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Fusion gene ID: 33109 |
FusionGeneSummary for SECISBP2_SECISBP2 |
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Fusion gene information | Fusion gene name: SECISBP2_SECISBP2 | Fusion gene ID: 33109 | Hgene | Tgene | Gene symbol | SECISBP2 | SECISBP2 | Gene ID | 79048 | 79048 |
Gene name | SECIS binding protein 2 | SECIS binding protein 2 | |
Synonyms | SBP2 | SBP2 | |
Cytomap | 9q22.2 | 9q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | selenocysteine insertion sequence-binding protein 2Sec insertion sequence-binding protein 2 | selenocysteine insertion sequence-binding protein 2Sec insertion sequence-binding protein 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96T21 | Q96T21 | |
Ensembl transtripts involved in fusion gene | ENST00000375807, ENST00000339901, ENST00000534113, ENST00000470305, | ENST00000375807, ENST00000339901, ENST00000534113, ENST00000470305, | |
Fusion gene scores | * DoF score | 5 X 6 X 2=60 | 4 X 4 X 2=32 |
# samples | 6 | 6 | |
** MAII score | log2(6/60*10)=0 | log2(6/32*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SECISBP2 [Title/Abstract] AND SECISBP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AU253387 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - | ||
ChiTaRS3.1 | CV416238 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000375807 | ENST00000375807 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
5CDS-intron | ENST00000375807 | ENST00000339901 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
5CDS-intron | ENST00000375807 | ENST00000534113 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
5CDS-intron | ENST00000375807 | ENST00000470305 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
5CDS-intron | ENST00000339901 | ENST00000375807 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
5CDS-intron | ENST00000339901 | ENST00000339901 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
5CDS-intron | ENST00000339901 | ENST00000534113 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
5CDS-intron | ENST00000339901 | ENST00000470305 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
5CDS-intron | ENST00000534113 | ENST00000375807 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
5CDS-intron | ENST00000534113 | ENST00000339901 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
5CDS-intron | ENST00000534113 | ENST00000534113 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
5CDS-intron | ENST00000534113 | ENST00000470305 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
intron-intron | ENST00000470305 | ENST00000375807 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
intron-intron | ENST00000470305 | ENST00000339901 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
intron-intron | ENST00000470305 | ENST00000534113 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
intron-intron | ENST00000470305 | ENST00000470305 | SECISBP2 | chr9 | 91949494 | - | SECISBP2 | chr9 | 91954864 | - |
intron-intron | ENST00000375807 | ENST00000375807 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
intron-intron | ENST00000375807 | ENST00000339901 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
intron-intron | ENST00000375807 | ENST00000534113 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
intron-3UTR | ENST00000375807 | ENST00000470305 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
intron-intron | ENST00000339901 | ENST00000375807 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
intron-intron | ENST00000339901 | ENST00000339901 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
intron-intron | ENST00000339901 | ENST00000534113 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
intron-3UTR | ENST00000339901 | ENST00000470305 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
intron-intron | ENST00000534113 | ENST00000375807 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
intron-intron | ENST00000534113 | ENST00000339901 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
intron-intron | ENST00000534113 | ENST00000534113 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
intron-3UTR | ENST00000534113 | ENST00000470305 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
3UTR-intron | ENST00000470305 | ENST00000375807 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
3UTR-intron | ENST00000470305 | ENST00000339901 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
3UTR-intron | ENST00000470305 | ENST00000534113 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
3UTR-3UTR | ENST00000470305 | ENST00000470305 | SECISBP2 | chr9 | 91939671 | + | SECISBP2 | chr9 | 91939346 | - |
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FusionProtFeatures for SECISBP2_SECISBP2 |
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Hgene | Tgene |
SECISBP2 | SECISBP2 |
Binds to the SECIS element in the 3'-UTR of some mRNAsencoding selenoproteins. Binding is stimulated by SELB. | Binds to the SECIS element in the 3'-UTR of some mRNAsencoding selenoproteins. Binding is stimulated by SELB. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SECISBP2_SECISBP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SECISBP2_SECISBP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SECISBP2_SECISBP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SECISBP2_SECISBP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SECISBP2 | C0002514 | Amino Acid Metabolism, Inborn Errors | 1 | CTD_human |
Hgene | SECISBP2 | C0018273 | Growth Disorders | 1 | CTD_human |
Hgene | SECISBP2 | C1864761 | Thyroid Hormone Metabolism, Abnormal | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | SECISBP2 | C0002514 | Amino Acid Metabolism, Inborn Errors | 1 | CTD_human |
Tgene | SECISBP2 | C0018273 | Growth Disorders | 1 | CTD_human |
Tgene | SECISBP2 | C1864761 | Thyroid Hormone Metabolism, Abnormal | 1 | CTD_human;ORPHANET;UNIPROT |