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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33086

FusionGeneSummary for SEC61A2_SEC61A2

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC61A2_SEC61A2
Fusion gene ID: 33086
HgeneTgene
Gene symbol

SEC61A2

SEC61A2

Gene ID

55176

55176

Gene nameSec61 translocon alpha 2 subunitSec61 translocon alpha 2 subunit
Synonyms--
Cytomap

10p14

10p14

Type of geneprotein-codingprotein-coding
Descriptionprotein transport protein Sec61 subunit alpha isoform 2Sec61 alpha 2 subunitSec61 alpha form 2protein transport protein Sec61 subunit alphasec61 alpha-2protein transport protein Sec61 subunit alpha isoform 2Sec61 alpha 2 subunitSec61 alpha form 2protein transport protein Sec61 subunit alphasec61 alpha-2
Modification date2018052320180523
UniProtAcc

Q9H9S3

Q9H9S3

Ensembl transtripts involved in fusion geneENST00000379051, ENST00000379033, 
ENST00000298428, ENST00000495368, 
ENST00000304267, ENST00000379020, 
ENST00000379017, 		ENST00000379051, 
ENST00000379033, ENST00000298428, 
ENST00000495368, ENST00000304267, 
ENST00000379020, ENST00000379017, 
Fusion gene scores* DoF score3 X 4 X 3=363 X 4 X 2=24
# samples 43
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/24*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SEC61A2 [Title/Abstract] AND SEC61A2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE618201SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
ChiTaRS3.1BU902594SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000379051ENST00000379051SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379051ENST00000379033SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379051ENST00000298428SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379051ENST00000495368SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379051ENST00000304267SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379051ENST00000379020SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379051ENST00000379017SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379033ENST00000379051SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379033ENST00000379033SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379033ENST00000298428SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379033ENST00000495368SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379033ENST00000304267SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379033ENST00000379020SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379033ENST00000379017SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000298428ENST00000379051SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000298428ENST00000379033SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000298428ENST00000298428SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000298428ENST00000495368SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000298428ENST00000304267SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000298428ENST00000379020SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000298428ENST00000379017SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000495368ENST00000379051SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000495368ENST00000379033SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000495368ENST00000298428SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000495368ENST00000495368SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000495368ENST00000304267SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000495368ENST00000379020SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000495368ENST00000379017SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000304267ENST00000379051SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000304267ENST00000379033SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000304267ENST00000298428SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000304267ENST00000495368SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000304267ENST00000304267SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000304267ENST00000379020SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000304267ENST00000379017SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379020ENST00000379051SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379020ENST00000379033SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379020ENST00000298428SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379020ENST00000495368SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379020ENST00000304267SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379020ENST00000379020SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379020ENST00000379017SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379017ENST00000379051SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379017ENST00000379033SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379017ENST00000298428SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379017ENST00000495368SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379017ENST00000304267SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379017ENST00000379020SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379017ENST00000379017SEC61A2chr10

12208431

+SEC61A2chr10

12208283

-
intron-intronENST00000379051ENST00000379051SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000379051ENST00000379033SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000379051ENST00000298428SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000379051ENST00000495368SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000379051ENST00000304267SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000379051ENST00000379020SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000379051ENST00000379017SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000379033ENST00000379051SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000379033ENST00000379033SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000379033ENST00000298428SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000379033ENST00000495368SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000379033ENST00000304267SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000379033ENST00000379020SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000379033ENST00000379017SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000298428ENST00000379051SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000298428ENST00000379033SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000298428ENST00000298428SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000298428ENST00000495368SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000298428ENST00000304267SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000298428ENST00000379020SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000298428ENST00000379017SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000495368ENST00000379051SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000495368ENST00000379033SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000495368ENST00000298428SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000495368ENST00000495368SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000495368ENST00000304267SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000495368ENST00000379020SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000495368ENST00000379017SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000304267ENST00000379051SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000304267ENST00000379033SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000304267ENST00000298428SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000304267ENST00000495368SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000304267ENST00000304267SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000304267ENST00000379020SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000304267ENST00000379017SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000379020ENST00000379051SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000379020ENST00000379033SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000379020ENST00000298428SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000379020ENST00000495368SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000379020ENST00000304267SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000379020ENST00000379020SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
5CDS-intronENST00000379020ENST00000379017SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000379017ENST00000379051SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000379017ENST00000379033SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000379017ENST00000298428SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000379017ENST00000495368SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000379017ENST00000304267SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000379017ENST00000379020SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+
intron-intronENST00000379017ENST00000379017SEC61A2chr10

12206309

-SEC61A2chr10

12206414

+

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FusionProtFeatures for SEC61A2_SEC61A2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC61A2

Q9H9S3

SEC61A2

Q9H9S3

Appears to play a crucial role in the insertion ofsecretory and membrane polypeptides into the ER. It is requiredfor assembly of membrane and secretory proteins. Found to betightly associated with membrane-bound ribosomes, either directlyor through adaptor proteins (By similarity). {ECO:0000250}. Appears to play a crucial role in the insertion ofsecretory and membrane polypeptides into the ER. It is requiredfor assembly of membrane and secretory proteins. Found to betightly associated with membrane-bound ribosomes, either directlyor through adaptor proteins (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEC61A2_SEC61A2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC61A2_SEC61A2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEC61A2_SEC61A2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEC61A2_SEC61A2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource