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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33080

FusionGeneSummary for SEC61A1_INPP4B

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC61A1_INPP4B
Fusion gene ID: 33080
HgeneTgene
Gene symbol

SEC61A1

INPP4B

Gene ID

29927

8821

Gene nameSec61 translocon alpha 1 subunitinositol polyphosphate-4-phosphatase type II B
SynonymsHNFJ4|HSEC61|SEC61|SEC61A-
Cytomap

3q21.3

4q31.21

Type of geneprotein-codingprotein-coding
Descriptionprotein transport protein Sec61 subunit alpha isoform 1Sec61 alpha 1 subunitSec61 alpha-1protein transport protein SEC61 alpha subunitprotein transport protein Sec61 subunit alphasec61 homologtype II inositol 3,4-bisphosphate 4-phosphataseinositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate-4-phosphatase, type II, 105kDa
Modification date2018052720180523
UniProtAcc

P61619

O15327

Ensembl transtripts involved in fusion geneENST00000464451, ENST00000243253, 
ENST00000424880, ENST00000483956, 
ENST00000513000, ENST00000509777, 
ENST00000262992, ENST00000308502, 
ENST00000508116, ENST00000507861, 
ENST00000506217, ENST00000508084, 
Fusion gene scores* DoF score8 X 9 X 6=4329 X 7 X 6=378
# samples 109
** MAII scorelog2(10/432*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/378*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEC61A1 [Title/Abstract] AND INPP4B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A3UA-01ASEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000464451ENST00000513000SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000464451ENST00000509777SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000464451ENST00000262992SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000464451ENST00000308502SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000464451ENST00000508116SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000464451ENST00000507861SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000464451ENST00000506217SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000464451ENST00000508084SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
Frame-shitENST00000243253ENST00000513000SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000243253ENST00000509777SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000243253ENST00000262992SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000243253ENST00000308502SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000243253ENST00000508116SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000243253ENST00000507861SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000243253ENST00000506217SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000243253ENST00000508084SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
Frame-shitENST00000424880ENST00000513000SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000424880ENST00000509777SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000424880ENST00000262992SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000424880ENST00000308502SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000424880ENST00000508116SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000424880ENST00000507861SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000424880ENST00000506217SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
5CDS-intronENST00000424880ENST00000508084SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
3UTR-3CDSENST00000483956ENST00000513000SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
3UTR-intronENST00000483956ENST00000509777SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
3UTR-intronENST00000483956ENST00000262992SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
3UTR-intronENST00000483956ENST00000308502SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
3UTR-intronENST00000483956ENST00000508116SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
3UTR-intronENST00000483956ENST00000507861SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
3UTR-intronENST00000483956ENST00000506217SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-
3UTR-intronENST00000483956ENST00000508084SEC61A1chr3

127786902

+INPP4Bchr4

142950067

-

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FusionProtFeatures for SEC61A1_INPP4B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC61A1

P61619

INPP4B

O15327

Catalyzes the hydrolysis of the 4-position phosphate ofphosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEC61A1_INPP4B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC61A1_INPP4B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEC61A1AP1S1, NDN, APOB, USP11, USP19, UBC, TMEM173, BAG6, ASNA1, HLA-A, PDIA3, BCAP31, SEC61B, CALM1, OPRD1, MDC1, HSPA5, MLH1, CFTR, CLN3, CLN5, ADRB2, EGFR, ILK, STAU1, MOV10, NXF1, CLGN, MAGT1, RPL13A, DDOST, IPO5, JAGN1, PSMC6, RPL17, RPL19, RPL3, RPL5, RPS14, RPS15, RPS5, SSR3, TECR, UQCRC2, SEC63, NTRK1, MED4, YWHAZ, PPP4R1, NUP107, UPF3B, TNF, SEC61G, ESRRB, PTPRN2, PTPN1, PTPN5, PTPRN, CYLD, NCDNINPP4BELAVL1, PYCARD, ZNF131


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEC61A1_INPP4B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEC61A1_INPP4B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSEC61A1C0376634Craniofacial Abnormalities1CTD_human