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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3307

FusionGeneSummary for ATP1A2_CPB1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP1A2_CPB1
Fusion gene ID: 3307
HgeneTgene
Gene symbol

ATP1A2

CPB1

Gene ID

477

1360

Gene nameATPase Na+/K+ transporting subunit alpha 2carboxypeptidase B1
SynonymsFHM2|MHP2CPB|PASP|PCPB
Cytomap

1q23.2

3q24

Type of geneprotein-codingprotein-coding
Descriptionsodium/potassium-transporting ATPase subunit alpha-2ATPase Na+/K+ transporting alpha 2 polypeptideNa(+)/K(+) ATPase alpha-2 subunitNa+/K+ ATPase, alpha-A(+) catalytic polypeptideNa+/K+ ATPase, alpha-B polypeptidesodium pump subunit alpha-2sodium-potcarboxypeptidase Bcarboxypeptidase B1 (tissue)pancreas-specific proteinpancreatic carboxypeptidase Bprocarboxypeptidase Bprotaminasetissue carboxypeptidase B
Modification date2018052320180523
UniProtAcc

P50993

P15086

Ensembl transtripts involved in fusion geneENST00000361216, ENST00000392233, 
ENST00000459972, 
ENST00000491148, 
ENST00000282957, ENST00000498639, 
Fusion gene scores* DoF score2 X 2 X 2=821 X 24 X 3=1512
# samples 219
** MAII scorelog2(2/8*10)=1.32192809488736log2(19/1512*10)=-2.99238681589013
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP1A2 [Title/Abstract] AND CPB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP1A2

GO:0006883

cellular sodium ion homeostasis

10636900

HgeneATP1A2

GO:0010107

potassium ion import

10636900

HgeneATP1A2

GO:0030007

cellular potassium ion homeostasis

10636900

HgeneATP1A2

GO:0036376

sodium ion export across plasma membrane

10636900

HgeneATP1A2

GO:0071383

cellular response to steroid hormone stimulus

14742675


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A041-01AATP1A2chr1

160112554

+CPB1chr3

148562275

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000361216ENST00000491148ATP1A2chr1

160112554

+CPB1chr3

148562275

+
3UTR-3CDSENST00000361216ENST00000282957ATP1A2chr1

160112554

+CPB1chr3

148562275

+
3UTR-intronENST00000361216ENST00000498639ATP1A2chr1

160112554

+CPB1chr3

148562275

+
intron-3CDSENST00000392233ENST00000491148ATP1A2chr1

160112554

+CPB1chr3

148562275

+
intron-3CDSENST00000392233ENST00000282957ATP1A2chr1

160112554

+CPB1chr3

148562275

+
intron-intronENST00000392233ENST00000498639ATP1A2chr1

160112554

+CPB1chr3

148562275

+
intron-3CDSENST00000459972ENST00000491148ATP1A2chr1

160112554

+CPB1chr3

148562275

+
intron-3CDSENST00000459972ENST00000282957ATP1A2chr1

160112554

+CPB1chr3

148562275

+
intron-intronENST00000459972ENST00000498639ATP1A2chr1

160112554

+CPB1chr3

148562275

+

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FusionProtFeatures for ATP1A2_CPB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP1A2

P50993

CPB1

P15086

This is the catalytic component of the active enzyme,which catalyzes the hydrolysis of ATP coupled with the exchange ofsodium and potassium ions across the plasma membrane. This actioncreates the electrochemical gradient of sodium and potassium,providing the energy for active transport of various nutrients.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP1A2_CPB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP1A2_CPB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP1A2FBXO25, ZNRF2, ZNRF1, CUL3, CAND1, LGR4, ROGDI, P2RY8, CLTC, RAB1A, ATP6V0D1, ATP6V1A, CCT7, VDAC1, VDAC2, SCLT1, DOCK5, HIST1H4A, ARHGEF16CPB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP1A2_CPB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneATP1A2P50993DB01092OuabainSodium/potassium-transporting ATPase subunit alpha-2small moleculeapproved
TgeneCPB1P15086DB04272Citric AcidCarboxypeptidase Bsmall moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for ATP1A2_CPB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATP1A2C1865322MIGRAINE, FAMILIAL HEMIPLEGIC, 26CTD_human;UNIPROT
HgeneATP1A2C0020538Hypertensive disease2CTD_human
HgeneATP1A2C0005586Bipolar Disorder1PSYGENET
HgeneATP1A2C3549447ALTERNATING HEMIPLEGIA OF CHILDHOOD 11UNIPROT