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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33109

FusionGeneSummary for SECISBP2_SECISBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: SECISBP2_SECISBP2
Fusion gene ID: 33109
HgeneTgene
Gene symbol

SECISBP2

SECISBP2

Gene ID

79048

79048

Gene nameSECIS binding protein 2SECIS binding protein 2
SynonymsSBP2SBP2
Cytomap

9q22.2

9q22.2

Type of geneprotein-codingprotein-coding
Descriptionselenocysteine insertion sequence-binding protein 2Sec insertion sequence-binding protein 2selenocysteine insertion sequence-binding protein 2Sec insertion sequence-binding protein 2
Modification date2018052320180523
UniProtAcc

Q96T21

Q96T21

Ensembl transtripts involved in fusion geneENST00000375807, ENST00000339901, 
ENST00000534113, ENST00000470305, 
ENST00000375807, ENST00000339901, 
ENST00000534113, ENST00000470305, 
Fusion gene scores* DoF score5 X 6 X 2=604 X 4 X 2=32
# samples 66
** MAII scorelog2(6/60*10)=0log2(6/32*10)=0.906890595608518
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SECISBP2 [Title/Abstract] AND SECISBP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AU253387SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
ChiTaRS3.1CV416238SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000375807ENST00000375807SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
5CDS-intronENST00000375807ENST00000339901SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
5CDS-intronENST00000375807ENST00000534113SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
5CDS-intronENST00000375807ENST00000470305SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
5CDS-intronENST00000339901ENST00000375807SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
5CDS-intronENST00000339901ENST00000339901SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
5CDS-intronENST00000339901ENST00000534113SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
5CDS-intronENST00000339901ENST00000470305SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
5CDS-intronENST00000534113ENST00000375807SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
5CDS-intronENST00000534113ENST00000339901SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
5CDS-intronENST00000534113ENST00000534113SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
5CDS-intronENST00000534113ENST00000470305SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
intron-intronENST00000470305ENST00000375807SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
intron-intronENST00000470305ENST00000339901SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
intron-intronENST00000470305ENST00000534113SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
intron-intronENST00000470305ENST00000470305SECISBP2chr9

91949494

-SECISBP2chr9

91954864

-
intron-intronENST00000375807ENST00000375807SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
intron-intronENST00000375807ENST00000339901SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
intron-intronENST00000375807ENST00000534113SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
intron-3UTRENST00000375807ENST00000470305SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
intron-intronENST00000339901ENST00000375807SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
intron-intronENST00000339901ENST00000339901SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
intron-intronENST00000339901ENST00000534113SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
intron-3UTRENST00000339901ENST00000470305SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
intron-intronENST00000534113ENST00000375807SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
intron-intronENST00000534113ENST00000339901SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
intron-intronENST00000534113ENST00000534113SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
intron-3UTRENST00000534113ENST00000470305SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
3UTR-intronENST00000470305ENST00000375807SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
3UTR-intronENST00000470305ENST00000339901SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
3UTR-intronENST00000470305ENST00000534113SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-
3UTR-3UTRENST00000470305ENST00000470305SECISBP2chr9

91939671

+SECISBP2chr9

91939346

-

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FusionProtFeatures for SECISBP2_SECISBP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SECISBP2

Q96T21

SECISBP2

Q96T21

Binds to the SECIS element in the 3'-UTR of some mRNAsencoding selenoproteins. Binding is stimulated by SELB. Binds to the SECIS element in the 3'-UTR of some mRNAsencoding selenoproteins. Binding is stimulated by SELB.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SECISBP2_SECISBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SECISBP2_SECISBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SECISBP2_SECISBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SECISBP2_SECISBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSECISBP2C0002514Amino Acid Metabolism, Inborn Errors1CTD_human
HgeneSECISBP2C0018273Growth Disorders1CTD_human
HgeneSECISBP2C1864761Thyroid Hormone Metabolism, Abnormal1CTD_human;ORPHANET;UNIPROT
TgeneSECISBP2C0002514Amino Acid Metabolism, Inborn Errors1CTD_human
TgeneSECISBP2C0018273Growth Disorders1CTD_human
TgeneSECISBP2C1864761Thyroid Hormone Metabolism, Abnormal1CTD_human;ORPHANET;UNIPROT