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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33064

FusionGeneSummary for SEC31A_EIF4G3

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC31A_EIF4G3
Fusion gene ID: 33064
HgeneTgene
Gene symbol

SEC31A

EIF4G3

Gene ID

22872

8672

Gene nameSEC31 homolog A, COPII coat complex componenteukaryotic translation initiation factor 4 gamma 3
SynonymsABP125|ABP130|HSPC275|HSPC334|SEC31L1eIF-4G 3|eIF4G 3|eIF4GII
Cytomap

4q21.22

1p36.12

Type of geneprotein-codingprotein-coding
Descriptionprotein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homologeukaryotic translation initiation factor 4 gamma 3eIF-4-gamma 3eIF-4-gamma II
Modification date2018052320180523
UniProtAcc

O94979

O43432

Ensembl transtripts involved in fusion geneENST00000348405, ENST00000513858, 
ENST00000395310, ENST00000443462, 
ENST00000509142, ENST00000326950, 
ENST00000432794, ENST00000311785, 
ENST00000448323, ENST00000505472, 
ENST00000500777, ENST00000508502, 
ENST00000355196, ENST00000264405, 
ENST00000505984, ENST00000508479, 
ENST00000436790, 
ENST00000264211, 
ENST00000400422, ENST00000602326, 
ENST00000374935, ENST00000374937, 
ENST00000536266, ENST00000374933, 
ENST00000544689, ENST00000356916, 
ENST00000374927, ENST00000537738, 
Fusion gene scores* DoF score15 X 14 X 8=168013 X 14 X 7=1274
# samples 1814
** MAII scorelog2(18/1680*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/1274*10)=-3.18586654531133
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEC31A [Title/Abstract] AND EIF4G3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSEC31A

GO:0051592

response to calcium ion

17196169

HgeneSEC31A

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVUCECTCGA-AX-A3GI-01ASEC31Achr4

83763293

-EIF4G3chr1

21377487

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000348405ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000348405ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000348405ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000348405ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000348405ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000348405ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000348405ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000348405ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000348405ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000348405ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000348405ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-3CDSENST00000513858ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000513858ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000513858ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000513858ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000513858ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000513858ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000513858ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000513858ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000513858ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000513858ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000513858ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
Frame-shiftENST00000395310ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000395310ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000395310ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000395310ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000395310ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000395310ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000395310ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000395310ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000395310ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000395310ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000395310ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-3CDSENST00000443462ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000443462ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000443462ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000443462ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000443462ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000443462ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000443462ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000443462ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000443462ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000443462ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000443462ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-3CDSENST00000509142ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000509142ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000509142ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000509142ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000509142ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000509142ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000509142ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000509142ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000509142ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000509142ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000509142ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
Frame-shiftENST00000326950ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000326950ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000326950ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000326950ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000326950ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000326950ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000326950ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000326950ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000326950ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000326950ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000326950ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
Frame-shiftENST00000432794ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000432794ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000432794ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000432794ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000432794ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000432794ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000432794ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000432794ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000432794ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000432794ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000432794ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-3CDSENST00000311785ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000311785ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000311785ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000311785ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000311785ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000311785ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000311785ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000311785ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000311785ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000311785ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000311785ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
Frame-shiftENST00000448323ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000448323ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000448323ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000448323ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000448323ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000448323ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000448323ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000448323ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000448323ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000448323ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000448323ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
Frame-shiftENST00000505472ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000505472ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000505472ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000505472ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000505472ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000505472ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000505472ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000505472ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000505472ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000505472ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000505472ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-3CDSENST00000500777ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000500777ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000500777ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000500777ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000500777ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000500777ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000500777ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000500777ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000500777ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000500777ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000500777ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-3CDSENST00000508502ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000508502ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000508502ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000508502ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000508502ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000508502ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000508502ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000508502ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000508502ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000508502ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000508502ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
Frame-shiftENST00000355196ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000355196ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000355196ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000355196ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000355196ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000355196ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000355196ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000355196ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000355196ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-5UTRENST00000355196ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
5CDS-intronENST00000355196ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-3CDSENST00000264405ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000264405ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000264405ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000264405ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000264405ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000264405ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000264405ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000264405ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000264405ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000264405ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000264405ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-3CDSENST00000505984ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000505984ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000505984ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000505984ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000505984ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000505984ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000505984ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000505984ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000505984ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000505984ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000505984ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-3CDSENST00000508479ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000508479ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000508479ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000508479ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000508479ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000508479ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000508479ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000508479ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000508479ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000508479ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000508479ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-3CDSENST00000436790ENST00000264211SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000436790ENST00000400422SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000436790ENST00000602326SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000436790ENST00000374935SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000436790ENST00000374937SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000436790ENST00000536266SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000436790ENST00000374933SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000436790ENST00000544689SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000436790ENST00000356916SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-5UTRENST00000436790ENST00000374927SEC31Achr4

83763293

-EIF4G3chr1

21377487

-
intron-intronENST00000436790ENST00000537738SEC31Achr4

83763293

-EIF4G3chr1

21377487

-

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FusionProtFeatures for SEC31A_EIF4G3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC31A

O94979

EIF4G3

O43432

Probable component of the protein complex eIF4F, whichis involved in the recognition of the mRNA cap, ATP-dependentunwinding of 5'-terminal secondary structure and recruitment ofmRNA to the ribosome. Thought to be a functional homolog ofEIF4G1. {ECO:0000269|PubMed:9418880}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEC31A_EIF4G3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC31A_EIF4G3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEC31ASEC13, APC, TNNT1, PFDN1, ALG2, STAM, STAM2, CUL3, CDK9, HSPA8, VCAM1, ITGA4, REL, SHMT2, MOV10, NXF1, TFG, SCYL1, C6orf211, ATP6V1C1, ENO2, FDPS, NUDT13, SEC23A, SEC23B, SEC24B, ALDH5A1, ATP6V1D, CBS, CTH, CYB5B, DHX15, HNRNPA1, HSD17B10, NAPRT, NSF, SAR1A, TBCA, TPD52L2, TRIM25, TSTA3, TCEB2, NTRK1, TMEM17, XPO1, TSC22D2, NOP14, SEC23IP, NOC4L, GNPDA1, CCDC88A, BRCA1EIF4G3EIF4A2, EIF4A1, PABPC1, USP10, EIF3H, EIF3F, MKNK1, VAV2, SIRT7, EIF4G1, EIF4G2, ESR1, LIG4, TARDBP, LGR4, EIF4E, COMTD1, QPRT, BCAT1, PNKD, RBFOX2, KPTN, PSMC3, ALDH3A2, HSPB1, EIF2B5, PUS7, PABPC4, SF3A2, NTRK1, EIF3B, CTR9, FAM46A, WDYHV1, NFATC2IP, EPHA1, SIGLECL1, HAO2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEC31A_EIF4G3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEC31A_EIF4G3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSEC31AC0079744Diffuse Large B-Cell Lymphoma1CTD_human