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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33061

FusionGeneSummary for SEC31A_ARFGAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC31A_ARFGAP1
Fusion gene ID: 33061
HgeneTgene
Gene symbol

SEC31A

ARFGAP1

Gene ID

22872

55738

Gene nameSEC31 homolog A, COPII coat complex componentADP ribosylation factor GTPase activating protein 1
SynonymsABP125|ABP130|HSPC275|HSPC334|SEC31L1ARF1GAP|HRIHFB2281
Cytomap

4q21.22

20q13.33

Type of geneprotein-codingprotein-coding
Descriptionprotein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homologADP-ribosylation factor GTPase-activating protein 1ARF1-directed GTPase-activating protein
Modification date2018052320180523
UniProtAcc

O94979

Q8N6T3

Ensembl transtripts involved in fusion geneENST00000348405, ENST00000513858, 
ENST00000395310, ENST00000443462, 
ENST00000509142, ENST00000326950, 
ENST00000432794, ENST00000311785, 
ENST00000448323, ENST00000505472, 
ENST00000500777, ENST00000508502, 
ENST00000355196, ENST00000264405, 
ENST00000505984, ENST00000508479, 
ENST00000436790, 
ENST00000370283, 
ENST00000547204, ENST00000519604, 
ENST00000519273, ENST00000370275, 
ENST00000353546, ENST00000518794, 
Fusion gene scores* DoF score15 X 14 X 8=16805 X 6 X 3=90
# samples 188
** MAII scorelog2(18/1680*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/90*10)=-0.169925001442312
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEC31A [Title/Abstract] AND ARFGAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSEC31A

GO:0051592

response to calcium ion

17196169

HgeneSEC31A

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP418474SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000348405ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000348405ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000348405ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000348405ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000348405ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000348405ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000348405ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000513858ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000513858ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000513858ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000513858ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000513858ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000513858ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000513858ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000395310ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000395310ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000395310ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000395310ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000395310ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000395310ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000395310ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000443462ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000443462ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000443462ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000443462ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000443462ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000443462ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000443462ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000509142ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000509142ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000509142ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000509142ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000509142ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000509142ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000509142ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000326950ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000326950ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000326950ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000326950ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000326950ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000326950ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000326950ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000432794ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000432794ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000432794ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000432794ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000432794ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000432794ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000432794ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000311785ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000311785ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000311785ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000311785ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000311785ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000311785ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000311785ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000448323ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000448323ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000448323ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000448323ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000448323ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000448323ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000448323ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000505472ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000505472ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000505472ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000505472ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000505472ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000505472ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000505472ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000500777ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000500777ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000500777ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000500777ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000500777ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000500777ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000500777ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000508502ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000508502ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000508502ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000508502ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000508502ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000508502ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000508502ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000355196ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000355196ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000355196ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000355196ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000355196ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000355196ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000355196ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000264405ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000264405ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000264405ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000264405ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000264405ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000264405ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000264405ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000505984ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000505984ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000505984ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000505984ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000505984ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000505984ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000505984ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000508479ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000508479ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000508479ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000508479ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000508479ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000508479ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000508479ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000436790ENST00000370283SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000436790ENST00000547204SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-intronENST00000436790ENST00000519604SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000436790ENST00000519273SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000436790ENST00000370275SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000436790ENST00000353546SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+
intron-3UTRENST00000436790ENST00000518794SEC31Achr4

83741680

+ARFGAP1chr20

61919448

+

Top

FusionProtFeatures for SEC31A_ARFGAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC31A

O94979

ARFGAP1

Q8N6T3


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SEC31A_ARFGAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SEC31A_ARFGAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SEC31A_ARFGAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SEC31A_ARFGAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSEC31AC0079744Diffuse Large B-Cell Lymphoma1CTD_human
TgeneARFGAP1C0008073Developmental Disabilities1CTD_human
TgeneARFGAP1C0027765nervous system disorder1CTD_human