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Fusion gene ID: 33021 |
FusionGeneSummary for SEC16B_EGF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SEC16B_EGF | Fusion gene ID: 33021 | Hgene | Tgene | Gene symbol | SEC16B | EGF | Gene ID | 89866 | 1950 |
| Gene name | SEC16 homolog B, endoplasmic reticulum export factor | epidermal growth factor | |
| Synonyms | LZTR2|PGPR-p117|RGPR|RGPR-p117|SEC16S | HOMG4|URG | |
| Cytomap | 1q25.2 | 4q25 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein transport protein Sec16Bleucine zipper transcription regulator 2protein SEC16 homolog Bregucalcin gene promoter region-related protein p117regucalcin gene promotor region related protein | pro-epidermal growth factorbeta-urogastrone | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q96JE7 | P01133 | |
| Ensembl transtripts involved in fusion gene | ENST00000495165, ENST00000308284, ENST00000464631, | ENST00000509793, ENST00000265171, ENST00000503392, ENST00000502723, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SEC16B [Title/Abstract] AND EGF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SEC16B | GO:0007029 | endoplasmic reticulum organization | 21768384 |
| Hgene | SEC16B | GO:0007031 | peroxisome organization | 21768384 |
| Tgene | EGF | GO:0001525 | angiogenesis | 15611079 |
| Tgene | EGF | GO:0002092 | positive regulation of receptor internalization | 22732145 |
| Tgene | EGF | GO:0008284 | positive regulation of cell proliferation | 7736574|15611079|20388803 |
| Tgene | EGF | GO:0010628 | positive regulation of gene expression | 25678558 |
| Tgene | EGF | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 16314496 |
| Tgene | EGF | GO:0030335 | positive regulation of cell migration | 25678558 |
| Tgene | EGF | GO:0042327 | positive regulation of phosphorylation | 15611079 |
| Tgene | EGF | GO:0043406 | positive regulation of MAP kinase activity | 15611079 |
| Tgene | EGF | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity | 15611079 |
| Tgene | EGF | GO:0045840 | positive regulation of mitotic nuclear division | 15611079 |
| Tgene | EGF | GO:0045893 | positive regulation of transcription, DNA-templated | 16314496 |
| Tgene | EGF | GO:0051048 | negative regulation of secretion | 10559227 |
| Tgene | EGF | GO:0070371 | ERK1 and ERK2 cascade | 16314496 |
| Tgene | EGF | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 20302655 |
| Tgene | EGF | GO:0090279 | regulation of calcium ion import | 19996314 |
| Tgene | EGF | GO:1900127 | positive regulation of hyaluronan biosynthetic process | 17324121 |
| Tgene | EGF | GO:2000008 | regulation of protein localization to cell surface | 19996314 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-VP-A87K-01A | SEC16B | chr1 | 177927269 | - | EGF | chr4 | 110914401 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000495165 | ENST00000509793 | SEC16B | chr1 | 177927269 | - | EGF | chr4 | 110914401 | + |
| intron-3CDS | ENST00000495165 | ENST00000265171 | SEC16B | chr1 | 177927269 | - | EGF | chr4 | 110914401 | + |
| intron-intron | ENST00000495165 | ENST00000503392 | SEC16B | chr1 | 177927269 | - | EGF | chr4 | 110914401 | + |
| intron-intron | ENST00000495165 | ENST00000502723 | SEC16B | chr1 | 177927269 | - | EGF | chr4 | 110914401 | + |
| In-frame | ENST00000308284 | ENST00000509793 | SEC16B | chr1 | 177927269 | - | EGF | chr4 | 110914401 | + |
| In-frame | ENST00000308284 | ENST00000265171 | SEC16B | chr1 | 177927269 | - | EGF | chr4 | 110914401 | + |
| 5CDS-intron | ENST00000308284 | ENST00000503392 | SEC16B | chr1 | 177927269 | - | EGF | chr4 | 110914401 | + |
| 5CDS-intron | ENST00000308284 | ENST00000502723 | SEC16B | chr1 | 177927269 | - | EGF | chr4 | 110914401 | + |
| In-frame | ENST00000464631 | ENST00000509793 | SEC16B | chr1 | 177927269 | - | EGF | chr4 | 110914401 | + |
| In-frame | ENST00000464631 | ENST00000265171 | SEC16B | chr1 | 177927269 | - | EGF | chr4 | 110914401 | + |
| 5CDS-intron | ENST00000464631 | ENST00000503392 | SEC16B | chr1 | 177927269 | - | EGF | chr4 | 110914401 | + |
| 5CDS-intron | ENST00000464631 | ENST00000502723 | SEC16B | chr1 | 177927269 | - | EGF | chr4 | 110914401 | + |
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FusionProtFeatures for SEC16B_EGF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SEC16B | EGF |
| Required for secretory cargo traffic from theendoplasmic reticulum to the Golgi apparatus and for normaltransitional endoplasmic reticulum (tER) organization.{ECO:0000269|PubMed:17192411}. | EGF stimulates the growth of various epidermal andepithelial tissues in vivo and in vitro and of some fibroblasts incell culture. Magnesiotropic hormone that stimulates magnesiumreabsorption in the renal distal convoluted tubule via engagementof EGFR and activation of the magnesium channel TRPM6. Can induceneurite outgrowth in motoneurons of the pond snail Lymnaeastagnalis in vitro (PubMed:10964941).{ECO:0000269|PubMed:10964941, ECO:0000269|PubMed:17671655}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SEC16B_EGF |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SEC16B_ENST00000308284_chr1_177927269_-_EGF_ENST00000509793_chr4_110914401_+_751aa MELWAPQRLPQTRGKATAPSKDPDRGFRRDGHHRPVPHSWHNGERFHQWQDNRGSPQPQQEPRADHQQQPHYASRPGDWHQPVSGVDYYE GGYRNQLYSRPGYENSYQSYQSPTMREEYAYGSYYYHGHPQWLQEERVPRQRSPYIWHEDYREQKYLDEHHYENQHSPFGTNSETHFQSN SRNPCKDSPASNSGQEWPGELFPGSLLAEAQKNKPSLASESNLLQQRESGLSSSSYELSQYIRDAPERDDPPASAAWSPVQADVSSAGPK APMKFYIPHVPVSFGPGGQLVHVGPSSPTDGQAALVELHSMEVILNDSEEQEEMRSFSGPLIREDVHKVDIMTFCQQKAAQSCKSETLGS RDSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDEDWPVLSSGTPNLLTGEIPPSVETPAQIVEKFTRLLY YGRKKILMSANWGSTAVERMPAAQIQREAIPACVLDACLNQDXFALTLLHPLTSGKMTTTIPXEIVTLNVPCPTMGTASMMVCACILKHW TSMHATVLLATSGSDVSTETXSGGNCATLATGSSRRSSWWLSAWWCLSCCSSXACGGPTTTGLRSCYRKTQRILMRSRAEMXGVAGLLTL RMGCPLALNLGLWLXKNTKTSRMGVNQWLVRMARQQMGQCNQLHGGRSPSYVEWAQSKAAGFQYPVIRAPVPRXWSEAFICPPMGHRPLK >In-frame_SEC16B_ENST00000308284_chr1_177927269_-_EGF_ENST00000265171_chr4_110914401_+_751aa MELWAPQRLPQTRGKATAPSKDPDRGFRRDGHHRPVPHSWHNGERFHQWQDNRGSPQPQQEPRADHQQQPHYASRPGDWHQPVSGVDYYE GGYRNQLYSRPGYENSYQSYQSPTMREEYAYGSYYYHGHPQWLQEERVPRQRSPYIWHEDYREQKYLDEHHYENQHSPFGTNSETHFQSN SRNPCKDSPASNSGQEWPGELFPGSLLAEAQKNKPSLASESNLLQQRESGLSSSSYELSQYIRDAPERDDPPASAAWSPVQADVSSAGPK APMKFYIPHVPVSFGPGGQLVHVGPSSPTDGQAALVELHSMEVILNDSEEQEEMRSFSGPLIREDVHKVDIMTFCQQKAAQSCKSETLGS RDSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDEDWPVLSSGTPNLLTGEIPPSVETPAQIVEKFTRLLY YGRKKILMSANWGSTAVERMPAAQIQREAIPACVLDACLNQDXFALTLLHPLTSGKMTTTIPXEIVTLNVPCPTMGTASMMVCACILKHW TSMHATVLLATSGSDVSTETXSGGNCATLATGSSRRSSWWLSAWWCLSCCSSXACGGPTTTGLRSCYRKTQRILMRSRAEMXGVAGLLTL RMGCPLALNLGLWLXKNTKTSRMGVNQWLVRMARQQMGQCNQLHGGRSPSYVEWAQSKAAGFQYPVIRAPVPRXWSEAFICPPMGHRPLK >In-frame_SEC16B_ENST00000464631_chr1_177927269_-_EGF_ENST00000509793_chr4_110914401_+_752aa MELWAPQRLPQTRGKATAPSKDPDRGFRRDGHHRPVPHSWHNGERFHQWQDNRGSPQPQQEPRADHQQQPHYASRPGDWHQPVSGVDYYE GGYRNQLYSRPGYENSYQSYQSPTMREEYAYGSYYYHGHPQWLQEERVPRQRSPYIWHEDYREQKYLDEHHYENQHSPFGTNSETHFQSN SRNPCKDSPASNSGQEWPGELFPGSLLAEAQKNKPSLASESNLLQQRESGLSSSSYELSQYIRDAPERDDPPASAAWSPVQAEDVSSAGP KAPMKFYIPHVPVSFGPGGQLVHVGPSSPTDGQAALVELHSMEVILNDSEEQEEMRSFSGPLIREDVHKVDIMTFCQQKAAQSCKSETLG SRDSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDEDWPVLSSGTPNLLTGEIPPSVETPAQIVEKFTRLL YYGRKKILMSANWGSTAVERMPAAQIQREAIPACVLDACLNQDXFALTLLHPLTSGKMTTTIPXEIVTLNVPCPTMGTASMMVCACILKH WTSMHATVLLATSGSDVSTETXSGGNCATLATGSSRRSSWWLSAWWCLSCCSSXACGGPTTTGLRSCYRKTQRILMRSRAEMXGVAGLLT LRMGCPLALNLGLWLXKNTKTSRMGVNQWLVRMARQQMGQCNQLHGGRSPSYVEWAQSKAAGFQYPVIRAPVPRXWSEAFICPPMGHRPL >In-frame_SEC16B_ENST00000464631_chr1_177927269_-_EGF_ENST00000265171_chr4_110914401_+_752aa MELWAPQRLPQTRGKATAPSKDPDRGFRRDGHHRPVPHSWHNGERFHQWQDNRGSPQPQQEPRADHQQQPHYASRPGDWHQPVSGVDYYE GGYRNQLYSRPGYENSYQSYQSPTMREEYAYGSYYYHGHPQWLQEERVPRQRSPYIWHEDYREQKYLDEHHYENQHSPFGTNSETHFQSN SRNPCKDSPASNSGQEWPGELFPGSLLAEAQKNKPSLASESNLLQQRESGLSSSSYELSQYIRDAPERDDPPASAAWSPVQAEDVSSAGP KAPMKFYIPHVPVSFGPGGQLVHVGPSSPTDGQAALVELHSMEVILNDSEEQEEMRSFSGPLIREDVHKVDIMTFCQQKAAQSCKSETLG SRDSALLWQLLVLLCRQNGSMVGSDIAELLMQDCKKLEKYKRQPPVANLINLTDEDWPVLSSGTPNLLTGEIPPSVETPAQIVEKFTRLL YYGRKKILMSANWGSTAVERMPAAQIQREAIPACVLDACLNQDXFALTLLHPLTSGKMTTTIPXEIVTLNVPCPTMGTASMMVCACILKH WTSMHATVLLATSGSDVSTETXSGGNCATLATGSSRRSSWWLSAWWCLSCCSSXACGGPTTTGLRSCYRKTQRILMRSRAEMXGVAGLLT LRMGCPLALNLGLWLXKNTKTSRMGVNQWLVRMARQQMGQCNQLHGGRSPSYVEWAQSKAAGFQYPVIRAPVPRXWSEAFICPPMGHRPL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SEC16B_ENST00000308284_chr1_177927269_-_EGF_ENST00000509793_chr4_110914401_+_2255nt ATGGAACTTTGGGCTCCCCAGAGGCTGCCCCAGACACGAGGGAAGGCCACAGCACCCTCAAAGGATCCAGACCGAGGGTTTCGGAGAGAT GGACATCATCGGCCTGTCCCTCACTCTTGGCACAATGGAGAGAGGTTTCACCAATGGCAAGACAACCGTGGGAGCCCCCAGCCACAGCAG GAGCCCAGGGCAGACCATCAGCAGCAGCCCCATTATGCATCCAGGCCAGGGGACTGGCATCAGCCTGTGTCTGGAGTTGACTATTACGAA GGTGGTTATCGCAATCAGTTGTATTCAAGGCCAGGTTATGAGAATTCATATCAGAGCTATCAGTCTCCCACAATGAGGGAGGAATATGCT TATGGAAGTTATTACTATCATGGACACCCACAGTGGCTGCAGGAAGAAAGAGTGCCAAGGCAACGGAGTCCTTATATCTGGCACGAAGAT TACCGAGAGCAAAAGTACCTTGATGAACATCATTATGAAAACCAGCACAGTCCATTTGGAACAAATAGTGAGACCCACTTCCAATCTAAC AGTAGGAACCCTTGTAAAGACAGCCCTGCTTCCAACTCTGGACAGGAGTGGCCGGGGGAGCTGTTTCCAGGGAGCCTGCTTGCTGAGGCC CAGAAAAATAAGCCATCATTGGCTAGTGAGTCCAACCTTCTCCAGCAGCGTGAGTCTGGTCTCAGCTCCAGCAGCTATGAGCTCAGTCAG TACATCAGAGATGCCCCGGAGCGGGATGATCCCCCAGCTTCAGCAGCTTGGAGTCCAGTTCAGGCTGATGTCTCCTCAGCTGGTCCCAAA GCACCCATGAAGTTCTACATCCCTCATGTTCCTGTGAGTTTCGGGCCAGGAGGTCAGCTGGTGCATGTAGGTCCCAGCTCTCCCACTGAC GGGCAAGCAGCCCTTGTTGAACTGCACAGCATGGAGGTTATTCTTAATGATTCCGAAGAGCAAGAGGAGATGAGAAGTTTCTCAGGACCC TTGATTAGGGAAGATGTACATAAGGTGGATATTATGACGTTTTGCCAGCAGAAAGCAGCTCAGAGCTGCAAATCTGAGACACTGGGGAGC AGAGACTCAGCTCTACTGTGGCAGCTCTTGGTTCTCCTTTGTCGCCAGAATGGGTCCATGGTGGGGTCTGACATCGCTGAGCTGCTAATG CAAGACTGCAAGAAGCTGGAGAAGTACAAGCGGCAGCCCCCTGTGGCCAACCTCATCAACCTGACCGATGAGGACTGGCCAGTGCTGAGC TCTGGGACCCCGAACCTGCTCACGGGAGAGATCCCCCCCAGTGTGGAGACACCTGCGCAGATCGTGGAGAAATTCACTAGGCTGCTCTAC TATGGAAGGAAGAAGATATTGATGAGTGCCAACTGGGGGAGCACAGCTGTGGAGAGAATGCCAGCTGCACAAATACAGAGGGAGGCTATA CCTGCATGTGTGCTGGACGCCTGTCTGAACCAGGACTGATTTGCCCTGACTCTACTCCACCCCCTCACCTCAGGGAAGATGACCACCACT ATTCCGTAAGAAATAGTGACTCTGAATGTCCCCTGTCCCACGATGGGTACTGCCTCCATGATGGTGTGTGCATGTATATTGAAGCATTGG ACAAGTATGCATGCAACTGTGTTGTTGGCTACATCGGGGAGCGATGTCAGTACCGAGACCTGAAGTGGTGGGAACTGCGCCACGCTGGCC ACGGGCAGCAGCAGAAGGTCATCGTGGTGGCTGTCTGCGTGGTGGTGCTTGTCATGCTGCTCCTCCTGAGCCTGTGGGGGGCCCACTACT ACAGGACTCAGAAGCTGCTATCGAAAAACCCAAAGAATCCTTATGAGGAGTCGAGCAGAGATGTGAGGAGTCGCAGGCCTGCTGACACTG AGGATGGGATGTCCTCTTGCCCTCAACCTTGGTTTGTGGTTATAAAAGAACACCAAGACCTCAAGAATGGGGGTCAACCAGTGGCTGGTG AGGATGGCCAGGCAGCAGATGGGTCAATGCAACCAACTTCATGGAGGCAGGAGCCCCAGTTATGTGGAATGGGCACAGAGCAAGGCTGCT GGATTCCAGTATCCAGTGATAAGGGCTCCTGTCCCCAGGTAATGGAGCGAAGCTTTCATATGCCCTCCTATGGGACACAGACCCTTGAAG GGGGTGTCGAGAAGCCCCATTCTCTCCTATCAGCTAACCCATTATGGCAACAAAGGGCCCTGGACCCACCACACCAAATGGAGCTGACTC >In-frame_SEC16B_ENST00000308284_chr1_177927269_-_EGF_ENST00000265171_chr4_110914401_+_2255nt ATGGAACTTTGGGCTCCCCAGAGGCTGCCCCAGACACGAGGGAAGGCCACAGCACCCTCAAAGGATCCAGACCGAGGGTTTCGGAGAGAT GGACATCATCGGCCTGTCCCTCACTCTTGGCACAATGGAGAGAGGTTTCACCAATGGCAAGACAACCGTGGGAGCCCCCAGCCACAGCAG GAGCCCAGGGCAGACCATCAGCAGCAGCCCCATTATGCATCCAGGCCAGGGGACTGGCATCAGCCTGTGTCTGGAGTTGACTATTACGAA GGTGGTTATCGCAATCAGTTGTATTCAAGGCCAGGTTATGAGAATTCATATCAGAGCTATCAGTCTCCCACAATGAGGGAGGAATATGCT TATGGAAGTTATTACTATCATGGACACCCACAGTGGCTGCAGGAAGAAAGAGTGCCAAGGCAACGGAGTCCTTATATCTGGCACGAAGAT TACCGAGAGCAAAAGTACCTTGATGAACATCATTATGAAAACCAGCACAGTCCATTTGGAACAAATAGTGAGACCCACTTCCAATCTAAC AGTAGGAACCCTTGTAAAGACAGCCCTGCTTCCAACTCTGGACAGGAGTGGCCGGGGGAGCTGTTTCCAGGGAGCCTGCTTGCTGAGGCC CAGAAAAATAAGCCATCATTGGCTAGTGAGTCCAACCTTCTCCAGCAGCGTGAGTCTGGTCTCAGCTCCAGCAGCTATGAGCTCAGTCAG TACATCAGAGATGCCCCGGAGCGGGATGATCCCCCAGCTTCAGCAGCTTGGAGTCCAGTTCAGGCTGATGTCTCCTCAGCTGGTCCCAAA GCACCCATGAAGTTCTACATCCCTCATGTTCCTGTGAGTTTCGGGCCAGGAGGTCAGCTGGTGCATGTAGGTCCCAGCTCTCCCACTGAC GGGCAAGCAGCCCTTGTTGAACTGCACAGCATGGAGGTTATTCTTAATGATTCCGAAGAGCAAGAGGAGATGAGAAGTTTCTCAGGACCC TTGATTAGGGAAGATGTACATAAGGTGGATATTATGACGTTTTGCCAGCAGAAAGCAGCTCAGAGCTGCAAATCTGAGACACTGGGGAGC AGAGACTCAGCTCTACTGTGGCAGCTCTTGGTTCTCCTTTGTCGCCAGAATGGGTCCATGGTGGGGTCTGACATCGCTGAGCTGCTAATG CAAGACTGCAAGAAGCTGGAGAAGTACAAGCGGCAGCCCCCTGTGGCCAACCTCATCAACCTGACCGATGAGGACTGGCCAGTGCTGAGC TCTGGGACCCCGAACCTGCTCACGGGAGAGATCCCCCCCAGTGTGGAGACACCTGCGCAGATCGTGGAGAAATTCACTAGGCTGCTCTAC TATGGAAGGAAGAAGATATTGATGAGTGCCAACTGGGGGAGCACAGCTGTGGAGAGAATGCCAGCTGCACAAATACAGAGGGAGGCTATA CCTGCATGTGTGCTGGACGCCTGTCTGAACCAGGACTGATTTGCCCTGACTCTACTCCACCCCCTCACCTCAGGGAAGATGACCACCACT ATTCCGTAAGAAATAGTGACTCTGAATGTCCCCTGTCCCACGATGGGTACTGCCTCCATGATGGTGTGTGCATGTATATTGAAGCATTGG ACAAGTATGCATGCAACTGTGTTGTTGGCTACATCGGGGAGCGATGTCAGTACCGAGACCTGAAGTGGTGGGAACTGCGCCACGCTGGCC ACGGGCAGCAGCAGAAGGTCATCGTGGTGGCTGTCTGCGTGGTGGTGCTTGTCATGCTGCTCCTCCTGAGCCTGTGGGGGGCCCACTACT ACAGGACTCAGAAGCTGCTATCGAAAAACCCAAAGAATCCTTATGAGGAGTCGAGCAGAGATGTGAGGAGTCGCAGGCCTGCTGACACTG AGGATGGGATGTCCTCTTGCCCTCAACCTTGGTTTGTGGTTATAAAAGAACACCAAGACCTCAAGAATGGGGGTCAACCAGTGGCTGGTG AGGATGGCCAGGCAGCAGATGGGTCAATGCAACCAACTTCATGGAGGCAGGAGCCCCAGTTATGTGGAATGGGCACAGAGCAAGGCTGCT GGATTCCAGTATCCAGTGATAAGGGCTCCTGTCCCCAGGTAATGGAGCGAAGCTTTCATATGCCCTCCTATGGGACACAGACCCTTGAAG GGGGTGTCGAGAAGCCCCATTCTCTCCTATCAGCTAACCCATTATGGCAACAAAGGGCCCTGGACCCACCACACCAAATGGAGCTGACTC >In-frame_SEC16B_ENST00000464631_chr1_177927269_-_EGF_ENST00000509793_chr4_110914401_+_2258nt ATGGAACTTTGGGCTCCCCAGAGGCTGCCCCAGACACGAGGGAAGGCCACAGCACCCTCAAAGGATCCAGACCGAGGGTTTCGGAGAGAT GGACATCATCGGCCTGTCCCTCACTCTTGGCACAATGGAGAGAGGTTTCACCAATGGCAAGACAACCGTGGGAGCCCCCAGCCACAGCAG GAGCCCAGGGCAGACCATCAGCAGCAGCCCCATTATGCATCCAGGCCAGGGGACTGGCATCAGCCTGTGTCTGGAGTTGACTATTACGAA GGTGGTTATCGCAATCAGTTGTATTCAAGGCCAGGTTATGAGAATTCATATCAGAGCTATCAGTCTCCCACAATGAGGGAGGAATATGCT TATGGAAGTTATTACTATCATGGACACCCACAGTGGCTGCAGGAAGAAAGAGTGCCAAGGCAACGGAGTCCTTATATCTGGCACGAAGAT TACCGAGAGCAAAAGTACCTTGATGAACATCATTATGAAAACCAGCACAGTCCATTTGGAACAAATAGTGAGACCCACTTCCAATCTAAC AGTAGGAACCCTTGTAAAGACAGCCCTGCTTCCAACTCTGGACAGGAGTGGCCGGGGGAGCTGTTTCCAGGGAGCCTGCTTGCTGAGGCC CAGAAAAATAAGCCATCATTGGCTAGTGAGTCCAACCTTCTCCAGCAGCGTGAGTCTGGTCTCAGCTCCAGCAGCTATGAGCTCAGTCAG TACATCAGAGATGCCCCGGAGCGGGATGATCCCCCAGCTTCAGCAGCTTGGAGTCCAGTTCAGGCTGAAGATGTCTCCTCAGCTGGTCCC AAAGCACCCATGAAGTTCTACATCCCTCATGTTCCTGTGAGTTTCGGGCCAGGAGGTCAGCTGGTGCATGTAGGTCCCAGCTCTCCCACT GACGGGCAAGCAGCCCTTGTTGAACTGCACAGCATGGAGGTTATTCTTAATGATTCCGAAGAGCAAGAGGAGATGAGAAGTTTCTCAGGA CCCTTGATTAGGGAAGATGTACATAAGGTGGATATTATGACGTTTTGCCAGCAGAAAGCAGCTCAGAGCTGCAAATCTGAGACACTGGGG AGCAGAGACTCAGCTCTACTGTGGCAGCTCTTGGTTCTCCTTTGTCGCCAGAATGGGTCCATGGTGGGGTCTGACATCGCTGAGCTGCTA ATGCAAGACTGCAAGAAGCTGGAGAAGTACAAGCGGCAGCCCCCTGTGGCCAACCTCATCAACCTGACCGATGAGGACTGGCCAGTGCTG AGCTCTGGGACCCCGAACCTGCTCACGGGAGAGATCCCCCCCAGTGTGGAGACACCTGCGCAGATCGTGGAGAAATTCACTAGGCTGCTC TACTATGGAAGGAAGAAGATATTGATGAGTGCCAACTGGGGGAGCACAGCTGTGGAGAGAATGCCAGCTGCACAAATACAGAGGGAGGCT ATACCTGCATGTGTGCTGGACGCCTGTCTGAACCAGGACTGATTTGCCCTGACTCTACTCCACCCCCTCACCTCAGGGAAGATGACCACC ACTATTCCGTAAGAAATAGTGACTCTGAATGTCCCCTGTCCCACGATGGGTACTGCCTCCATGATGGTGTGTGCATGTATATTGAAGCAT TGGACAAGTATGCATGCAACTGTGTTGTTGGCTACATCGGGGAGCGATGTCAGTACCGAGACCTGAAGTGGTGGGAACTGCGCCACGCTG GCCACGGGCAGCAGCAGAAGGTCATCGTGGTGGCTGTCTGCGTGGTGGTGCTTGTCATGCTGCTCCTCCTGAGCCTGTGGGGGGCCCACT ACTACAGGACTCAGAAGCTGCTATCGAAAAACCCAAAGAATCCTTATGAGGAGTCGAGCAGAGATGTGAGGAGTCGCAGGCCTGCTGACA CTGAGGATGGGATGTCCTCTTGCCCTCAACCTTGGTTTGTGGTTATAAAAGAACACCAAGACCTCAAGAATGGGGGTCAACCAGTGGCTG GTGAGGATGGCCAGGCAGCAGATGGGTCAATGCAACCAACTTCATGGAGGCAGGAGCCCCAGTTATGTGGAATGGGCACAGAGCAAGGCT GCTGGATTCCAGTATCCAGTGATAAGGGCTCCTGTCCCCAGGTAATGGAGCGAAGCTTTCATATGCCCTCCTATGGGACACAGACCCTTG AAGGGGGTGTCGAGAAGCCCCATTCTCTCCTATCAGCTAACCCATTATGGCAACAAAGGGCCCTGGACCCACCACACCAAATGGAGCTGA >In-frame_SEC16B_ENST00000464631_chr1_177927269_-_EGF_ENST00000265171_chr4_110914401_+_2258nt ATGGAACTTTGGGCTCCCCAGAGGCTGCCCCAGACACGAGGGAAGGCCACAGCACCCTCAAAGGATCCAGACCGAGGGTTTCGGAGAGAT GGACATCATCGGCCTGTCCCTCACTCTTGGCACAATGGAGAGAGGTTTCACCAATGGCAAGACAACCGTGGGAGCCCCCAGCCACAGCAG GAGCCCAGGGCAGACCATCAGCAGCAGCCCCATTATGCATCCAGGCCAGGGGACTGGCATCAGCCTGTGTCTGGAGTTGACTATTACGAA GGTGGTTATCGCAATCAGTTGTATTCAAGGCCAGGTTATGAGAATTCATATCAGAGCTATCAGTCTCCCACAATGAGGGAGGAATATGCT TATGGAAGTTATTACTATCATGGACACCCACAGTGGCTGCAGGAAGAAAGAGTGCCAAGGCAACGGAGTCCTTATATCTGGCACGAAGAT TACCGAGAGCAAAAGTACCTTGATGAACATCATTATGAAAACCAGCACAGTCCATTTGGAACAAATAGTGAGACCCACTTCCAATCTAAC AGTAGGAACCCTTGTAAAGACAGCCCTGCTTCCAACTCTGGACAGGAGTGGCCGGGGGAGCTGTTTCCAGGGAGCCTGCTTGCTGAGGCC CAGAAAAATAAGCCATCATTGGCTAGTGAGTCCAACCTTCTCCAGCAGCGTGAGTCTGGTCTCAGCTCCAGCAGCTATGAGCTCAGTCAG TACATCAGAGATGCCCCGGAGCGGGATGATCCCCCAGCTTCAGCAGCTTGGAGTCCAGTTCAGGCTGAAGATGTCTCCTCAGCTGGTCCC AAAGCACCCATGAAGTTCTACATCCCTCATGTTCCTGTGAGTTTCGGGCCAGGAGGTCAGCTGGTGCATGTAGGTCCCAGCTCTCCCACT GACGGGCAAGCAGCCCTTGTTGAACTGCACAGCATGGAGGTTATTCTTAATGATTCCGAAGAGCAAGAGGAGATGAGAAGTTTCTCAGGA CCCTTGATTAGGGAAGATGTACATAAGGTGGATATTATGACGTTTTGCCAGCAGAAAGCAGCTCAGAGCTGCAAATCTGAGACACTGGGG AGCAGAGACTCAGCTCTACTGTGGCAGCTCTTGGTTCTCCTTTGTCGCCAGAATGGGTCCATGGTGGGGTCTGACATCGCTGAGCTGCTA ATGCAAGACTGCAAGAAGCTGGAGAAGTACAAGCGGCAGCCCCCTGTGGCCAACCTCATCAACCTGACCGATGAGGACTGGCCAGTGCTG AGCTCTGGGACCCCGAACCTGCTCACGGGAGAGATCCCCCCCAGTGTGGAGACACCTGCGCAGATCGTGGAGAAATTCACTAGGCTGCTC TACTATGGAAGGAAGAAGATATTGATGAGTGCCAACTGGGGGAGCACAGCTGTGGAGAGAATGCCAGCTGCACAAATACAGAGGGAGGCT ATACCTGCATGTGTGCTGGACGCCTGTCTGAACCAGGACTGATTTGCCCTGACTCTACTCCACCCCCTCACCTCAGGGAAGATGACCACC ACTATTCCGTAAGAAATAGTGACTCTGAATGTCCCCTGTCCCACGATGGGTACTGCCTCCATGATGGTGTGTGCATGTATATTGAAGCAT TGGACAAGTATGCATGCAACTGTGTTGTTGGCTACATCGGGGAGCGATGTCAGTACCGAGACCTGAAGTGGTGGGAACTGCGCCACGCTG GCCACGGGCAGCAGCAGAAGGTCATCGTGGTGGCTGTCTGCGTGGTGGTGCTTGTCATGCTGCTCCTCCTGAGCCTGTGGGGGGCCCACT ACTACAGGACTCAGAAGCTGCTATCGAAAAACCCAAAGAATCCTTATGAGGAGTCGAGCAGAGATGTGAGGAGTCGCAGGCCTGCTGACA CTGAGGATGGGATGTCCTCTTGCCCTCAACCTTGGTTTGTGGTTATAAAAGAACACCAAGACCTCAAGAATGGGGGTCAACCAGTGGCTG GTGAGGATGGCCAGGCAGCAGATGGGTCAATGCAACCAACTTCATGGAGGCAGGAGCCCCAGTTATGTGGAATGGGCACAGAGCAAGGCT GCTGGATTCCAGTATCCAGTGATAAGGGCTCCTGTCCCCAGGTAATGGAGCGAAGCTTTCATATGCCCTCCTATGGGACACAGACCCTTG AAGGGGGTGTCGAGAAGCCCCATTCTCTCCTATCAGCTAACCCATTATGGCAACAAAGGGCCCTGGACCCACCACACCAAATGGAGCTGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SEC16B_ENST00000308284_chr1_177927269_-_EGF_ENST00000509793_chr4_110914401_+_2884nt CGCTGAAGGAAGGTGGGAAGCCATCAGAGCAGGAAGATAAAATAACTGCACAACTTACTCAAAACCCAGGACAAATTCAGAGAGTCAAGG ATGGAACTTTGGGCTCCCCAGAGGCTGCCCCAGACACGAGGGAAGGCCACAGCACCCTCAAAGGATCCAGACCGAGGGTTTCGGAGAGAT GGACATCATCGGCCTGTCCCTCACTCTTGGCACAATGGAGAGAGGTTTCACCAATGGCAAGACAACCGTGGGAGCCCCCAGCCACAGCAG GAGCCCAGGGCAGACCATCAGCAGCAGCCCCATTATGCATCCAGGCCAGGGGACTGGCATCAGCCTGTGTCTGGAGTTGACTATTACGAA GGTGGTTATCGCAATCAGTTGTATTCAAGGCCAGGTTATGAGAATTCATATCAGAGCTATCAGTCTCCCACAATGAGGGAGGAATATGCT TATGGAAGTTATTACTATCATGGACACCCACAGTGGCTGCAGGAAGAAAGAGTGCCAAGGCAACGGAGTCCTTATATCTGGCACGAAGAT TACCGAGAGCAAAAGTACCTTGATGAACATCATTATGAAAACCAGCACAGTCCATTTGGAACAAATAGTGAGACCCACTTCCAATCTAAC AGTAGGAACCCTTGTAAAGACAGCCCTGCTTCCAACTCTGGACAGGAGTGGCCGGGGGAGCTGTTTCCAGGGAGCCTGCTTGCTGAGGCC CAGAAAAATAAGCCATCATTGGCTAGTGAGTCCAACCTTCTCCAGCAGCGTGAGTCTGGTCTCAGCTCCAGCAGCTATGAGCTCAGTCAG TACATCAGAGATGCCCCGGAGCGGGATGATCCCCCAGCTTCAGCAGCTTGGAGTCCAGTTCAGGCTGATGTCTCCTCAGCTGGTCCCAAA GCACCCATGAAGTTCTACATCCCTCATGTTCCTGTGAGTTTCGGGCCAGGAGGTCAGCTGGTGCATGTAGGTCCCAGCTCTCCCACTGAC GGGCAAGCAGCCCTTGTTGAACTGCACAGCATGGAGGTTATTCTTAATGATTCCGAAGAGCAAGAGGAGATGAGAAGTTTCTCAGGACCC TTGATTAGGGAAGATGTACATAAGGTGGATATTATGACGTTTTGCCAGCAGAAAGCAGCTCAGAGCTGCAAATCTGAGACACTGGGGAGC AGAGACTCAGCTCTACTGTGGCAGCTCTTGGTTCTCCTTTGTCGCCAGAATGGGTCCATGGTGGGGTCTGACATCGCTGAGCTGCTAATG CAAGACTGCAAGAAGCTGGAGAAGTACAAGCGGCAGCCCCCTGTGGCCAACCTCATCAACCTGACCGATGAGGACTGGCCAGTGCTGAGC TCTGGGACCCCGAACCTGCTCACGGGAGAGATCCCCCCCAGTGTGGAGACACCTGCGCAGATCGTGGAGAAATTCACTAGGCTGCTCTAC TATGGAAGGAAGAAGATATTGATGAGTGCCAACTGGGGGAGCACAGCTGTGGAGAGAATGCCAGCTGCACAAATACAGAGGGAGGCTATA CCTGCATGTGTGCTGGACGCCTGTCTGAACCAGGACTGATTTGCCCTGACTCTACTCCACCCCCTCACCTCAGGGAAGATGACCACCACT ATTCCGTAAGAAATAGTGACTCTGAATGTCCCCTGTCCCACGATGGGTACTGCCTCCATGATGGTGTGTGCATGTATATTGAAGCATTGG ACAAGTATGCATGCAACTGTGTTGTTGGCTACATCGGGGAGCGATGTCAGTACCGAGACCTGAAGTGGTGGGAACTGCGCCACGCTGGCC ACGGGCAGCAGCAGAAGGTCATCGTGGTGGCTGTCTGCGTGGTGGTGCTTGTCATGCTGCTCCTCCTGAGCCTGTGGGGGGCCCACTACT ACAGGACTCAGAAGCTGCTATCGAAAAACCCAAAGAATCCTTATGAGGAGTCGAGCAGAGATGTGAGGAGTCGCAGGCCTGCTGACACTG AGGATGGGATGTCCTCTTGCCCTCAACCTTGGTTTGTGGTTATAAAAGAACACCAAGACCTCAAGAATGGGGGTCAACCAGTGGCTGGTG AGGATGGCCAGGCAGCAGATGGGTCAATGCAACCAACTTCATGGAGGCAGGAGCCCCAGTTATGTGGAATGGGCACAGAGCAAGGCTGCT GGATTCCAGTATCCAGTGATAAGGGCTCCTGTCCCCAGGTAATGGAGCGAAGCTTTCATATGCCCTCCTATGGGACACAGACCCTTGAAG GGGGTGTCGAGAAGCCCCATTCTCTCCTATCAGCTAACCCATTATGGCAACAAAGGGCCCTGGACCCACCACACCAAATGGAGCTGACTC AGTGAAAACTGGAATTAAAAGGAAAGTCAAGAAGAATGAACTATGTCGATGCACAGTATCTTTTCTTTCAAAAGTAGAGCAAAACTATAG GTTTTGGTTCCACAATCTCTACGACTAATCACCTACTCAATGCCTGGAGACAGATACGTAGTTGTGCTTTTGTTTGCTCTTTTAAGCAGT CTCACTGCAGTCTTATTTCCAAGTAAGAGTACTGGGAGAATCACTAGGTAACTTATTAGAAACCCAAATTGGGACAACAGTGCTTTGTAA ATTGTGTTGTCTTCAGCAGTCAATACAAATAGATTTTTGTTTTTGTTGTTCCTGCAGCCCCAGAAGAAATTAGGGGTTAAAGCAGACAGT CACACTGGTTTGGTCAGTTACAAAGTAATTTCTTTGATCTGGACAGAACATTTATATCAGTTTCATGAAATGATTGGAATATTACAATAC CGTTAAGATACAGTGTAGGCATTTAACTCCTCATTGGCGTGGTCCATGCTGATGATTTTGCAAAATGAGTTGTGATGAATCAATGAAAAA >In-frame_SEC16B_ENST00000308284_chr1_177927269_-_EGF_ENST00000265171_chr4_110914401_+_3156nt CGCTGAAGGAAGGTGGGAAGCCATCAGAGCAGGAAGATAAAATAACTGCACAACTTACTCAAAACCCAGGACAAATTCAGAGAGTCAAGG ATGGAACTTTGGGCTCCCCAGAGGCTGCCCCAGACACGAGGGAAGGCCACAGCACCCTCAAAGGATCCAGACCGAGGGTTTCGGAGAGAT GGACATCATCGGCCTGTCCCTCACTCTTGGCACAATGGAGAGAGGTTTCACCAATGGCAAGACAACCGTGGGAGCCCCCAGCCACAGCAG GAGCCCAGGGCAGACCATCAGCAGCAGCCCCATTATGCATCCAGGCCAGGGGACTGGCATCAGCCTGTGTCTGGAGTTGACTATTACGAA GGTGGTTATCGCAATCAGTTGTATTCAAGGCCAGGTTATGAGAATTCATATCAGAGCTATCAGTCTCCCACAATGAGGGAGGAATATGCT TATGGAAGTTATTACTATCATGGACACCCACAGTGGCTGCAGGAAGAAAGAGTGCCAAGGCAACGGAGTCCTTATATCTGGCACGAAGAT TACCGAGAGCAAAAGTACCTTGATGAACATCATTATGAAAACCAGCACAGTCCATTTGGAACAAATAGTGAGACCCACTTCCAATCTAAC AGTAGGAACCCTTGTAAAGACAGCCCTGCTTCCAACTCTGGACAGGAGTGGCCGGGGGAGCTGTTTCCAGGGAGCCTGCTTGCTGAGGCC CAGAAAAATAAGCCATCATTGGCTAGTGAGTCCAACCTTCTCCAGCAGCGTGAGTCTGGTCTCAGCTCCAGCAGCTATGAGCTCAGTCAG TACATCAGAGATGCCCCGGAGCGGGATGATCCCCCAGCTTCAGCAGCTTGGAGTCCAGTTCAGGCTGATGTCTCCTCAGCTGGTCCCAAA GCACCCATGAAGTTCTACATCCCTCATGTTCCTGTGAGTTTCGGGCCAGGAGGTCAGCTGGTGCATGTAGGTCCCAGCTCTCCCACTGAC GGGCAAGCAGCCCTTGTTGAACTGCACAGCATGGAGGTTATTCTTAATGATTCCGAAGAGCAAGAGGAGATGAGAAGTTTCTCAGGACCC TTGATTAGGGAAGATGTACATAAGGTGGATATTATGACGTTTTGCCAGCAGAAAGCAGCTCAGAGCTGCAAATCTGAGACACTGGGGAGC AGAGACTCAGCTCTACTGTGGCAGCTCTTGGTTCTCCTTTGTCGCCAGAATGGGTCCATGGTGGGGTCTGACATCGCTGAGCTGCTAATG CAAGACTGCAAGAAGCTGGAGAAGTACAAGCGGCAGCCCCCTGTGGCCAACCTCATCAACCTGACCGATGAGGACTGGCCAGTGCTGAGC TCTGGGACCCCGAACCTGCTCACGGGAGAGATCCCCCCCAGTGTGGAGACACCTGCGCAGATCGTGGAGAAATTCACTAGGCTGCTCTAC TATGGAAGGAAGAAGATATTGATGAGTGCCAACTGGGGGAGCACAGCTGTGGAGAGAATGCCAGCTGCACAAATACAGAGGGAGGCTATA CCTGCATGTGTGCTGGACGCCTGTCTGAACCAGGACTGATTTGCCCTGACTCTACTCCACCCCCTCACCTCAGGGAAGATGACCACCACT ATTCCGTAAGAAATAGTGACTCTGAATGTCCCCTGTCCCACGATGGGTACTGCCTCCATGATGGTGTGTGCATGTATATTGAAGCATTGG ACAAGTATGCATGCAACTGTGTTGTTGGCTACATCGGGGAGCGATGTCAGTACCGAGACCTGAAGTGGTGGGAACTGCGCCACGCTGGCC ACGGGCAGCAGCAGAAGGTCATCGTGGTGGCTGTCTGCGTGGTGGTGCTTGTCATGCTGCTCCTCCTGAGCCTGTGGGGGGCCCACTACT ACAGGACTCAGAAGCTGCTATCGAAAAACCCAAAGAATCCTTATGAGGAGTCGAGCAGAGATGTGAGGAGTCGCAGGCCTGCTGACACTG AGGATGGGATGTCCTCTTGCCCTCAACCTTGGTTTGTGGTTATAAAAGAACACCAAGACCTCAAGAATGGGGGTCAACCAGTGGCTGGTG AGGATGGCCAGGCAGCAGATGGGTCAATGCAACCAACTTCATGGAGGCAGGAGCCCCAGTTATGTGGAATGGGCACAGAGCAAGGCTGCT GGATTCCAGTATCCAGTGATAAGGGCTCCTGTCCCCAGGTAATGGAGCGAAGCTTTCATATGCCCTCCTATGGGACACAGACCCTTGAAG GGGGTGTCGAGAAGCCCCATTCTCTCCTATCAGCTAACCCATTATGGCAACAAAGGGCCCTGGACCCACCACACCAAATGGAGCTGACTC AGTGAAAACTGGAATTAAAAGGAAAGTCAAGAAGAATGAACTATGTCGATGCACAGTATCTTTTCTTTCAAAAGTAGAGCAAAACTATAG GTTTTGGTTCCACAATCTCTACGACTAATCACCTACTCAATGCCTGGAGACAGATACGTAGTTGTGCTTTTGTTTGCTCTTTTAAGCAGT CTCACTGCAGTCTTATTTCCAAGTAAGAGTACTGGGAGAATCACTAGGTAACTTATTAGAAACCCAAATTGGGACAACAGTGCTTTGTAA ATTGTGTTGTCTTCAGCAGTCAATACAAATAGATTTTTGTTTTTGTTGTTCCTGCAGCCCCAGAAGAAATTAGGGGTTAAAGCAGACAGT CACACTGGTTTGGTCAGTTACAAAGTAATTTCTTTGATCTGGACAGAACATTTATATCAGTTTCATGAAATGATTGGAATATTACAATAC CGTTAAGATACAGTGTAGGCATTTAACTCCTCATTGGCGTGGTCCATGCTGATGATTTTGCAAAATGAGTTGTGATGAATCAATGAAAAA TGTAATTTAGAAACTGATTTCTTCAGAATTAGATGGCTTATTTTTTAAAATATTTGAATGAAAACATTTTATTTTTAAAATATTACACAG GAGGCTTCGGAGTTTCTTAGTCATTACTGTCCTTTTCCCCTACAGAATTTTCCCTCTTGGTGTGATTGCACAGAATTTGTATGTATTTTC AGTTACAAGATTGTAAGTAAATTGCCTGATTTGTTTTCATTATAGACAACGATGAATTTCTTCTAATTATTTAAATAAAATCACCAAAAA >In-frame_SEC16B_ENST00000464631_chr1_177927269_-_EGF_ENST00000509793_chr4_110914401_+_2879nt GTGGGAATTTGGATGATTTCTCATGAAGATAAAATAACTGCACAACTTACTCAAAACCCAGGACAAATTCAGAGAGTCAAGGATGGAACT TTGGGCTCCCCAGAGGCTGCCCCAGACACGAGGGAAGGCCACAGCACCCTCAAAGGATCCAGACCGAGGGTTTCGGAGAGATGGACATCA TCGGCCTGTCCCTCACTCTTGGCACAATGGAGAGAGGTTTCACCAATGGCAAGACAACCGTGGGAGCCCCCAGCCACAGCAGGAGCCCAG GGCAGACCATCAGCAGCAGCCCCATTATGCATCCAGGCCAGGGGACTGGCATCAGCCTGTGTCTGGAGTTGACTATTACGAAGGTGGTTA TCGCAATCAGTTGTATTCAAGGCCAGGTTATGAGAATTCATATCAGAGCTATCAGTCTCCCACAATGAGGGAGGAATATGCTTATGGAAG TTATTACTATCATGGACACCCACAGTGGCTGCAGGAAGAAAGAGTGCCAAGGCAACGGAGTCCTTATATCTGGCACGAAGATTACCGAGA GCAAAAGTACCTTGATGAACATCATTATGAAAACCAGCACAGTCCATTTGGAACAAATAGTGAGACCCACTTCCAATCTAACAGTAGGAA CCCTTGTAAAGACAGCCCTGCTTCCAACTCTGGACAGGAGTGGCCGGGGGAGCTGTTTCCAGGGAGCCTGCTTGCTGAGGCCCAGAAAAA TAAGCCATCATTGGCTAGTGAGTCCAACCTTCTCCAGCAGCGTGAGTCTGGTCTCAGCTCCAGCAGCTATGAGCTCAGTCAGTACATCAG AGATGCCCCGGAGCGGGATGATCCCCCAGCTTCAGCAGCTTGGAGTCCAGTTCAGGCTGAAGATGTCTCCTCAGCTGGTCCCAAAGCACC CATGAAGTTCTACATCCCTCATGTTCCTGTGAGTTTCGGGCCAGGAGGTCAGCTGGTGCATGTAGGTCCCAGCTCTCCCACTGACGGGCA AGCAGCCCTTGTTGAACTGCACAGCATGGAGGTTATTCTTAATGATTCCGAAGAGCAAGAGGAGATGAGAAGTTTCTCAGGACCCTTGAT TAGGGAAGATGTACATAAGGTGGATATTATGACGTTTTGCCAGCAGAAAGCAGCTCAGAGCTGCAAATCTGAGACACTGGGGAGCAGAGA CTCAGCTCTACTGTGGCAGCTCTTGGTTCTCCTTTGTCGCCAGAATGGGTCCATGGTGGGGTCTGACATCGCTGAGCTGCTAATGCAAGA CTGCAAGAAGCTGGAGAAGTACAAGCGGCAGCCCCCTGTGGCCAACCTCATCAACCTGACCGATGAGGACTGGCCAGTGCTGAGCTCTGG GACCCCGAACCTGCTCACGGGAGAGATCCCCCCCAGTGTGGAGACACCTGCGCAGATCGTGGAGAAATTCACTAGGCTGCTCTACTATGG AAGGAAGAAGATATTGATGAGTGCCAACTGGGGGAGCACAGCTGTGGAGAGAATGCCAGCTGCACAAATACAGAGGGAGGCTATACCTGC ATGTGTGCTGGACGCCTGTCTGAACCAGGACTGATTTGCCCTGACTCTACTCCACCCCCTCACCTCAGGGAAGATGACCACCACTATTCC GTAAGAAATAGTGACTCTGAATGTCCCCTGTCCCACGATGGGTACTGCCTCCATGATGGTGTGTGCATGTATATTGAAGCATTGGACAAG TATGCATGCAACTGTGTTGTTGGCTACATCGGGGAGCGATGTCAGTACCGAGACCTGAAGTGGTGGGAACTGCGCCACGCTGGCCACGGG CAGCAGCAGAAGGTCATCGTGGTGGCTGTCTGCGTGGTGGTGCTTGTCATGCTGCTCCTCCTGAGCCTGTGGGGGGCCCACTACTACAGG ACTCAGAAGCTGCTATCGAAAAACCCAAAGAATCCTTATGAGGAGTCGAGCAGAGATGTGAGGAGTCGCAGGCCTGCTGACACTGAGGAT GGGATGTCCTCTTGCCCTCAACCTTGGTTTGTGGTTATAAAAGAACACCAAGACCTCAAGAATGGGGGTCAACCAGTGGCTGGTGAGGAT GGCCAGGCAGCAGATGGGTCAATGCAACCAACTTCATGGAGGCAGGAGCCCCAGTTATGTGGAATGGGCACAGAGCAAGGCTGCTGGATT CCAGTATCCAGTGATAAGGGCTCCTGTCCCCAGGTAATGGAGCGAAGCTTTCATATGCCCTCCTATGGGACACAGACCCTTGAAGGGGGT GTCGAGAAGCCCCATTCTCTCCTATCAGCTAACCCATTATGGCAACAAAGGGCCCTGGACCCACCACACCAAATGGAGCTGACTCAGTGA AAACTGGAATTAAAAGGAAAGTCAAGAAGAATGAACTATGTCGATGCACAGTATCTTTTCTTTCAAAAGTAGAGCAAAACTATAGGTTTT GGTTCCACAATCTCTACGACTAATCACCTACTCAATGCCTGGAGACAGATACGTAGTTGTGCTTTTGTTTGCTCTTTTAAGCAGTCTCAC TGCAGTCTTATTTCCAAGTAAGAGTACTGGGAGAATCACTAGGTAACTTATTAGAAACCCAAATTGGGACAACAGTGCTTTGTAAATTGT GTTGTCTTCAGCAGTCAATACAAATAGATTTTTGTTTTTGTTGTTCCTGCAGCCCCAGAAGAAATTAGGGGTTAAAGCAGACAGTCACAC TGGTTTGGTCAGTTACAAAGTAATTTCTTTGATCTGGACAGAACATTTATATCAGTTTCATGAAATGATTGGAATATTACAATACCGTTA >In-frame_SEC16B_ENST00000464631_chr1_177927269_-_EGF_ENST00000265171_chr4_110914401_+_3151nt GTGGGAATTTGGATGATTTCTCATGAAGATAAAATAACTGCACAACTTACTCAAAACCCAGGACAAATTCAGAGAGTCAAGGATGGAACT TTGGGCTCCCCAGAGGCTGCCCCAGACACGAGGGAAGGCCACAGCACCCTCAAAGGATCCAGACCGAGGGTTTCGGAGAGATGGACATCA TCGGCCTGTCCCTCACTCTTGGCACAATGGAGAGAGGTTTCACCAATGGCAAGACAACCGTGGGAGCCCCCAGCCACAGCAGGAGCCCAG GGCAGACCATCAGCAGCAGCCCCATTATGCATCCAGGCCAGGGGACTGGCATCAGCCTGTGTCTGGAGTTGACTATTACGAAGGTGGTTA TCGCAATCAGTTGTATTCAAGGCCAGGTTATGAGAATTCATATCAGAGCTATCAGTCTCCCACAATGAGGGAGGAATATGCTTATGGAAG TTATTACTATCATGGACACCCACAGTGGCTGCAGGAAGAAAGAGTGCCAAGGCAACGGAGTCCTTATATCTGGCACGAAGATTACCGAGA GCAAAAGTACCTTGATGAACATCATTATGAAAACCAGCACAGTCCATTTGGAACAAATAGTGAGACCCACTTCCAATCTAACAGTAGGAA CCCTTGTAAAGACAGCCCTGCTTCCAACTCTGGACAGGAGTGGCCGGGGGAGCTGTTTCCAGGGAGCCTGCTTGCTGAGGCCCAGAAAAA TAAGCCATCATTGGCTAGTGAGTCCAACCTTCTCCAGCAGCGTGAGTCTGGTCTCAGCTCCAGCAGCTATGAGCTCAGTCAGTACATCAG AGATGCCCCGGAGCGGGATGATCCCCCAGCTTCAGCAGCTTGGAGTCCAGTTCAGGCTGAAGATGTCTCCTCAGCTGGTCCCAAAGCACC CATGAAGTTCTACATCCCTCATGTTCCTGTGAGTTTCGGGCCAGGAGGTCAGCTGGTGCATGTAGGTCCCAGCTCTCCCACTGACGGGCA AGCAGCCCTTGTTGAACTGCACAGCATGGAGGTTATTCTTAATGATTCCGAAGAGCAAGAGGAGATGAGAAGTTTCTCAGGACCCTTGAT TAGGGAAGATGTACATAAGGTGGATATTATGACGTTTTGCCAGCAGAAAGCAGCTCAGAGCTGCAAATCTGAGACACTGGGGAGCAGAGA CTCAGCTCTACTGTGGCAGCTCTTGGTTCTCCTTTGTCGCCAGAATGGGTCCATGGTGGGGTCTGACATCGCTGAGCTGCTAATGCAAGA CTGCAAGAAGCTGGAGAAGTACAAGCGGCAGCCCCCTGTGGCCAACCTCATCAACCTGACCGATGAGGACTGGCCAGTGCTGAGCTCTGG GACCCCGAACCTGCTCACGGGAGAGATCCCCCCCAGTGTGGAGACACCTGCGCAGATCGTGGAGAAATTCACTAGGCTGCTCTACTATGG AAGGAAGAAGATATTGATGAGTGCCAACTGGGGGAGCACAGCTGTGGAGAGAATGCCAGCTGCACAAATACAGAGGGAGGCTATACCTGC ATGTGTGCTGGACGCCTGTCTGAACCAGGACTGATTTGCCCTGACTCTACTCCACCCCCTCACCTCAGGGAAGATGACCACCACTATTCC GTAAGAAATAGTGACTCTGAATGTCCCCTGTCCCACGATGGGTACTGCCTCCATGATGGTGTGTGCATGTATATTGAAGCATTGGACAAG TATGCATGCAACTGTGTTGTTGGCTACATCGGGGAGCGATGTCAGTACCGAGACCTGAAGTGGTGGGAACTGCGCCACGCTGGCCACGGG CAGCAGCAGAAGGTCATCGTGGTGGCTGTCTGCGTGGTGGTGCTTGTCATGCTGCTCCTCCTGAGCCTGTGGGGGGCCCACTACTACAGG ACTCAGAAGCTGCTATCGAAAAACCCAAAGAATCCTTATGAGGAGTCGAGCAGAGATGTGAGGAGTCGCAGGCCTGCTGACACTGAGGAT GGGATGTCCTCTTGCCCTCAACCTTGGTTTGTGGTTATAAAAGAACACCAAGACCTCAAGAATGGGGGTCAACCAGTGGCTGGTGAGGAT GGCCAGGCAGCAGATGGGTCAATGCAACCAACTTCATGGAGGCAGGAGCCCCAGTTATGTGGAATGGGCACAGAGCAAGGCTGCTGGATT CCAGTATCCAGTGATAAGGGCTCCTGTCCCCAGGTAATGGAGCGAAGCTTTCATATGCCCTCCTATGGGACACAGACCCTTGAAGGGGGT GTCGAGAAGCCCCATTCTCTCCTATCAGCTAACCCATTATGGCAACAAAGGGCCCTGGACCCACCACACCAAATGGAGCTGACTCAGTGA AAACTGGAATTAAAAGGAAAGTCAAGAAGAATGAACTATGTCGATGCACAGTATCTTTTCTTTCAAAAGTAGAGCAAAACTATAGGTTTT GGTTCCACAATCTCTACGACTAATCACCTACTCAATGCCTGGAGACAGATACGTAGTTGTGCTTTTGTTTGCTCTTTTAAGCAGTCTCAC TGCAGTCTTATTTCCAAGTAAGAGTACTGGGAGAATCACTAGGTAACTTATTAGAAACCCAAATTGGGACAACAGTGCTTTGTAAATTGT GTTGTCTTCAGCAGTCAATACAAATAGATTTTTGTTTTTGTTGTTCCTGCAGCCCCAGAAGAAATTAGGGGTTAAAGCAGACAGTCACAC TGGTTTGGTCAGTTACAAAGTAATTTCTTTGATCTGGACAGAACATTTATATCAGTTTCATGAAATGATTGGAATATTACAATACCGTTA AGATACAGTGTAGGCATTTAACTCCTCATTGGCGTGGTCCATGCTGATGATTTTGCAAAATGAGTTGTGATGAATCAATGAAAAATGTAA TTTAGAAACTGATTTCTTCAGAATTAGATGGCTTATTTTTTAAAATATTTGAATGAAAACATTTTATTTTTAAAATATTACACAGGAGGC TTCGGAGTTTCTTAGTCATTACTGTCCTTTTCCCCTACAGAATTTTCCCTCTTGGTGTGATTGCACAGAATTTGTATGTATTTTCAGTTA CAAGATTGTAAGTAAATTGCCTGATTTGTTTTCATTATAGACAACGATGAATTTCTTCTAATTATTTAAATAAAATCACCAAAAACATAA |
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FusionGenePPI for SEC16B_EGF |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SEC16B | SEC13, SRPK2, POTEF | EGF | FNBP1, RPS6KA5, MAPKAPK2, EGF, EGFR, ERBB2, ERBB3, VTN, ZFYVE28, LMNA, PCGF2, LMNB1, SREBF1, EMD, UBE2I, FGF5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SEC16B_EGF |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | EGF | P01133 | DB00364 | Sucralfate | Pro-epidermal growth factor | small molecule | approved |
| Tgene | EGF | P01133 | DB08862 | Cholecystokinin | Pro-epidermal growth factor | small molecule | approved|investigational |
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RelatedDiseases for SEC16B_EGF |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SEC16B | C0005910 | Body Weight | 2 | CTD_human |
| Tgene | EGF | C0027626 | Neoplasm Invasiveness | 4 | CTD_human |
| Tgene | EGF | C0007621 | Neoplastic Cell Transformation | 3 | CTD_human |
| Tgene | EGF | C1458155 | Mammary Neoplasms | 3 | CTD_human |
| Tgene | EGF | C0001973 | Alcoholic Intoxication, Chronic | 2 | PSYGENET |
| Tgene | EGF | C0027627 | Neoplasm Metastasis | 2 | CTD_human |
| Tgene | EGF | C0038358 | Gastric ulcer | 2 | CTD_human |
| Tgene | EGF | C0001418 | Adenocarcinoma | 1 | CTD_human |
| Tgene | EGF | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | EGF | C0008925 | Cleft Palate | 1 | CTD_human |
| Tgene | EGF | C0017636 | Glioblastoma | 1 | CTD_human |
| Tgene | EGF | C0022658 | Kidney Diseases | 1 | CTD_human |
| Tgene | EGF | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | EGF | C0025568 | Metaplasia | 1 | CTD_human |
| Tgene | EGF | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Tgene | EGF | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | EGF | C0034069 | Pulmonary Fibrosis | 1 | CTD_human |
| Tgene | EGF | C0035126 | Reperfusion Injury | 1 | CTD_human |
| Tgene | EGF | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | EGF | C0041696 | Unipolar Depression | 1 | PSYGENET |
| Tgene | EGF | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
| Tgene | EGF | C2239176 | Liver carcinoma | 1 | CTD_human |
| Tgene | EGF | C2673648 | Hypomagnesemia 4, Renal | 1 | CTD_human;UNIPROT |
| Tgene | EGF | C3495559 | Juvenile arthritis | 1 | CTD_human |
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