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Fusion gene ID: 33085 |
FusionGeneSummary for SEC61A2_IGHJ4 |
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Fusion gene information | Fusion gene name: SEC61A2_IGHJ4 | Fusion gene ID: 33085 | Hgene | Tgene | Gene symbol | SEC61A2 | IGHJ4 | Gene ID | 55176 | 28477 |
Gene name | Sec61 translocon alpha 2 subunit | immunoglobulin heavy joining 4 | |
Synonyms | - | JH4b | |
Cytomap | 10p14 | 14q32.33 | |
Type of gene | protein-coding | other | |
Description | protein transport protein Sec61 subunit alpha isoform 2Sec61 alpha 2 subunitSec61 alpha form 2protein transport protein Sec61 subunit alphasec61 alpha-2 | - | |
Modification date | 20180523 | 20180329 | |
UniProtAcc | Q9H9S3 | ||
Ensembl transtripts involved in fusion gene | ENST00000379051, ENST00000379033, ENST00000298428, ENST00000495368, ENST00000304267, ENST00000379020, ENST00000379017, | ENST00000461719, | |
Fusion gene scores | * DoF score | 3 X 4 X 3=36 | 12 X 7 X 6=504 |
# samples | 4 | 12 | |
** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/504*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SEC61A2 [Title/Abstract] AND IGHJ4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUAD | TCGA-L9-A743-01A | SEC61A2 | chr10 | 12171768 | + | IGHJ4 | chr14 | 106330462 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000379051 | ENST00000461719 | SEC61A2 | chr10 | 12171768 | + | IGHJ4 | chr14 | 106330462 | - |
5UTR-3CDS | ENST00000379033 | ENST00000461719 | SEC61A2 | chr10 | 12171768 | + | IGHJ4 | chr14 | 106330462 | - |
5UTR-3CDS | ENST00000298428 | ENST00000461719 | SEC61A2 | chr10 | 12171768 | + | IGHJ4 | chr14 | 106330462 | - |
3UTR-3CDS | ENST00000495368 | ENST00000461719 | SEC61A2 | chr10 | 12171768 | + | IGHJ4 | chr14 | 106330462 | - |
5UTR-3CDS | ENST00000304267 | ENST00000461719 | SEC61A2 | chr10 | 12171768 | + | IGHJ4 | chr14 | 106330462 | - |
5UTR-3CDS | ENST00000379020 | ENST00000461719 | SEC61A2 | chr10 | 12171768 | + | IGHJ4 | chr14 | 106330462 | - |
5UTR-3CDS | ENST00000379017 | ENST00000461719 | SEC61A2 | chr10 | 12171768 | + | IGHJ4 | chr14 | 106330462 | - |
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FusionProtFeatures for SEC61A2_IGHJ4 |
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Hgene | Tgene |
SEC61A2 | IGHJ4 |
Appears to play a crucial role in the insertion ofsecretory and membrane polypeptides into the ER. It is requiredfor assembly of membrane and secretory proteins. Found to betightly associated with membrane-bound ribosomes, either directlyor through adaptor proteins (By similarity). {ECO:0000250}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SEC61A2_IGHJ4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SEC61A2_IGHJ4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SEC61A2 | USP19, CLN3, CFTR, PTPN5, PTPRE, PTPRN, PTPRO | IGHJ4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SEC61A2_IGHJ4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEC61A2_IGHJ4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |