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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33070

FusionGeneSummary for SEC31A_MUC7

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC31A_MUC7
Fusion gene ID: 33070
HgeneTgene
Gene symbol

SEC31A

MUC7

Gene ID

22872

4589

Gene nameSEC31 homolog A, COPII coat complex componentmucin 7, secreted
SynonymsABP125|ABP130|HSPC275|HSPC334|SEC31L1MG2
Cytomap

4q21.22

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionprotein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homologmucin-7MUC-7apo-MG2mucin 7, salivarysalivary mucin-7
Modification date2018052320180522
UniProtAcc

O94979

Q8TAX7

Ensembl transtripts involved in fusion geneENST00000348405, ENST00000513858, 
ENST00000395310, ENST00000443462, 
ENST00000509142, ENST00000326950, 
ENST00000432794, ENST00000311785, 
ENST00000448323, ENST00000505472, 
ENST00000500777, ENST00000508502, 
ENST00000355196, ENST00000264405, 
ENST00000505984, ENST00000508479, 
ENST00000436790, 		ENST00000413702, 
ENST00000456088, ENST00000304887, 
ENST00000514512, 
Fusion gene scores* DoF score15 X 14 X 8=16804 X 4 X 3=48
# samples 185
** MAII scorelog2(18/1680*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SEC31A [Title/Abstract] AND MUC7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSEC31A

GO:0051592

response to calcium ion

17196169

HgeneSEC31A

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296

TgeneMUC7

GO:0031640

killing of cells of other organism

12543672

TgeneMUC7

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

12543672


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A8-A09A-01ASEC31Achr4

83778105

-MUC7chr4

71337932

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000348405ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000348405ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000348405ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000348405ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000513858ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000513858ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000513858ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000513858ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000395310ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000395310ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000395310ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000395310ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000443462ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000443462ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000443462ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000443462ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000509142ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000509142ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000509142ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000509142ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000326950ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000326950ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000326950ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000326950ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000432794ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000432794ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000432794ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000432794ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000311785ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000311785ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000311785ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000311785ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000448323ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000448323ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000448323ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000448323ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000505472ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000505472ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000505472ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000505472ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000500777ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000500777ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000500777ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000500777ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000508502ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000508502ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000508502ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000508502ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000355196ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000355196ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000355196ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000355196ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000264405ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000264405ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000264405ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000264405ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000505984ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000505984ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000505984ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000505984ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000508479ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000508479ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-5UTRENST00000508479ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
5CDS-3UTRENST00000508479ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+
intron-5UTRENST00000436790ENST00000413702SEC31Achr4

83778105

-MUC7chr4

71337932

+
intron-5UTRENST00000436790ENST00000456088SEC31Achr4

83778105

-MUC7chr4

71337932

+
intron-5UTRENST00000436790ENST00000304887SEC31Achr4

83778105

-MUC7chr4

71337932

+
intron-3UTRENST00000436790ENST00000514512SEC31Achr4

83778105

-MUC7chr4

71337932

+

Top

FusionProtFeatures for SEC31A_MUC7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC31A

O94979

MUC7

Q8TAX7

May function in a protective capacity by promoting theclearance of bacteria in the oral cavity and aiding inmastication, speech, and swallowing. Binds P.aeruginosa pili.{ECO:0000269|PubMed:11378823, ECO:0000269|PubMed:8104046}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEC31A_MUC7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC31A_MUC7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEC31ASEC13, APC, TNNT1, PFDN1, ALG2, STAM, STAM2, CUL3, CDK9, HSPA8, VCAM1, ITGA4, REL, SHMT2, MOV10, NXF1, TFG, SCYL1, C6orf211, ATP6V1C1, ENO2, FDPS, NUDT13, SEC23A, SEC23B, SEC24B, ALDH5A1, ATP6V1D, CBS, CTH, CYB5B, DHX15, HNRNPA1, HSD17B10, NAPRT, NSF, SAR1A, TBCA, TPD52L2, TRIM25, TSTA3, TCEB2, NTRK1, TMEM17, XPO1, TSC22D2, NOP14, SEC23IP, NOC4L, GNPDA1, CCDC88A, BRCA1MUC7LTF, GALNT14, SELL, UCP2, GTF2B, KIR2DS2, CAMK1D, RCAN2, FRMD1, ZNF491, NPB, GKN1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SEC31A_MUC7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEC31A_MUC7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSEC31AC0079744Diffuse Large B-Cell Lymphoma1CTD_human