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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33098

FusionGeneSummary for SEC62_SEC62

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC62_SEC62
Fusion gene ID: 33098
HgeneTgene
Gene symbol

SEC62

SEC62

Gene ID

7095

7095

Gene nameSEC62 homolog, preprotein translocation factorSEC62 homolog, preprotein translocation factor
SynonymsDtrp1|HTP1|TLOC1|TP-1Dtrp1|HTP1|TLOC1|TP-1
Cytomap

3q26.2

3q26.2

Type of geneprotein-codingprotein-coding
Descriptiontranslocation protein SEC62SEC62 preprotein translocation factorhTP-1membrane protein SEC62, S.cerevisiae, homolog oftranslocation protein 1translocation protein SEC62SEC62 preprotein translocation factorhTP-1membrane protein SEC62, S.cerevisiae, homolog oftranslocation protein 1
Modification date2018052220180522
UniProtAcc

Q99442

Q99442

Ensembl transtripts involved in fusion geneENST00000337002, ENST00000480708, 
ENST00000470355, 		ENST00000337002, 
ENST00000480708, ENST00000470355, 
Fusion gene scores* DoF score3 X 6 X 3=546 X 9 X 3=162
# samples 811
** MAII scorelog2(8/54*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(11/162*10)=-0.558490289359965
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEC62 [Title/Abstract] AND SEC62 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC105971SEC62chr3

169706153

+SEC62chr3

169693395

+
ChiTaRS3.1BE763851SEC62chr3

169713376

+SEC62chr3

169713449

-
ChiTaRS3.1BE763842SEC62chr3

169713376

+SEC62chr3

169713449

-
ChiTaRS3.1BU608812SEC62chr3

169712136

-SEC62chr3

169711530

+
ChiTaRS3.1CB250599SEC62chr3

169694789

-SEC62chr3

169710761

-
ChiTaRS3.1BU676684SEC62chr3

169700555

-SEC62chr3

169710538

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000337002ENST00000337002SEC62chr3

169706153

+SEC62chr3

169693395

+
Frame-shiftENST00000337002ENST00000480708SEC62chr3

169706153

+SEC62chr3

169693395

+
5CDS-intronENST00000337002ENST00000470355SEC62chr3

169706153

+SEC62chr3

169693395

+
Frame-shiftENST00000480708ENST00000337002SEC62chr3

169706153

+SEC62chr3

169693395

+
Frame-shiftENST00000480708ENST00000480708SEC62chr3

169706153

+SEC62chr3

169693395

+
5CDS-intronENST00000480708ENST00000470355SEC62chr3

169706153

+SEC62chr3

169693395

+
3UTR-3CDSENST00000470355ENST00000337002SEC62chr3

169706153

+SEC62chr3

169693395

+
3UTR-3CDSENST00000470355ENST00000480708SEC62chr3

169706153

+SEC62chr3

169693395

+
3UTR-intronENST00000470355ENST00000470355SEC62chr3

169706153

+SEC62chr3

169693395

+
3UTR-3UTRENST00000337002ENST00000337002SEC62chr3

169713376

+SEC62chr3

169713449

-
3UTR-intronENST00000337002ENST00000480708SEC62chr3

169713376

+SEC62chr3

169713449

-
3UTR-intronENST00000337002ENST00000470355SEC62chr3

169713376

+SEC62chr3

169713449

-
intron-3UTRENST00000480708ENST00000337002SEC62chr3

169713376

+SEC62chr3

169713449

-
intron-intronENST00000480708ENST00000480708SEC62chr3

169713376

+SEC62chr3

169713449

-
intron-intronENST00000480708ENST00000470355SEC62chr3

169713376

+SEC62chr3

169713449

-
intron-3UTRENST00000470355ENST00000337002SEC62chr3

169713376

+SEC62chr3

169713449

-
intron-intronENST00000470355ENST00000480708SEC62chr3

169713376

+SEC62chr3

169713449

-
intron-intronENST00000470355ENST00000470355SEC62chr3

169713376

+SEC62chr3

169713449

-
3UTR-3UTRENST00000337002ENST00000337002SEC62chr3

169712136

-SEC62chr3

169711530

+
3UTR-3UTRENST00000337002ENST00000480708SEC62chr3

169712136

-SEC62chr3

169711530

+
3UTR-intronENST00000337002ENST00000470355SEC62chr3

169712136

-SEC62chr3

169711530

+
intron-3UTRENST00000480708ENST00000337002SEC62chr3

169712136

-SEC62chr3

169711530

+
intron-3UTRENST00000480708ENST00000480708SEC62chr3

169712136

-SEC62chr3

169711530

+
intron-intronENST00000480708ENST00000470355SEC62chr3

169712136

-SEC62chr3

169711530

+
intron-3UTRENST00000470355ENST00000337002SEC62chr3

169712136

-SEC62chr3

169711530

+
intron-3UTRENST00000470355ENST00000480708SEC62chr3

169712136

-SEC62chr3

169711530

+
intron-intronENST00000470355ENST00000470355SEC62chr3

169712136

-SEC62chr3

169711530

+
Frame-shiftENST00000337002ENST00000337002SEC62chr3

169694789

-SEC62chr3

169710761

-
Frame-shiftENST00000337002ENST00000480708SEC62chr3

169694789

-SEC62chr3

169710761

-
5CDS-intronENST00000337002ENST00000470355SEC62chr3

169694789

-SEC62chr3

169710761

-
Frame-shiftENST00000480708ENST00000337002SEC62chr3

169694789

-SEC62chr3

169710761

-
Frame-shiftENST00000480708ENST00000480708SEC62chr3

169694789

-SEC62chr3

169710761

-
5CDS-intronENST00000480708ENST00000470355SEC62chr3

169694789

-SEC62chr3

169710761

-
intron-3CDSENST00000470355ENST00000337002SEC62chr3

169694789

-SEC62chr3

169710761

-
intron-3CDSENST00000470355ENST00000480708SEC62chr3

169694789

-SEC62chr3

169710761

-
intron-intronENST00000470355ENST00000470355SEC62chr3

169694789

-SEC62chr3

169710761

-
In-frameENST00000337002ENST00000337002SEC62chr3

169700555

-SEC62chr3

169710538

-
Frame-shiftENST00000337002ENST00000480708SEC62chr3

169700555

-SEC62chr3

169710538

-
5CDS-intronENST00000337002ENST00000470355SEC62chr3

169700555

-SEC62chr3

169710538

-
In-frameENST00000480708ENST00000337002SEC62chr3

169700555

-SEC62chr3

169710538

-
Frame-shiftENST00000480708ENST00000480708SEC62chr3

169700555

-SEC62chr3

169710538

-
5CDS-intronENST00000480708ENST00000470355SEC62chr3

169700555

-SEC62chr3

169710538

-
intron-3CDSENST00000470355ENST00000337002SEC62chr3

169700555

-SEC62chr3

169710538

-
intron-3CDSENST00000470355ENST00000480708SEC62chr3

169700555

-SEC62chr3

169710538

-
intron-intronENST00000470355ENST00000470355SEC62chr3

169700555

-SEC62chr3

169710538

-

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FusionProtFeatures for SEC62_SEC62


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC62

Q99442

SEC62

Q99442

Required for preprotein translocation. {ECO:0000250}. Required for preprotein translocation. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEC62_SEC62


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC62_SEC62


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEC62_SEC62


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEC62_SEC62


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource