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Fusion gene ID: 33080 |
FusionGeneSummary for SEC61A1_INPP4B |
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Fusion gene information | Fusion gene name: SEC61A1_INPP4B | Fusion gene ID: 33080 | Hgene | Tgene | Gene symbol | SEC61A1 | INPP4B | Gene ID | 29927 | 8821 |
Gene name | Sec61 translocon alpha 1 subunit | inositol polyphosphate-4-phosphatase type II B | |
Synonyms | HNFJ4|HSEC61|SEC61|SEC61A | - | |
Cytomap | 3q21.3 | 4q31.21 | |
Type of gene | protein-coding | protein-coding | |
Description | protein transport protein Sec61 subunit alpha isoform 1Sec61 alpha 1 subunitSec61 alpha-1protein transport protein SEC61 alpha subunitprotein transport protein Sec61 subunit alphasec61 homolog | type II inositol 3,4-bisphosphate 4-phosphataseinositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate-4-phosphatase, type II, 105kDa | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P61619 | O15327 | |
Ensembl transtripts involved in fusion gene | ENST00000464451, ENST00000243253, ENST00000424880, ENST00000483956, | ENST00000513000, ENST00000509777, ENST00000262992, ENST00000308502, ENST00000508116, ENST00000507861, ENST00000506217, ENST00000508084, | |
Fusion gene scores | * DoF score | 8 X 9 X 6=432 | 9 X 7 X 6=378 |
# samples | 10 | 9 | |
** MAII score | log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SEC61A1 [Title/Abstract] AND INPP4B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-A3UA-01A | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000464451 | ENST00000513000 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000464451 | ENST00000509777 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000464451 | ENST00000262992 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000464451 | ENST00000308502 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000464451 | ENST00000508116 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000464451 | ENST00000507861 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000464451 | ENST00000506217 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000464451 | ENST00000508084 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
Frame-shift | ENST00000243253 | ENST00000513000 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000243253 | ENST00000509777 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000243253 | ENST00000262992 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000243253 | ENST00000308502 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000243253 | ENST00000508116 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000243253 | ENST00000507861 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000243253 | ENST00000506217 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000243253 | ENST00000508084 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
Frame-shift | ENST00000424880 | ENST00000513000 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000424880 | ENST00000509777 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000424880 | ENST00000262992 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000424880 | ENST00000308502 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000424880 | ENST00000508116 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000424880 | ENST00000507861 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000424880 | ENST00000506217 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
5CDS-intron | ENST00000424880 | ENST00000508084 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
3UTR-3CDS | ENST00000483956 | ENST00000513000 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
3UTR-intron | ENST00000483956 | ENST00000509777 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
3UTR-intron | ENST00000483956 | ENST00000262992 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
3UTR-intron | ENST00000483956 | ENST00000308502 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
3UTR-intron | ENST00000483956 | ENST00000508116 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
3UTR-intron | ENST00000483956 | ENST00000507861 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
3UTR-intron | ENST00000483956 | ENST00000506217 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
3UTR-intron | ENST00000483956 | ENST00000508084 | SEC61A1 | chr3 | 127786902 | + | INPP4B | chr4 | 142950067 | - |
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FusionProtFeatures for SEC61A1_INPP4B |
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Hgene | Tgene |
SEC61A1 | INPP4B |
Catalyzes the hydrolysis of the 4-position phosphate ofphosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SEC61A1_INPP4B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SEC61A1_INPP4B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SEC61A1 | AP1S1, NDN, APOB, USP11, USP19, UBC, TMEM173, BAG6, ASNA1, HLA-A, PDIA3, BCAP31, SEC61B, CALM1, OPRD1, MDC1, HSPA5, MLH1, CFTR, CLN3, CLN5, ADRB2, EGFR, ILK, STAU1, MOV10, NXF1, CLGN, MAGT1, RPL13A, DDOST, IPO5, JAGN1, PSMC6, RPL17, RPL19, RPL3, RPL5, RPS14, RPS15, RPS5, SSR3, TECR, UQCRC2, SEC63, NTRK1, MED4, YWHAZ, PPP4R1, NUP107, UPF3B, TNF, SEC61G, ESRRB, PTPRN2, PTPN1, PTPN5, PTPRN, CYLD, NCDN | INPP4B | ELAVL1, PYCARD, ZNF131 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SEC61A1_INPP4B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEC61A1_INPP4B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SEC61A1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |