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Fusion gene ID: 33115 |
FusionGeneSummary for SEL1L3_HSD17B13 |
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Fusion gene information | Fusion gene name: SEL1L3_HSD17B13 | Fusion gene ID: 33115 | Hgene | Tgene | Gene symbol | SEL1L3 | HSD17B13 | Gene ID | 23231 | 345275 |
Gene name | SEL1L family member 3 | hydroxysteroid 17-beta dehydrogenase 13 | |
Synonyms | Sel-1L3 | HMFN0376|NIIL497|SCDR9|SDR16C3 | |
Cytomap | 4p15.2 | 4q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | protein sel-1 homolog 3sel-1 suppressor of lin-12-like 3suppressor of lin-12-like protein 3 | 17-beta-hydroxysteroid dehydrogenase 1317-beta hydroxysteroid dehydrogenase17-beta-HSD 13short chain dehydrogenase/reductase family 16C member 3short-chain dehydrogenase/reductase 9 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q68CR1 | Q7Z5P4 | |
Ensembl transtripts involved in fusion gene | ENST00000399878, ENST00000264868, ENST00000502949, ENST00000513364, | ENST00000302219, ENST00000328546, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
# samples | 3 | 1 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: SEL1L3 [Title/Abstract] AND HSD17B13 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | HSD17B13 | GO:0046889 | positive regulation of lipid biosynthetic process | 25028495 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PAAD | TCGA-HZ-A49I-01A | SEL1L3 | chr4 | 25835070 | - | HSD17B13 | chr4 | 88239588 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000399878 | ENST00000302219 | SEL1L3 | chr4 | 25835070 | - | HSD17B13 | chr4 | 88239588 | - |
5CDS-intron | ENST00000399878 | ENST00000328546 | SEL1L3 | chr4 | 25835070 | - | HSD17B13 | chr4 | 88239588 | - |
5CDS-intron | ENST00000264868 | ENST00000302219 | SEL1L3 | chr4 | 25835070 | - | HSD17B13 | chr4 | 88239588 | - |
5CDS-intron | ENST00000264868 | ENST00000328546 | SEL1L3 | chr4 | 25835070 | - | HSD17B13 | chr4 | 88239588 | - |
5CDS-intron | ENST00000502949 | ENST00000302219 | SEL1L3 | chr4 | 25835070 | - | HSD17B13 | chr4 | 88239588 | - |
5CDS-intron | ENST00000502949 | ENST00000328546 | SEL1L3 | chr4 | 25835070 | - | HSD17B13 | chr4 | 88239588 | - |
5UTR-intron | ENST00000513364 | ENST00000302219 | SEL1L3 | chr4 | 25835070 | - | HSD17B13 | chr4 | 88239588 | - |
5UTR-intron | ENST00000513364 | ENST00000328546 | SEL1L3 | chr4 | 25835070 | - | HSD17B13 | chr4 | 88239588 | - |
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FusionProtFeatures for SEL1L3_HSD17B13 |
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Hgene | Tgene |
SEL1L3 | HSD17B13 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SEL1L3_HSD17B13 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SEL1L3_HSD17B13 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SEL1L3 | TUBB3, FBXO6, PLTP, SCGB1D1, LAMP3, FAM63A | HSD17B13 | ECI2, TSPAN10, RHOU |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SEL1L3_HSD17B13 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEL1L3_HSD17B13 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |