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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33115

FusionGeneSummary for SEL1L3_HSD17B13

check button Fusion gene summary
Fusion gene informationFusion gene name: SEL1L3_HSD17B13
Fusion gene ID: 33115
HgeneTgene
Gene symbol

SEL1L3

HSD17B13

Gene ID

23231

345275

Gene nameSEL1L family member 3hydroxysteroid 17-beta dehydrogenase 13
SynonymsSel-1L3HMFN0376|NIIL497|SCDR9|SDR16C3
Cytomap

4p15.2

4q22.1

Type of geneprotein-codingprotein-coding
Descriptionprotein sel-1 homolog 3sel-1 suppressor of lin-12-like 3suppressor of lin-12-like protein 317-beta-hydroxysteroid dehydrogenase 1317-beta hydroxysteroid dehydrogenase17-beta-HSD 13short chain dehydrogenase/reductase family 16C member 3short-chain dehydrogenase/reductase 9
Modification date2018051920180523
UniProtAcc

Q68CR1

Q7Z5P4

Ensembl transtripts involved in fusion geneENST00000399878, ENST00000264868, 
ENST00000502949, ENST00000513364, 
ENST00000302219, ENST00000328546, 
Fusion gene scores* DoF score3 X 3 X 3=271 X 1 X 1=1
# samples 31
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: SEL1L3 [Title/Abstract] AND HSD17B13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHSD17B13

GO:0046889

positive regulation of lipid biosynthetic process

25028495


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPAADTCGA-HZ-A49I-01ASEL1L3chr4

25835070

-HSD17B13chr4

88239588

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000399878ENST00000302219SEL1L3chr4

25835070

-HSD17B13chr4

88239588

-
5CDS-intronENST00000399878ENST00000328546SEL1L3chr4

25835070

-HSD17B13chr4

88239588

-
5CDS-intronENST00000264868ENST00000302219SEL1L3chr4

25835070

-HSD17B13chr4

88239588

-
5CDS-intronENST00000264868ENST00000328546SEL1L3chr4

25835070

-HSD17B13chr4

88239588

-
5CDS-intronENST00000502949ENST00000302219SEL1L3chr4

25835070

-HSD17B13chr4

88239588

-
5CDS-intronENST00000502949ENST00000328546SEL1L3chr4

25835070

-HSD17B13chr4

88239588

-
5UTR-intronENST00000513364ENST00000302219SEL1L3chr4

25835070

-HSD17B13chr4

88239588

-
5UTR-intronENST00000513364ENST00000328546SEL1L3chr4

25835070

-HSD17B13chr4

88239588

-

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FusionProtFeatures for SEL1L3_HSD17B13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEL1L3

Q68CR1

HSD17B13

Q7Z5P4


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEL1L3_HSD17B13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEL1L3_HSD17B13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEL1L3TUBB3, FBXO6, PLTP, SCGB1D1, LAMP3, FAM63AHSD17B13ECI2, TSPAN10, RHOU


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEL1L3_HSD17B13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEL1L3_HSD17B13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource