	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 33061

FusionGeneSummary for SEC31A_ARFGAP1

Fusion gene summary

Fusion gene information	Fusion gene name: SEC31A_ARFGAP1
	Fusion gene ID: 33061
		Hgene	Tgene
	Gene symbol	SEC31A	ARFGAP1
	Gene ID	22872	55738
	Gene name	SEC31 homolog A, COPII coat complex component	ADP ribosylation factor GTPase activating protein 1
	Synonyms	ABP125\|ABP130\|HSPC275\|HSPC334\|SEC31L1	ARF1GAP\|HRIHFB2281
	Cytomap	4q21.22	20q13.33
	Type of gene	protein-coding	protein-coding
	Description	protein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homolog	ADP-ribosylation factor GTPase-activating protein 1ARF1-directed GTPase-activating protein
	Modification date	20180523	20180523
	UniProtAcc	O94979	Q8N6T3
	Ensembl transtripts involved in fusion gene	ENST00000348405, ENST00000513858, ENST00000395310, ENST00000443462, ENST00000509142, ENST00000326950, ENST00000432794, ENST00000311785, ENST00000448323, ENST00000505472, ENST00000500777, ENST00000508502, ENST00000355196, ENST00000264405, ENST00000505984, ENST00000508479, ENST00000436790,	ENST00000370283, ENST00000547204, ENST00000519604, ENST00000519273, ENST00000370275, ENST00000353546, ENST00000518794,
Fusion gene scores	* DoF score	15 X 14 X 8=1680	5 X 6 X 3=90
	# samples	18	8
	** MAII score	log2(18/1680*10)=-3.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/90*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SEC31A [Title/Abstract] AND ARFGAP1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SEC31A	GO:0051592	response to calcium ion	17196169
Hgene	SEC31A	GO:0090110	cargo loading into COPII-coated vesicle	17499046\|18843296

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BP418474	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000348405	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000348405	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000348405	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000348405	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000348405	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000348405	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000348405	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000513858	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000513858	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000513858	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000513858	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000513858	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000513858	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000513858	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000395310	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000395310	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000395310	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000395310	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000395310	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000395310	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000395310	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000443462	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000443462	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000443462	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000443462	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000443462	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000443462	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000443462	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000509142	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000509142	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000509142	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000509142	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000509142	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000509142	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000509142	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000326950	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000326950	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000326950	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000326950	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000326950	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000326950	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000326950	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000432794	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000432794	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000432794	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000432794	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000432794	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000432794	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000432794	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000311785	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000311785	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000311785	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000311785	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000311785	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000311785	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000311785	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000448323	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000448323	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000448323	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000448323	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000448323	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000448323	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000448323	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000505472	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000505472	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000505472	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000505472	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000505472	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000505472	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000505472	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000500777	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000500777	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000500777	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000500777	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000500777	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000500777	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000500777	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000508502	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000508502	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000508502	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000508502	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000508502	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000508502	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000508502	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000355196	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000355196	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000355196	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000355196	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000355196	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000355196	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000355196	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000264405	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000264405	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000264405	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000264405	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000264405	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000264405	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000264405	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000505984	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000505984	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000505984	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000505984	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000505984	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000505984	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000505984	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000508479	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000508479	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000508479	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000508479	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000508479	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000508479	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000508479	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000436790	ENST00000370283	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000436790	ENST00000547204	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-intron	ENST00000436790	ENST00000519604	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000436790	ENST00000519273	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000436790	ENST00000370275	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000436790	ENST00000353546	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+
intron-3UTR	ENST00000436790	ENST00000518794	SEC31A	chr4	83741680	+	ARFGAP1	chr20	61919448	+

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FusionProtFeatures for SEC31A_ARFGAP1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SEC31A O94979	ARFGAP1 Q8N6T3

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for SEC31A_ARFGAP1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC31A_ARFGAP1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for SEC31A_ARFGAP1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SEC31A_ARFGAP1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	SEC31A	C0079744	Diffuse Large B-Cell Lymphoma	1	CTD_human
Tgene	ARFGAP1	C0008073	Developmental Disabilities	1	CTD_human
Tgene	ARFGAP1	C0027765	nervous system disorder	1	CTD_human

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Fusion gene ID: 33061

FusionGeneSummary for SEC31A_ARFGAP1

FusionProtFeatures for SEC31A_ARFGAP1

FusionGeneSequence for SEC31A_ARFGAP1

FusionGenePPI for SEC31A_ARFGAP1

RelatedDrugs for SEC31A_ARFGAP1

RelatedDiseases for SEC31A_ARFGAP1