTTAAGAAAGCTGCTGACATGGGCAACCCAGTTGGACAG
AGTGGGCTTGGAATGGCCTACCTCTATGGGAGAGGAGTTCAAGTTAATTATGATCTAGCCCTTAAGTATTTCCAGAAAGCTGCTGAACAA
GGCTGGGTGGATGGGCAGCTACAGCTTGGTTCCATGTACTATAATGGCATTGGAGTCAAGAGAGATTATAAACAGGCCTTGAAGTATTTT
AATTTAGCTTCTCAGGGAGGCCATATCTTGGCTTTCTATAACCTAGCTCAGATGCATGCCAGTGGCACCGGCGTGATGCGATCATGTCAC
ACTGCAGTGGAGTTGTTTAAGAATGTATGTGAACGAGGCCGTTGGTCTGAAAGGCTTATGACTGCCTATAACAGCTATAAAGATGGCGAT
TACAATGCTGCAGTGATCCAGTACCTCCTCCTGGCTGAACAGGGCTATGAAGTGGCACAAAGCAATGCAGCCTTTATTCTTGATCAGAGA
GAAGCAAGCATTGTAGGTGAGAATGAAACTTATCCCAGAGCTTTGCTACATTGGAACAGGGCCGCCTCTCAAGATGCTTTCTTCACATGT
CGAAAAAATGTCCTTCTGGCGAACAGCTCATCCCCCCAGGTAGAGGGCGACTTTGCCATGGCCCCTCGGGGCCCTGAGCAGGAGGAATGT
GAGGGCCTGCTGCAGCAGTGGCGAGAAGAAGGGTTGAGCCAGGTGCTCTCAACTGCAAGTGAGGGGCCCCTTATAGATAAAGGACTAGCC
CAGAGCAGCCTGGCACTTCTGATGGATAATCCTGGAGAAGAGAATGCTGCTTCAGAGGACAGGTGGTCCAGCAGGCAGCTGAGTGACCTT
CGGGCTGCAGAGAACCTGGATGAGCCTTTCCCTGAGATGCTAGGAGAGGAGCCACTGCTGGAGGTGGAGGGGGTGGAGGGCTCCATGTGG
GCAGCTATCCCCATGCAGTCGGAGCCCCAGTATGCAGACTGTGCTGCCCTCCCAGTGGGTGCCCTGGCCACAGAGCAGTGGGAAGAGGAC
CCAGCGGTGTTGGCCTGGAGCATAGCACCTGAGCCTGTGCCCCAGGAAGAGGCTTCCATCTGGCCCTTTGAGGGCCTGGGGCAGTTGCAG
CCTCCCGCAGTGGAAATACCATATCATGAAATTTTGTGGCGAGAATGGGAGGATTTCTCCACCCAGCCAGATGCTCAGGGCCTGAAGGCA
GGAGATGGCCCTCAGTTCCAGTTCACTCTGATGTCTTATAACATCCTGGCTCAGGACCTGATGCAGCAGAGCTCAGAGCTCTATCTACAT
TGCCATCCAGACATCCTCAATTGGAACTATCGCTTCGTGAACCTCATGCAGGAATTCCAGCACTGGGACCCTGATATCCTGTGTCTCCAG
GAAGTCCAGGAAGATCATTACTGGGAGCAGCTGGAACCCTCTCTGCGAATGATGGGCTTTACCTGTTTCTACAAGAGGAGGACTGGGTGT
AAAACCGATGGCTGTGCTGTCTGCTACAAGCCTACCAGATTCCGCCTGCTCTGTGCTAGCCCTGTGGAGTACTTCCGGCCTGGCTTGGAG
CTACTTAATCGGGATAATGTGGGCTTAGTGTTGCTACTGCAACCACTCGTCCCAGAAGGCCTGGGACAAGTCTCGGTGGCCCCGCTGTGT
GTGGCAAATACCCATATCCTTTACAACCCACGCCGGGGCGATGTCAAGCTGGCCCAGATGGCCATTCTCCTGGCGGAAGTGGACAAGGTG
GCCAGACTGTCAGATGGCAGCCACTGCCCCATCATCTTGTGCGGGGACCTAAATTCTGTCCCTGATTCACCTCTCTACAACTTCATCAGG
GATGGAGAGCTCCAGTACCATGGGATGCCAGCCTGGAAGGTATCTGGACAGGAAGACTTCTCCCATCAGCTTTACCAGAGGAAGCTGCAG
GCCCCACTGTGGCCCAGCTCCCTGGGCATCACTGATTGCTGTCAGTATGTCACCTCCTGTCACCCCAAGAGATCAGAGAGACGCAAGTAT
GGCCGAGACTTCCTGCTACGTTTCCGCTTCTGCAGCATCGCTTGTCAGCGACCAGTAGGACTGGTCCTTATGGAAGGAGTGACAGATACT
AAGCCAGAGCGACCTGCGGGTTGGGCTGAGTCTGTCCTTGAGGAAGATGCATCGGAGCTTGAGCCTGCCTTCTCCAGGACTGTAGGTACC
ATCCAGCACTGCCTCCACCTGACGTCAGTATATACCCACTTCCTGCCCCAGCGTGGCCGCCCAGAGGTCACTACAATGCCATTGGGTCTT
GGAATGACAGTAGATTACATCTTCTTCTCAGCTGAGTCCTGTGAGAATGGGAACAGAACTGATCACAGGCTGTATCGAGATGGAACTCTC
AAGCTCCTGGGTCGTCTCTCCCTTCTCTCTGAAGAGATACTCTGGGCTGCCAATGGCTTACCCAACCCCTTCTGCTCTTCAGACCACCTC


* Fusion transcript sequences (Full-length transcript).
>In-frame_SEL1L_ENST00000336735_chr14_81952016_-_ANGEL1_ENST00000251089_chr14_77275986_-_5922nt
GCGGAGGAAGGAGACTAGAGCAGGAAGAGCAGCGGCGAGGCGGCGGTGGTGGCTGAGTCCGTGGTGGCAGAGGCGAAGGCGACAGCTCTA
GGGGTTGGCACCGGCCCCGAGAGGAGGATGCGGGTCCGGATAGGGCTGACGCTGCTGCTGTGTGCGGTGCTGCTGAGCTTGGCCTCGGCG
TCCTCGGATGAAGAAGGCAGCCAGGATGAATCCTTAGATTCCAAGACTACTTTGACATCAGATGAGTCAGTAAAGGACCATACTACTGCA
GGCAGAGTAGTTGCTGGTCAAATATTTCTTGATTCAGAAGAATCTGAATTAGAATCCTCTATTCAAGAAGAGGAAGACAGCCTCAAGAGC
CAAGAGGGGGAAAGTGTCACAGAAGATATCAGCTTTCTAGAGTCTCCAAATCCAGAAAACAAGGACTATGAAGAGCCAAAGAAAGTACGG
AAACCAGCTTTGACCGCCATTGAAGGCACAGCACATGGGGAGCCCTGCCACTTCCCTTTTCTTTTCCTAGATAAGGAGTATGATGAATGT
ACATCAGATGGGAGGGAAGATGGCAGACTGTGGTGTGCTACAACCTATGACTACAAAGCAGATGAAAAGTGGGGCTTTTGTGAAACTGAA
GAAGAGGCTGCTAAGAGACGGCAGATGCAGGAAGCAGAAATGATGTATCAAACTGGAATGAAAATCCTTAATGGAAGCAATAAGAAAAGC
CAAAAAAGAGAAGCATATCGGTATCTCCAAAAGGCAGCAAGCATGAACCATACCAAAGCCCTGGAGAGAGTGTCATATGCTCTTTTATTT
GGTGATTACTTGCCACAGAATATCCAGGCAGCGAGAGAGATGTTTGAGAAGCTGACTGAGGAAGGCTCTCCCAAGGGACAGACTGCTCTT
GGCTTTCTGTATGCCTCTGGACTTGGTGTTAATTCAAGTCAGGCAAAGGCTCTTGTATATTATACATTTGGAGCTCTTGGGGGCAATCTA
ATAGCCCACATGGTTTTGGGTTACAGATACTGGGCTGGCATCGGCGTCCTCCAGAGTTGTGAATCTGCCCTGACTCACTATCGTCTTGTT
GCCAATCATGTTGCTAGTGATATCTCGCTAACAGGAGGCTCAGTAGTACAGAGAATACGGCTGCCTGATGAAGTGGAAAATCCAGGAATG
AACAGTGGAATGCTAGAAGAAGATTTGATTCAATATTACCAGTTCCTAGCTGAAAAAGGTGATGTACAAGCACAGGTTGGTCTTGGACAA
CTGCACCTGCACGGAGGGCGTGGAGTAGAACAGAATCATCAGAGAGCATTTGACTACTTCAATTTAGCAGCAAATGCTGGCAATTCACAT
GCCATGGCCTTTTTGGGAAAGATGTATTCGGAAGGAAGTGACATTGTACCTCAGAGTAATGAGACAGCTCTCCACTACTTTAAGAAAGCT
GCTGACATGGGCAACCCAGTTGGACAGAGTGGGCTTGGAATGGCCTACCTCTATGGGAGAGGAGTTCAAGTTAATTATGATCTAGCCCTT
AAGTATTTCCAGAAAGCTGCTGAACAAGGCTGGGTGGATGGGCAGCTACAGCTTGGTTCCATGTACTATAATGGCATTGGAGTCAAGAGA
GATTATAAACAGGCCTTGAAGTATTTTAATTTAGCTTCTCAGGGAGGCCATATCTTGGCTTTCTATAACCTAGCTCAGATGCATGCCAGT
GGCACCGGCGTGATGCGATCATGTCACACTGCAGTGGAGTTGTTTAAGAATGTATGTGAACGAGGCCGTTGGTCTGAAAGGCTTATGACT
GCCTATAACAGCTATAAAGATGGCGATTACAATGCTGCAGTGATCCAGTACCTCCTCCTGGCTGAACAGGGCTATGAAGTGGCACAAAGC
AATGCAGCCTTTATTCTTGATCAGAGAGAAGCAAGCATTGTAGGTGAGAATGAAACTTATCCCAGAGCTTTGCTACATTGGAACAGGGCC
GCCTCTCAAGATGCTTTCTTCACATGTCGAAAAAATGTCCTTCTGGCGAACAGCTCATCCCCCCAGGTAGAGGGCGACTTTGCCATGGCC
CCTCGGGGCCCTGAGCAGGAGGAATGTGAGGGCCTGCTGCAGCAGTGGCGAGAAGAAGGGTTGAGCCAGGTGCTCTCAACTGCAAGTGAG
GGGCCCCTTATAGATAAAGGACTAGCCCAGAGCAGCCTGGCACTTCTGATGGATAATCCTGGAGAAGAGAATGCTGCTTCAGAGGACAGG
TGGTCCAGCAGGCAGCTGAGTGACCTTCGGGCTGCAGAGAACCTGGATGAGCCTTTCCCTGAGATGCTAGGAGAGGAGCCACTGCTGGAG
GTGGAGGGGGTGGAGGGCTCCATGTGGGCAGCTATCCCCATGCAGTCGGAGCCCCAGTATGCAGACTGTGCTGCCCTCCCAGTGGGTGCC
CTGGCCACAGAGCAGTGGGAAGAGGACCCAGCGGTGTTGGCCTGGAGCATAGCACCTGAGCCTGTGCCCCAGGAAGAGGCTTCCATCTGG
CCCTTTGAGGGCCTGGGGCAGTTGCAGCCTCCCGCAGTGGAAATACCATATCATGAAATTTTGTGGCGAGAATGGGAGGATTTCTCCACC
CAGCCAGATGCTCAGGGCCTGAAGGCAGGAGATGGCCCTCAGTTCCAGTTCACTCTGATGTCTTATAACATCCTGGCTCAGGACCTGATG
CAGCAGAGCTCAGAGCTCTATCTACATTGCCATCCAGACATCCTCAATTGGAACTATCGCTTCGTGAACCTCATGCAGGAATTCCAGCAC
TGGGACCCTGATATCCTGTGTCTCCAGGAAGTCCAGGAAGATCATTACTGGGAGCAGCTGGAACCCTCTCTGCGAATGATGGGCTTTACC
TGTTTCTACAAGAGGAGGACTGGGTGTAAAACCGATGGCTGTGCTGTCTGCTACAAGCCTACCAGATTCCGCCTGCTCTGTGCTAGCCCT
GTGGAGTACTTCCGGCCTGGCTTGGAGCTACTTAATCGGGATAATGTGGGCTTAGTGTTGCTACTGCAACCACTCGTCCCAGAAGGCCTG
GGACAAGTCTCGGTGGCCCCGCTGTGTGTGGCAAATACCCATATCCTTTACAACCCACGCCGGGGCGATGTCAAGCTGGCCCAGATGGCC
ATTCTCCTGGCGGAAGTGGACAAGGTGGCCAGACTGTCAGATGGCAGCCACTGCCCCATCATCTTGTGCGGGGACCTAAATTCTGTCCCT
GATTCACCTCTCTACAACTTCATCAGGGATGGAGAGCTCCAGTACCATGGGATGCCAGCCTGGAAGGTATCTGGACAGGAAGACTTCTCC
CATCAGCTTTACCAGAGGAAGCTGCAGGCCCCACTGTGGCCCAGCTCCCTGGGCATCACTGATTGCTGTCAGTATGTCACCTCCTGTCAC
CCCAAGAGATCAGAGAGACGCAAGTATGGCCGAGACTTCCTGCTACGTTTCCGCTTCTGCAGCATCGCTTGTCAGCGACCAGTAGGACTG
GTCCTTATGGAAGGAGTGACAGATACTAAGCCAGAGCGACCTGCGGGTTGGGCTGAGTCTGTCCTTGAGGAAGATGCATCGGAGCTTGAG
CCTGCCTTCTCCAGGACTGTAGGTACCATCCAGCACTGCCTCCACCTGACGTCAGTATATACCCACTTCCTGCCCCAGCGTGGCCGCCCA
GAGGTCACTACAATGCCATTGGGTCTTGGAATGACAGTAGATTACATCTTCTTCTCAGCTGAGTCCTGTGAGAATGGGAACAGAACTGAT
CACAGGCTGTATCGAGATGGAACTCTCAAGCTCCTGGGTCGTCTCTCCCTTCTCTCTGAAGAGATACTCTGGGCTGCCAATGGCTTACCC
AACCCCTTCTGCTCTTCAGACCACCTCTGCCTGCTAGCCAGCTTCGGGATGGAAGTCACCGCCCCATGACAGGGCTCCCAGGGGAAGAGA
GCTTCTCTTCCAGAAGAGCTCACTGGATCAGAGACTGTGGAAAAATCCCATGCATCTAGAAACTTAGATCCAAGAAACTTACATCCCCTC
CCTTCCCCCTCCTCGTTCCCTTTTTCCCACGGTTAGACTTTCTCCAGGCCTGGCTGCGTTCTCTGCCTGTGGTCCTTGCCCCACCCCAGC
CTCTTCCTAATCCTGTGCCACACACTCAGTGGCCCTGGGAGAGGCAGAAGGGGGGCTCCCCCTTCCTTCCATGTATCCAGCGCTCCCCCT
TGATTTTTAATTACCAGGGTTATGGGAGTTCTTGATTTCATTGGTTATTTGCTTTCAGGCCGTTTCTTGATGTACCTTCTGACCTGACCT
TTTCCCTGCCTTCAGGACTTCTGGGCCCAGCCCTCTTGCCAGGCATGCATATGTGAGATATGCATATCATGTATGTGTCCTCTTGGGGTG
AGACTTCTGCACAGCCATGCCTGCCTCTGACCAGTCCACTTTTCATGTTGGGGCTGTAGGCCTGGGGCAGGTTCAGAGTCTACCCAAGTA
CCTATGTATGAGCAGGCAGCAGCAGGGCATGGCCCCATCTCTCCTTTTAGCCTCTGTGTTTCATTAGGCATTCATCCTGCCAACCAGGGC
AGGCCCGGCGTCTGGGCTCTGGGAACAAATGGGGCCCACATCCTGGAGTGGCAAATTTTGGGGGATGCGCTACCTGTCCCAGCTGGCCCT
GTGCCTCCAACCCAGAGCTCCCCACAGACCTGGTGTAATTTCACAAGGGCCATCCCTTTCCCCAGGCTTCCCTGAGGGAGGCGGAAGTTT
GAACCCTTATGTGGGGTTCATTGGGCTAGGGTAGTGGTATGAGGTTTAAAACTATTTAAGGATTAGGAGGAGAAAGAGTCTTCAGGAAAC
TCTTGTTTCACTGGACTCTGCAGCCTGCAGAACTGGGGCAAGGGTAGGAGTTCCAGTAGGGGAAGGAGCAGGTAGACTCTTCAGCTGCCT
CAGCTGGGACTGAAGACCTAAGCTGATTCTCTTTCCTCTCCACTCCTAAGAAGCAATTTTCTGTTCCTCTCCTTCCACCACTTTTTACTT
TCTGCTATCTCCCATCTCCCGCTTCCCTTCCATTTCCTTTCTAGAAAACCCTGGTATTTAGCTCAGGCCAAACTGCCTCAGCAGAAAGGT
GGCCTTGGACAAAACTGGTCCAAGAATTTGAAGTGGCAGTACTTGCGGATTGGCTCTGTCCAGCAAGGCCTCAGCTGCTTGTTGCGTCTG
CTTTCCCTCCCCTAACAGAAGGGTACCCTGGCTTATTCAGGGGACTCCTTAGTCCACACTGTGTCACCTGCATGCCTTAATCTTTCATTG
CTGGGGTGTGGCCTTGGGAGATCCTGGGCCAGCCCCTCCACACATCTCCCTAAGTCAGAGTGGCTGCTGGCCCTGGTAGATTTGACTTGC
TCTTGCCTCACTCGACCTCCAAAGTGGGACTGAAGACAGTGGTCAAGAGACTTGAGTTCGGGACAGTAAGCCAGGGGTTAAGGTTCTTTC
CTTTTTTTGAAAGCCAAAGACCCAGTTTGCATTGTGCTGCTGCATTCATGGTTAGAAGCTTTCCATGCCTAGGTTCTAGGGAATTTATTT
TTCTATGTGTATATATTTTCAAACTTTGTTTCCTGGGTACTGGGCATGTGCCTGTCTGAGCCCCAGGTCTGTCTACACCCCACCATTCAT
TCTGTCTGTCTGTTCCCTGGACACTGCCTAAAAGGGTCTCAAGACAGTGCCCTGTGGGTTCCTAGGACTAGGGCCCATCACTGTTCTCTT
CTGCTGGGAAATGCAGCTTTAAAATGGCTAACCACAGCAGAGGGCAGATGCTTGATAGATTATCTTTTCCTTGCTTTCTTGTTTCTGTTT


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FusionGenePPI for SEL1L_ANGEL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEL1LIGHM, TRA, DERL2, SYVN1, DERL1, EDEM1, FOXRED2, RPN1, UNC93B1, FAM8A1, SARAF, OS9, AUP1, UBXN4, FAF2, UBE2J1, ERN1, ERLEC1, FLOT1, MYH9, SYNJ2BP, BSG, CLN5, EGFR, RPL6, FBXO6, USP19, HEY2, HEY1, SHH, ITGB1, ITGA5, ITGB4, TMEM129, HYOU1, NTRK1, TCTN1, HSP90B1, METTL3, AMFR, EDEM2, EDEM3, HSPA5, ACP5, AMIGO3, SLAMF1, TMEM5, CHST12, CPA5, TPSB2, SMPD1, PSG8, ZPBP2, PTPRE, PTPRO, TRIM25ANGEL1EIF4E, ZNF414, ARHGAP25, APOBEC3D, KIAA1683, FGFRL1, SCNN1D, MICU1, HTR2C, SSH3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-182122_737624795ERLEC1%2C OS9 and SYVN1
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-1822_737-30302ERLEC1%2C OS9 and SYVN1
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000336735-1821643_723624795SYVN1
HgeneSEL1Lchr14:81952016chr14:77275986ENST00000555824-18643_723-30302SYVN1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEL1L_ANGEL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEL1L_ANGEL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource