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Fusion gene ID: 33083 |
FusionGeneSummary for SEC61A1_SMR3B |
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Fusion gene information | Fusion gene name: SEC61A1_SMR3B | Fusion gene ID: 33083 | Hgene | Tgene | Gene symbol | SEC61A1 | SMR3B | Gene ID | 29927 | 10879 |
Gene name | Sec61 translocon alpha 1 subunit | submaxillary gland androgen regulated protein 3B | |
Synonyms | HNFJ4|HSEC61|SEC61|SEC61A | P-B|PBII|PRL3|PROL3|SMR1B | |
Cytomap | 3q21.3 | 4q13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein transport protein Sec61 subunit alpha isoform 1Sec61 alpha 1 subunitSec61 alpha-1protein transport protein SEC61 alpha subunitprotein transport protein Sec61 subunit alphasec61 homolog | submaxillary gland androgen-regulated protein 3Bproline rich 3proline-rich peptide P-Bproline-rich protein 3salivary proline-rich proteinsubmaxillary gland androgen regulated protein 3 homolog B | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P61619 | P02814 | |
Ensembl transtripts involved in fusion gene | ENST00000464451, ENST00000243253, ENST00000424880, ENST00000483956, | ENST00000504825, ENST00000304915, | |
Fusion gene scores | * DoF score | 8 X 9 X 6=432 | 9 X 8 X 2=144 |
# samples | 10 | 3 | |
** MAII score | log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/144*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SEC61A1 [Title/Abstract] AND SMR3B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AN-A0G0-01A | SEC61A1 | chr3 | 127790079 | + | SMR3B | chr4 | 71255575 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000464451 | ENST00000504825 | SEC61A1 | chr3 | 127790079 | + | SMR3B | chr4 | 71255575 | + |
intron-3UTR | ENST00000464451 | ENST00000304915 | SEC61A1 | chr3 | 127790079 | + | SMR3B | chr4 | 71255575 | + |
3UTR-3UTR | ENST00000243253 | ENST00000504825 | SEC61A1 | chr3 | 127790079 | + | SMR3B | chr4 | 71255575 | + |
3UTR-3UTR | ENST00000243253 | ENST00000304915 | SEC61A1 | chr3 | 127790079 | + | SMR3B | chr4 | 71255575 | + |
3UTR-3UTR | ENST00000424880 | ENST00000504825 | SEC61A1 | chr3 | 127790079 | + | SMR3B | chr4 | 71255575 | + |
3UTR-3UTR | ENST00000424880 | ENST00000304915 | SEC61A1 | chr3 | 127790079 | + | SMR3B | chr4 | 71255575 | + |
3UTR-3UTR | ENST00000483956 | ENST00000504825 | SEC61A1 | chr3 | 127790079 | + | SMR3B | chr4 | 71255575 | + |
3UTR-3UTR | ENST00000483956 | ENST00000304915 | SEC61A1 | chr3 | 127790079 | + | SMR3B | chr4 | 71255575 | + |
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FusionProtFeatures for SEC61A1_SMR3B |
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Hgene | Tgene |
SEC61A1 | SMR3B |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SEC61A1_SMR3B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SEC61A1_SMR3B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SEC61A1 | AP1S1, NDN, APOB, USP11, USP19, UBC, TMEM173, BAG6, ASNA1, HLA-A, PDIA3, BCAP31, SEC61B, CALM1, OPRD1, MDC1, HSPA5, MLH1, CFTR, CLN3, CLN5, ADRB2, EGFR, ILK, STAU1, MOV10, NXF1, CLGN, MAGT1, RPL13A, DDOST, IPO5, JAGN1, PSMC6, RPL17, RPL19, RPL3, RPL5, RPS14, RPS15, RPS5, SSR3, TECR, UQCRC2, SEC63, NTRK1, MED4, YWHAZ, PPP4R1, NUP107, UPF3B, TNF, SEC61G, ESRRB, PTPRN2, PTPN1, PTPN5, PTPRN, CYLD, NCDN | SMR3B | RAD21, UBQLN1, UBTD2, RASSF10, BCHE, TNFRSF19, SNRPF |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SEC61A1_SMR3B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEC61A1_SMR3B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SEC61A1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |