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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 3300

FusionGeneSummary for ATP1A1_SORT1

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP1A1_SORT1
Fusion gene ID: 3300
HgeneTgene
Gene symbol

ATP1A1

SORT1

Gene ID

480

6272

Gene nameATPase Na+/K+ transporting subunit alpha 4sortilin 1
SynonymsATP1A1|ATP1AL2Gp95|LDLCQ6|NT3|NTR3
Cytomap

1q23.2

1p13.3|1p21.3-p13.1

Type of geneprotein-codingprotein-coding
Descriptionsodium/potassium-transporting ATPase subunit alpha-4ATPase, Na+/K+ transporting, alpha 4 polypeptideATPase, Na+/K+ transporting, alpha polypeptide-like 2Na(+)/K(+) ATPase alpha-4 subunitNa+/K+ ATPase 4Na+/K+ ATPase, alpha-D polypeptideNa,K-ATPase susortilin100 kDa NT receptorglycoprotein 95neurotensin receptor 3
Modification date2018052320180522
UniProtAcc

P05023

Q99523

Ensembl transtripts involved in fusion geneENST00000295598, ENST00000537345, 
ENST00000369496, ENST00000491156, 
ENST00000256637, ENST00000538502, 
ENST00000482236, 
Fusion gene scores* DoF score15 X 20 X 7=21007 X 8 X 5=280
# samples 259
** MAII scorelog2(25/2100*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP1A1 [Title/Abstract] AND SORT1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP1A1

GO:0030317

flagellated sperm motility

12112599

HgeneATP1A1

GO:0030641

regulation of cellular pH

12112599

TgeneSORT1

GO:0006895

Golgi to endosome transport

11331584

TgeneSORT1

GO:0006897

endocytosis

11331584

TgeneSORT1

GO:0007218

neuropeptide signaling pathway

9756851

TgeneSORT1

GO:0008333

endosome to lysosome transport

11331584

TgeneSORT1

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

14985763

TgeneSORT1

GO:0016050

vesicle organization

15992544

TgeneSORT1

GO:0032509

endosome transport via multivesicular body sorting pathway

11331584

TgeneSORT1

GO:0048227

plasma membrane to endosome transport

11331584

TgeneSORT1

GO:0051005

negative regulation of lipoprotein lipase activity

10085125


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-85-7697-01AATP1A1chr1

116930113

+SORT1chr1

109912211

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000295598ENST00000256637ATP1A1chr1

116930113

+SORT1chr1

109912211

-
5CDS-5UTRENST00000295598ENST00000538502ATP1A1chr1

116930113

+SORT1chr1

109912211

-
5CDS-5UTRENST00000295598ENST00000482236ATP1A1chr1

116930113

+SORT1chr1

109912211

-
In-frameENST00000537345ENST00000256637ATP1A1chr1

116930113

+SORT1chr1

109912211

-
5CDS-5UTRENST00000537345ENST00000538502ATP1A1chr1

116930113

+SORT1chr1

109912211

-
5CDS-5UTRENST00000537345ENST00000482236ATP1A1chr1

116930113

+SORT1chr1

109912211

-
In-frameENST00000369496ENST00000256637ATP1A1chr1

116930113

+SORT1chr1

109912211

-
5CDS-5UTRENST00000369496ENST00000538502ATP1A1chr1

116930113

+SORT1chr1

109912211

-
5CDS-5UTRENST00000369496ENST00000482236ATP1A1chr1

116930113

+SORT1chr1

109912211

-
intron-3CDSENST00000491156ENST00000256637ATP1A1chr1

116930113

+SORT1chr1

109912211

-
intron-5UTRENST00000491156ENST00000538502ATP1A1chr1

116930113

+SORT1chr1

109912211

-
intron-5UTRENST00000491156ENST00000482236ATP1A1chr1

116930113

+SORT1chr1

109912211

-

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FusionProtFeatures for ATP1A1_SORT1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP1A1

P05023

SORT1

Q99523

Functions as a sorting receptor in the Golgi compartmentand as a clearance receptor on the cell surface. Required forprotein transport from the Golgi apparatus to the lysosomes by apathway that is independent of the mannose-6-phosphate receptor(M6PR). Also required for protein transport from the Golgiapparatus to the endosomes. Promotes neuronal apoptosis bymediating endocytosis of the proapoptotic precursor forms of BDNF(proBDNF) and NGFB (proNGFB). Also acts as a receptor forneurotensin. May promote mineralization of the extracellularmatrix during osteogenic differentiation by scavengingextracellular LPL. Probably required in adipocytes for theformation of specialized storage vesicles containing the glucosetransporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). Thesevesicles provide a stable pool of SLC2A4 and confer increasedresponsiveness to insulin. May also mediate transport from theendoplasmic reticulum to the Golgi. {ECO:0000269|PubMed:10085125,ECO:0000269|PubMed:11331584, ECO:0000269|PubMed:11390366,ECO:0000269|PubMed:12209882, ECO:0000269|PubMed:12598608,ECO:0000269|PubMed:14657016, ECO:0000269|PubMed:14985763,ECO:0000269|PubMed:15313463, ECO:0000269|PubMed:15930396,ECO:0000269|PubMed:15987945}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+42382_841291024RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+42382_8498993RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+42382_841291024RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423109_1311291024Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+4236_871291024Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+4236_8798993Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423109_1311291024Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+4236_871291024Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+42388_1081291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+42388_1081291024TransmembraneHelical
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637-020787_792102832MotifEndocytosis signal
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502-020787_792-34695MotifEndocytosis signal
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502-02050_61-34695RegionNote=Intrachain binding of the propeptide and the extracellular domain
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637-020145_156102832RepeatNote=BNR 1
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637-020198_209102832RepeatNote=BNR 2
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637-020240_251102832RepeatNote=BNR 3
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637-020287_298102832RepeatNote=BNR 4
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637-020328_339102832RepeatNote=BNR 5
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637-020377_388102832RepeatNote=BNR 6
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637-020428_439102832RepeatNote=BNR 7
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637-020506_517102832RepeatNote=BNR 8
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637-020548_559102832RepeatNote=BNR 9
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502-020145_156-34695RepeatNote=BNR 1
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502-020198_209-34695RepeatNote=BNR 2
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502-020240_251-34695RepeatNote=BNR 3
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502-020287_298-34695RepeatNote=BNR 4
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502-020328_339-34695RepeatNote=BNR 5
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502-020377_388-34695RepeatNote=BNR 6
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502-020428_439-34695RepeatNote=BNR 7
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502-020506_517-34695RepeatNote=BNR 8
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502-020548_559-34695RepeatNote=BNR 9
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502-02078_755-34695Topological domainExtracellular
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637-020756_778102832TransmembraneHelical
TgeneSORT1chr1:116930113chr1:109912211ENST00000538502-020756_778-34695TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+4231007_10231291024Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423153_2881291024Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423309_3201291024Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423339_7721291024Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423793_8021291024Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423824_8431291024Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423867_9181291024Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423939_9511291024Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423971_9851291024Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+4231007_102398993Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423109_13198993Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423153_28898993Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423309_32098993Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423339_77298993Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423793_80298993Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423824_84398993Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423867_91898993Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423939_95198993Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423971_98598993Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+4231007_10231291024Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423153_2881291024Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423309_3201291024Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423339_7721291024Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423793_8021291024Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423824_8431291024Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423867_9181291024Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423939_9511291024Topological domainCytoplasmic
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423971_9851291024Topological domainExtracellular
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423132_1521291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423289_3081291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423321_3381291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423773_7921291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423803_8231291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423844_8661291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423919_9381291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423952_9701291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000295598+423986_10061291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423132_15298993TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423289_30898993TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423321_33898993TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423773_79298993TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423803_82398993TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423844_86698993TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+42388_10898993TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423919_93898993TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423952_97098993TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000369496+423986_100698993TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423132_1521291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423289_3081291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423321_3381291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423773_7921291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423803_8231291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423844_8661291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423919_9381291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423952_9701291024TransmembraneHelical
HgeneATP1A1chr1:116930113chr1:109912211ENST00000537345+423986_10061291024TransmembraneHelical
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637-02050_61102832RegionNote=Intrachain binding of the propeptide and the extracellular domain
TgeneSORT1chr1:116930113chr1:109912211ENST00000256637-02078_755102832Topological domainExtracellular


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FusionGeneSequence for ATP1A1_SORT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ATP1A1_ENST00000295598_chr1_116930113_+_SORT1_ENST00000256637_chr1_109912211_-_859aa
MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWI
KFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKN
FKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSK
NFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQ
GDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDN
SIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGY
SWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTID
FKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPE
LKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSPEKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKKYVC

>In-frame_ATP1A1_ENST00000537345_chr1_116930113_+_SORT1_ENST00000256637_chr1_109912211_-_859aa
MAFKVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWI
KFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKN
FKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSK
NFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQ
GDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDN
SIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGY
SWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTID
FKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPE
LKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSPEKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKKYVC

>In-frame_ATP1A1_ENST00000369496_chr1_116930113_+_SORT1_ENST00000256637_chr1_109912211_-_828aa
MDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAAT
EEEPQNDNHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVL
TAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYAN
GSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMH
VDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDATAKN
KNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPI
NVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGC
ILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQ
GGVNPVREVKDLKKKCTSNFLSPEKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRFLVHRYSVLQQHAEANGVDGVDALDTAS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ATP1A1_ENST00000295598_chr1_116930113_+_SORT1_ENST00000256637_chr1_109912211_-_2577nt
ATGGGGAAGGGGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGACAGG
GACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGC
CGGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATC
AAGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCT
ACAGAAGAGGAACCTCAAAACGATAATCATGTGTTTGATGATCTCAGAGGCTCAGTATCCTTGTCCTGGGTTGGAGATAGCACTGGGGTC
ATTCTAGTCTTGACTACCTTCCATGTACCACTGGTAATTATGACTTTTGGACAGTCCAAGCTATATCGAAGTGAGGATTATGGGAAGAAC
TTTAAGGATATTACAGATCTCATCAATAACACCTTTATTCGGACTGAATTTGGCATGGCTATTGGTCCTGAGAACTCTGGAAAGGTGGTG
TTAACAGCAGAGGTGTCTGGAGGAAGTCGTGGAGGAAGAATCTTTAGATCATCAGATTTTGCGAAGAATTTTGTGCAAACAGATCTCCCT
TTTCATCCTCTCACTCAGATGATGTATAGCCCTCAGAATTCTGATTATCTTTTAGCTCTCAGCACTGAAAATGGCCTGTGGGTGTCCAAG
AATTTTGGGGGAAAATGGGAAGAAATCCACAAAGCAGTATGTTTGGCCAAATGGGGATCAGACAACACCATCTTCTTTACAACCTATGCA
AATGGCTCCTGCAAAGCTGACCTTGGGGCTCTGGAATTATGGAGAACTTCAGACTTGGGAAAAAGCTTCAAAACTATTGGTGTGAAAATC
TACTCATTTGGTCTTGGGGGACGTTTCCTTTTTGCCTCTGTGATGGCTGATAAGGATACAACAAGAAGGATCCACGTTTCAACAGATCAA
GGGGACACATGGAGCATGGCCCAGCTCCCCTCCGTGGGACAGGAACAGTTCTATTCTATTCTGGCAGCAAATGATGACATGGTATTCATG
CATGTAGATGAACCTGGAGACACTGGGTTTGGCACAATCTTTACCTCAGATGATCGAGGCATTGTCTATTCCAAGTCTTTGGACCGACAT
CTCTACACTACCACAGGCGGAGAGACGGACTTTACCAACGTGACCTCCCTCCGCGGCGTCTACATAACAAGCGTGCTCTCCGAAGATAAT
TCTATCCAGACCATGATCACTTTTGACCAAGGAGGAAGGTGGACGCACCTGAGGAAGCCTGAAAACAGTGAATGTGATGCTACAGCAAAA
AACAAGAATGAGTGCAGCCTTCATATTCATGCTTCCTACAGCATCTCCCAGAAACTGAATGTTCCAATGGCCCCACTCTCAGAGCCGAAT
GCCGTAGGCATTGTCATTGCTCATGGTAGCGTGGGGGATGCCATCTCAGTGATGGTTCCAGATGTGTACATCTCAGATGATGGGGGTTAC
TCCTGGACAAAGATGCTGGAAGGACCCCACTATTACACCATCCTGGATTCTGGAGGCATCATTGTGGCCATTGAGCACAGCAGCCGTCCT
ATCAATGTGATTAAGTTCTCCACAGACGAAGGTCAATGCTGGCAAACCTACACGTTCACCAGGGACCCCATCTATTTCACTGGCCTAGCT
TCAGAACCTGGAGCTAGGTCCATGAATATCAGCATTTGGGGCTTCACAGAATCTTTCCTGACCAGCCAGTGGGTCTCCTACACCATTGAT
TTTAAAGATATCCTTGAAAGGAACTGTGAAGAGAAGGACTATACCATATGGCTGGCACACTCCACAGACCCTGAAGATTATGAAGATGGC
TGCATTTTGGGCTACAAAGAACAGTTTCTGCGGCTACGCAAGTCATCCGTGTGTCAGAATGGTCGAGACTATGTTGTGACCAAGCAGCCC
TCCATCTGCCTCTGTTCCCTGGAGGACTTTCTCTGTGATTTTGGCTACTACCGTCCAGAAAATGACTCCAAGTGTGTGGAACAGCCAGAA
CTGAAGGGCCACGACCTGGAGTTTTGTCTGTACGGAAGAGAAGAACACCTAACAACAAATGGGTACCGGAAAATTCCAGGGGACAAATGC
CAGGGTGGGGTAAATCCAGTTCGAGAAGTAAAAGACTTGAAAAAGAAATGCACAAGCAACTTTTTGAGTCCGGAAAAACAGAATTCCAAG
TCAAATTCTGTTCCAATTATCCTGGCCATCGTGGGATTGATGCTGGTCACAGTCGTAGCAGGAGTGCTCATTGTGAAGAAATATGTCTGT
GGGGGAAGGTTCCTGGTGCATCGATACTCTGTGCTGCAGCAGCATGCAGAGGCCAATGGTGTGGATGGTGTGGATGCTTTGGACACAGCC

>In-frame_ATP1A1_ENST00000537345_chr1_116930113_+_SORT1_ENST00000256637_chr1_109912211_-_2577nt
ATGGCCTTTAAGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGACAGG
GACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGC
CGGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATC
AAGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCT
ACAGAAGAGGAACCTCAAAACGATAATCATGTGTTTGATGATCTCAGAGGCTCAGTATCCTTGTCCTGGGTTGGAGATAGCACTGGGGTC
ATTCTAGTCTTGACTACCTTCCATGTACCACTGGTAATTATGACTTTTGGACAGTCCAAGCTATATCGAAGTGAGGATTATGGGAAGAAC
TTTAAGGATATTACAGATCTCATCAATAACACCTTTATTCGGACTGAATTTGGCATGGCTATTGGTCCTGAGAACTCTGGAAAGGTGGTG
TTAACAGCAGAGGTGTCTGGAGGAAGTCGTGGAGGAAGAATCTTTAGATCATCAGATTTTGCGAAGAATTTTGTGCAAACAGATCTCCCT
TTTCATCCTCTCACTCAGATGATGTATAGCCCTCAGAATTCTGATTATCTTTTAGCTCTCAGCACTGAAAATGGCCTGTGGGTGTCCAAG
AATTTTGGGGGAAAATGGGAAGAAATCCACAAAGCAGTATGTTTGGCCAAATGGGGATCAGACAACACCATCTTCTTTACAACCTATGCA
AATGGCTCCTGCAAAGCTGACCTTGGGGCTCTGGAATTATGGAGAACTTCAGACTTGGGAAAAAGCTTCAAAACTATTGGTGTGAAAATC
TACTCATTTGGTCTTGGGGGACGTTTCCTTTTTGCCTCTGTGATGGCTGATAAGGATACAACAAGAAGGATCCACGTTTCAACAGATCAA
GGGGACACATGGAGCATGGCCCAGCTCCCCTCCGTGGGACAGGAACAGTTCTATTCTATTCTGGCAGCAAATGATGACATGGTATTCATG
CATGTAGATGAACCTGGAGACACTGGGTTTGGCACAATCTTTACCTCAGATGATCGAGGCATTGTCTATTCCAAGTCTTTGGACCGACAT
CTCTACACTACCACAGGCGGAGAGACGGACTTTACCAACGTGACCTCCCTCCGCGGCGTCTACATAACAAGCGTGCTCTCCGAAGATAAT
TCTATCCAGACCATGATCACTTTTGACCAAGGAGGAAGGTGGACGCACCTGAGGAAGCCTGAAAACAGTGAATGTGATGCTACAGCAAAA
AACAAGAATGAGTGCAGCCTTCATATTCATGCTTCCTACAGCATCTCCCAGAAACTGAATGTTCCAATGGCCCCACTCTCAGAGCCGAAT
GCCGTAGGCATTGTCATTGCTCATGGTAGCGTGGGGGATGCCATCTCAGTGATGGTTCCAGATGTGTACATCTCAGATGATGGGGGTTAC
TCCTGGACAAAGATGCTGGAAGGACCCCACTATTACACCATCCTGGATTCTGGAGGCATCATTGTGGCCATTGAGCACAGCAGCCGTCCT
ATCAATGTGATTAAGTTCTCCACAGACGAAGGTCAATGCTGGCAAACCTACACGTTCACCAGGGACCCCATCTATTTCACTGGCCTAGCT
TCAGAACCTGGAGCTAGGTCCATGAATATCAGCATTTGGGGCTTCACAGAATCTTTCCTGACCAGCCAGTGGGTCTCCTACACCATTGAT
TTTAAAGATATCCTTGAAAGGAACTGTGAAGAGAAGGACTATACCATATGGCTGGCACACTCCACAGACCCTGAAGATTATGAAGATGGC
TGCATTTTGGGCTACAAAGAACAGTTTCTGCGGCTACGCAAGTCATCCGTGTGTCAGAATGGTCGAGACTATGTTGTGACCAAGCAGCCC
TCCATCTGCCTCTGTTCCCTGGAGGACTTTCTCTGTGATTTTGGCTACTACCGTCCAGAAAATGACTCCAAGTGTGTGGAACAGCCAGAA
CTGAAGGGCCACGACCTGGAGTTTTGTCTGTACGGAAGAGAAGAACACCTAACAACAAATGGGTACCGGAAAATTCCAGGGGACAAATGC
CAGGGTGGGGTAAATCCAGTTCGAGAAGTAAAAGACTTGAAAAAGAAATGCACAAGCAACTTTTTGAGTCCGGAAAAACAGAATTCCAAG
TCAAATTCTGTTCCAATTATCCTGGCCATCGTGGGATTGATGCTGGTCACAGTCGTAGCAGGAGTGCTCATTGTGAAGAAATATGTCTGT
GGGGGAAGGTTCCTGGTGCATCGATACTCTGTGCTGCAGCAGCATGCAGAGGCCAATGGTGTGGATGGTGTGGATGCTTTGGACACAGCC

>In-frame_ATP1A1_ENST00000369496_chr1_116930113_+_SORT1_ENST00000256637_chr1_109912211_-_2484nt
ATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGCCGG
GGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATCAAG
TTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCTACA
GAAGAGGAACCTCAAAACGATAATCATGTGTTTGATGATCTCAGAGGCTCAGTATCCTTGTCCTGGGTTGGAGATAGCACTGGGGTCATT
CTAGTCTTGACTACCTTCCATGTACCACTGGTAATTATGACTTTTGGACAGTCCAAGCTATATCGAAGTGAGGATTATGGGAAGAACTTT
AAGGATATTACAGATCTCATCAATAACACCTTTATTCGGACTGAATTTGGCATGGCTATTGGTCCTGAGAACTCTGGAAAGGTGGTGTTA
ACAGCAGAGGTGTCTGGAGGAAGTCGTGGAGGAAGAATCTTTAGATCATCAGATTTTGCGAAGAATTTTGTGCAAACAGATCTCCCTTTT
CATCCTCTCACTCAGATGATGTATAGCCCTCAGAATTCTGATTATCTTTTAGCTCTCAGCACTGAAAATGGCCTGTGGGTGTCCAAGAAT
TTTGGGGGAAAATGGGAAGAAATCCACAAAGCAGTATGTTTGGCCAAATGGGGATCAGACAACACCATCTTCTTTACAACCTATGCAAAT
GGCTCCTGCAAAGCTGACCTTGGGGCTCTGGAATTATGGAGAACTTCAGACTTGGGAAAAAGCTTCAAAACTATTGGTGTGAAAATCTAC
TCATTTGGTCTTGGGGGACGTTTCCTTTTTGCCTCTGTGATGGCTGATAAGGATACAACAAGAAGGATCCACGTTTCAACAGATCAAGGG
GACACATGGAGCATGGCCCAGCTCCCCTCCGTGGGACAGGAACAGTTCTATTCTATTCTGGCAGCAAATGATGACATGGTATTCATGCAT
GTAGATGAACCTGGAGACACTGGGTTTGGCACAATCTTTACCTCAGATGATCGAGGCATTGTCTATTCCAAGTCTTTGGACCGACATCTC
TACACTACCACAGGCGGAGAGACGGACTTTACCAACGTGACCTCCCTCCGCGGCGTCTACATAACAAGCGTGCTCTCCGAAGATAATTCT
ATCCAGACCATGATCACTTTTGACCAAGGAGGAAGGTGGACGCACCTGAGGAAGCCTGAAAACAGTGAATGTGATGCTACAGCAAAAAAC
AAGAATGAGTGCAGCCTTCATATTCATGCTTCCTACAGCATCTCCCAGAAACTGAATGTTCCAATGGCCCCACTCTCAGAGCCGAATGCC
GTAGGCATTGTCATTGCTCATGGTAGCGTGGGGGATGCCATCTCAGTGATGGTTCCAGATGTGTACATCTCAGATGATGGGGGTTACTCC
TGGACAAAGATGCTGGAAGGACCCCACTATTACACCATCCTGGATTCTGGAGGCATCATTGTGGCCATTGAGCACAGCAGCCGTCCTATC
AATGTGATTAAGTTCTCCACAGACGAAGGTCAATGCTGGCAAACCTACACGTTCACCAGGGACCCCATCTATTTCACTGGCCTAGCTTCA
GAACCTGGAGCTAGGTCCATGAATATCAGCATTTGGGGCTTCACAGAATCTTTCCTGACCAGCCAGTGGGTCTCCTACACCATTGATTTT
AAAGATATCCTTGAAAGGAACTGTGAAGAGAAGGACTATACCATATGGCTGGCACACTCCACAGACCCTGAAGATTATGAAGATGGCTGC
ATTTTGGGCTACAAAGAACAGTTTCTGCGGCTACGCAAGTCATCCGTGTGTCAGAATGGTCGAGACTATGTTGTGACCAAGCAGCCCTCC
ATCTGCCTCTGTTCCCTGGAGGACTTTCTCTGTGATTTTGGCTACTACCGTCCAGAAAATGACTCCAAGTGTGTGGAACAGCCAGAACTG
AAGGGCCACGACCTGGAGTTTTGTCTGTACGGAAGAGAAGAACACCTAACAACAAATGGGTACCGGAAAATTCCAGGGGACAAATGCCAG
GGTGGGGTAAATCCAGTTCGAGAAGTAAAAGACTTGAAAAAGAAATGCACAAGCAACTTTTTGAGTCCGGAAAAACAGAATTCCAAGTCA
AATTCTGTTCCAATTATCCTGGCCATCGTGGGATTGATGCTGGTCACAGTCGTAGCAGGAGTGCTCATTGTGAAGAAATATGTCTGTGGG
GGAAGGTTCCTGGTGCATCGATACTCTGTGCTGCAGCAGCATGCAGAGGCCAATGGTGTGGATGGTGTGGATGCTTTGGACACAGCCTCC


* Fusion transcript sequences (Full-length transcript).
>In-frame_ATP1A1_ENST00000295598_chr1_116930113_+_SORT1_ENST00000256637_chr1_109912211_-_7302nt
CTGGGGCGCAGAGCAGCGGCGGGAGGAGGCGGACACGTGGCAACAGCGGTAGCAGCCCGGGCGGCGGCAGCAACAGCGGCGGCGGCATCG
GCCCGAGCCGCCGGCCGCCCTCCCACCCTCCCGCCCCGCGGCAGCCCTAGCTCCCTCCACTTGGCTCCCCTGGTCCCGCTCGCTCGGCCG
GGAGCTGCTCTGTGCTTTTCTCTCTGATTCTCCAGCGACAGGACCCGGCGCCGGGCACTGAGCACCGCCACCATGGGGAAGGGGGTTGGA
CGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGACAGGGACATGGATGAACTGAAG
AAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGCCGGGGATTAACATCTGCT
CGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATCAAGTTTTGTCGGCAGCTC
TTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCTACAGAAGAGGAACCTCAA
AACGATAATCATGTGTTTGATGATCTCAGAGGCTCAGTATCCTTGTCCTGGGTTGGAGATAGCACTGGGGTCATTCTAGTCTTGACTACC
TTCCATGTACCACTGGTAATTATGACTTTTGGACAGTCCAAGCTATATCGAAGTGAGGATTATGGGAAGAACTTTAAGGATATTACAGAT
CTCATCAATAACACCTTTATTCGGACTGAATTTGGCATGGCTATTGGTCCTGAGAACTCTGGAAAGGTGGTGTTAACAGCAGAGGTGTCT
GGAGGAAGTCGTGGAGGAAGAATCTTTAGATCATCAGATTTTGCGAAGAATTTTGTGCAAACAGATCTCCCTTTTCATCCTCTCACTCAG
ATGATGTATAGCCCTCAGAATTCTGATTATCTTTTAGCTCTCAGCACTGAAAATGGCCTGTGGGTGTCCAAGAATTTTGGGGGAAAATGG
GAAGAAATCCACAAAGCAGTATGTTTGGCCAAATGGGGATCAGACAACACCATCTTCTTTACAACCTATGCAAATGGCTCCTGCAAAGCT
GACCTTGGGGCTCTGGAATTATGGAGAACTTCAGACTTGGGAAAAAGCTTCAAAACTATTGGTGTGAAAATCTACTCATTTGGTCTTGGG
GGACGTTTCCTTTTTGCCTCTGTGATGGCTGATAAGGATACAACAAGAAGGATCCACGTTTCAACAGATCAAGGGGACACATGGAGCATG
GCCCAGCTCCCCTCCGTGGGACAGGAACAGTTCTATTCTATTCTGGCAGCAAATGATGACATGGTATTCATGCATGTAGATGAACCTGGA
GACACTGGGTTTGGCACAATCTTTACCTCAGATGATCGAGGCATTGTCTATTCCAAGTCTTTGGACCGACATCTCTACACTACCACAGGC
GGAGAGACGGACTTTACCAACGTGACCTCCCTCCGCGGCGTCTACATAACAAGCGTGCTCTCCGAAGATAATTCTATCCAGACCATGATC
ACTTTTGACCAAGGAGGAAGGTGGACGCACCTGAGGAAGCCTGAAAACAGTGAATGTGATGCTACAGCAAAAAACAAGAATGAGTGCAGC
CTTCATATTCATGCTTCCTACAGCATCTCCCAGAAACTGAATGTTCCAATGGCCCCACTCTCAGAGCCGAATGCCGTAGGCATTGTCATT
GCTCATGGTAGCGTGGGGGATGCCATCTCAGTGATGGTTCCAGATGTGTACATCTCAGATGATGGGGGTTACTCCTGGACAAAGATGCTG
GAAGGACCCCACTATTACACCATCCTGGATTCTGGAGGCATCATTGTGGCCATTGAGCACAGCAGCCGTCCTATCAATGTGATTAAGTTC
TCCACAGACGAAGGTCAATGCTGGCAAACCTACACGTTCACCAGGGACCCCATCTATTTCACTGGCCTAGCTTCAGAACCTGGAGCTAGG
TCCATGAATATCAGCATTTGGGGCTTCACAGAATCTTTCCTGACCAGCCAGTGGGTCTCCTACACCATTGATTTTAAAGATATCCTTGAA
AGGAACTGTGAAGAGAAGGACTATACCATATGGCTGGCACACTCCACAGACCCTGAAGATTATGAAGATGGCTGCATTTTGGGCTACAAA
GAACAGTTTCTGCGGCTACGCAAGTCATCCGTGTGTCAGAATGGTCGAGACTATGTTGTGACCAAGCAGCCCTCCATCTGCCTCTGTTCC
CTGGAGGACTTTCTCTGTGATTTTGGCTACTACCGTCCAGAAAATGACTCCAAGTGTGTGGAACAGCCAGAACTGAAGGGCCACGACCTG
GAGTTTTGTCTGTACGGAAGAGAAGAACACCTAACAACAAATGGGTACCGGAAAATTCCAGGGGACAAATGCCAGGGTGGGGTAAATCCA
GTTCGAGAAGTAAAAGACTTGAAAAAGAAATGCACAAGCAACTTTTTGAGTCCGGAAAAACAGAATTCCAAGTCAAATTCTGTTCCAATT
ATCCTGGCCATCGTGGGATTGATGCTGGTCACAGTCGTAGCAGGAGTGCTCATTGTGAAGAAATATGTCTGTGGGGGAAGGTTCCTGGTG
CATCGATACTCTGTGCTGCAGCAGCATGCAGAGGCCAATGGTGTGGATGGTGTGGATGCTTTGGACACAGCCTCCCACACTAATAAAAGT
GGTTATCATGATGACTCAGATGAGGACCTCTTGGAATAGCTCTTCAGAGGAGCTGGACCCAGCATGGATGGTGGAACCACAGTACCTCTT
ACACTCCCTGTGGCTCCAACTTCAGGAAATAAATTTCCCATTGCGAGGGACCCAGCTCTGTTTCTGCTGCTTCCATCAAAGCCAAAAGGA
CCTACACTAAAGAAATGCAGGGTGGGGGTGGGGAACCCTGAGCACTTTTTTACAATTGGCTCTGAGAAAAAGGGAGACATTTTAAATTCT
TTAACTTCTTATTTCTCGTCCTGTCTCTTTGCAAAGTATGGGCTTTTTTGTTTTTGTTTTTTAAGGGAAACGAAATGGAATTCGAAGGGA
CCTTTTCACTAACCCCACTTCTGTGTGTTCTGCATGGCGCCTGCCCCAGGGCATCTGCCAACTCCAGTATCAGCTCTCACAGTGTACTTG
GTACCATCCCTGGGCTCTGCTGGCGAGACGAAACAGCTGTAGAGATGAAAACAGGCTGCAGAGGCTGGCACAGCCTGGCCGGCTTTTCTC
CATCTGGGGACAGTCCTACTCCAAGAACACTGCACACCAGCTCCTCACACAGATCCCACTTACTCTTTTTTTTTTTTTCAGAGACCACAG
ACCACAGTGATTTTTCTTTTCCCTTGTTTAATTAGGCAATACCCTTGTTAATTGCCCTTTGGCAACTAACTTAACCATGTGCTTCCCACA
CAGTACATCAGGAAAACTTACAGGGCAATATTTTTAACTTGGGGCAGGAAGAAGGGAGCAGCAGAGAATTGACTAGATATAGCACCTATT
AAAAGAGAACTCTTGCTTCTTCTGAGATTTTTCAAGCTGTGCTTTGTGTGTGTGCCAGTAGACTTACGCAAGGACAGGGTACAAACTTAG
CTGGAAGTCTGCCCAGGCTGAATGATCTCTTCCCTAGAGTTGATTGTCGGGTACACAGTGTGAACCCCCGAAGACGGAACCTCACAGTCT
TCCATGTTCCCTTCTTAACTGTCGTGTGGCTCGTTGCTAAATCATGACAATGGCTGCCTATCTGCTGCTTCTTAGGTTGCTGTTGTACAT
GGAACCAGGACTAGAGATTTTTTCAGATTTATAGACTTAAAAAATTAGAATTTTATTACCAGGCTTTCCTTCTCACCCCTTTTTTCTGAC
TTTGCCAAGTAATTTGTTGACACGAAAATTTTGGAGGAACCAATTGAAAACACACTTCCAGTCTAGATGATGCTTTGTGTGATACATTAA
GTTCTTATTTTGGATTAAAAGAAGTTTTCCATTTGATACCTCTCTAAATTAAATAAATTATAGAATGTAGTTGGGTGGATTTTGGGGTGG
CCATATAGTAATGGAAAGCTGCAATAATTAGTTTTAATACAGCTTGAATATTTGCTATATAGAAATATAGTATGGAAAGTTTTTGGTCTT
AATGTAGCTACTGTGCGGGTCACAGTTTCTCCCAATGATTATGACTGGGACATTCTTTGGTAGATACCATTTGCTACTAGTTTATTTTGT
GGCTAGAAAGTCAGTTTTGTGTGTTTTTTTTTTTTTTTATTTGAAGTGCCAAATTAACTTTAGTCAGAATGTGAGCAGATGGCTAAGTTC
TCTCCTCCCCAGAATGGATTAACAGCTGCGTGGAAAGTGGGGGAGAGAGTGGATGGAGACTTTTAGAGATGTTAAAACTGCAGTAGAATG
AAATGAGTCAGGGAGCTTCAGTTAGAAAATAAAGTTGAGGCAGTTTTTGTGAAGATAATATGGTTAGGGCTGGAGTGCACTAGTCTTTTT
GCTTATTCATTTTGCATGGTTTTAAAATTAAAAATAATTCCGAAGATACACCAGCTCACAAATGAAAACGTCAGCCTCTGCCCCACCCTC
CCTCCTGCCCAAAGTGAATTTGGTACTCAGAAAAGAACTGTTTATACCACTCACCTTTCTCCCAGCATGTACTCACTGTGGGCAGATGCA
CCAATACATGGTAATCCTCTTACTCATTTTAAGACGTAGGAAACTCAATATTCTTCTCTAACCATATACGATAGGGCTCTTCGCTTTTAA
TGATATCTGGGATTTCTGTGGAACTTGGCAAATTTTCAGAGCACCTTCACTCACATAATGTCATTTGAACCTCACAATGTTCTTGGGATG
GAGTCAGTTGTTCAGGGTCCCCGTGTGTGTGATAAGCAGTGCTGGCTGGCTGTCTTCAGAACTCTTGGAAATCTTTACACATGCGAGTGC
TAACCACTTTGAGCAAGGCTGCCTTCTTGTAGATGACTTGCTGTTCTTTATGACAGGGATCAGTGGCATTTGTTTCCTAGCAGTATTTAG
CACCTTTTTGCCACCTTGGTGAACAGAAAATTGTATTTTCCTGTCTTTCATGGCTGAAAACAAAAGTAATGGGAATTTTAAATACGTTTG
CAGAAACTGCCCCTCCCCTCATTGAGGGTCACTGCTCAAGAGTGCAGGAGTGGACTCTCCACTGATGGGTCTCCCTCCCCATCCTGGTTT
CCACCCCGGGCTGGCTAGCTCTGTTGGTTTGAAGACTGACAGCCAGCCTGGCTCATTCTCATTATTGGCTAGTTAGCTTTCTTTATCAAC
CTGCTCACTCACAAATGTGTGCCCTCAGCCAGAGAGTAAGAAAGCCCAAATCTGTTACAGCTTCTAAAAAAATAGATTTCTAATTTGTCC
TACTCATGTTAGGAGCATTATCTTTGAAGGTAAAACATAGTGTATCATTGTGTAAACTCCCAGGCTTGATGTAGCAGAAGAGATCATTTC
TGGAGGCTTCAGCAATGGAATTTAGCATTATAAGAGAGATTGGACAAACCAGTCCAAAGTGGTCCGAGTTCTTAAATCCAGGTAGGGAAC
TCACTCTTCTTTCTTCTCTGGACCTAATTGGGCATTGGGCTTTAGTGAGACCACAGACCAGGCCCGTCTCTCCTGTAGGCTTTTAATTCA
ATGGCAACTCTATTTCAAAGAATAAAAGCCTTTGGAGAGTTGCGGCAGTTCTGGGGGCGGGCTCAGGAGAGTCCATAGATCAGCCGTAAC
TGGAACGTAGAATCTACGTCTGCCTCTGAATGGACTTCCCACCTCCTCTCTCTTGCTCTGATGCTTGCCTCTGGGCCTCTCCATGCCCAA
GGTGGTCTTTCATCCTTGACAGGCTGGTAATGTGCTGGCCACCTCCAGCTCCTGCATCGAGTCTGTAAACCAGAGCTGGTTCTCATGGCC
TTCGTCACGATACCAGGATACGGAGGGGAGCCCAGGGCCATCCATACCCACCCCAGGGTAACGGGGCTGGCCTGGCATTAGTCATTATTT
AGTTTCCAGGCCAACCATCCAGATAGAGATTCCCTCTTTCCTTTGAGCAGTGCTCTCAAGAGCTCCGTGCCTGTCCACAATGACCTAGAG
TGCATCCTGCTCATTGTCAGTGTAGCCCCTCGCCCCTATATTCATCCAGGATACTTGGAAGTGCTAAAATAGGAAGGGATTCGGCTTTCA
ACTTTGCTACCATCTTCCCTGAAGCAGGAAAATGAACATGGACTTAAATGTTCTTTGAAAAAACCAAAGTTTTAAGATTTGCTGTGTGAT
GAAGTGACAGGGAGGGCCGGAGTCAGCAGGTGCCAGACTTTCTGTTCTGTCTGCCATGGGTTTGTCCAGCTCAGGTAGCTCTAGGAGCAC
CATCCTGCCCTAGCAGAGCCCAGGCCTTGCCCTCATGAAGCATCATTGAAATAGCAGGAGCATGTTGATTTCTTGGTTAGGTTGCATTAT
AATAACAAGAGTCAGAACATTAATTCGAAACAACTTGCAGTATGCATTTCTTCACACCAGTACATTCTTAAGTGTACTTGTTTATAAGGA
ATAACATAAACTAATCTGTACCTTTATATATATGTGTGTGTACATATATACATATATAAACTGTATAGTGTACATGGTAATGATTTATTG
CTATGCCCCAGATCCTTAATGTAGTTCTCATCCTCCGCATGCCCTCAGCCACAAGCGGGTGACTGACTGTTCCCTGATGATTTGGCCCAC
CTCCTGTGTTTGGACCTCTAGGGAGGAGGGTTTTGGTCATACTCTCCTTATCCTCGTGCACAGAAATGCTCAGGGTCCCCATGTGCCTGT
TGTTCAGCCCTCTCTCTTGTTCCCTTTCTGAGCATGTGGTCCTTCCCCAGGCTGTGGGACAGCTGCCTTCCCACGAAAGTGTAAAGCAGT
ATTAAGATCATTACTGCATGTGCCCTAAAAACCCAAGTTTTCTATTCCCTTAGGACAGAAAATTGCATGTGAGGTGGGATAATCGAGTTT
CAGTGACCCACGTCAGTTACACATTAAAGCCAGACCCCATGATAAAATTCCACAAAATGGAAATAAAACTCAAATTTCTTTAGCATTGTG
TAAATAAATCTGAATGTGTTTAACTTTGTACTGGTAATTTTCTGTATATTTGGAATATTTGGGTTAAAAATAAAACAGACTGGACTTTGT

>In-frame_ATP1A1_ENST00000537345_chr1_116930113_+_SORT1_ENST00000256637_chr1_109912211_-_7413nt
AGCAGCGGGGGCGGCCCCGGGACTGAGCCGGCATCCCTGAGCCTGGCTCCCCTCCCTGCGACCGCCGTCACCTCCTTCTCCTTCCTTTTC
CCTCCGCCCTCCGTGCCCTGAGGAAAGGCGCGCTCCTCCCCTTCCCCTGGGGCGCTCCGCCGGGGCCTCCTCCCGGGCCTCCGTTCCCGC
CGCGGCCCCGGTTCCGGCGGGGGCAGCCTCCGGGTTCGGGGCTCCTTCTCCTGGGGACGCTGGGGCTTAGCTTGCTCCGCGCAGAGGCGG
CCGCCCTCCCCCAAAGAAAAAACTGGCTGCTTCTAAGTGCGAAGCCGGCTGGGCGGGCTGGTGCCAGAAAGGGTGTGTCTTCACTGCCCT
AAGATGGCCTTTAAGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGAC
AGGGACATGGATGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTG
AGCCGGGGATTAACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGG
ATCAAGTTTTGTCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCT
GCTACAGAAGAGGAACCTCAAAACGATAATCATGTGTTTGATGATCTCAGAGGCTCAGTATCCTTGTCCTGGGTTGGAGATAGCACTGGG
GTCATTCTAGTCTTGACTACCTTCCATGTACCACTGGTAATTATGACTTTTGGACAGTCCAAGCTATATCGAAGTGAGGATTATGGGAAG
AACTTTAAGGATATTACAGATCTCATCAATAACACCTTTATTCGGACTGAATTTGGCATGGCTATTGGTCCTGAGAACTCTGGAAAGGTG
GTGTTAACAGCAGAGGTGTCTGGAGGAAGTCGTGGAGGAAGAATCTTTAGATCATCAGATTTTGCGAAGAATTTTGTGCAAACAGATCTC
CCTTTTCATCCTCTCACTCAGATGATGTATAGCCCTCAGAATTCTGATTATCTTTTAGCTCTCAGCACTGAAAATGGCCTGTGGGTGTCC
AAGAATTTTGGGGGAAAATGGGAAGAAATCCACAAAGCAGTATGTTTGGCCAAATGGGGATCAGACAACACCATCTTCTTTACAACCTAT
GCAAATGGCTCCTGCAAAGCTGACCTTGGGGCTCTGGAATTATGGAGAACTTCAGACTTGGGAAAAAGCTTCAAAACTATTGGTGTGAAA
ATCTACTCATTTGGTCTTGGGGGACGTTTCCTTTTTGCCTCTGTGATGGCTGATAAGGATACAACAAGAAGGATCCACGTTTCAACAGAT
CAAGGGGACACATGGAGCATGGCCCAGCTCCCCTCCGTGGGACAGGAACAGTTCTATTCTATTCTGGCAGCAAATGATGACATGGTATTC
ATGCATGTAGATGAACCTGGAGACACTGGGTTTGGCACAATCTTTACCTCAGATGATCGAGGCATTGTCTATTCCAAGTCTTTGGACCGA
CATCTCTACACTACCACAGGCGGAGAGACGGACTTTACCAACGTGACCTCCCTCCGCGGCGTCTACATAACAAGCGTGCTCTCCGAAGAT
AATTCTATCCAGACCATGATCACTTTTGACCAAGGAGGAAGGTGGACGCACCTGAGGAAGCCTGAAAACAGTGAATGTGATGCTACAGCA
AAAAACAAGAATGAGTGCAGCCTTCATATTCATGCTTCCTACAGCATCTCCCAGAAACTGAATGTTCCAATGGCCCCACTCTCAGAGCCG
AATGCCGTAGGCATTGTCATTGCTCATGGTAGCGTGGGGGATGCCATCTCAGTGATGGTTCCAGATGTGTACATCTCAGATGATGGGGGT
TACTCCTGGACAAAGATGCTGGAAGGACCCCACTATTACACCATCCTGGATTCTGGAGGCATCATTGTGGCCATTGAGCACAGCAGCCGT
CCTATCAATGTGATTAAGTTCTCCACAGACGAAGGTCAATGCTGGCAAACCTACACGTTCACCAGGGACCCCATCTATTTCACTGGCCTA
GCTTCAGAACCTGGAGCTAGGTCCATGAATATCAGCATTTGGGGCTTCACAGAATCTTTCCTGACCAGCCAGTGGGTCTCCTACACCATT
GATTTTAAAGATATCCTTGAAAGGAACTGTGAAGAGAAGGACTATACCATATGGCTGGCACACTCCACAGACCCTGAAGATTATGAAGAT
GGCTGCATTTTGGGCTACAAAGAACAGTTTCTGCGGCTACGCAAGTCATCCGTGTGTCAGAATGGTCGAGACTATGTTGTGACCAAGCAG
CCCTCCATCTGCCTCTGTTCCCTGGAGGACTTTCTCTGTGATTTTGGCTACTACCGTCCAGAAAATGACTCCAAGTGTGTGGAACAGCCA
GAACTGAAGGGCCACGACCTGGAGTTTTGTCTGTACGGAAGAGAAGAACACCTAACAACAAATGGGTACCGGAAAATTCCAGGGGACAAA
TGCCAGGGTGGGGTAAATCCAGTTCGAGAAGTAAAAGACTTGAAAAAGAAATGCACAAGCAACTTTTTGAGTCCGGAAAAACAGAATTCC
AAGTCAAATTCTGTTCCAATTATCCTGGCCATCGTGGGATTGATGCTGGTCACAGTCGTAGCAGGAGTGCTCATTGTGAAGAAATATGTC
TGTGGGGGAAGGTTCCTGGTGCATCGATACTCTGTGCTGCAGCAGCATGCAGAGGCCAATGGTGTGGATGGTGTGGATGCTTTGGACACA
GCCTCCCACACTAATAAAAGTGGTTATCATGATGACTCAGATGAGGACCTCTTGGAATAGCTCTTCAGAGGAGCTGGACCCAGCATGGAT
GGTGGAACCACAGTACCTCTTACACTCCCTGTGGCTCCAACTTCAGGAAATAAATTTCCCATTGCGAGGGACCCAGCTCTGTTTCTGCTG
CTTCCATCAAAGCCAAAAGGACCTACACTAAAGAAATGCAGGGTGGGGGTGGGGAACCCTGAGCACTTTTTTACAATTGGCTCTGAGAAA
AAGGGAGACATTTTAAATTCTTTAACTTCTTATTTCTCGTCCTGTCTCTTTGCAAAGTATGGGCTTTTTTGTTTTTGTTTTTTAAGGGAA
ACGAAATGGAATTCGAAGGGACCTTTTCACTAACCCCACTTCTGTGTGTTCTGCATGGCGCCTGCCCCAGGGCATCTGCCAACTCCAGTA
TCAGCTCTCACAGTGTACTTGGTACCATCCCTGGGCTCTGCTGGCGAGACGAAACAGCTGTAGAGATGAAAACAGGCTGCAGAGGCTGGC
ACAGCCTGGCCGGCTTTTCTCCATCTGGGGACAGTCCTACTCCAAGAACACTGCACACCAGCTCCTCACACAGATCCCACTTACTCTTTT
TTTTTTTTTCAGAGACCACAGACCACAGTGATTTTTCTTTTCCCTTGTTTAATTAGGCAATACCCTTGTTAATTGCCCTTTGGCAACTAA
CTTAACCATGTGCTTCCCACACAGTACATCAGGAAAACTTACAGGGCAATATTTTTAACTTGGGGCAGGAAGAAGGGAGCAGCAGAGAAT
TGACTAGATATAGCACCTATTAAAAGAGAACTCTTGCTTCTTCTGAGATTTTTCAAGCTGTGCTTTGTGTGTGTGCCAGTAGACTTACGC
AAGGACAGGGTACAAACTTAGCTGGAAGTCTGCCCAGGCTGAATGATCTCTTCCCTAGAGTTGATTGTCGGGTACACAGTGTGAACCCCC
GAAGACGGAACCTCACAGTCTTCCATGTTCCCTTCTTAACTGTCGTGTGGCTCGTTGCTAAATCATGACAATGGCTGCCTATCTGCTGCT
TCTTAGGTTGCTGTTGTACATGGAACCAGGACTAGAGATTTTTTCAGATTTATAGACTTAAAAAATTAGAATTTTATTACCAGGCTTTCC
TTCTCACCCCTTTTTTCTGACTTTGCCAAGTAATTTGTTGACACGAAAATTTTGGAGGAACCAATTGAAAACACACTTCCAGTCTAGATG
ATGCTTTGTGTGATACATTAAGTTCTTATTTTGGATTAAAAGAAGTTTTCCATTTGATACCTCTCTAAATTAAATAAATTATAGAATGTA
GTTGGGTGGATTTTGGGGTGGCCATATAGTAATGGAAAGCTGCAATAATTAGTTTTAATACAGCTTGAATATTTGCTATATAGAAATATA
GTATGGAAAGTTTTTGGTCTTAATGTAGCTACTGTGCGGGTCACAGTTTCTCCCAATGATTATGACTGGGACATTCTTTGGTAGATACCA
TTTGCTACTAGTTTATTTTGTGGCTAGAAAGTCAGTTTTGTGTGTTTTTTTTTTTTTTTATTTGAAGTGCCAAATTAACTTTAGTCAGAA
TGTGAGCAGATGGCTAAGTTCTCTCCTCCCCAGAATGGATTAACAGCTGCGTGGAAAGTGGGGGAGAGAGTGGATGGAGACTTTTAGAGA
TGTTAAAACTGCAGTAGAATGAAATGAGTCAGGGAGCTTCAGTTAGAAAATAAAGTTGAGGCAGTTTTTGTGAAGATAATATGGTTAGGG
CTGGAGTGCACTAGTCTTTTTGCTTATTCATTTTGCATGGTTTTAAAATTAAAAATAATTCCGAAGATACACCAGCTCACAAATGAAAAC
GTCAGCCTCTGCCCCACCCTCCCTCCTGCCCAAAGTGAATTTGGTACTCAGAAAAGAACTGTTTATACCACTCACCTTTCTCCCAGCATG
TACTCACTGTGGGCAGATGCACCAATACATGGTAATCCTCTTACTCATTTTAAGACGTAGGAAACTCAATATTCTTCTCTAACCATATAC
GATAGGGCTCTTCGCTTTTAATGATATCTGGGATTTCTGTGGAACTTGGCAAATTTTCAGAGCACCTTCACTCACATAATGTCATTTGAA
CCTCACAATGTTCTTGGGATGGAGTCAGTTGTTCAGGGTCCCCGTGTGTGTGATAAGCAGTGCTGGCTGGCTGTCTTCAGAACTCTTGGA
AATCTTTACACATGCGAGTGCTAACCACTTTGAGCAAGGCTGCCTTCTTGTAGATGACTTGCTGTTCTTTATGACAGGGATCAGTGGCAT
TTGTTTCCTAGCAGTATTTAGCACCTTTTTGCCACCTTGGTGAACAGAAAATTGTATTTTCCTGTCTTTCATGGCTGAAAACAAAAGTAA
TGGGAATTTTAAATACGTTTGCAGAAACTGCCCCTCCCCTCATTGAGGGTCACTGCTCAAGAGTGCAGGAGTGGACTCTCCACTGATGGG
TCTCCCTCCCCATCCTGGTTTCCACCCCGGGCTGGCTAGCTCTGTTGGTTTGAAGACTGACAGCCAGCCTGGCTCATTCTCATTATTGGC
TAGTTAGCTTTCTTTATCAACCTGCTCACTCACAAATGTGTGCCCTCAGCCAGAGAGTAAGAAAGCCCAAATCTGTTACAGCTTCTAAAA
AAATAGATTTCTAATTTGTCCTACTCATGTTAGGAGCATTATCTTTGAAGGTAAAACATAGTGTATCATTGTGTAAACTCCCAGGCTTGA
TGTAGCAGAAGAGATCATTTCTGGAGGCTTCAGCAATGGAATTTAGCATTATAAGAGAGATTGGACAAACCAGTCCAAAGTGGTCCGAGT
TCTTAAATCCAGGTAGGGAACTCACTCTTCTTTCTTCTCTGGACCTAATTGGGCATTGGGCTTTAGTGAGACCACAGACCAGGCCCGTCT
CTCCTGTAGGCTTTTAATTCAATGGCAACTCTATTTCAAAGAATAAAAGCCTTTGGAGAGTTGCGGCAGTTCTGGGGGCGGGCTCAGGAG
AGTCCATAGATCAGCCGTAACTGGAACGTAGAATCTACGTCTGCCTCTGAATGGACTTCCCACCTCCTCTCTCTTGCTCTGATGCTTGCC
TCTGGGCCTCTCCATGCCCAAGGTGGTCTTTCATCCTTGACAGGCTGGTAATGTGCTGGCCACCTCCAGCTCCTGCATCGAGTCTGTAAA
CCAGAGCTGGTTCTCATGGCCTTCGTCACGATACCAGGATACGGAGGGGAGCCCAGGGCCATCCATACCCACCCCAGGGTAACGGGGCTG
GCCTGGCATTAGTCATTATTTAGTTTCCAGGCCAACCATCCAGATAGAGATTCCCTCTTTCCTTTGAGCAGTGCTCTCAAGAGCTCCGTG
CCTGTCCACAATGACCTAGAGTGCATCCTGCTCATTGTCAGTGTAGCCCCTCGCCCCTATATTCATCCAGGATACTTGGAAGTGCTAAAA
TAGGAAGGGATTCGGCTTTCAACTTTGCTACCATCTTCCCTGAAGCAGGAAAATGAACATGGACTTAAATGTTCTTTGAAAAAACCAAAG
TTTTAAGATTTGCTGTGTGATGAAGTGACAGGGAGGGCCGGAGTCAGCAGGTGCCAGACTTTCTGTTCTGTCTGCCATGGGTTTGTCCAG
CTCAGGTAGCTCTAGGAGCACCATCCTGCCCTAGCAGAGCCCAGGCCTTGCCCTCATGAAGCATCATTGAAATAGCAGGAGCATGTTGAT
TTCTTGGTTAGGTTGCATTATAATAACAAGAGTCAGAACATTAATTCGAAACAACTTGCAGTATGCATTTCTTCACACCAGTACATTCTT
AAGTGTACTTGTTTATAAGGAATAACATAAACTAATCTGTACCTTTATATATATGTGTGTGTACATATATACATATATAAACTGTATAGT
GTACATGGTAATGATTTATTGCTATGCCCCAGATCCTTAATGTAGTTCTCATCCTCCGCATGCCCTCAGCCACAAGCGGGTGACTGACTG
TTCCCTGATGATTTGGCCCACCTCCTGTGTTTGGACCTCTAGGGAGGAGGGTTTTGGTCATACTCTCCTTATCCTCGTGCACAGAAATGC
TCAGGGTCCCCATGTGCCTGTTGTTCAGCCCTCTCTCTTGTTCCCTTTCTGAGCATGTGGTCCTTCCCCAGGCTGTGGGACAGCTGCCTT
CCCACGAAAGTGTAAAGCAGTATTAAGATCATTACTGCATGTGCCCTAAAAACCCAAGTTTTCTATTCCCTTAGGACAGAAAATTGCATG
TGAGGTGGGATAATCGAGTTTCAGTGACCCACGTCAGTTACACATTAAAGCCAGACCCCATGATAAAATTCCACAAAATGGAAATAAAAC
TCAAATTTCTTTAGCATTGTGTAAATAAATCTGAATGTGTTTAACTTTGTACTGGTAATTTTCTGTATATTTGGAATATTTGGGTTAAAA

>In-frame_ATP1A1_ENST00000369496_chr1_116930113_+_SORT1_ENST00000256637_chr1_109912211_-_7222nt
GATATGTAATAATGTCTTTGCAAAGCAAAGAATATAAACAGTATAAAAGTACTAGCATTTAGATGTATTGTATCATTTAATCCTTAAAAA
CATGAAATGAGGTTGGCACTATTCTTTATCTCCACGCTGTGGAAGAGGAAATTGAAATGTAGAAGTTAGTAACTTGCCTAAGGATACACT
GCTGGTTGGACGTGATAAGTATGAGCCTGCAGCTGTTTCAGAACAAGGTGATAAAAAGGGCAAAAAGGGCAAAAAAGACAGGGACATGGA
TGAACTGAAGAAAGAAGTTTCTATGGATGATCATAAACTTAGCCTTGATGAACTTCATCGTAAATATGGAACAGACTTGAGCCGGGGATT
AACATCTGCTCGTGCAGCTGAGATCCTGGCGCGAGATGGTCCCAACGCCCTCACTCCCCCTCCCACTACTCCTGAATGGATCAAGTTTTG
TCGGCAGCTCTTTGGGGGGTTCTCAATGTTACTGTGGATTGGAGCGATTCTTTGTTTCTTGGCTTATAGCATCCAAGCTGCTACAGAAGA
GGAACCTCAAAACGATAATCATGTGTTTGATGATCTCAGAGGCTCAGTATCCTTGTCCTGGGTTGGAGATAGCACTGGGGTCATTCTAGT
CTTGACTACCTTCCATGTACCACTGGTAATTATGACTTTTGGACAGTCCAAGCTATATCGAAGTGAGGATTATGGGAAGAACTTTAAGGA
TATTACAGATCTCATCAATAACACCTTTATTCGGACTGAATTTGGCATGGCTATTGGTCCTGAGAACTCTGGAAAGGTGGTGTTAACAGC
AGAGGTGTCTGGAGGAAGTCGTGGAGGAAGAATCTTTAGATCATCAGATTTTGCGAAGAATTTTGTGCAAACAGATCTCCCTTTTCATCC
TCTCACTCAGATGATGTATAGCCCTCAGAATTCTGATTATCTTTTAGCTCTCAGCACTGAAAATGGCCTGTGGGTGTCCAAGAATTTTGG
GGGAAAATGGGAAGAAATCCACAAAGCAGTATGTTTGGCCAAATGGGGATCAGACAACACCATCTTCTTTACAACCTATGCAAATGGCTC
CTGCAAAGCTGACCTTGGGGCTCTGGAATTATGGAGAACTTCAGACTTGGGAAAAAGCTTCAAAACTATTGGTGTGAAAATCTACTCATT
TGGTCTTGGGGGACGTTTCCTTTTTGCCTCTGTGATGGCTGATAAGGATACAACAAGAAGGATCCACGTTTCAACAGATCAAGGGGACAC
ATGGAGCATGGCCCAGCTCCCCTCCGTGGGACAGGAACAGTTCTATTCTATTCTGGCAGCAAATGATGACATGGTATTCATGCATGTAGA
TGAACCTGGAGACACTGGGTTTGGCACAATCTTTACCTCAGATGATCGAGGCATTGTCTATTCCAAGTCTTTGGACCGACATCTCTACAC
TACCACAGGCGGAGAGACGGACTTTACCAACGTGACCTCCCTCCGCGGCGTCTACATAACAAGCGTGCTCTCCGAAGATAATTCTATCCA
GACCATGATCACTTTTGACCAAGGAGGAAGGTGGACGCACCTGAGGAAGCCTGAAAACAGTGAATGTGATGCTACAGCAAAAAACAAGAA
TGAGTGCAGCCTTCATATTCATGCTTCCTACAGCATCTCCCAGAAACTGAATGTTCCAATGGCCCCACTCTCAGAGCCGAATGCCGTAGG
CATTGTCATTGCTCATGGTAGCGTGGGGGATGCCATCTCAGTGATGGTTCCAGATGTGTACATCTCAGATGATGGGGGTTACTCCTGGAC
AAAGATGCTGGAAGGACCCCACTATTACACCATCCTGGATTCTGGAGGCATCATTGTGGCCATTGAGCACAGCAGCCGTCCTATCAATGT
GATTAAGTTCTCCACAGACGAAGGTCAATGCTGGCAAACCTACACGTTCACCAGGGACCCCATCTATTTCACTGGCCTAGCTTCAGAACC
TGGAGCTAGGTCCATGAATATCAGCATTTGGGGCTTCACAGAATCTTTCCTGACCAGCCAGTGGGTCTCCTACACCATTGATTTTAAAGA
TATCCTTGAAAGGAACTGTGAAGAGAAGGACTATACCATATGGCTGGCACACTCCACAGACCCTGAAGATTATGAAGATGGCTGCATTTT
GGGCTACAAAGAACAGTTTCTGCGGCTACGCAAGTCATCCGTGTGTCAGAATGGTCGAGACTATGTTGTGACCAAGCAGCCCTCCATCTG
CCTCTGTTCCCTGGAGGACTTTCTCTGTGATTTTGGCTACTACCGTCCAGAAAATGACTCCAAGTGTGTGGAACAGCCAGAACTGAAGGG
CCACGACCTGGAGTTTTGTCTGTACGGAAGAGAAGAACACCTAACAACAAATGGGTACCGGAAAATTCCAGGGGACAAATGCCAGGGTGG
GGTAAATCCAGTTCGAGAAGTAAAAGACTTGAAAAAGAAATGCACAAGCAACTTTTTGAGTCCGGAAAAACAGAATTCCAAGTCAAATTC
TGTTCCAATTATCCTGGCCATCGTGGGATTGATGCTGGTCACAGTCGTAGCAGGAGTGCTCATTGTGAAGAAATATGTCTGTGGGGGAAG
GTTCCTGGTGCATCGATACTCTGTGCTGCAGCAGCATGCAGAGGCCAATGGTGTGGATGGTGTGGATGCTTTGGACACAGCCTCCCACAC
TAATAAAAGTGGTTATCATGATGACTCAGATGAGGACCTCTTGGAATAGCTCTTCAGAGGAGCTGGACCCAGCATGGATGGTGGAACCAC
AGTACCTCTTACACTCCCTGTGGCTCCAACTTCAGGAAATAAATTTCCCATTGCGAGGGACCCAGCTCTGTTTCTGCTGCTTCCATCAAA
GCCAAAAGGACCTACACTAAAGAAATGCAGGGTGGGGGTGGGGAACCCTGAGCACTTTTTTACAATTGGCTCTGAGAAAAAGGGAGACAT
TTTAAATTCTTTAACTTCTTATTTCTCGTCCTGTCTCTTTGCAAAGTATGGGCTTTTTTGTTTTTGTTTTTTAAGGGAAACGAAATGGAA
TTCGAAGGGACCTTTTCACTAACCCCACTTCTGTGTGTTCTGCATGGCGCCTGCCCCAGGGCATCTGCCAACTCCAGTATCAGCTCTCAC
AGTGTACTTGGTACCATCCCTGGGCTCTGCTGGCGAGACGAAACAGCTGTAGAGATGAAAACAGGCTGCAGAGGCTGGCACAGCCTGGCC
GGCTTTTCTCCATCTGGGGACAGTCCTACTCCAAGAACACTGCACACCAGCTCCTCACACAGATCCCACTTACTCTTTTTTTTTTTTTCA
GAGACCACAGACCACAGTGATTTTTCTTTTCCCTTGTTTAATTAGGCAATACCCTTGTTAATTGCCCTTTGGCAACTAACTTAACCATGT
GCTTCCCACACAGTACATCAGGAAAACTTACAGGGCAATATTTTTAACTTGGGGCAGGAAGAAGGGAGCAGCAGAGAATTGACTAGATAT
AGCACCTATTAAAAGAGAACTCTTGCTTCTTCTGAGATTTTTCAAGCTGTGCTTTGTGTGTGTGCCAGTAGACTTACGCAAGGACAGGGT
ACAAACTTAGCTGGAAGTCTGCCCAGGCTGAATGATCTCTTCCCTAGAGTTGATTGTCGGGTACACAGTGTGAACCCCCGAAGACGGAAC
CTCACAGTCTTCCATGTTCCCTTCTTAACTGTCGTGTGGCTCGTTGCTAAATCATGACAATGGCTGCCTATCTGCTGCTTCTTAGGTTGC
TGTTGTACATGGAACCAGGACTAGAGATTTTTTCAGATTTATAGACTTAAAAAATTAGAATTTTATTACCAGGCTTTCCTTCTCACCCCT
TTTTTCTGACTTTGCCAAGTAATTTGTTGACACGAAAATTTTGGAGGAACCAATTGAAAACACACTTCCAGTCTAGATGATGCTTTGTGT
GATACATTAAGTTCTTATTTTGGATTAAAAGAAGTTTTCCATTTGATACCTCTCTAAATTAAATAAATTATAGAATGTAGTTGGGTGGAT
TTTGGGGTGGCCATATAGTAATGGAAAGCTGCAATAATTAGTTTTAATACAGCTTGAATATTTGCTATATAGAAATATAGTATGGAAAGT
TTTTGGTCTTAATGTAGCTACTGTGCGGGTCACAGTTTCTCCCAATGATTATGACTGGGACATTCTTTGGTAGATACCATTTGCTACTAG
TTTATTTTGTGGCTAGAAAGTCAGTTTTGTGTGTTTTTTTTTTTTTTTATTTGAAGTGCCAAATTAACTTTAGTCAGAATGTGAGCAGAT
GGCTAAGTTCTCTCCTCCCCAGAATGGATTAACAGCTGCGTGGAAAGTGGGGGAGAGAGTGGATGGAGACTTTTAGAGATGTTAAAACTG
CAGTAGAATGAAATGAGTCAGGGAGCTTCAGTTAGAAAATAAAGTTGAGGCAGTTTTTGTGAAGATAATATGGTTAGGGCTGGAGTGCAC
TAGTCTTTTTGCTTATTCATTTTGCATGGTTTTAAAATTAAAAATAATTCCGAAGATACACCAGCTCACAAATGAAAACGTCAGCCTCTG
CCCCACCCTCCCTCCTGCCCAAAGTGAATTTGGTACTCAGAAAAGAACTGTTTATACCACTCACCTTTCTCCCAGCATGTACTCACTGTG
GGCAGATGCACCAATACATGGTAATCCTCTTACTCATTTTAAGACGTAGGAAACTCAATATTCTTCTCTAACCATATACGATAGGGCTCT
TCGCTTTTAATGATATCTGGGATTTCTGTGGAACTTGGCAAATTTTCAGAGCACCTTCACTCACATAATGTCATTTGAACCTCACAATGT
TCTTGGGATGGAGTCAGTTGTTCAGGGTCCCCGTGTGTGTGATAAGCAGTGCTGGCTGGCTGTCTTCAGAACTCTTGGAAATCTTTACAC
ATGCGAGTGCTAACCACTTTGAGCAAGGCTGCCTTCTTGTAGATGACTTGCTGTTCTTTATGACAGGGATCAGTGGCATTTGTTTCCTAG
CAGTATTTAGCACCTTTTTGCCACCTTGGTGAACAGAAAATTGTATTTTCCTGTCTTTCATGGCTGAAAACAAAAGTAATGGGAATTTTA
AATACGTTTGCAGAAACTGCCCCTCCCCTCATTGAGGGTCACTGCTCAAGAGTGCAGGAGTGGACTCTCCACTGATGGGTCTCCCTCCCC
ATCCTGGTTTCCACCCCGGGCTGGCTAGCTCTGTTGGTTTGAAGACTGACAGCCAGCCTGGCTCATTCTCATTATTGGCTAGTTAGCTTT
CTTTATCAACCTGCTCACTCACAAATGTGTGCCCTCAGCCAGAGAGTAAGAAAGCCCAAATCTGTTACAGCTTCTAAAAAAATAGATTTC
TAATTTGTCCTACTCATGTTAGGAGCATTATCTTTGAAGGTAAAACATAGTGTATCATTGTGTAAACTCCCAGGCTTGATGTAGCAGAAG
AGATCATTTCTGGAGGCTTCAGCAATGGAATTTAGCATTATAAGAGAGATTGGACAAACCAGTCCAAAGTGGTCCGAGTTCTTAAATCCA
GGTAGGGAACTCACTCTTCTTTCTTCTCTGGACCTAATTGGGCATTGGGCTTTAGTGAGACCACAGACCAGGCCCGTCTCTCCTGTAGGC
TTTTAATTCAATGGCAACTCTATTTCAAAGAATAAAAGCCTTTGGAGAGTTGCGGCAGTTCTGGGGGCGGGCTCAGGAGAGTCCATAGAT
CAGCCGTAACTGGAACGTAGAATCTACGTCTGCCTCTGAATGGACTTCCCACCTCCTCTCTCTTGCTCTGATGCTTGCCTCTGGGCCTCT
CCATGCCCAAGGTGGTCTTTCATCCTTGACAGGCTGGTAATGTGCTGGCCACCTCCAGCTCCTGCATCGAGTCTGTAAACCAGAGCTGGT
TCTCATGGCCTTCGTCACGATACCAGGATACGGAGGGGAGCCCAGGGCCATCCATACCCACCCCAGGGTAACGGGGCTGGCCTGGCATTA
GTCATTATTTAGTTTCCAGGCCAACCATCCAGATAGAGATTCCCTCTTTCCTTTGAGCAGTGCTCTCAAGAGCTCCGTGCCTGTCCACAA
TGACCTAGAGTGCATCCTGCTCATTGTCAGTGTAGCCCCTCGCCCCTATATTCATCCAGGATACTTGGAAGTGCTAAAATAGGAAGGGAT
TCGGCTTTCAACTTTGCTACCATCTTCCCTGAAGCAGGAAAATGAACATGGACTTAAATGTTCTTTGAAAAAACCAAAGTTTTAAGATTT
GCTGTGTGATGAAGTGACAGGGAGGGCCGGAGTCAGCAGGTGCCAGACTTTCTGTTCTGTCTGCCATGGGTTTGTCCAGCTCAGGTAGCT
CTAGGAGCACCATCCTGCCCTAGCAGAGCCCAGGCCTTGCCCTCATGAAGCATCATTGAAATAGCAGGAGCATGTTGATTTCTTGGTTAG
GTTGCATTATAATAACAAGAGTCAGAACATTAATTCGAAACAACTTGCAGTATGCATTTCTTCACACCAGTACATTCTTAAGTGTACTTG
TTTATAAGGAATAACATAAACTAATCTGTACCTTTATATATATGTGTGTGTACATATATACATATATAAACTGTATAGTGTACATGGTAA
TGATTTATTGCTATGCCCCAGATCCTTAATGTAGTTCTCATCCTCCGCATGCCCTCAGCCACAAGCGGGTGACTGACTGTTCCCTGATGA
TTTGGCCCACCTCCTGTGTTTGGACCTCTAGGGAGGAGGGTTTTGGTCATACTCTCCTTATCCTCGTGCACAGAAATGCTCAGGGTCCCC
ATGTGCCTGTTGTTCAGCCCTCTCTCTTGTTCCCTTTCTGAGCATGTGGTCCTTCCCCAGGCTGTGGGACAGCTGCCTTCCCACGAAAGT
GTAAAGCAGTATTAAGATCATTACTGCATGTGCCCTAAAAACCCAAGTTTTCTATTCCCTTAGGACAGAAAATTGCATGTGAGGTGGGAT
AATCGAGTTTCAGTGACCCACGTCAGTTACACATTAAAGCCAGACCCCATGATAAAATTCCACAAAATGGAAATAAAACTCAAATTTCTT
TAGCATTGTGTAAATAAATCTGAATGTGTTTAACTTTGTACTGGTAATTTTCTGTATATTTGGAATATTTGGGTTAAAAATAAAACAGAC


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FusionGenePPI for ATP1A1_SORT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP1A1PRKCA, MAPK1, MAPK3, FXYD1, EZH2, HGS, HDAC5, NDRG1, CDK9, NELFB, NELFCD, NELFA, SIRT7, FBXO25, CUL3, CDK2, AKT1, A2M, PKD1, PKD2, ATF2, IQCB1, MMS19, CLN3, ADRB2, ATP4A, DYRK4, HIPK4, MAPK4, CDK20, EGFR, FBXO6, LGR4, UBC, STAU1, SPRTN, HUWE1, AP2A2, CUL7, CCDC8, ZNRF1, ZNRF2, ILK, IRAK1, LIMK2, PPT1, RPS6KB2, LGALS3, ACADM, AFG3L2, ATP1B1, ATP1B2, ATP1B3, ATP2B1, ATP2B4, ATP6V0D1, CCT6A, CCT8, CLTC, CLTCL1, HADHB, HSD17B12, LMAN1, MTCH1, MTCH2, NDUFS1, PPP2R1A, RAB1A, RAB1B, RAB2A, TPM3, ATP5C1, ATP5L, ATP6V1A, CAD, CCT7, CYB5B, CYC1, DDOST, EIF3B, IPO5, ITGA5, MRPL40, NDUFB8, NDUFS4, NDUFV1, PC, PHB, RPN1, SLC25A3, SSR2, TECR, TMCO1, TMED2, TPM4, UQCRC2, UQCRQ, VDAC1, VDAC2, VDAC3, NTRK1, TCTN3, TMEM17, AHSA1, ERBB2, NCSTN, GOLT1B, TMEM63B, YIPF5, TUBA1C, MBOAT1, KIAA0368, SKI, CRY2, ESRRB, C3orf17, ZNF746, CYLD, NCDN, COX15, PDHA1, SDHA, SOD1SORT1GGA2, CDK2, NGF, LRPAP1, GGA1, ELAVL1, GGA3, STAM, SORCS1, NUDCD3, NTRK1, APBB2, XIAP, ASS1, BAD, BLMH, CDK1, COPA, CSNK1G2, CSPG4, PHC2, EIF2B1, GOLGA3, HP, HSD17B4, KLC1, MAP3K4, MYH1, MYH6, NDUFB5, NHS, NOP2, YBX1, PI4KA, PLCB3, PRCC, RAB13, UPF1, RET, SRSF2, UAP1, SPTBN2, SSR1, TCOF1, TEC, ICAM5, TLN1, USP1, XRCC2, USP11, YARS, OASL, KRT75, GTF2IRD1, ARHGAP32, URB2, C2CD5, URB1, USP15, MPHOSPH6, TCIRG1, ABCA7, SYNCRIP, LAMTOR5, WWP2, TRIOBP, COBLL1, LMTK2, FNDC3A, MORC2, DIS3, RRP1B, FAF2, MED13L, DICER1, SIRT5, KLHDC2, RAB11FIP5, LSM14A, TXNDC11, FBXL19, APTX, PALMD, SSH3, UACA, RBM28, BRIX1, UFSP2, DNAJA4, DDX60, IPO9, UGGT2, BIN3, BAIAP2L1, ZC3HAV1, KIAA1191, FANCM, PAPD5, GPBP1, NOL6, MRPL24, ICE2, ZNF768, PEAK1, MRM1, MUS81, TSEN2, SBF2, PARP9, UTP15, USP32, TUBA1C, SLC25A25, MRPL55, EME1, CENPV, PDE12, TUBB, C2orf69, LEMD2, TMEM9, CDRT4, SH3PXD2B, NSMCE2, DDX51, MIA3, IRF3, FOXR1, PTPRN2, BACE1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP1A1_SORT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneATP1A1P05023DB00390DigoxinSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
HgeneATP1A1P05023DB00511AcetyldigitoxinSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
HgeneATP1A1P05023DB01078DeslanosideSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
HgeneATP1A1P05023DB01092OuabainSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
HgeneATP1A1P05023DB01119DiazoxideSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
HgeneATP1A1P05023DB01430AlmitrineSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved
HgeneATP1A1P05023DB00774HydroflumethiazideSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
HgeneATP1A1P05023DB00903Etacrynic acidSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
HgeneATP1A1P05023DB01188CiclopiroxSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
HgeneATP1A1P05023DB01345PotassiumSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
HgeneATP1A1P05023DB01370AluminiumSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
HgeneATP1A1P05023DB01396DigitoxinSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|investigational
HgeneATP1A1P05023DB01378MagnesiumSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|nutraceutical
HgeneATP1A1P05023DB01021TrichlormethiazideSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|vet_approved
HgeneATP1A1P05023DB01244BepridilSodium/potassium-transporting ATPase subunit alpha-1small moleculeapproved|withdrawn

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RelatedDiseases for ATP1A1_SORT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATP1A1C0001430Adenoma2CTD_human
HgeneATP1A1C0005586Bipolar Disorder1PSYGENET
HgeneATP1A1C0020428Hyperaldosteronism1CTD_human
HgeneATP1A1C0020538Hypertensive disease1CTD_human
HgeneATP1A1C0042594Vestibular Diseases1CTD_human
HgeneATP1A1C0151744Myocardial Ischemia1CTD_human
TgeneSORT1C0007222Cardiovascular Diseases1CTD_human
TgeneSORT1C1956346Coronary Artery Disease1CTD_human